PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11544106-4 2001 While it is constitutively detected in human cancer tissues and established cell lines, IL-8 expression is regulated by various tumor microenvironment factors, such as hypoxia, acidosis, nitric oxide, and cell density. Nitric Oxide 187-199 C-X-C motif chemokine ligand 8 Homo sapiens 88-92 11521757-0 2001 Endogenous nitric oxide inhibits neutrophil adherence to lung epithelial cells to modulate interleukin-8 release. Nitric Oxide 11-23 C-X-C motif chemokine ligand 8 Homo sapiens 91-104 11521757-12 2001 In conclusion, endogenous nitric oxide may play a role in preventing neutrophil adherence to lung epithelial cells, thus modulating concomitant IL-8 release. Nitric Oxide 26-38 C-X-C motif chemokine ligand 8 Homo sapiens 144-148 11399048-0 2001 Nitric oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 24-28 11506748-0 2001 Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma. Nitric Oxide 42-54 C-X-C motif chemokine ligand 8 Homo sapiens 14-27 11506748-1 2001 The regulation of interleukin-8 (IL-8) expression by nitric oxide (NO) was determined in human pancreatic cancer cell lines. Nitric Oxide 53-65 C-X-C motif chemokine ligand 8 Homo sapiens 18-31 11506748-1 2001 The regulation of interleukin-8 (IL-8) expression by nitric oxide (NO) was determined in human pancreatic cancer cell lines. Nitric Oxide 53-65 C-X-C motif chemokine ligand 8 Homo sapiens 33-37 10540334-2 1999 Exposure of U937 cells to etoposide (VP-16) or the nitric oxide (NO) donor DETA-NO, both inducers of apoptosis in these cells, was associated with increased expression of the chemokines IL-8 and macrophage inflammatory protein-1 alpha. Nitric Oxide 51-63 C-X-C motif chemokine ligand 8 Homo sapiens 186-190 11358991-1 2001 Recent studies indicate that nitric oxide (NO) or related compounds may regulate the production of interleukin (IL)-8, a potent proinflammatory chemokine. Nitric Oxide 29-41 C-X-C motif chemokine ligand 8 Homo sapiens 99-117 9820546-2 1998 Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood. Nitric Oxide 67-79 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 10353264-0 1999 Up-regulation of interleukin-1beta-stimulated interleukin-8 in human keratinocytes by nitric oxide. Nitric Oxide 86-98 C-X-C motif chemokine ligand 8 Homo sapiens 46-59 10362412-0 1999 Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line. Nitric Oxide 14-26 C-X-C motif chemokine ligand 8 Homo sapiens 102-115 10076137-5 1999 RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone. Nitric Oxide 93-105 C-X-C motif chemokine ligand 8 Homo sapiens 9-22 10505790-0 1999 Nitric oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA: effects on endothelial function. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 23-36 10505790-2 1999 We showed that exogenous nitric oxide in the form of a nitric oxide donor significantly reduced IL-8 mRNA in cytokine-activated ECV304. Nitric Oxide 25-37 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 10505790-2 1999 We showed that exogenous nitric oxide in the form of a nitric oxide donor significantly reduced IL-8 mRNA in cytokine-activated ECV304. Nitric Oxide 55-67 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 10505790-3 1999 Similarly, nitric oxide significantly reduced migration of polymorphonuclear neutrophils through cytokine-activated ECV304 monolayers, an IL-8-dependent process. Nitric Oxide 11-23 C-X-C motif chemokine ligand 8 Homo sapiens 138-142 10505790-4 1999 Using a luciferase reporter construct containing the NF-kappaB site of the IL-8 gene, we showed that exposing cytokine-activated ECV304 to exogenous nitric oxide resulted in significant reduction of NF-kappaB binding. Nitric Oxide 149-161 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 9820546-2 1998 Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood. Nitric Oxide 67-79 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 9712106-0 1998 Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 9809627-0 1998 Nitric oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 36-49 9809627-6 1998 Because RAW cells produce large amounts of nitric oxide (NO), we assumed that the suppression of IL-8 production was ascribable to the NO produced by the RAW cells. Nitric Oxide 43-55 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 8989833-0 1997 Nitric oxide regulation of interleukin-8 gene expression. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 27-40 9459261-10 1998 Nitric oxide and peroxynitrite had marked effects on elastase and interleukin-8, which suggests modulation of the inflammatory response. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 66-79 9419178-0 1998 Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils. Nitric Oxide 11-23 C-X-C motif chemokine ligand 8 Homo sapiens 60-73 9350989-0 1997 Intracellular Ca2+ dependence of nitric oxide mediated enhancement of interleukin-8 secretion in human endothelial cells. Nitric Oxide 33-45 C-X-C motif chemokine ligand 8 Homo sapiens 70-83 9215025-0 1997 Effect of exogenous nitric oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes. Nitric Oxide 20-32 C-X-C motif chemokine ligand 8 Homo sapiens 51-64 9215025-8 1997 In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P < 0.01) and also increased IL-8 accumulation in unstimulated cells (P < 0.002). Nitric Oxide 22-34 C-X-C motif chemokine ligand 8 Homo sapiens 114-118 9215025-8 1997 In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P < 0.01) and also increased IL-8 accumulation in unstimulated cells (P < 0.002). Nitric Oxide 22-34 C-X-C motif chemokine ligand 8 Homo sapiens 165-169 9215025-9 1997 Nitric oxide and superoxide have profound effects on IL-8. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 8613691-7 1996 Inhibition of nitric oxide synthase will decrease production of IL-8, whereas addition of nitric oxide (NO)-generating compounds will increase production of IL-8. Nitric Oxide 14-26 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 8915775-8 1996 NaF also increased cellular production of prostaglandin E2 (PGE2) and nitric oxide (NO) and induced expression of inducible nitric oxide synthase (iNOS); 1,25(OH)2D3 once again augmented these NaF-induced effects. Nitric Oxide 70-82 C-X-C motif chemokine ligand 8 Homo sapiens 0-3 8707887-0 1996 Proinflammatory agents, IL-8 and IL-10, upregulate inducible nitric oxide synthase expression and nitric oxide production in avian osteoclast-like cells. Nitric Oxide 61-73 C-X-C motif chemokine ligand 8 Homo sapiens 24-28 7794282-0 1995 Nitric oxide regulation of IL-8 expression in human endothelial cells. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 7575568-0 1995 Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 7575568-1 1995 We investigated the role of nitric oxide (NO) in the expression of interleukin-8 (IL-8) in the human melanoma cell line, G361. Nitric Oxide 28-40 C-X-C motif chemokine ligand 8 Homo sapiens 67-80 7575568-1 1995 We investigated the role of nitric oxide (NO) in the expression of interleukin-8 (IL-8) in the human melanoma cell line, G361. Nitric Oxide 28-40 C-X-C motif chemokine ligand 8 Homo sapiens 82-86 7575568-5 1995 The nitric oxide synthase inhibitor, NG-amino-L-homoarginine (NAHA), inhibited TNF-alpha-stimulated IL-8 promoter activity by 60%. Nitric Oxide 4-16 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 7794282-2 1995 We examined the role of nitric oxide (NO) in IL-8 regulation. Nitric Oxide 24-36 C-X-C motif chemokine ligand 8 Homo sapiens 45-49 7524285-0 1993 L-arginine/nitric oxide pathway: a possible signal transduction mechanism for the regulation of the chemokine IL-8 in human mesangial cells. Nitric Oxide 11-23 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 25051116-11 2014 CONCLUSIONS: Out of ten analyzed cytokines and nitric oxide, IL-8 correlated with the observed increase in mitochondrial respiration. Nitric Oxide 47-59 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 30486522-3 2018 The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Nitric Oxide 335-347 C-X-C motif chemokine ligand 8 Homo sapiens 381-385 29849682-8 2017 The area under curve (AUC) for serum IL-8 level, indicative of uncontrolled asthma, was 0.816 (95% CI, 0.7605 to 0.8721; P< 0.0001), which was greater than the AUC of fractional exhaled nitric oxide (AUC, 0.711; 95% CI, 0.6057 to 0.8153; P= .0188). Nitric Oxide 189-201 C-X-C motif chemokine ligand 8 Homo sapiens 37-41 20388952-0 2009 Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 21-25 24828117-11 2014 CONCLUSIONS: Out of ten analyzed cytokines and nitric oxide, IL-8 correlated with the observed increase in mitochondrial respiration. Nitric Oxide 47-59 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 19010201-0 2008 Analysis of interleukin-6 and interleukin-8 in lung transplantation: correlation with nitric oxide administration. Nitric Oxide 86-98 C-X-C motif chemokine ligand 8 Homo sapiens 30-43 18023202-0 2008 IL-8 induces imbalances between nitric oxide and endothelin-1, and also between plasminogen activator inhibitor-1 and tissue-type plasminogen activator in cultured endothelial cells. Nitric Oxide 32-44 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 18442745-0 2008 Involvement of mitogen-activated protein kinases and nuclear factor-kappa B activation in nitric oxide-induced interleukin-8 expression in human pulp cells. Nitric Oxide 90-102 C-X-C motif chemokine ligand 8 Homo sapiens 111-124 18442745-1 2008 OBJECTIVE: This study examined the effect of nitric oxide (NO) on interleukin-8 (IL-8) production and the involvement of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathways in primary cultured human pulp cells. Nitric Oxide 45-57 C-X-C motif chemokine ligand 8 Homo sapiens 66-79 17850672-11 2007 The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase. Nitric Oxide 52-64 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 16308450-6 2005 Spontaneous secretion of IL-4 and IL-8 correlates with synthesis of nitric oxide, suggesting that NO and transitory S-nitrosylation of up-stream proteins participate in the sigma ligand dependent expression of IL-4 and IL-8 genes. Nitric Oxide 68-80 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 17470570-4 2007 We hypothesized that exercise-induced nitric oxide (NO) production is an important signaling event for IL-6, IL-8, HO-1, and HSP72 expression in muscle. Nitric Oxide 38-50 C-X-C motif chemokine ligand 8 Homo sapiens 109-113 17483743-8 2007 Inhibition of nitric oxide production results in high CAM and IL-8 expressions comparable with groups with low Arg administration. Nitric Oxide 14-26 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 16308450-6 2005 Spontaneous secretion of IL-4 and IL-8 correlates with synthesis of nitric oxide, suggesting that NO and transitory S-nitrosylation of up-stream proteins participate in the sigma ligand dependent expression of IL-4 and IL-8 genes. Nitric Oxide 68-80 C-X-C motif chemokine ligand 8 Homo sapiens 219-223 15540988-6 2005 Chemoattractant cytokines [e.g. VEGF (vascular endothelial growth factor), TGF-beta1 (transforming growth factor-beta1) and IL-8] are important regulators of inflammation-induced angiogenesis and are directly modulated by nitric oxide. Nitric Oxide 222-234 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 15178710-0 2004 Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 15169673-0 2004 Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 15169673-0 2004 Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells. Nitric Oxide 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 15169673-3 2004 The association between elevated levels of nitric oxide (NO) and IL-8 in acute lung injury associated with sepsis, acute respiratory distress syndrome, respiratory syncytial virus infection in infants, and other inflammatory diseases suggested that NO may play important roles in the control of IL-8 gene expression in the lung. Nitric Oxide 43-55 C-X-C motif chemokine ligand 8 Homo sapiens 65-69 15169673-3 2004 The association between elevated levels of nitric oxide (NO) and IL-8 in acute lung injury associated with sepsis, acute respiratory distress syndrome, respiratory syncytial virus infection in infants, and other inflammatory diseases suggested that NO may play important roles in the control of IL-8 gene expression in the lung. Nitric Oxide 43-55 C-X-C motif chemokine ligand 8 Homo sapiens 295-299 12626343-1 2003 Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes. Nitric Oxide 25-37 C-X-C motif chemokine ligand 8 Homo sapiens 140-158 12880368-5 2003 NaF at subtoxic concentrations (<0.5 mM) significantly up-regulated activities of several intracellular enzymes (lactate dehydrogenase, beta-glucuronidase, acid phosphatase), cellular reduction of nitroblue tetrazolium, and nitric oxide (NO) production; which are all accepted as general differentiation markers. Nitric Oxide 227-239 C-X-C motif chemokine ligand 8 Homo sapiens 0-3