PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11733941-7	2001	For Bcl-2-transfected cells, the release of Ca2+ was incomplete as determined by a further [Ca2+]i transient produced by the addition of the Ca2+ ionophore ionomycin after PDT.	Ionomycin	156-165	BCL2 apoptosis regulator	Homo sapiens	4-9	
10458408-0	1999	Calcium ionophore, ionomycin inhibits growth of human bladder cancer cells both in vitro and in vivo with alteration of Bcl-2 and Bax expression levels.	Ionomycin	19-28	BCL2 apoptosis regulator	Homo sapiens	120-125	
10458408-4	1999	Bcl-2 and Bax expression levels in HT1376 after ionomycin treatment were examined by Northern and Western blot analyses.	Ionomycin	48-57	BCL2 apoptosis regulator	Homo sapiens	0-5	
10458408-8	1999	Ionomycin treatment caused a marked decrease in the ratios of Bcl-2 to Bax mRNA and protein in HT1376 cells.	Ionomycin	0-9	BCL2 apoptosis regulator	Homo sapiens	62-67	
10458408-11	1999	CONCLUSIONS: These findings suggest that ionomycin-based therapy could be used as a novel therapeutic strategy for advanced bladder cancer through the effective induction of apoptosis by decreasing the ratio of Bcl-2 to Bax.	Ionomycin	41-50	BCL2 apoptosis regulator	Homo sapiens	211-216	
9823934-8	1998	Bcl-2 was constitutively expressed on unstimulated PBLs, but its expression was significantly augmented by IL-2 or PMA plus ionomycin.	Ionomycin	124-133	BCL2 apoptosis regulator	Homo sapiens	0-5	
8814273-5	1996	Burkitt lymphoma (BL)-derived, Bcl-2- B cells were induced into apoptosis either by the Ca(2+)-ionophore ionomycin or by the inhibitor of protein synthesis cycloheximide.	Ionomycin	105-114	BCL2 apoptosis regulator	Homo sapiens	31-36	
8647264-6	1996	Both ionomycin and anti-IgM trigger activation of CPP32 and cleavage of PARP prior to the onset of apoptosis; this process is abrogated by treatment with anti-CD40 and is independent of Bcl-2 expression.	Ionomycin	5-14	BCL2 apoptosis regulator	Homo sapiens	186-191	
1459737-8	1992	Expression of the bcl-2 protein in BL group-I cells following gene transfer affords protection from apoptosis induced by ionomycin or anti-Ig.	Ionomycin	121-130	BCL2 apoptosis regulator	Homo sapiens	18-23	
12000759-10	2002	We conclude that ionomycin-induced calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway.	Ionomycin	17-26	BCL2 apoptosis regulator	Homo sapiens	75-80	
11476900-4	2001	Here we report that DP cells that were treated with PMA and ionomycin up-regulated bcl-2 and down-regulated CD1 expression.	Ionomycin	60-69	BCL2 apoptosis regulator	Homo sapiens	83-88	
9432028-0	1997	Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis.	Ionomycin	69-78	BCL2 apoptosis regulator	Homo sapiens	15-20	
9432028-4	1997	A side-scatter shift and a decrease in the Bcl-2/Bax protein ratio were observed by flow cytometry analysis after stimulation with ionomycin.	Ionomycin	131-140	BCL2 apoptosis regulator	Homo sapiens	43-48	
8710376-6	1996	In Bcl-2-expressing cells in which apoptosis was repressed, Rb remained hyperphosphorylated, even during G1-arrest induced by ionomycin.	Ionomycin	126-135	BCL2 apoptosis regulator	Homo sapiens	3-8