PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10064062-5	1999	Stimulation of transfected Jurkat clones with phorbol-12-myristate-13 alone or in the presence of ionomycin resulted in significant reduction of IL-2R alpha expression, TNF-alpha production, and the induction of transcriptional activity of a pIL-2/Luc construct in both as PKC alpha-reduced clones.	Ionomycin	98-107	interleukin 2 receptor subunit alpha	Homo sapiens	145-156	
11731334-2	2001	PMA/Ionomycin treatment caused significant time-dependent increases in mobile lipid and in oil red O-positive lipid droplets that were accompanied by lymphocyte proliferation and increases in activation antigens, CD25, CD69 and CD71.	Ionomycin	4-13	interleukin 2 receptor subunit alpha	Homo sapiens	213-217	
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Ionomycin	112-121	interleukin 2 receptor subunit alpha	Homo sapiens	53-57	
8565319-4	1996	Rapamycin surprisingly inhibits CD25 upregulation subsequent to anti-CD3 or ionomycin stimulation.	Ionomycin	76-85	interleukin 2 receptor subunit alpha	Homo sapiens	32-36	
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Ionomycin	176-185	interleukin 2 receptor subunit alpha	Homo sapiens	232-236	
9636688-6	1998	The CD4 mAb inhibited the CD3-induced expression of the CD25 and CD69 activation markers on the T cell surface and suppressed CD40 ligand expression, but not that of CD25 and CD69, when their expression was induced by phorbol ester plus ionomycin.	Ionomycin	237-246	interleukin 2 receptor subunit alpha	Homo sapiens	56-60	
9367861-1	1997	Mobile lipid levels, IL-2R alpha expression and proliferation increased after treatment with PMA and ionomycin.	Ionomycin	101-110	interleukin 2 receptor subunit alpha	Homo sapiens	21-32	
9367861-2	1997	PMA or ionomycin stimulation alone induced increased IL-2R alpha expression but not proliferation.	Ionomycin	7-16	interleukin 2 receptor subunit alpha	Homo sapiens	53-64	
9162220-4	1996	Thus, maximal expression of CD23 and CD25 was obtained with a 30 (or 120) second pulse with phorbol ester and/or ionomycin followed by a sustained (20 minute) treatment with forskolin.	Ionomycin	113-122	interleukin 2 receptor subunit alpha	Homo sapiens	37-41	
7679691-7	1993	Proliferation in response to either LCM alone or LCM together with ionomycin was almost completely abrogated by anti-IL-2R antibodies.	Ionomycin	67-76	interleukin 2 receptor subunit alpha	Homo sapiens	117-122	
7554401-5	1995	Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes.	Ionomycin	147-156	interleukin 2 receptor subunit alpha	Homo sapiens	48-59	
8557519-2	1995	We demonstrate that CsA and FK506 inhibited IL-2R (CD25) gene transcription and protein expression after stimulation by anti-CD3 or ionomycin, but not by phorbol ester or IL-2.	Ionomycin	132-141	interleukin 2 receptor subunit alpha	Homo sapiens	44-49	
8557519-2	1995	We demonstrate that CsA and FK506 inhibited IL-2R (CD25) gene transcription and protein expression after stimulation by anti-CD3 or ionomycin, but not by phorbol ester or IL-2.	Ionomycin	132-141	interleukin 2 receptor subunit alpha	Homo sapiens	51-55	
8557519-3	1995	Rapamycin, which does not affect IL-2 transcription, surprisingly inhibited IL-2R upregulation after anti-CD3- or ionomycin-induced stimulation, but not by phorbol ester or IL-2.	Ionomycin	114-123	interleukin 2 receptor subunit alpha	Homo sapiens	76-81	
2320954-2	1990	The proliferative response was inhibited by addition of a monoclonal antibody directed against the IL-2R (Tac antigen) demonstrating that PDBu and ionomycin induce T-cell growth through an IL-2-dependent autocrine pathway.	Ionomycin	147-156	interleukin 2 receptor subunit alpha	Homo sapiens	99-104	
1717576-4	1991	We found that nonmitogenic amounts of ionomycin selectively and maximally up-regulated T cell CD7 on mature (peripheral blood) T cells after 24 h. Whereas CD7 expression was increased 78 +/- 25% by 0.5 microM ionomycin, expression of CD25 (IL-2R alpha), class II MHC, 4F2, transferrin receptor, CD2, CD3, CD4, CD5, and CD8 molecules was not increased.	Ionomycin	38-47	interleukin 2 receptor subunit alpha	Homo sapiens	234-238	
1717576-4	1991	We found that nonmitogenic amounts of ionomycin selectively and maximally up-regulated T cell CD7 on mature (peripheral blood) T cells after 24 h. Whereas CD7 expression was increased 78 +/- 25% by 0.5 microM ionomycin, expression of CD25 (IL-2R alpha), class II MHC, 4F2, transferrin receptor, CD2, CD3, CD4, CD5, and CD8 molecules was not increased.	Ionomycin	38-47	interleukin 2 receptor subunit alpha	Homo sapiens	240-251	
1717576-4	1991	We found that nonmitogenic amounts of ionomycin selectively and maximally up-regulated T cell CD7 on mature (peripheral blood) T cells after 24 h. Whereas CD7 expression was increased 78 +/- 25% by 0.5 microM ionomycin, expression of CD25 (IL-2R alpha), class II MHC, 4F2, transferrin receptor, CD2, CD3, CD4, CD5, and CD8 molecules was not increased.	Ionomycin	209-218	interleukin 2 receptor subunit alpha	Homo sapiens	234-238	
1717576-4	1991	We found that nonmitogenic amounts of ionomycin selectively and maximally up-regulated T cell CD7 on mature (peripheral blood) T cells after 24 h. Whereas CD7 expression was increased 78 +/- 25% by 0.5 microM ionomycin, expression of CD25 (IL-2R alpha), class II MHC, 4F2, transferrin receptor, CD2, CD3, CD4, CD5, and CD8 molecules was not increased.	Ionomycin	209-218	interleukin 2 receptor subunit alpha	Homo sapiens	240-251	
2320954-2	1990	The proliferative response was inhibited by addition of a monoclonal antibody directed against the IL-2R (Tac antigen) demonstrating that PDBu and ionomycin induce T-cell growth through an IL-2-dependent autocrine pathway.	Ionomycin	147-156	interleukin 2 receptor subunit alpha	Homo sapiens	106-117	
2474594-2	1989	Treatment with PMA or OAG caused down-regulation of the TCR-CD3 complex, but only PMA, in combination with ionomycin, was capable of stimulating IL-2R expression and proliferation.	Ionomycin	107-116	interleukin 2 receptor subunit alpha	Homo sapiens	145-150	
2506637-7	1989	Furthermore, a correlation between the number of HA-IL-2R and free cytoplasmic calcium upon stimulation with ionomycin was observed.	Ionomycin	109-118	interleukin 2 receptor subunit alpha	Homo sapiens	52-57	
2506637-10	1989	Finally, OAG and ionomycin acted synergistically on expression of HA-IL-2R.	Ionomycin	17-26	interleukin 2 receptor subunit alpha	Homo sapiens	69-74	
30348688-5	2018	RESULTS: Candesartan significantly suppressed PMA and ionomycin-induced CD25 expression and IL-2 production.	Ionomycin	54-63	interleukin 2 receptor subunit alpha	Homo sapiens	72-76	
2545785-2	1989	Ionomycin induces highly purified resting human T cells to proliferate in the presence of monocytes with accompanying IL-2R expression and IL-2 synthesis.	Ionomycin	0-9	interleukin 2 receptor subunit alpha	Homo sapiens	118-123	
21242520-8	2011	In the presence of rCIL-2, PMA plus ionomycin or Con A stimulated CD4(+)CD25(+) cell proliferation, whereas anti-CD3 plus CD28 did not stimulate CD4(+)CD25(+) cell proliferation.	Ionomycin	36-45	interleukin 2 receptor subunit alpha	Homo sapiens	72-76	
21242520-11	2011	Both naive and PMA plus ionomycin-stimulated thymic CD4(+)CD25(+) cells suppressed naive T cell proliferation.	Ionomycin	24-33	interleukin 2 receptor subunit alpha	Homo sapiens	58-62	
19507195-4	2009	The results showed that PAB dose-dependently suppressed human T lymphocyte proliferation, IL-2 production and CD25 expression induced by co-stimulation of PMA plus ionomycin or of anti-OKT-3 plus anti-CD28.	Ionomycin	164-173	interleukin 2 receptor subunit alpha	Homo sapiens	110-114