PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35550220-0 2022 beta-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats. caryophyllene 0-18 heme oxygenase 1 Rattus norvegicus 110-114 26801169-0 2016 beta-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2/HO-1 Pathway in Rats. caryophyllene 0-18 heme oxygenase 1 Rattus norvegicus 81-85 26801169-11 2016 And the protein and mRNA expressions of Nrf2 and HO-1 were significantly up-regulated in the BCP pretreated I-R group. caryophyllene 93-96 heme oxygenase 1 Rattus norvegicus 49-53 26801169-13 2016 All the above suggested that BCP pretreatment played a neuroprotective role in cerebral I-R injury, which might be exerted by upregulating the expression of Nrf2 and HO-1 to ameliorate oxidative damage and neuronal apoptosis. caryophyllene 29-32 heme oxygenase 1 Rattus norvegicus 166-170 34314522-0 2021 Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by beta-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. caryophyllene 77-95 heme oxygenase 1 Rattus norvegicus 43-47 34314522-6 2021 In the present study, we evaluated the anti-pseudo-allergic effects of beta-caryophyllene, an FDA approved food additive, in activating AdipoR1/AdipoR2 and Nrf2/HO-1 axis signaling pathway. caryophyllene 71-89 heme oxygenase 1 Rattus norvegicus 161-165 35550220-3 2022 PURPOSE: This research was to determine the existence of ferroptosis in the pathogenesis of acute ischemic stroke and investigate whether BCP can inhibit ferroptosis to improve cerebral ischemia injury by activating the NRF2/HO-1 signaling pathway in rats. caryophyllene 138-141 heme oxygenase 1 Rattus norvegicus 225-229 35550220-11 2022 We demonstrated that BCP evidently enhanced NRF2 nuclear translocation, activated the NRF2/HO-1 pathway, which protected against ferroptosis. caryophyllene 21-24 heme oxygenase 1 Rattus norvegicus 91-95 35550220-16 2022 For the first time, we showed that the significant neuroprotective effects of BCP in attenuating ischemic stroke injury are correlated with ferroptosis regulation, and its mechanism is associated with activation of the NRF2/HO-1 axis. caryophyllene 78-81 heme oxygenase 1 Rattus norvegicus 224-228 35621844-0 2022 beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways. caryophyllene 0-18 heme oxygenase 1 Rattus norvegicus 114-117 35621844-16 2022 CONCLUSION: BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFkappaB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses. caryophyllene 12-15 heme oxygenase 1 Rattus norvegicus 66-69