PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9768595-9	1998	Pretreatment with IL-3 (1 to 10 ng/mL) markedly enhanced ionomycin (0.1 microg/mL)-mediated AA and LTC4 generation.	Ionomycin	57-66	interleukin 3	Homo sapiens	18-22	
7629513-2	1995	Ionomycin, but not IgE immune complexes, causes these cells to release serotonin and to express IL-3 and IL-13 mRNA, consistent with their being FC epsilon RI-deficient mast cells.	Ionomycin	0-9	interleukin 3	Homo sapiens	96-100	
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Ionomycin	103-112	interleukin 3	Homo sapiens	135-139	
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Ionomycin	103-112	interleukin 3	Homo sapiens	236-240	
9020523-5	1997	Treatment of the cells with the corticosteroid DEX at 10(-5) M but not 10(-6) M significantly reduced the ionomycin-induced expression of IL-3 but not IL-4 or IL-8 mRNA.	Ionomycin	106-115	interleukin 3	Homo sapiens	138-142	
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Ionomycin	131-140	interleukin 3	Homo sapiens	64-68	
7751024-3	1995	Stimulation of non-IL-4-treated cells with ionomycin (10 microM) for periods of 30 min to 8 hr induced expression of mRNA encoding IL-3, IL-4 and IL-8 but was without effect on levels of mRNA for tumour necrosis factor (TNF)-alpha or beta-actin.	Ionomycin	43-52	interleukin 3	Homo sapiens	131-135	
7631148-4	1995	After treatment with the phorbol ester TPA or the calcium ionophore ionomycin expression of several cytokines, i.e. IL-1 beta, IL-3, IL-6, GM-CSF, TNF-beta and PDGF-A, could be detected.	Ionomycin	68-77	interleukin 3	Homo sapiens	127-131	
7542063-3	1995	IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.	Ionomycin	28-37	interleukin 3	Homo sapiens	116-120	
7751024-5	1995	More notably, the IL-4 treatment produced a pronounced elevation of mRNA for IL-3 and IL-8 when the cells were subsequently activated with ionomycin.	Ionomycin	139-148	interleukin 3	Homo sapiens	77-81	
7751024-7	1995	Quantitation of cDNA by competitive polymerase chain reaction (PCR) revealed that the IL-4 treatment produced a sixfold increase in ionomycin-induced levels of cellular IL-3 mRNA, a fourfold increase in induced IL-8 mRNA and less than a twofold increase in induced IL-4 mRNA.	Ionomycin	132-141	interleukin 3	Homo sapiens	169-173	
7751024-8	1995	The IL-4 treatment led to a 15- to 20-fold increase in ionomycin-induced secretion of IL-3 product and a doubling of induced IL-8 product.	Ionomycin	55-64	interleukin 3	Homo sapiens	86-90	
8233727-11	1993	Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha.	Ionomycin	110-119	interleukin 3	Homo sapiens	192-196	
1718740-1	1991	IL-3 dependent mast cell lines produce cytokines in response to Fc receptor cross-linkage or to ionomycin.	Ionomycin	96-105	interleukin 3	Homo sapiens	0-4	
1875171-4	1991	Moreover, IL-3 and GM-CSF were measurable in ionomycin-stimulated eosinophil supernatants by immunoassay.	Ionomycin	45-54	interleukin 3	Homo sapiens	10-14	
2556442-4	1989	IL-3 expression could also be induced by costimulation of T cells with both phorbol ester and ionomycin, which are thought to mimic the intracellular effects of T cell receptor-antigen interaction.	Ionomycin	94-103	interleukin 3	Homo sapiens	0-4	
2676015-5	1989	On stimulation of BMCs with phorbol myristate acetate (PMA) and phytohemagglutinin or PMA and the calcium ionophore ionomycin, approximately 5% expressed GM-CSF mRNA and approximately 1% IL-3 mRNA.	Ionomycin	116-125	interleukin 3	Homo sapiens	187-191	
2676015-11	1989	Treatment of BMCs with high-dose interleukin-2 (IL-2) for 1 week followed by PMA plus ionomycin resulted in a lymphocyte population in which 50% and 3% of cells expressed GM-CSF and IL-3 mRNA, respectively.	Ionomycin	86-95	interleukin 3	Homo sapiens	182-186