PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Ionomycin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	196-200	
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Ionomycin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	175-179	
20538801-4	2010	WPBs could also contain tPA, and in IL-1beta-treated cells, IL-8, IL-6, MCP-1, and GRO-alpha, and were the primary source for histamine or ionomycin-stimulated secretion of these molecules.	Ionomycin	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	60-64	
18281166-7	2008	Exogenous addition of ionomycin rescued both the IL-8 protein levels and phosphorylation of p38 MAP kinase inhibited by Trp-P-1.	Ionomycin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	49-53	
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	Ionomycin	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p < 0.05).	Ionomycin	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	145-149	
21969073-10	2012	Finally, the destabilization effect of isoeugenol on IL-8 mRNA expression together with SOCS-3 expression resulted in an anti-inflammatory effect, as demonstrated by the ability of isoeugenol to modulate LPS or ionomycin-induced cytokine release.	Ionomycin	211-220	C-X-C motif chemokine ligand 8	Homo sapiens	53-57	
17166736-5	2006	In PMA/ionomycin stimulated cells, pre-incubated with increasing concentrations of NIV, transcription was induced in the range 0.06-2 microM; higher concentrations of NIV were found non-stimulating (4 microM) or inhibitory (8 microM) for IFNgamma and IL-2 whereas IL-8 was still induced.	Ionomycin	7-16	C-X-C motif chemokine ligand 8	Homo sapiens	264-268	
9449504-5	1998	DEX also dampened formyl-methionyl-leucyl-phenylalanine-or ionomycin-induced eosinophil IL-8 production.	Ionomycin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	88-92	
9469462-7	1998	Moreover, RIA indicates that the activation of cellular p38 MAP kinase was required for the neutrophil IL-8 production stimulated by granulocyte-macrophage CSF or LPS as well as TNF-alpha, but not for that induced by PMA or ionomycin.	Ionomycin	224-233	C-X-C motif chemokine ligand 8	Homo sapiens	103-107	
9758900-0	1998	Suppressive effects of SP-A on ionomycin-induced IL-8 production and release by eosinophils.	Ionomycin	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53	
9473671-6	1998	Glutathione depletion also potentiated the inhibition by H2O2 of carbachol- or G-protein (NaF)-stimulated phosphoinositide hydrolysis, whereas phospholipase C activated by the calcium ionophore ionomycin was not inhibited.	Ionomycin	194-203	C-X-C motif chemokine ligand 8	Homo sapiens	90-93	
7542063-3	1995	IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.	Ionomycin	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	178-182	
9363923-3	1997	IL-8 secretion increased in a time-dependent manner throughout the 24 h of observation; in contrast, EDN release reached a plateau value after 12 h. Furthermore, at least 2 microM ionomycin was necessary for induction of IL-8 secretion, whereas 0.5 microM induced detectable EDN release by eosinophils.	Ionomycin	180-189	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
9363923-3	1997	IL-8 secretion increased in a time-dependent manner throughout the 24 h of observation; in contrast, EDN release reached a plateau value after 12 h. Furthermore, at least 2 microM ionomycin was necessary for induction of IL-8 secretion, whereas 0.5 microM induced detectable EDN release by eosinophils.	Ionomycin	180-189	C-X-C motif chemokine ligand 8	Homo sapiens	221-225	
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Ionomycin	103-112	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Ionomycin	103-112	C-X-C motif chemokine ligand 8	Homo sapiens	245-249	
8385495-5	1993	This inhibitory effect of NaF on Ca2+ influx occurred after a lag of at least 30 s. However, Ca2+ influx induced by ionomycin-induced Ca2+ depletion or by thapsigargin, a Ca(2+)-ATPase inhibitor, was only partially suppressed by NaF treatment.	Ionomycin	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	26-29	
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Ionomycin	219-228	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Ionomycin	219-228	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
7510691-3	1994	By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.	Ionomycin	142-151	C-X-C motif chemokine ligand 8	Homo sapiens	39-43	
7510691-7	1994	Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.	Ionomycin	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	243-247	
7751024-3	1995	Stimulation of non-IL-4-treated cells with ionomycin (10 microM) for periods of 30 min to 8 hr induced expression of mRNA encoding IL-3, IL-4 and IL-8 but was without effect on levels of mRNA for tumour necrosis factor (TNF)-alpha or beta-actin.	Ionomycin	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	146-150	
7751024-5	1995	More notably, the IL-4 treatment produced a pronounced elevation of mRNA for IL-3 and IL-8 when the cells were subsequently activated with ionomycin.	Ionomycin	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	86-90	
8385495-5	1993	This inhibitory effect of NaF on Ca2+ influx occurred after a lag of at least 30 s. However, Ca2+ influx induced by ionomycin-induced Ca2+ depletion or by thapsigargin, a Ca(2+)-ATPase inhibitor, was only partially suppressed by NaF treatment.	Ionomycin	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	229-232	
1827816-3	1991	However T cells stimulated with a combination of PMA and ionomycin or PMA and PHA expressed IL-8 mRNA in a PMA dose-dependent manner and maximally after 3 to 6 h of culture.	Ionomycin	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	92-96	
7901957-15	1993	We showed that mRNA for IL-8 could be expressed in highly purified T lymphocytes only upon stimulation with ionomycin and PHA or PMA and PHA, and to a lesser extent PMA and IL-2.	Ionomycin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	24-28	
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Ionomycin	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	121-125	
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Ionomycin	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	183-187	
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Ionomycin	99-108	C-X-C motif chemokine ligand 8	Homo sapiens	72-77	
31620139-9	2019	Within Bangladeshi 1-year-olds, stunting (as measured by height-for-age z-scores) was found to be associated with IL-8 and TGFbeta expression in PMA-ionomycin stimulated samples.	Ionomycin	145-158	C-X-C motif chemokine ligand 8	Homo sapiens	114-118	
32840447-12	2020	A limited amount of IL-6 and IL-8 was released by ionomycin-exposed HMC-1 cells.	Ionomycin	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	29-33	
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Ionomycin	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	186-190	
28671563-5	2017	The results showed that I3C and DIM pretreatment, at higher concentrations of 50 and 10 muM, respectively, significantly increased PMA/ionomycin-induced interleukin-2 (IL-2), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) production, measured by real time polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA).	Ionomycin	135-144	C-X-C motif chemokine ligand 8	Homo sapiens	175-188	
28671563-5	2017	The results showed that I3C and DIM pretreatment, at higher concentrations of 50 and 10 muM, respectively, significantly increased PMA/ionomycin-induced interleukin-2 (IL-2), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) production, measured by real time polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA).	Ionomycin	135-144	C-X-C motif chemokine ligand 8	Homo sapiens	190-194