PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31610207-0	2019	beta-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway.	caryophyllene	0-18	toll-like receptor 4	Mus musculus	119-123	
31610207-1	2019	AIMS: The objective of the study was to determine whether beta-caryophyllene (BCP) exerts a neuroprotective effect in cerebral ischemia-reperfusion (I/R) injury by inhibiting microglial activation and modulating their polarization via the TLR4 pathway.	caryophyllene	58-76	toll-like receptor 4	Mus musculus	239-243	
31610207-1	2019	AIMS: The objective of the study was to determine whether beta-caryophyllene (BCP) exerts a neuroprotective effect in cerebral ischemia-reperfusion (I/R) injury by inhibiting microglial activation and modulating their polarization via the TLR4 pathway.	caryophyllene	78-81	toll-like receptor 4	Mus musculus	239-243	
29123466-11	2017	BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels.	caryophyllene	0-3	toll-like receptor 4	Mus musculus	54-74	
29123466-11	2017	BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels.	caryophyllene	0-3	toll-like receptor 4	Mus musculus	76-80	
31610207-6	2019	BCP inhibited the level of TLR4 in WT mice, and partially reduced neurologic deficits, infarct volume, and brain edema in TLR4 KO mice.	caryophyllene	0-3	toll-like receptor 4	Mus musculus	27-31	
31610207-6	2019	BCP inhibited the level of TLR4 in WT mice, and partially reduced neurologic deficits, infarct volume, and brain edema in TLR4 KO mice.	caryophyllene	0-3	toll-like receptor 4	Mus musculus	122-126	
31610207-7	2019	Importantly, BCP reduced the number of activated M1-type microglia and increased the number of M2-type microglia in the ipsilateral cortex of both WT and TLR4 KO mice.	caryophyllene	13-16	toll-like receptor 4	Mus musculus	154-158	
31610207-8	2019	In vitro, BCP decreased the secretion of proinflammatory cytokines induced by LPS plus IFN-gamma, downregulated the level of TLR4 protein, and polarized microglia towards the M2 phenotype.	caryophyllene	10-13	toll-like receptor 4	Mus musculus	125-129	
31610207-9	2019	SIGNIFICANCES: The decrease in TLR4 activity mediated, at least in part, the anti-inflammatory effects of BCP and its ability to shift microglia polarization from the M1 to M2 phenotype.	caryophyllene	106-109	toll-like receptor 4	Mus musculus	31-35	
28821008-7	2017	Notably, our results indicate that TC remarkably attenuated Abeta1-42-activated overexpression of toll-like receptor 4 (TLR4).	caryophyllene	35-37	toll-like receptor 4	Mus musculus	98-118	
28821008-7	2017	Notably, our results indicate that TC remarkably attenuated Abeta1-42-activated overexpression of toll-like receptor 4 (TLR4).	caryophyllene	35-37	toll-like receptor 4	Mus musculus	120-124	
19704783-8	2008	Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response.	caryophyllene	30-48	toll-like receptor 4	Mus musculus	134-138