PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15930030-0	2005	Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line.	Ionomycin	0-9	hepatocyte nuclear factor 4 alpha	Homo sapiens	37-40	
15930030-3	2005	Reporter gene assay showed that ionomycin inhibited beta-catenin/Tcf signaling efficiently.	Ionomycin	32-41	hepatocyte nuclear factor 4 alpha	Homo sapiens	65-68	
15930030-4	2005	In addition, the inhibition of beta-catenin/Tcf signaling by ionomycin in HEK293 cells transiently transfected with a constitutively mutant beta-catenin gene, whose product is not phosphorylated by GSK3beta, indicates that its inhibitory mechanism is related to beta-catenin itself or downstream components.	Ionomycin	61-70	hepatocyte nuclear factor 4 alpha	Homo sapiens	44-47	
15930030-7	2005	Moreover, ionomycin strongly suppressed the binding of the Tcf complexes to its specific DNA-binding sites.	Ionomycin	10-19	hepatocyte nuclear factor 4 alpha	Homo sapiens	59-62	
15930030-8	2005	The significance of the current work is that ionomycin is a negative regulator of beta-catenin/Tcf signaling in colon cancer cells and its inhibitory mechanism is related to the decreased nuclear beta-catenin products and to the suppressed binding of Tcf complexes to consensus DNA.	Ionomycin	45-54	hepatocyte nuclear factor 4 alpha	Homo sapiens	95-98	
15930030-8	2005	The significance of the current work is that ionomycin is a negative regulator of beta-catenin/Tcf signaling in colon cancer cells and its inhibitory mechanism is related to the decreased nuclear beta-catenin products and to the suppressed binding of Tcf complexes to consensus DNA.	Ionomycin	45-54	hepatocyte nuclear factor 4 alpha	Homo sapiens	251-254	
15492240-8	2004	Treatment of MCF-7 cells with ionomycin led to increased accumulation of beta-cat(75) in the nucleus and TCF-dependent transcriptional activity.	Ionomycin	30-39	hepatocyte nuclear factor 4 alpha	Homo sapiens	105-108	
28551638-5	2017	Ionomycin was used to inhibit beta-catenin/T-cell-specific transcription factor (TCF) association, essential in HA-CD44-ERBB2 signaling.	Ionomycin	0-9	hepatocyte nuclear factor 4 alpha	Homo sapiens	30-79	
28551638-5	2017	Ionomycin was used to inhibit beta-catenin/T-cell-specific transcription factor (TCF) association, essential in HA-CD44-ERBB2 signaling.	Ionomycin	0-9	hepatocyte nuclear factor 4 alpha	Homo sapiens	81-84