PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15922518-3 2005 IL-4 alters macrophage arginine metabolism by inducing arginase I expression and inhibiting nitric oxide production. Nitric Oxide 92-104 interleukin 4 Mus musculus 0-4 21256824-5 2011 Arginase-1 was over 100-fold more strongly induced by IL-4 than by chitosan, which induced only sporadic and weak arginase-1 activity over untreated BMDM, and no nitric oxide. Nitric Oxide 162-174 interleukin 4 Mus musculus 54-58 17308792-3 2006 Our results suggest that in iNOS deficient, malnourished mice, 90 days after of infection, nitric oxide has a downregulating effect on IL-4 and IL-10 production. Nitric Oxide 91-103 interleukin 4 Mus musculus 135-139 11355674-4 2001 Both parasitemia and mortality were decreased in IL-4 depleted mice compared with control mice when IFN-gamma and nitric oxide productions were increased in IL-4 depleted mice compared with control mice. Nitric Oxide 114-126 interleukin 4 Mus musculus 49-53 15039362-4 2004 Alveolar macrophages from infected IL-4(-/-) mice controlled in vitro fungal growth more efficiently than macrophages from WT mice and secreted higher levels of nitric oxide. Nitric Oxide 161-173 interleukin 4 Mus musculus 35-39 11748180-0 2002 Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis. Nitric Oxide 45-57 interleukin 4 Mus musculus 17-30 11355674-4 2001 Both parasitemia and mortality were decreased in IL-4 depleted mice compared with control mice when IFN-gamma and nitric oxide productions were increased in IL-4 depleted mice compared with control mice. Nitric Oxide 114-126 interleukin 4 Mus musculus 157-161 11355674-6 2001 Thus, it is suggested that endogenous IL-4 induces susceptibility to T. cruzi mainly by suppressing the production of IFN-gamma and nitric oxide, which has trypanocidal activity. Nitric Oxide 132-144 interleukin 4 Mus musculus 38-42 9918806-3 1998 Previous work has shown that IL-4 downregulates iNOS and nitric oxide expression by macrophages stimulated with LPS and IFN-gamma. Nitric Oxide 57-69 interleukin 4 Mus musculus 29-33 10669116-0 1999 Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages. Nitric Oxide 60-72 interleukin 4 Mus musculus 24-37 10669116-1 1999 OBJECTIVE: To study the effect of interleukin (IL)-4 and IL-10 on nitric oxide (NO) production by macrophages. Nitric Oxide 66-78 interleukin 4 Mus musculus 34-52 9918806-4 1998 In this study, we found that IL-4 also downregulated iNOS and nitric oxide expression induced by IFN-gamma and TNF-alpha and in mouse macrophages. Nitric Oxide 62-74 interleukin 4 Mus musculus 29-33 9247589-5 1997 Although B and T cells require gamma c for IL-4 responses, IL-4 up-regulated major histocompatibility class II molecules and inhibited nitric oxide production from gamma c- macrophages following stimulation with lipopolysaccharide and interferon-gamma. Nitric Oxide 135-147 interleukin 4 Mus musculus 59-63 9305732-0 1997 Effect of IL-4 and IL-13 on IFN-gamma-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2. Nitric Oxide 60-72 interleukin 4 Mus musculus 10-14 9305732-3 1997 Here we demonstrate that IL-4 and IL-13 totally abrogate IFN-gamma-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) mRNA and protein synthesis in a murine macrophage cell line. Nitric Oxide 75-87 interleukin 4 Mus musculus 25-29 9218595-3 1997 Data point toward morbidity in the IL-4(-/-) C57BL/6 mice being mediated by TNF-alpha, possibly through the uncontrolled production of nitric oxide in target organs such as the ileum. Nitric Oxide 135-147 interleukin 4 Mus musculus 35-39 18475707-0 1996 Opposite effects of interleukin-4 and interleukin-10 on nitric oxide production in murine macrophages. Nitric Oxide 56-68 interleukin 4 Mus musculus 20-33 9155642-0 1997 Nitric oxide increased interleukin-4 expression in T lymphocytes. Nitric Oxide 0-12 interleukin 4 Mus musculus 23-36 8794356-7 1996 IL-4 also inhibited the production of nitric oxide (NO), a potent mediator of antimicrobial activity. Nitric Oxide 38-50 interleukin 4 Mus musculus 0-4 18475707-1 1996 Interleukin-4 (IL-4) and interleukin-10 (IL-10) were evaluated for their ability to inhibit the production of nitric oxide (NO) by interferon-gamma (IFN-gamma)- or lipopolysaccharide (LPS)-activated murine macrophages (RAW 264.7 and J774.2). Nitric Oxide 110-122 interleukin 4 Mus musculus 0-13 18475707-1 1996 Interleukin-4 (IL-4) and interleukin-10 (IL-10) were evaluated for their ability to inhibit the production of nitric oxide (NO) by interferon-gamma (IFN-gamma)- or lipopolysaccharide (LPS)-activated murine macrophages (RAW 264.7 and J774.2). Nitric Oxide 110-122 interleukin 4 Mus musculus 15-19 30962497-3 2019 The levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in the serum and brain homogenates were reduced by the LPS treatment, while the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), prostaglandin E2 (PGE2) and nitric oxide (NO) were increased. Nitric Oxide 251-263 interleukin 4 Mus musculus 14-27 7747279-7 1995 Interleukin-4 did not mediate the inhibition; instead, interleukin-4 appeared to be an enhancing factor for nitric oxide production in vitro. Nitric Oxide 108-120 interleukin 4 Mus musculus 55-68 7530004-0 1995 Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages. Nitric Oxide 37-49 interleukin 4 Mus musculus 61-65 7523136-0 1994 Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C epsilon. Nitric Oxide 14-26 interleukin 4 Mus musculus 40-53 7523136-8 1994 These results, therefore, suggest that the inhibition of nitric oxide synthesis in activated murine macrophages by IL-4 is at the transcriptional level and may involve the inhibition of the activation of PKC-epsilon. Nitric Oxide 57-69 interleukin 4 Mus musculus 115-119 1516618-0 1992 Immunosuppression induced by nitric oxide and its inhibition by interleukin-4. Nitric Oxide 29-41 interleukin 4 Mus musculus 64-77 1516618-3 1992 The present report identifies the suppressor factor as nitric oxide (NO), and provides evidence for a mechanism by which IL-4 abrogates suppression. Nitric Oxide 55-67 interleukin 4 Mus musculus 121-125 30206632-2 2018 Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation. Nitric Oxide 80-92 interleukin 4 Mus musculus 30-43 30206632-2 2018 Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation. Nitric Oxide 80-92 interleukin 4 Mus musculus 45-49 28917204-6 2017 Specifically, (i) it reversed IL-4 mediated inhibition of IFN-gamma induced nitric oxide release by macrophages, (ii) inhibited IL-4 mediated induction of T cell proliferation, and (iii) prevented IL-4 stimulation of IgE synthesis by B cells. Nitric Oxide 76-88 interleukin 4 Mus musculus 30-34