PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34318533-0	2021	beta-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study.	caryophyllene	0-18	signal transducer and activator of transcription 3	Homo sapiens	88-94	
34318533-1	2021	The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism.	caryophyllene	59-77	signal transducer and activator of transcription 3	Homo sapiens	216-222	
34318533-1	2021	The current study aimed to explore the antitumor effect of beta-caryophyllene (BCP) on two different cell lines of T24 and 5637 human bladder cancer (BC) cells and its potential molecular mechanisms in inhibition of STAT-3/mTOR/AKT signaling pathways and the inductive process of apoptosis mechanism.	caryophyllene	79-82	signal transducer and activator of transcription 3	Homo sapiens	216-222	
32252311-0	2020	Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by beta-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention.	caryophyllene	81-99	signal transducer and activator of transcription 3	Homo sapiens	14-19	
32359221-0	2020	JAK1/STAT3 regulatory effect of beta-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation.	caryophyllene	32-50	signal transducer and activator of transcription 3	Homo sapiens	5-10	
32359221-7	2020	Our results also showed stimulation of Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway in bone cancer MG-63 cells upon BCP treatment along with the induction of proinflammatory genes at the messenger RNA level.	caryophyllene	168-171	signal transducer and activator of transcription 3	Homo sapiens	54-104	
32359221-7	2020	Our results also showed stimulation of Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) signaling pathway in bone cancer MG-63 cells upon BCP treatment along with the induction of proinflammatory genes at the messenger RNA level.	caryophyllene	168-171	signal transducer and activator of transcription 3	Homo sapiens	111-116	
32359221-8	2020	Overall results suggest that the treatment of MG-63 cells with BCP promotes apoptosis and inflammation via ROS and JAK1/STAT3 signaling pathway.	caryophyllene	63-66	signal transducer and activator of transcription 3	Homo sapiens	120-125	
32252311-6	2020	A lowered expression of doxorubicin-induced STAT3 activation was found in the presence of beta-caryophyllene in both cancer and normal cholangiocytes.	caryophyllene	90-108	signal transducer and activator of transcription 3	Homo sapiens	44-49	
32252311-8	2020	This evidence highlighted a possible role of STAT3 as a final effector of a complex network regulated by beta-caryophyllene, which leads to an enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and a lowered chemotherapy toxicity in nonmalignant cholangiocytes, thus strengthening the interest for this natural sesquiterpene as a dual-acting chemosensitizing and chemopreventive agent.	caryophyllene	105-123	signal transducer and activator of transcription 3	Homo sapiens	45-50