PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11880263-2 2002 Previously, we demonstrated that ionomycin-, angiotensin II-, and thrombin-induced activation of extracellular signal-regulated kinase (ERK)1/2 in VSM cells was attenuated by pretreatment with KN-93, a selective inhibitor of the multifunctional Ca(2+)/calmodulin-dependent protein kinase (CaM kinase II). Ionomycin 33-42 coagulation factor II, thrombin Homo sapiens 66-74 11970839-0 2002 Ionomycin-induced neutrophil NADPH oxidase activity is selectively inhibited by the serine protease inhibitor diisopropyl fluorophosphate. Ionomycin 0-9 coagulation factor II, thrombin Homo sapiens 84-99 11389019-3 2001 Treatment of intact platelets with thrombin or the stable thromboxane A(2) analog STA(2) resulted in increased phosphorylation of both CPI and MBS at Thr-696, whereas phorbol myristate acetate (PMA) and the Ca(++) ionophore ionomycin only induced CPI phosphorylation. Ionomycin 224-233 coagulation factor II, thrombin Homo sapiens 35-43 10374640-6 1998 Depletion of intracellular Ca2+ store with ionomycin in the presence of EGTA, no increment in pHi was observed, the basal value of pHi was even more acidic, this response of pHi to thrombin was rehabilitated after refilling of intracellular Ca2+ store with extracellular Ca2+ 1 mmol.L-1. Ionomycin 43-52 coagulation factor II, thrombin Homo sapiens 181-189 9134653-5 1997 In contrast, with plasmin-pretreated platelets, aggregation and release of 14C-serotonin were strongly potentiated in response to low concentrations of the thrombin receptor-activating peptide SFLLRN, ADP, platelet-activating factor, collagen, arachidonic acid, the thromboxane mimetic U46619, and the calcium ionophores A23187 and ionomycin. Ionomycin 332-341 coagulation factor II, thrombin Homo sapiens 156-164 7592862-6 1995 Among stimuli tested (ionomycin, alpha-thrombin, phorbol ester, hyperosmotic stress, and platelet-derived growth factor) that are all known to activate NHE1, only ionomycin and thrombin induced a significant intracellular Ca2+ mobilization and early activation of 22Na+ uptake, implying that Ca2+ is a main regulator of NHE1 in the early phase of the agonist response. Ionomycin 22-31 coagulation factor II, thrombin Homo sapiens 177-185 8984102-4 1996 During the low salt diet, basal [Ca2+]i, thrombin-evoked maximal Ca2+ responses, irrespective of the presence of 1 mM extracellular Ca2+, and ionomycin-sensitive intracellular Ca2+ discharge capacity were similar in salt-sensitive and salt-resistant patients. Ionomycin 142-151 coagulation factor II, thrombin Homo sapiens 41-49 7592862-6 1995 Among stimuli tested (ionomycin, alpha-thrombin, phorbol ester, hyperosmotic stress, and platelet-derived growth factor) that are all known to activate NHE1, only ionomycin and thrombin induced a significant intracellular Ca2+ mobilization and early activation of 22Na+ uptake, implying that Ca2+ is a main regulator of NHE1 in the early phase of the agonist response. Ionomycin 163-172 coagulation factor II, thrombin Homo sapiens 39-47 8383434-6 1993 In cAMP-resistant, TG-blocked cells, ionomycin (or alpha-thrombin) induced a further elevation in [Ca2+]i, which then declined rapidly to the original basal level. Ionomycin 37-46 coagulation factor II, thrombin Homo sapiens 57-65 7666362-12 1995 Specifically, thrombin evokes an increase in intracellular [Ca2+] in the Muller cells; the Ca2+ chelator BAPTA blocks the effects of thrombin on both the inhibition of IK(IR) and the rise in intracellular [Ca2+]; exposure to ionomycin, a calcium ionophore, induces a reduction in the IK(IR) of Muller cells. Ionomycin 225-234 coagulation factor II, thrombin Homo sapiens 14-22 7666362-12 1995 Specifically, thrombin evokes an increase in intracellular [Ca2+] in the Muller cells; the Ca2+ chelator BAPTA blocks the effects of thrombin on both the inhibition of IK(IR) and the rise in intracellular [Ca2+]; exposure to ionomycin, a calcium ionophore, induces a reduction in the IK(IR) of Muller cells. Ionomycin 225-234 coagulation factor II, thrombin Homo sapiens 133-141 8011683-4 1994 Ionomycin together with 1-oleoyl-2-acetyl glycerol, a synthetic analog of diacylglycerols enhanced LAT activity in a similar degree to thrombin in the presence of LDL. Ionomycin 0-9 coagulation factor II, thrombin Homo sapiens 135-143 2378868-7 1990 In contrast to thrombin, stimulation of TMA-DPH-labeled platelets with the Ca2(+)-ionophore ionomycin results in a much larger increase in fluorescence intensity. Ionomycin 92-101 coagulation factor II, thrombin Homo sapiens 15-23 1537879-6 1992 Interestingly thrombin-stimulated cell proliferation measured by 3H thymidine incorporation was inhibited by 300 nM nicardipine, and restored by addition of 10(-8) M ionomycin, indicating that calcium entry was critical for the mitogenic signal of thrombin. Ionomycin 166-175 coagulation factor II, thrombin Homo sapiens 14-22 1537879-6 1992 Interestingly thrombin-stimulated cell proliferation measured by 3H thymidine incorporation was inhibited by 300 nM nicardipine, and restored by addition of 10(-8) M ionomycin, indicating that calcium entry was critical for the mitogenic signal of thrombin. Ionomycin 166-175 coagulation factor II, thrombin Homo sapiens 248-256 1900287-3 1991 Furthermore, the addition of thrombin after ionomycin or histamine lowered the raised Ca2+ back to near control levels. Ionomycin 44-53 coagulation factor II, thrombin Homo sapiens 29-37 1900287-7 1991 The mechanism by which thrombin lowers cytoplasmic Ca2+ is due mainly to inhibition of Ca2+ entry since thrombin prevented the stimulated influx of Mn2+ caused by histamine or ionomycin. Ionomycin 176-185 coagulation factor II, thrombin Homo sapiens 23-31 1900287-7 1991 The mechanism by which thrombin lowers cytoplasmic Ca2+ is due mainly to inhibition of Ca2+ entry since thrombin prevented the stimulated influx of Mn2+ caused by histamine or ionomycin. Ionomycin 176-185 coagulation factor II, thrombin Homo sapiens 104-112 2451743-6 1987 The addition of thrombin after ionomycin accelerated the decline in [Ca2+]i back towards basal levels, an action mimicked by phorbol myristate acetate (PMA). Ionomycin 31-40 coagulation factor II, thrombin Homo sapiens 16-24 2451743-9 1987 Ionomycin also promoted an efflux of 45Ca2+ which was increased by the subsequent addition of thrombin or PMA. Ionomycin 0-9 coagulation factor II, thrombin Homo sapiens 94-102 2846297-4 1988 The thrombin-induced enhancement of inositol phospholipid metabolism was strongly inhibited by the presence of neomycin whereas the TPA- or ionomycin-induced increase in inositol [32P]polyphospholipids remained unaffected. Ionomycin 140-149 coagulation factor II, thrombin Homo sapiens 4-12 3792558-4 1987 Thrombin added shortly after ionomycin could accelerate the recovery of [Ca2+]i and restore resting levels within 5 min, an effect that was mimicked by phorbol-12-myristate-13-acetate (PMA). Ionomycin 29-38 coagulation factor II, thrombin Homo sapiens 0-8 3792558-5 1987 Since the continued presence of ionomycin precluded reuptake into the internal stores we conclude that thrombin and PMA stimulate Ca2+ efflux, perhaps via protein kinase C actions on a plasma membrane Ca2+ pump. Ionomycin 32-41 coagulation factor II, thrombin Homo sapiens 103-111