PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3495445-5	1987	Stimulation of B lymphocytes with TPA plus ionomycin resulted in increased magnitude and a shift in the kinetics of c-fos and c-myc expression compared with either agent used alone.	Ionomycin	43-52	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121	
3141428-11	1988	The calcium ionophores, A23187 and ionomycin, previously shown to induce an increase in c-myc and c-fos mRNA levels in fibroblasts, induced a marked increase in the synthesis of a nuclear protein at 80 kD/pI-5 but failed to induce an increase in the synthesis of numatrin indicating that an increase in intracellular Ca++ level is not sufficient for induction of the synthesis of numatrin.	Ionomycin	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103	
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Ionomycin	200-209	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70	
9670939-9	1998	The intracellular incorporation of Abs specific for c-Fos and c-Jun family members by scrape loading inhibited the production and intracellular accumulation of IL-2 within 6 h of costimulation with PMA/ionomycin, or costimulation by CD28 and CD3 ligation.	Ionomycin	202-211	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57	
9650640-4	1998	We report that c-fos is induced in these cells by both protein kinase C- (PKC-) dependent (phorbol ester, platelet-derived growth factor), and independent (serum, ionomycin) mechanisms.	Ionomycin	163-172	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-20	
30777021-6	2019	Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation-quantitative polymerase chain reaction (ChIP-qPCR) assays showed that the risk allele of the variant was bound to activator protein 1 transcription factors (c-Fos and c-Jun) with a significantly reduced affinity and associated with decreased mRNA expression of FGF7 in fibroblast cells at both resting and PMA/Ionomycin-stimulated conditions.	Ionomycin	388-397	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	235-240	
20432446-3	2010	Here we report the effects of low-concentration (1 microg/ml) heparin on activation of several kinases and subsequent induction of the c-fos gene in mesangial cells in response to the calcium ionophore, ionomycin, in the absence of serum factors.	Ionomycin	203-212	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-140	
9133600-7	1997	The PMA/ionomycin-inducible complex contains NF-ATp/c, Fos and Jun.	Ionomycin	8-17	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-58	
8485167-4	1993	On the other hand, a calcium ionophore ionomycin elevated both cytosolic Ca2+ and c-fos mRNA but could not antagonize the vacuole formation induced by teleocidin.	Ionomycin	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87	
8928840-6	1996	In addition, a selective PTK inhibitor blocked induction of c-fos mRNA by ionomycin, suggesting that Ca(2+)-stimulated PTKs contribute to a signaling pathway regulating immediate early gene expression.	Ionomycin	74-83	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-65	
7994752-2	1994	Data presented here demonstrate that stimulation of mIgM-bearing cells with either anti-IgM or the combination of PDB plus ionomycin generated comparable levels of c-fos RNA.	Ionomycin	123-132	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-169	
7962120-5	1994	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induced an intense expression of the c-fos gene, while 4 alpha-phorbol 12,13-didecanoate (4 alpha PDD), incapable of activating PKC, and calcium ionophores (A23187 and ionomycin) did not.	Ionomycin	247-256	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121	
7693480-5	1993	c-fos and 1R20 were also the only ERG inducible in response to IL-4 stimulation and whilst ionomycin induced only c-fos, dibutyryl cyclic adenosine monophosphate stimulation led to induction of both c-fos and 1R20.	Ionomycin	91-100	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-119	
7693480-5	1993	c-fos and 1R20 were also the only ERG inducible in response to IL-4 stimulation and whilst ionomycin induced only c-fos, dibutyryl cyclic adenosine monophosphate stimulation led to induction of both c-fos and 1R20.	Ionomycin	91-100	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-119	
1902229-10	1991	Experiments using phorbol ester (phorbol 12-myristate 13-acetate) in combination with the Ca2+ ionophore ionomycin confirm that activation of protein kinase C induces c-fos and c-jun expression and that a concomitant increase in cytosolic [Ca2+] potentiates the induction of c-fos while repressing that of c-jun.	Ionomycin	105-114	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172	
1902229-10	1991	Experiments using phorbol ester (phorbol 12-myristate 13-acetate) in combination with the Ca2+ ionophore ionomycin confirm that activation of protein kinase C induces c-fos and c-jun expression and that a concomitant increase in cytosolic [Ca2+] potentiates the induction of c-fos while repressing that of c-jun.	Ionomycin	105-114	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	275-280	
2119237-9	1990	Interleukin-1 beta (IL-1 beta) and basic fibroblast growth factor (bFGF) stimulation of c-fos mRNA level were not inhibited by quin2; on the contrary, ionomycin effect was blocked by this agent.	Ionomycin	151-160	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-93