PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26801169-0	2016	beta-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2/HO-1 Pathway in Rats.	caryophyllene	0-18	heme oxygenase 1	Rattus norvegicus	81-85	
26801169-11	2016	And the protein and mRNA expressions of Nrf2 and HO-1 were significantly up-regulated in the BCP pretreated I-R group.	caryophyllene	93-96	heme oxygenase 1	Rattus norvegicus	49-53	
26801169-13	2016	All the above suggested that BCP pretreatment played a neuroprotective role in cerebral I-R injury, which might be exerted by upregulating the expression of Nrf2 and HO-1 to ameliorate oxidative damage and neuronal apoptosis.	caryophyllene	29-32	heme oxygenase 1	Rattus norvegicus	166-170	
35550220-0	2022	beta-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats.	caryophyllene	0-18	heme oxygenase 1	Rattus norvegicus	110-114	
34314522-0	2021	Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by beta-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions.	caryophyllene	77-95	heme oxygenase 1	Rattus norvegicus	43-47	
34314522-6	2021	In the present study, we evaluated the anti-pseudo-allergic effects of beta-caryophyllene, an FDA approved food additive, in activating AdipoR1/AdipoR2 and Nrf2/HO-1 axis signaling pathway.	caryophyllene	71-89	heme oxygenase 1	Rattus norvegicus	161-165	
35550220-3	2022	PURPOSE: This research was to determine the existence of ferroptosis in the pathogenesis of acute ischemic stroke and investigate whether BCP can inhibit ferroptosis to improve cerebral ischemia injury by activating the NRF2/HO-1 signaling pathway in rats.	caryophyllene	138-141	heme oxygenase 1	Rattus norvegicus	225-229	
35550220-11	2022	We demonstrated that BCP evidently enhanced NRF2 nuclear translocation, activated the NRF2/HO-1 pathway, which protected against ferroptosis.	caryophyllene	21-24	heme oxygenase 1	Rattus norvegicus	91-95	
35550220-16	2022	For the first time, we showed that the significant neuroprotective effects of BCP in attenuating ischemic stroke injury are correlated with ferroptosis regulation, and its mechanism is associated with activation of the NRF2/HO-1 axis.	caryophyllene	78-81	heme oxygenase 1	Rattus norvegicus	224-228	
35621844-0	2022	beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways.	caryophyllene	0-18	heme oxygenase 1	Rattus norvegicus	114-117	
35621844-16	2022	CONCLUSION: BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFkappaB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses.	caryophyllene	12-15	heme oxygenase 1	Rattus norvegicus	66-69