PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11560868-1	2001	The antipsychotic agent risperidone, is metabolized by different cytochrome P-450 (CYP) enzymes, including CYP2D6, to the active 9-hydroxyrisperidone, which is the major metabolite in plasma.	Risperidone	24-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81	
11560868-1	2001	The antipsychotic agent risperidone, is metabolized by different cytochrome P-450 (CYP) enzymes, including CYP2D6, to the active 9-hydroxyrisperidone, which is the major metabolite in plasma.	Risperidone	24-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	83-86	
10422890-1	1999	The introduction of the atypical antipsychotics clozapine, risperidone, olanzapine, quetiapine and sertindole for the treatment of schizophrenia has coincided with an increased awareness of the potential of drug-drug interactions, particularly involving the cytochrome P450 (CYP) enzymes.	Risperidone	59-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	258-273	
10422890-1	1999	The introduction of the atypical antipsychotics clozapine, risperidone, olanzapine, quetiapine and sertindole for the treatment of schizophrenia has coincided with an increased awareness of the potential of drug-drug interactions, particularly involving the cytochrome P450 (CYP) enzymes.	Risperidone	59-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	275-278	
17381666-1	2007	BACKGROUND: Although cytochrome P450 (CYP) 2D6 is often thought to be the only CYP responsible for the metabolism of risperidone, many reports suggest that CYP3A may be involved too.	Risperidone	117-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-36	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-130	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	132-135	
25200585-10	2015	Clozapine and risperidone concentration-to-dose ratios are provided as two examples of this approach of how to integrate CYP genotyping and TDM in psychiatry.	Risperidone	14-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-124	
17381666-1	2007	BACKGROUND: Although cytochrome P450 (CYP) 2D6 is often thought to be the only CYP responsible for the metabolism of risperidone, many reports suggest that CYP3A may be involved too.	Risperidone	117-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-41	
17381666-1	2007	BACKGROUND: Although cytochrome P450 (CYP) 2D6 is often thought to be the only CYP responsible for the metabolism of risperidone, many reports suggest that CYP3A may be involved too.	Risperidone	117-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82	
12665390-6	2003	Atypical antipsychotics are metabolised predominantly by cytochrome p450 (CYP) isoenzymes, particularly CYP1A2 (clozapine and olanzapine), CYP3A4 (clozapine, quetiapine and ziprasidone) and CYP2D6 (olanzapine and risperidone).	Risperidone	213-224	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-72	
12665390-6	2003	Atypical antipsychotics are metabolised predominantly by cytochrome p450 (CYP) isoenzymes, particularly CYP1A2 (clozapine and olanzapine), CYP3A4 (clozapine, quetiapine and ziprasidone) and CYP2D6 (olanzapine and risperidone).	Risperidone	213-224	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	74-77