PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26491028-12	2016	Increased IL-6 levels may prime the expression of genes (AKT1, DICER1, DROSHA, and COMT) in response to risperidone, suggesting that cytokine x treatment x gene interactions may improve cell function profiles.	Risperidone	104-115	interleukin 6	Homo sapiens	10-14	
29902518-5	2018	Risperidone showed an anti-inflammatory activity, decreasing the release of tumor necrosis factor alpha (TNF-alpha), interleukins 1beta (IL-1 beta) and 6 (IL-6), and increasing interleukin 10 (IL-10).	Risperidone	0-11	interleukin 6	Homo sapiens	155-159	
26491028-9	2016	IL-6 levels significantly increased the risperidone-induced expression of AKT1, DICER1, DROSHA, and COMT mRNA.	Risperidone	40-51	interleukin 6	Homo sapiens	0-4	
32121312-6	2020	Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha.	Risperidone	0-11	interleukin 6	Homo sapiens	121-125	
29558759-5	2017	Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-beta, tumor necrosis factor (TNF)-alpha, and endothelin (ET)-1).	Risperidone	95-106	interleukin 6	Homo sapiens	239-243	
23981042-6	2013	Also, that APDs inhibited the production of LPS-stimulated macrophages IL-6 and IL-8 suggests that risperidone and clozapine may inhibit inflammation.	Risperidone	99-110	interleukin 6	Homo sapiens	71-75	
27337797-5	2015	After treating the schizophrenics with the neuroleptic risperidone for 6 months, the serum levels of HMGB1, IL-1beta, TNF-alpha and IL-6 were decreased.	Risperidone	55-66	interleukin 6	Homo sapiens	132-136	
23246638-8	2013	Moreover the antipsychotics, haloperidol and risperidone, were able to inhibit the secretion of S100B following IL-6 stimulation in C6 glioma cells.	Risperidone	45-56	interleukin 6	Homo sapiens	112-116	
22154580-7	2012	Risperidone increased the production of IL-10 and MDC as well as the proinflammatory cytokines, such as IL-6, IL-8, and TNF-alpha, but decreased the production of IP-10 and IL-12.	Risperidone	0-11	interleukin 6	Homo sapiens	104-108	
15886721-11	2005	In all, 12 weeks of risperidone treatment significantly decreased elevated cortisol and improved negative symptoms, but produced similar effects on IL-2 and IL-6 as well as on positive symptoms compared to haloperidol.	Risperidone	20-31	interleukin 6	Homo sapiens	157-161	
15567770-4	2004	RESULT: In patients treated with risperidone, the levels of serum IL-6 and IL-2 after 4 weeks, TNFalpha after 8 weeks, and IL-18 after 6 months were all significantly lowered in comparison with the pretreatment levels (P<0.01 or 0.05).	Risperidone	33-44	interleukin 6	Homo sapiens	66-70	
15567770-12	2004	CONCLUSION: Clozapine and risperidone have similar immunosuppression actions and may affect serum IL-6 levels in patients with paranoid schizophrenia, in the psychopathology of which the cytokines play their roles of various importance.	Risperidone	26-37	interleukin 6	Homo sapiens	98-102