PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8409385-4	1993	The presence of ionomycin during the cytolytic assay restores lytic activity to cells rendered unresponsive by exposure to rIL-2.	Ionomycin	16-25	interleukin 2	Rattus norvegicus	123-128	
7868299-7	1994	When primary T-cells were stimulated with rIL2 plus phorbol ester in the presence of the calcium ionophore ionomycin, treatment with CsA resulted in marked unresponsiveness of the T-cells, compared to untreated controls.	Ionomycin	107-116	interleukin 2	Rattus norvegicus	42-46	
1730954-4	1992	In contrast, when T cell populations were stimulated with mitogenic combinations of phorbol ester, calcium ionophore, and rIL-2, those from steroid-dependent patients with glial tumors had a significantly lower response than those from normal control subjects, suggesting that a population of T cells capable of responding to phorbol ester/ionomycin and not PHA stimulation is inhibited by corticosteroid therapy in glioma patients.	Ionomycin	340-349	interleukin 2	Rattus norvegicus	122-127	
8104885-6	1993	However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats.	Ionomycin	55-64	interleukin 2	Rattus norvegicus	108-112	
8359866-1	1993	CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2.	Ionomycin	135-144	interleukin 2	Rattus norvegicus	164-169	
2787455-10	1989	Three of the five ALL samples also retained rIL-2 induced cytotoxic capabilities when exposed simultaneously to the combination of PDBu and ionomycin, whereas rIL-2 induced tumoricidal activity in normal PBL and bone marrow cultures was inhibited by these reagents.	Ionomycin	140-149	interleukin 2	Rattus norvegicus	44-49	
2565932-4	1989	Recombinant interleukin 2 (rIL-2), albeit ineffective by itself, leads to vigorous proliferation of DETC when used with either ConA or PMA + ionomycin + IL-1.	Ionomycin	141-150	interleukin 2	Rattus norvegicus	27-32	
3257170-4	1988	The addition of both PDBu and ionomycin to recombinant interleukin 2 (rIL-2)-exposed cultures produced a strong mitogenic response and high cell yield, although Daudi cell killing measured at Day 5 was completely abolished.	Ionomycin	30-39	interleukin 2	Rattus norvegicus	70-75	
23985769-5	2013	The results revealed a rapid increase of IL-2, IFN-gamma, TNF-alpha, RANTES and TGF-beta secretion within 6 h after stimulation with 25 ng/mL PMA and 1 mug/mL ionomycin.	Ionomycin	159-168	interleukin 2	Rattus norvegicus	41-45