PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26527422-0	2016	Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.	tetrandrine	0-11	nitric oxide synthase 2	Rattus norvegicus	131-162	
27082007-7	2016	Treatment with tetrandrine reduced the expression levels of COX-2, IL-1beta, TNF-alpha, NF-kappaB, iNOS and caspase-3, and increased the Bcl-2 protein expression in sevoflurane-treated aged rats.	tetrandrine	15-26	nitric oxide synthase 2	Rattus norvegicus	99-103	
24442958-6	2014	RAW 264.7 macrophages cultured in TET-loading PLLA films maintained lower levels of chemokines, cytokines, and enzymes involved in the inflammatory process, such as NO, TNF-alpha, IL-6, iNOS, COX-2 than control PLLA films, suggesting that TET-loading PLLA films could regulate the mRNA expression and protein expression to reduce the inflammatory response in macrophages.	tetrandrine	34-37	nitric oxide synthase 2	Rattus norvegicus	186-190	
23561481-1	2013	OBJECTIVES: To investigate the effects of tetrandrine (Tet) on cognitive impairment induced by chronic cerebral hypoperfusion and its potential anti-inflammatory mechanism by modulating the expression of S100B, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS).	tetrandrine	42-53	nitric oxide synthase 2	Rattus norvegicus	288-319	
23561481-1	2013	OBJECTIVES: To investigate the effects of tetrandrine (Tet) on cognitive impairment induced by chronic cerebral hypoperfusion and its potential anti-inflammatory mechanism by modulating the expression of S100B, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS).	tetrandrine	42-53	nitric oxide synthase 2	Rattus norvegicus	321-325	
23561481-11	2013	Tetrandrine may be a novel and promising candidate for future treatment and/or prevention of chronic cerebral hypoperfusion via inhibiting S100B activation and decreasing the expression of IL-1 beta, TNF-alpha, and iNOS in the hippocampal CA1 region.	tetrandrine	0-11	nitric oxide synthase 2	Rattus norvegicus	215-219	
22001142-9	2011	TET attenuated the IL-1beta-provoked expression of iNOS and release of NO.	tetrandrine	0-3	nitric oxide synthase 2	Rattus norvegicus	51-55	
17218962-7	2006	Moreover, Tet and silymarin treatments attenuated the mRNA expression levels of TGF-beta1,alpha-SMA, collagen 1alpha2, iNOS, ICAM-1, VEGF, and VEGFR2 genes, and induced the mRNA expression of the metallothionein gene.	tetrandrine	10-13	nitric oxide synthase 2	Rattus norvegicus	119-123