PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19491923-5 2009 Ca2+ accumulation induced with high [K+] (to open voltage-gated calcium channels) or ionomycin (a Ca2+ ionophore) caused a moderate neuronal injury that was reduced significantly by the application of the Zn2+ chelator N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN). Ionomycin 85-94 carbonic anhydrase 2 Rattus norvegicus 0-3 29247648-3 2018 We used calcium ionophore ionomycin to raise intracellular cytosolic Ca2+ level to explore the underlying mechanism. Ionomycin 26-35 carbonic anhydrase 2 Rattus norvegicus 69-72 19491923-5 2009 Ca2+ accumulation induced with high [K+] (to open voltage-gated calcium channels) or ionomycin (a Ca2+ ionophore) caused a moderate neuronal injury that was reduced significantly by the application of the Zn2+ chelator N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN). Ionomycin 85-94 carbonic anhydrase 2 Rattus norvegicus 98-101 9083261-4 1997 After ACh or TG, ionomycin elicited a further Ca2+ release. Ionomycin 17-26 carbonic anhydrase 2 Rattus norvegicus 46-49 9688860-2 1998 In SPOC1 cells, the mobilization of intracellular Ca2+ by ionomycin or the activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) stimulates mucin secretion in a fully additive fashion [L. H. Abdullah, J. D. Conway, J. Ionomycin 58-67 carbonic anhydrase 2 Rattus norvegicus 50-53 7525020-1 1994 The neurotoxicity of ionomycin, a Ca2+ ionophore, was investigated in cultured cortical neurons from embryonic rats. Ionomycin 21-30 carbonic anhydrase 2 Rattus norvegicus 34-37 8641741-7 1996 Ionomycin (5 micromol/L)-stimulated [Ca2+]i rise was similar in WKY, SHR, and SHRSP (731 +/- 97, 743 +/- 88, and 683 +/- 70 nmol/L, respectively). Ionomycin 0-9 carbonic anhydrase 2 Rattus norvegicus 37-40 2531141-5 1989 These results suggested that during antigen stimulation of cells under normal physiological conditions, release of Ca2+ from intracellular stores makes an important contribution to the initial increase in [Ca2+]i. Oscillations in [Ca2+]i are not induced by elevating [Ca2+]i with the calcium ionophore ionomycin. Ionomycin 302-311 carbonic anhydrase 2 Rattus norvegicus 115-118 8393065-7 1993 Raising intracellular Ca2+ by addition of 2 microM ionomycin mimicked the effect of pump inhibition on K+ channel activity. Ionomycin 51-60 carbonic anhydrase 2 Rattus norvegicus 22-25 1743757-2 1991 In the present study, we compared the platelet intracellular Ca2+ response to the receptor-linked agonist thrombin with the response to the Ca2+ ionophore ionomycin. Ionomycin 155-164 carbonic anhydrase 2 Rattus norvegicus 140-143 1743757-5 1991 In contrast, the peak platelet intracellular Ca2+ response to ionomycin (50 nM and 5 microM) was not different between the two strains, and the rate of recovery from the peak response was only slightly depressed in hypertensive rats after the low dose of ionomycin. Ionomycin 62-71 carbonic anhydrase 2 Rattus norvegicus 45-48 1743757-6 1991 Internal Ca2+ discharge capacity, assessed by the intracellular Ca2+ response to a maximal dose of ionomycin in Ca(2+)-free medium, was not different between platelets of the two strains. Ionomycin 99-108 carbonic anhydrase 2 Rattus norvegicus 64-67 8142369-4 1994 Addition of the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol 13-acetate (TPA), or the Ca2+ ionophore, ionomycin, mimicked the profile of GnRH-induced alpha and LH beta mRNA elevation. Ionomycin 117-126 carbonic anhydrase 2 Rattus norvegicus 101-104 2531141-5 1989 These results suggested that during antigen stimulation of cells under normal physiological conditions, release of Ca2+ from intracellular stores makes an important contribution to the initial increase in [Ca2+]i. Oscillations in [Ca2+]i are not induced by elevating [Ca2+]i with the calcium ionophore ionomycin. Ionomycin 302-311 carbonic anhydrase 2 Rattus norvegicus 206-209 2531141-5 1989 These results suggested that during antigen stimulation of cells under normal physiological conditions, release of Ca2+ from intracellular stores makes an important contribution to the initial increase in [Ca2+]i. Oscillations in [Ca2+]i are not induced by elevating [Ca2+]i with the calcium ionophore ionomycin. Ionomycin 302-311 carbonic anhydrase 2 Rattus norvegicus 206-209 2531141-5 1989 These results suggested that during antigen stimulation of cells under normal physiological conditions, release of Ca2+ from intracellular stores makes an important contribution to the initial increase in [Ca2+]i. Oscillations in [Ca2+]i are not induced by elevating [Ca2+]i with the calcium ionophore ionomycin. Ionomycin 302-311 carbonic anhydrase 2 Rattus norvegicus 206-209 2984215-4 1985 Cells incubated in Ca2+-free medium were depleted of their cytoplasmic Ca2+ stores by pretreatment with ionomycin. Ionomycin 104-113 carbonic anhydrase 2 Rattus norvegicus 19-22 3026361-12 1986 In intact cells, [3H]IP3 formation was stimulated when ionomycin was used to increase the cytosolic free [Ca2+]. Ionomycin 55-64 carbonic anhydrase 2 Rattus norvegicus 106-109 2478028-4 1989 Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx. Ionomycin 231-240 carbonic anhydrase 2 Rattus norvegicus 92-95 2478028-4 1989 Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx. Ionomycin 231-240 carbonic anhydrase 2 Rattus norvegicus 147-150 2478028-4 1989 Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx. Ionomycin 231-240 carbonic anhydrase 2 Rattus norvegicus 147-150 2478028-4 1989 Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx. Ionomycin 231-240 carbonic anhydrase 2 Rattus norvegicus 147-150 2478028-4 1989 Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx. Ionomycin 231-240 carbonic anhydrase 2 Rattus norvegicus 147-150 6813324-2 1982 A23187 and ionomycin cause the release of Ca2+, Mg2+, and K+ from the mitochondrial matrix. Ionomycin 11-20 carbonic anhydrase 2 Rattus norvegicus 42-45 6813324-5 1982 A23187 and ionomycin differ in their affinities for CA2+ and Mg2+, having relative affinity ratios (Ca2+/Mg2+) in respiring mitochondria of 3 and 35, respectively. Ionomycin 11-20 carbonic anhydrase 2 Rattus norvegicus 52-55 6813324-5 1982 A23187 and ionomycin differ in their affinities for CA2+ and Mg2+, having relative affinity ratios (Ca2+/Mg2+) in respiring mitochondria of 3 and 35, respectively. Ionomycin 11-20 carbonic anhydrase 2 Rattus norvegicus 100-103 6766939-2 1980 Based on the effects of ionomycin upon mitochondrial respiration, ionomycin was shown to be an effective ionophore for Ca2+ in rat liver mitochondria. Ionomycin 66-75 carbonic anhydrase 2 Rattus norvegicus 119-122 6766939-3 1980 The ionomycin-induced efflux of Ca2+ across the inner membrane was more sensitive to loading the mitochondria with Ca2+ than was efflux catalyzed by A23187. Ionomycin 4-13 carbonic anhydrase 2 Rattus norvegicus 32-35 6766939-3 1980 The ionomycin-induced efflux of Ca2+ across the inner membrane was more sensitive to loading the mitochondria with Ca2+ than was efflux catalyzed by A23187. Ionomycin 4-13 carbonic anhydrase 2 Rattus norvegicus 115-118 6766939-4 1980 At saturating concentrations of Ca2+, the turnover number for ionomycin was 3- to 5-fold greater than that of A23187. Ionomycin 62-71 carbonic anhydrase 2 Rattus norvegicus 32-35