PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28551638-5 2017 Ionomycin was used to inhibit beta-catenin/T-cell-specific transcription factor (TCF) association, essential in HA-CD44-ERBB2 signaling. Ionomycin 0-9 hepatocyte nuclear factor 4 alpha Homo sapiens 30-79 28551638-5 2017 Ionomycin was used to inhibit beta-catenin/T-cell-specific transcription factor (TCF) association, essential in HA-CD44-ERBB2 signaling. Ionomycin 0-9 hepatocyte nuclear factor 4 alpha Homo sapiens 81-84 15930030-0 2005 Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. Ionomycin 0-9 hepatocyte nuclear factor 4 alpha Homo sapiens 37-40 15930030-3 2005 Reporter gene assay showed that ionomycin inhibited beta-catenin/Tcf signaling efficiently. Ionomycin 32-41 hepatocyte nuclear factor 4 alpha Homo sapiens 65-68 15930030-4 2005 In addition, the inhibition of beta-catenin/Tcf signaling by ionomycin in HEK293 cells transiently transfected with a constitutively mutant beta-catenin gene, whose product is not phosphorylated by GSK3beta, indicates that its inhibitory mechanism is related to beta-catenin itself or downstream components. Ionomycin 61-70 hepatocyte nuclear factor 4 alpha Homo sapiens 44-47 15930030-7 2005 Moreover, ionomycin strongly suppressed the binding of the Tcf complexes to its specific DNA-binding sites. Ionomycin 10-19 hepatocyte nuclear factor 4 alpha Homo sapiens 59-62 15930030-8 2005 The significance of the current work is that ionomycin is a negative regulator of beta-catenin/Tcf signaling in colon cancer cells and its inhibitory mechanism is related to the decreased nuclear beta-catenin products and to the suppressed binding of Tcf complexes to consensus DNA. Ionomycin 45-54 hepatocyte nuclear factor 4 alpha Homo sapiens 95-98 15930030-8 2005 The significance of the current work is that ionomycin is a negative regulator of beta-catenin/Tcf signaling in colon cancer cells and its inhibitory mechanism is related to the decreased nuclear beta-catenin products and to the suppressed binding of Tcf complexes to consensus DNA. Ionomycin 45-54 hepatocyte nuclear factor 4 alpha Homo sapiens 251-254 15492240-8 2004 Treatment of MCF-7 cells with ionomycin led to increased accumulation of beta-cat(75) in the nucleus and TCF-dependent transcriptional activity. Ionomycin 30-39 hepatocyte nuclear factor 4 alpha Homo sapiens 105-108