PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28498408-8 2017 However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells. Ionomycin 82-91 interleukin 17A Homo sapiens 113-118 30208917-8 2018 However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-gamma and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response. Ionomycin 49-58 interleukin 17A Homo sapiens 123-128 30208917-8 2018 However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-gamma and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response. Ionomycin 49-58 interleukin 17A Homo sapiens 219-224 30838000-8 2019 Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar. Ionomycin 39-48 interleukin 17A Homo sapiens 142-147 29292524-8 2018 When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion. Ionomycin 25-34 interleukin 17A Homo sapiens 126-145 29270166-6 2017 The whole blood of the patient produced 35% less IFN-gamma compared to controls assessed by ELISA and flow cytometry, but IL-17 producing T cells from patient were almost absent in PBMC stimulated with PMA plus ionomycin. Ionomycin 211-220 interleukin 17A Homo sapiens 122-127 29201026-12 2017 Conclusion: Childhood obesity is an independent factor that is associated with an elevated frequency of circulating TH17 cells and higher expression of RORC- and IL-17A-mRNA after in vitro stimulation with Ionomycin. Ionomycin 206-215 interleukin 17A Homo sapiens 162-168 25948100-5 2015 The levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) secreted by T cells stimulated with PMA and ionomycin were also determined by flow cytometry. Ionomycin 114-123 interleukin 17A Homo sapiens 63-68 24554396-7 2014 Re-stimulation with unspecific stimuli (PMA and ionomycin) generated a mixed Th1 (CD4(+)/IFN-gamma(+)) and Th17 (CD4(+)/IL-17(+)) phenotype in comparison with the vehicle-matched group. Ionomycin 48-57 interleukin 17A Homo sapiens 120-125 18063670-5 2008 IL17 (IL17A) positive T cells were identified by a flow cytometer after ex vivo stimulation with phorbol myristate acetate and ionomycin. Ionomycin 127-136 interleukin 17A Homo sapiens 0-4 24340045-4 2013 Multicolour fluorescence analysis of IL-17-expressing peripheral blood mononuclear cells (PBMC) revealed larger proportions of IL-17(+)CD3(-) non-T cells in RA patients than in healthy controls (constitutive, 13.6% vs. 8.4%, and after stimulation with PMA/ionomycin 17.4% vs. 7.9% p < 0.001 in both cases). Ionomycin 256-265 interleukin 17A Homo sapiens 37-42 23416458-5 2013 Higher levels of IL-17 and IFN-gamma were produced by stimulation with PMA/Ionomycin compared to anti-CD3/anti-CD28. Ionomycin 75-84 interleukin 17A Homo sapiens 17-22 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Ionomycin 44-53 interleukin 17A Homo sapiens 85-90 22736020-9 2012 FOXP3+ mucosal CD4+ T cells from both IBD and control specimens were able to make IL-17A in vitro after phorbol myristate acetate (PMA) and ionomycin stimulation, but these cells did not preferentially express Deltaexon2. Ionomycin 140-149 interleukin 17A Homo sapiens 82-88 22415432-6 2012 After stimulation with PMA and ionomycin, gammadelta T cells from HBV-ACLF patients produced the greatest amount of TNF-alpha or IL-17 among the three groups. Ionomycin 31-40 interleukin 17A Homo sapiens 129-134 19056110-6 2009 RESULTS: Approximately 10% of APT-infiltrating T cells secreted IL-17 after phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation. Ionomycin 114-123 interleukin 17A Homo sapiens 64-69 21639870-8 2011 The PMA/ionomycin and HBcAg -stimulated up-regulation of IL-17 production by CD4+ T cells could be reversed by a neutralizing antibody against IL-6R. Ionomycin 8-17 interleukin 17A Homo sapiens 57-62 20045653-6 2010 Following stimulation with phorbol ester and ionomycin, PBMCs taken from MS patients in relapse developed a more inflammatory profile than those taken from controls or non-relapse patients, with greater expression of CD154, IL-17 and dual expression of IL-17/IFN-gamma. Ionomycin 45-54 interleukin 17A Homo sapiens 224-229 20045653-6 2010 Following stimulation with phorbol ester and ionomycin, PBMCs taken from MS patients in relapse developed a more inflammatory profile than those taken from controls or non-relapse patients, with greater expression of CD154, IL-17 and dual expression of IL-17/IFN-gamma. Ionomycin 45-54 interleukin 17A Homo sapiens 253-258 18063670-5 2008 IL17 (IL17A) positive T cells were identified by a flow cytometer after ex vivo stimulation with phorbol myristate acetate and ionomycin. Ionomycin 127-136 interleukin 17A Homo sapiens 6-11 10328864-2 1999 Our data showed that IL-17 mRNA was highly expressed in memory human peripheral CD8(+)45RO+T cells and CD4(+)45RO+T cells when peripheral blood mononuclear cells were first stimulated with ionomycin/PMA. Ionomycin 189-198 interleukin 17A Homo sapiens 21-26 17425422-8 2007 With PMA/ionomycin stimulation, the percent IL-17 expression in CD4(+) cells (median) was 1.45 versus 0.65 (p< 0.0001) and in CD4() T cells it was 1.0 versus 0.12 (p< 0.0001). Ionomycin 9-18 interleukin 17A Homo sapiens 44-49 17425422-10 2007 IL-17 expression was further inducible by PMA/ionomycin stimulation in vitro only in CD4(+) T cells. Ionomycin 46-55 interleukin 17A Homo sapiens 0-5 10679127-5 2000 Among tested factors, LPS and TNF-alpha failed, IL-15 and IL-2 were equipotent, and PMA + ionomycin was far more efficient in the induction of IL-17 secretion by PBMCs isolated from healthy blood donors. Ionomycin 90-99 interleukin 17A Homo sapiens 143-148 10679127-7 2000 Moreover, PMA + ionomycin-triggered IL-17 secretion is completely or partially blocked in the presence of low doses of cyclosporin A or high doses of methylprednisolone, respectively. Ionomycin 16-25 interleukin 17A Homo sapiens 36-41 10328864-3 1999 IL-17 expression in memory CD8(+)T cells required accessory signals since culture of ionomycin/PMA-activated CD8(+)45RO+T cells alone did not result to IL-17 expression. Ionomycin 85-94 interleukin 17A Homo sapiens 0-5 33475942-5 2021 IFN-beta-induced STAT1 phosphorylation/dephosphorylation levels and PMA/ionomycin-stimulated intracellular IL-17A/IFN-gamma production in CD4+ T cells were evaluated. Ionomycin 72-81 interleukin 17A Homo sapiens 107-113 34421897-7 2021 Flow cytometry suggested that the Y287N mutation might reduce the expression of IL-17 of Th17 cells in peripheral blood mononuclear cells stimulated by phorbol myristate acetate and ionomycin. Ionomycin 182-191 interleukin 17A Homo sapiens 80-85 34899697-7 2021 They also decreased IL-17+ T and NKT cells following PMA and Ionomycin-stimulation. Ionomycin 61-70 interleukin 17A Homo sapiens 20-25 31975436-6 2020 Following ex vivo stimulation with PMA/Ionomycin, PSC patients showed significantly increased numbers of IL-17A-producing peripheral blood CD4+ T cells compared to PBC patients and healthy controls, indicating increased Th17 differentiation in vivo. Ionomycin 39-48 interleukin 17A Homo sapiens 105-111 33090557-6 2020 Following ex vivo stimulation with phorbol myristate acetate/ionomycin, PSC patients showed significantly increased numbers of IL-17A-producing peripheral blood CD4+ T cells compared to PBC patients and healthy controls, indicating increased Th17 differentiation in vivo. Ionomycin 61-70 interleukin 17A Homo sapiens 127-133