PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23017670-4 2013 Sixteen hours PMA/Ionomycin stimulation induced iTreg subsets with the phenotype CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) co-expressing CD95, CD152, CD178, CD279, Granzyme A, Granzyme B, Perforin, IL-10, and TGFbeta(1). Ionomycin 18-27 interleukin 10 Homo sapiens 234-239 28157399-5 2017 After PMA+ionomycin stimulation, CXCR5+ CD8+ T cells from CHB patients presented significantly higher transcription level of interferon gamma (IFN-gamma), interleukin 10 (IL-10), and IL-21, as well as higher IL-10 and IL-21 protein secretion, than CXCR5- CD8+ T cells. Ionomycin 10-19 interleukin 10 Homo sapiens 155-169 28157399-5 2017 After PMA+ionomycin stimulation, CXCR5+ CD8+ T cells from CHB patients presented significantly higher transcription level of interferon gamma (IFN-gamma), interleukin 10 (IL-10), and IL-21, as well as higher IL-10 and IL-21 protein secretion, than CXCR5- CD8+ T cells. Ionomycin 10-19 interleukin 10 Homo sapiens 171-176 28157399-5 2017 After PMA+ionomycin stimulation, CXCR5+ CD8+ T cells from CHB patients presented significantly higher transcription level of interferon gamma (IFN-gamma), interleukin 10 (IL-10), and IL-21, as well as higher IL-10 and IL-21 protein secretion, than CXCR5- CD8+ T cells. Ionomycin 10-19 interleukin 10 Homo sapiens 208-213 26836805-13 2016 The frequencies of B10 cells were similar in the three groups, irrespective of whether IL-10 was induced by a combination of phorbol 12-myristate 13-acetate (PMA) and ionomycin, by CpG oligodeoxynucletodies (ODN) 2006, or by TG. Ionomycin 167-176 interleukin 10 Homo sapiens 87-92 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Ionomycin 44-53 interleukin 10 Homo sapiens 67-72 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Ionomycin 163-172 interleukin 10 Homo sapiens 67-72 22192260-5 2011 In the presence of phorbol-12-myristate-13-acetate-ionomycin, with or without CAPE treatment, the asthmatic children showed significantly decreased levels of IL-10 secretion compared with the healthy controls. Ionomycin 51-60 interleukin 10 Homo sapiens 158-163 21646795-8 2011 Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin. Ionomycin 136-145 interleukin 10 Homo sapiens 71-76 12508773-3 2002 IL-2, IL-10, and IFN-gamma expression was determined in PMA + ionomycin stimulated T cells on the single cell level. Ionomycin 62-71 interleukin 10 Homo sapiens 6-11 15096183-8 2004 Cyclic-AMP augmented IL-10 production and cAMP response element binding protein activation upon stimulation by PMA/ionomycin. Ionomycin 115-124 interleukin 10 Homo sapiens 21-26 14680506-9 2003 Interestingly, macrophages stimulated with phorbol 12-myristate 13-acetate/ionomycin displayed an augmented IL-10 response upon addition of dibutyryl cAMP, with corresponding downregulation in TNF-alpha, suggesting a complex interaction between protein kinase C and protein kinase A in cytokine regulation. Ionomycin 75-84 interleukin 10 Homo sapiens 108-113 18023089-6 2007 Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin. Ionomycin 165-174 interleukin 10 Homo sapiens 63-77 18023089-6 2007 Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin. Ionomycin 165-174 interleukin 10 Homo sapiens 79-84 18023089-11 2007 Interestingly, approximately 4% of mucosal NKR(+) T cells expressing IL-10 were detected by in vitro stimulation with PMA and ionomycin. Ionomycin 126-135 interleukin 10 Homo sapiens 69-74 16265694-5 2005 Intracellular staining of interleukin 10 (IL-10) was performed after stimulation with PMA and ionomycin. Ionomycin 94-103 interleukin 10 Homo sapiens 26-40 16265694-5 2005 Intracellular staining of interleukin 10 (IL-10) was performed after stimulation with PMA and ionomycin. Ionomycin 94-103 interleukin 10 Homo sapiens 42-47 16265694-8 2005 PD-1-positive SS salivary lymphocytes expressed IL-10 intracellularly upon PMA/ionomycin stimulation. Ionomycin 79-88 interleukin 10 Homo sapiens 48-53 15010730-5 2004 RESULTS: A kinetic study in healthy controls showed that stimulation with phorbol 12-myristate 13-acetate and ionomycin significantly increased the frequencies of IL-10-producing CD3+, CD4+ and CD8+ cells. Ionomycin 110-119 interleukin 10 Homo sapiens 163-168 11113096-7 2000 Upon in vitro stimulation with PDB/ionomycin, they showed predominantly interferon gamma and interleukin (IL)-4 but also tumor necrosis factor alpha and IL-10 production and did not specifically lyse autologous T-cell blasts, B-cell lines, or other autologous or allogeneic target or CD1d-transfected cells. Ionomycin 35-44 interleukin 10 Homo sapiens 153-158 11678905-4 2001 Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13. Ionomycin 47-56 interleukin 10 Homo sapiens 121-126 12051768-7 2002 By contrast, PBLs stimulated with PHA or PMA + ionomycin showed a biphasic expression with a sharp increase at 6 h. This induction was closely parallel to IFN-gamma expression and partially to IL-4 and IL-10. Ionomycin 47-56 interleukin 10 Homo sapiens 202-207 8233727-11 1993 Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha. Ionomycin 110-119 interleukin 10 Homo sapiens 204-209 10929069-8 2000 In response to ionomycin and dibutyryl cAMP, cord blood cells were more prone than adult lymphocytes to secrete the T helper type 2-derived immunosuppressive cytokines IL-4 and IL-10. Ionomycin 15-24 interleukin 10 Homo sapiens 177-182 9518518-9 1998 Additionally, IL-10 mRNA transcription could be induced in U937 cells without pulse application by means of the calcium ionophore ionomycin. Ionomycin 130-139 interleukin 10 Homo sapiens 14-19 9518518-11 1998 However, down-regulation of TNF-alpha mRNA levels after ionomycin stimulation provided an indirect proof that IL-10 protein production occurred. Ionomycin 56-65 interleukin 10 Homo sapiens 110-115 8625537-9 1996 Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures. Ionomycin 131-140 interleukin 10 Homo sapiens 82-87 7909823-6 1994 Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10. Ionomycin 86-95 interleukin 10 Homo sapiens 165-170 10328864-7 1999 Naive CD4(+)and CD8(+)T cells were sensitive to the PKA regulatory pathway since they represent a significant source of IL-10 when PBMC were first cultured with ionomycin/PMA in the presence of either PGE2 or db-cAMP. Ionomycin 161-170 interleukin 10 Homo sapiens 120-125 7905497-7 1994 In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells. Ionomycin 48-57 interleukin 10 Homo sapiens 113-118