PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22160839-4 2012 Th1 and Th2 cells, levels of INF-gamma, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin. Ionomycin 148-157 negative elongation factor complex member C/D Homo sapiens 0-3 30651883-6 2019 Th1 and Th2 cells were significantly increased by PMA and ionomycin stimulation; however, Th1 cells and the Th1/Th2 ratio in PMA and ionomycin treatments were significantly decreased in the CRC group compared with the control group. Ionomycin 58-67 negative elongation factor complex member C/D Homo sapiens 0-3 30651883-7 2019 Following incubation with PMA and ionomycin, morphine significantly decreased Th1 cells and the Th1/Th2 ratio in the CRC group. Ionomycin 34-43 negative elongation factor complex member C/D Homo sapiens 78-81 30651883-7 2019 Following incubation with PMA and ionomycin, morphine significantly decreased Th1 cells and the Th1/Th2 ratio in the CRC group. Ionomycin 34-43 negative elongation factor complex member C/D Homo sapiens 96-99 30061889-6 2018 Moreover, CD49dhigh CD4+ T cells showed a Th1-like memory phenotype, characterized by high expression of CD44 and CXCR3; low expression of CD62L and CCR7; rapid production of IFN-gamma, tumor necrosis factor-alpha, and IL-2 upon stimulation with phorbol myristate acetate and ionomycin; and rapid proliferation upon stimulation with anti-CD3 and anti-CD28 antibodies. Ionomycin 276-285 negative elongation factor complex member C/D Homo sapiens 42-45 27467093-7 2018 The tubercular uveitis group demonstrated heightened Th1, Th17 responses following in vitro stimulation with phorbol myristate acetate (PMA)/ionomycin. Ionomycin 141-150 negative elongation factor complex member C/D Homo sapiens 53-56 25559223-0 2015 Quantification of Th1 and Th17 Cells with Intracellular Staining Following PMA/Ionomycin Stimulation. Ionomycin 79-88 negative elongation factor complex member C/D Homo sapiens 18-21 24554396-7 2014 Re-stimulation with unspecific stimuli (PMA and ionomycin) generated a mixed Th1 (CD4(+)/IFN-gamma(+)) and Th17 (CD4(+)/IL-17(+)) phenotype in comparison with the vehicle-matched group. Ionomycin 48-57 negative elongation factor complex member C/D Homo sapiens 77-80 23945300-3 2013 The proportion of Th1 and Th17 cells in the PBMCs was detected with flow cytometry after stimulated by PMA and ionomycin. Ionomycin 111-120 negative elongation factor complex member C/D Homo sapiens 18-21 18045946-3 2008 Cytokine flow cytometry was utilized to assess production of Th1 cytokines tumor necrosis factor alpha and gamma interferon following ex vivo stimulation with either phorbol myristate acetate/ionomycin or the Vdelta2 gammadelta T-cell receptor agonist isopentenyl pyrophosphate. Ionomycin 192-201 negative elongation factor complex member C/D Homo sapiens 61-64 21795061-6 2011 TH1 cells, TH2 cells, IFN-gamma and IL-4 levels were significantly increased after PMA and ionomycin stimulation. Ionomycin 91-100 negative elongation factor complex member C/D Homo sapiens 0-3 21795061-12 2011 CONCLUSION: NMDA antagonist can suppress TH cell differentiation and subsequent cytokines production but increase TH1/TH2 ratio following PMA and ionomycin stimulation, it may be related to its regulation on T-bet and GATA3 activities. Ionomycin 146-155 negative elongation factor complex member C/D Homo sapiens 114-117 20233578-8 2010 While IL-2 expression was still diminished by the re-stimulation with anti-CD3, PMA plus ionomycin restored IL-2 production in Galpha12-deficient Th1 and Th2 cells. Ionomycin 89-98 negative elongation factor complex member C/D Homo sapiens 146-149 18691343-2 2009 Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry. Ionomycin 174-183 negative elongation factor complex member C/D Homo sapiens 65-68 15034076-9 2004 Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2. Ionomycin 57-66 negative elongation factor complex member C/D Homo sapiens 157-160 17103408-7 2007 A significant increase in Th1 and Th2 CD4+ T cells was observed in the patients after ex vivo stimulation with phorbol 12-myristate 13-acetate /ionomycin. Ionomycin 144-153 negative elongation factor complex member C/D Homo sapiens 26-29 15311213-6 2004 After stimulation for 3 h with PMA plus ionomycin, cellular responses were associated with surface TNFalpha expression on the majority of CD3+ T cells and secretion of Th1-associated cytokines: interferon gamma, interleukin (IL)-2, and to a lesser extent IL4. Ionomycin 40-49 negative elongation factor complex member C/D Homo sapiens 168-171 10735602-7 2000 However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy. Ionomycin 79-88 negative elongation factor complex member C/D Homo sapiens 182-185 10419652-9 1999 Not surprisingly, PMA/ionomycin induced a greater percentage of BAL T cells to produce TH1 cytokines. Ionomycin 22-31 negative elongation factor complex member C/D Homo sapiens 87-90