PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18281166-7 2008 Exogenous addition of ionomycin rescued both the IL-8 protein levels and phosphorylation of p38 MAP kinase inhibited by Trp-P-1. Ionomycin 22-31 mitogen-activated protein kinase 14 Homo sapiens 92-95 19766325-8 2009 Patients with HAM/TSP had a higher p38/ERK ratio (p<0.05) associated with a reduced response to mitogens (phytohaemagglutinin or PMA+ionomycin) (p<0.001) and higher sensitivity to dexamethasone (p<0.05). Ionomycin 136-145 mitogen-activated protein kinase 14 Homo sapiens 35-38 10652349-5 2000 Moreover, we found that overexpression of JNK, ERK, or p38 is able to block ionomycin-induced NFATc nuclear translocation, whereas treatment of cells with both PD98059 and SB202190, which inhibit MAPK/SAPK signaling pathways, is sufficient to trigger NFATc nuclear localization. Ionomycin 76-85 mitogen-activated protein kinase 14 Homo sapiens 55-58 11401859-0 2001 Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Ionomycin 0-9 mitogen-activated protein kinase 14 Homo sapiens 31-34 11401859-5 2001 Dual phosphorylation of p38 MAP kinase and phosphorylation of its substrate activating transcription factor-2 were detected at ionomycin concentrations that prime or activate the PMN oxidase, while dual phosphorylation of p42/44 MAP kinase and phosphorylation of its substrate Elk-1 were elicited at 0.2-2 microM. Ionomycin 127-136 mitogen-activated protein kinase 14 Homo sapiens 24-38 11401859-6 2001 SB-203580, a p38 MAP kinase antagonist, inhibited ionomycin-induced activation of the oxidase (68 +/- 8%, P < 0.05) and tyrosine phosphorylation of 105- and 72-kDa proteins; conversely, PD-98059, an inhibitor of MAP/extracellular signal-related kinase 1, had no effect. Ionomycin 50-59 mitogen-activated protein kinase 14 Homo sapiens 13-27 11401859-8 2001 Chelation of cytosolic but not extracellular Ca2+ completely inhibited ionomycin activation of p38 MAP kinase, whereas chelation of extracellular Ca2+ abrogated activation of p42/44 MAP kinase. Ionomycin 71-80 mitogen-activated protein kinase 14 Homo sapiens 95-109 15263067-6 2004 CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment. Ionomycin 51-60 mitogen-activated protein kinase 14 Homo sapiens 69-72 12758252-6 2003 Using human primary lymphocytes and Jurkat CD4(+) T cells stimulated with PMA/ionomycin, we demonstrate activation (phosphorylation) of JNK and p38, which is further confirmed by two additional established techniques (WB and confocal microscopy). Ionomycin 78-87 mitogen-activated protein kinase 14 Homo sapiens 144-147 9933633-8 1999 Selective inhibition of one or more MAPK pathways impairs TNF-alpha induction by TPA/ionomycin, indicating a cooperation between these signal transduction pathways. Ionomycin 85-94 mitogen-activated protein kinase 14 Homo sapiens 36-40 10518804-3 1999 In these primary human cells, CsA significantly inhibited PMA/ionomycin-mediated and ionomycin-mediated activation of the MAPK kinase MKK6, as well as its downstream kinases SAPK2a (p38alpha) and MAPKAP-K2. Ionomycin 85-94 mitogen-activated protein kinase 14 Homo sapiens 182-190 9553058-4 1998 TPA/ionomycin treatment of T cells stimulates both mitogen-activated ERK, as well as the stress-activated mitogen-activated protein kinase family members JNK/SAPK and p38. Ionomycin 4-13 mitogen-activated protein kinase 14 Homo sapiens 167-170 31295519-10 2019 Thapsigargin or ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-alpha-induced NF-kappaB phosphorylation. Ionomycin 16-25 mitogen-activated protein kinase 14 Homo sapiens 45-48 9469462-3 1998 Protein phosphorylation analysis of cellular MAP kinases indicates that exposure of human neutrophils to chemotactic factor FMLP as well as granulocyte-macrophage CSF, PMA, or ionomycin rapidly induced the activation of p38 and p44/42 MAP kinases, but stimulation with inflammatory cytokine TNF-alpha triggered the activation of p38 MAP kinase only. Ionomycin 176-185 mitogen-activated protein kinase 14 Homo sapiens 220-223 9469462-3 1998 Protein phosphorylation analysis of cellular MAP kinases indicates that exposure of human neutrophils to chemotactic factor FMLP as well as granulocyte-macrophage CSF, PMA, or ionomycin rapidly induced the activation of p38 and p44/42 MAP kinases, but stimulation with inflammatory cytokine TNF-alpha triggered the activation of p38 MAP kinase only. Ionomycin 176-185 mitogen-activated protein kinase 14 Homo sapiens 329-343 9469462-7 1998 Moreover, RIA indicates that the activation of cellular p38 MAP kinase was required for the neutrophil IL-8 production stimulated by granulocyte-macrophage CSF or LPS as well as TNF-alpha, but not for that induced by PMA or ionomycin. Ionomycin 224-233 mitogen-activated protein kinase 14 Homo sapiens 56-70 8943018-5 1996 The calcium ionophore ionomycin, which also induces apoptosis in B104 cells, stimulated a similar SAPK and p38 MAPK response. Ionomycin 22-31 mitogen-activated protein kinase 14 Homo sapiens 107-110 8943018-6 1996 Cyclosporin A, a potent inhibitor of apoptosis induced by either mIgM or ionomycin, inhibited activation of both SAPK and p38 MAPK, suggesting that stimulation of these kinases may be required for induction of apoptosis. Ionomycin 73-82 mitogen-activated protein kinase 14 Homo sapiens 122-125 22569127-5 2012 Oxidative stress and ionomycin also induce p38-mediated phosphorylation of p57 and cells lacking p38 or p57 display reduced viability to these stresses. Ionomycin 21-30 mitogen-activated protein kinase 14 Homo sapiens 97-100 29170390-4 2017 Stimulation with CD3/CD28, PMA/ionomycin, or latency reversing agents prostratin and SAHA, yielded increased phosphorylation of IkappaBalpha, ERK, p38, and JNK in HIV-infected cells across two in vitro latency models. Ionomycin 31-40 mitogen-activated protein kinase 14 Homo sapiens 147-150 22569127-5 2012 Oxidative stress and ionomycin also induce p38-mediated phosphorylation of p57 and cells lacking p38 or p57 display reduced viability to these stresses. Ionomycin 21-30 mitogen-activated protein kinase 14 Homo sapiens 43-46