PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18552833-0 2008 Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 29-34 18552833-2 2008 Diverse apoptotic stimuli activate inducible nitric oxide synthase (iNOS) or neuronal NOS (nNOS), with the generated nitric oxide (NO) S-nitrosylating GAPDH, abolishing its catalytic activity and conferring on it the ability to bind to Siah1, an E3-ubiquitin-ligase with a nuclear localization signal (NLS). Nitric Oxide 45-57 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 151-156 16391220-6 2006 Cytotoxic stimuli, via nitric oxide generation, lead to the binding of GAPDH to the protein Siah1, translocation of GAPDH-Siah1 to the nucleus, and ultimately cell death. Nitric Oxide 23-35 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 71-76 17540725-8 2007 These data indicate that nitric oxide-mediated S-nitrosylation of GAPDH and subsequent nuclear translocation of GAPDH might function as a mediator of TRAIL-induced cell death in thyroid cancer cells. Nitric Oxide 25-37 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 66-71 17540725-8 2007 These data indicate that nitric oxide-mediated S-nitrosylation of GAPDH and subsequent nuclear translocation of GAPDH might function as a mediator of TRAIL-induced cell death in thyroid cancer cells. Nitric Oxide 25-37 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 112-117 16633896-0 2006 Nitric oxide-GAPDH-Siah: a novel cell death cascade. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 13-18 16391220-6 2006 Cytotoxic stimuli, via nitric oxide generation, lead to the binding of GAPDH to the protein Siah1, translocation of GAPDH-Siah1 to the nucleus, and ultimately cell death. Nitric Oxide 23-35 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 116-121 15951807-2 2005 Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to Siah1 (an E3 ubiquitin ligase), nuclear translocation and apoptosis. Nitric Oxide 45-57 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 136-141 11997668-6 2002 Instead, we observed that incubation of HIT and RIN lysates with peroxynitrite, a reactive intermediate of nitric oxide with superoxide anion, resulted in significant reduction in the GAPDH activity. Nitric Oxide 107-119 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 184-189 15288814-7 2004 Nitric oxide predictably inhibited both endothelial nitric oxide synthase and glyceraldehyde 3-phosphate dehydrogenase, and ascorbate partially prevented inhibition of the latter enzyme. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 78-118 11890743-1 2002 Nitric oxide (NO) can modulate red blood cell (RBC) glycolysis by translocation of the enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPD) (EC 1.2.1.12) from the cytosolic domain of the membrane protein band 3 (cdb3) in the cytosol. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 94-134 11890743-1 2002 Nitric oxide (NO) can modulate red blood cell (RBC) glycolysis by translocation of the enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPD) (EC 1.2.1.12) from the cytosolic domain of the membrane protein band 3 (cdb3) in the cytosol. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 136-140 10696095-5 2000 The activity of other enzymes also known to be susceptible to inhibition by S-nitrosylation, i.e. glyceraldehyde-3-phosphate dehydrogenase and glutathione reductase, was progressively decreased by exposure to nitric oxide with a similar time course to that observed for the inhibition of complex I. Nitric Oxide 209-221 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 98-138 11804836-7 2002 Results: (i) GAPD was recovered from the plasma-membrane-enriched fraction, in internal membranes, and in the cytosol; (ii) GAPD could be phosphorylated, a phenomenon inhibited by both GAP and NADH; and (iii) GAPD exhibits ADP-ribosyltransferase activity, which is stimulated by nitric oxide in a concentration-dependent manner. Nitric Oxide 279-291 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 13-17 11804836-7 2002 Results: (i) GAPD was recovered from the plasma-membrane-enriched fraction, in internal membranes, and in the cytosol; (ii) GAPD could be phosphorylated, a phenomenon inhibited by both GAP and NADH; and (iii) GAPD exhibits ADP-ribosyltransferase activity, which is stimulated by nitric oxide in a concentration-dependent manner. Nitric Oxide 279-291 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 124-128 11804836-7 2002 Results: (i) GAPD was recovered from the plasma-membrane-enriched fraction, in internal membranes, and in the cytosol; (ii) GAPD could be phosphorylated, a phenomenon inhibited by both GAP and NADH; and (iii) GAPD exhibits ADP-ribosyltransferase activity, which is stimulated by nitric oxide in a concentration-dependent manner. Nitric Oxide 279-291 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 124-128 11525879-3 2001 Nitric oxide exerts its influence by activation of guanylate cyclase and nitrosylation of proteins, which include glyceraldehyde-3-phosphate dehydrogenase, the ryanodine receptor and actomyosin ATPase. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 114-154 11251191-0 2001 Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 35-75 12369901-0 2001 Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase and caspase-3 by nitric oxide. Nitric Oxide 88-100 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 30-70 12369901-5 2001 Here, we summarize current knowledge on active site thiol modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and caspase-3 by nitric oxide. Nitric Oxide 140-152 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 74-114 12369901-5 2001 Here, we summarize current knowledge on active site thiol modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and caspase-3 by nitric oxide. Nitric Oxide 140-152 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 116-121 10403526-6 1999 Since similar results were obtained in the case of hydrogen peroxide (H2O2) treatment, which is known to oxidize the thiols, these effects of nitric oxide donors were probably due to modification of thiol groups present in a GAPDH molecule. Nitric Oxide 142-154 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 225-230 10407139-8 1999 Intriguingly, GAPDH is also a unique target of nitric oxide. Nitric Oxide 47-59 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 14-19 10403526-0 1999 Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide. Nitric Oxide 118-130 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 74-114 10403526-1 1999 The relationship between possible modifications of the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by nitric oxide (NO) and modified enzyme activity was examined. Nitric Oxide 123-135 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 71-111 10403526-12 1999 These findings suggest that nitric oxide inhibits GAPDH activity by modifications of the thiols which are essential for this activity, and that the modification includes formation of sulfenic acid, which is not restored by DTT. Nitric Oxide 28-40 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 50-55 10403526-1 1999 The relationship between possible modifications of the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by nitric oxide (NO) and modified enzyme activity was examined. Nitric Oxide 123-135 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 113-118 10391884-1 1999 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is covalently modified by NAD in the presence of nitric oxide (NO) and dithiothreitol. Nitric Oxide 98-110 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 10391884-1 1999 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is covalently modified by NAD in the presence of nitric oxide (NO) and dithiothreitol. Nitric Oxide 98-110 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 42-47 8562445-0 1995 Glyceraldehyde-3-phosphate dehydrogenase: a target for nitric oxide signaling. Nitric Oxide 55-67 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 10385084-0 1999 Modification of glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide in intestinal preconditioning. Nitric Oxide 72-84 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 16-56 10385084-3 1999 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the glycolytic cascade that could be modulated by nitric oxide. Nitric Oxide 118-130 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 10385084-3 1999 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the glycolytic cascade that could be modulated by nitric oxide. Nitric Oxide 118-130 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 42-47 10385084-4 1999 The purpose of the present study is to evaluate a possible inhibitory effect on intestinal GAPDH by the nitric oxide generated during preconditioning. Nitric Oxide 104-116 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 91-96 10385084-11 1999 CONCLUSIONS: In summary, this study indicates that nitric oxide generated during ischemic preconditioning could act as a glycolytic modulator during subsequent ischemia, through its effect on GAPDH activity. Nitric Oxide 51-63 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 192-197 10092623-0 1999 Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 61-101 9354374-0 1997 Nitric oxide-induced modification of glyceraldehyde-3-phosphate dehydrogenase with NAD+ is not ADP-ribosylation. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 37-77 9354374-1 1997 One biological effect of nitric oxide (NO) has been believed to be exerted through induction of the ADP-ribosyltransferase activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 25-37 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 135-175 9354374-1 1997 One biological effect of nitric oxide (NO) has been believed to be exerted through induction of the ADP-ribosyltransferase activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 25-37 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 177-182 9038816-0 1997 Glutathione redox cycle regulates nitric oxide-mediated glyceraldehyde-3-phosphate dehydrogenase inhibition. Nitric Oxide 34-46 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 56-96 9038816-1 1997 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been identified as a potential target for nitric oxide (NO)-mediated cellular toxicity. Nitric Oxide 95-107 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 9038816-1 1997 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been identified as a potential target for nitric oxide (NO)-mediated cellular toxicity. Nitric Oxide 95-107 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 42-47 8626764-1 1996 Nitric oxide (NO)-related activity has been associated with an NAD+-dependent modification of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 117-157 8626764-1 1996 Nitric oxide (NO)-related activity has been associated with an NAD+-dependent modification of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 159-164 9706739-1 1998 The effects of nitric oxide (NO) or related molecules on the binding of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to the red blood cell (RBC) membrane were investigated. Nitric Oxide 15-27 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 72-112 9706739-1 1998 The effects of nitric oxide (NO) or related molecules on the binding of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to the red blood cell (RBC) membrane were investigated. Nitric Oxide 15-27 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 114-119 8912669-0 1996 Nitric oxide-dependent NAD linkage to glyceraldehyde-3-phosphate dehydrogenase: possible involvement of a cysteine thiyl radical intermediate. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 38-78 8791669-0 1996 Nitric oxide-induced covalent modification of glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 64-104 7639707-0 1995 Oxygen free radicals enhance the nitric oxide-induced covalent NAD(+)-linkage to neuronal glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 33-45 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 90-130 7639707-1 1995 Nitric oxide (NO) induces a covalent modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from various tissues. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 53-93 7639707-1 1995 Nitric oxide (NO) induces a covalent modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from various tissues. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 95-100 8327504-0 1993 Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 15-27 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 49-89 7540026-0 1995 Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase as a target for nitric oxide signaling. Nitric Oxide 87-99 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 30-70 8034046-0 1994 Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents. Nitric Oxide 107-119 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 38-78 7902582-0 1993 Glyceraldehyde-3-phosphate dehydrogenase is required for the transport of nitric oxide in platelets. Nitric Oxide 74-86 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-40 7902582-1 1993 Nitric oxide (NO) or NO-generating compounds like sodium nitroprusside (SNP) increase cellular levels of cGMP and produce S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12]. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 141-181 7902582-1 1993 Nitric oxide (NO) or NO-generating compounds like sodium nitroprusside (SNP) increase cellular levels of cGMP and produce S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12]. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 183-188 8349672-1 1993 Nitric oxide inhibits the activity of glyceraldehyde-3-phosphate dehydrogenase and stimulates NAD-dependent automodification of a cysteine (Dimmeler, S., Lottspeich, F., and Brune, B. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 38-78 8504856-1 1993 Nitric oxide was recently demonstrated to stimulate ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 72-112 8504856-1 1993 Nitric oxide was recently demonstrated to stimulate ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 114-119 8327504-1 1993 Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 40-80 8327504-1 1993 Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 82-87 8443164-4 1993 Using avidin affinity chromatography, we have purified a protein whose ADP-ribosylation is enhanced by nitric oxide and which has been identified as glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 103-115 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 149-189 8416805-0 1993 Nitric oxide preferentially stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase compared to alcohol or lactate dehydrogenase. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 64-104 8416805-1 1993 Recently we demonstrated that the radical nitric oxide (NO) stimulates the auto-ADP-ribosylation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) resulting in enzyme inhibition. Nitric Oxide 42-54 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 122-162 8416805-1 1993 Recently we demonstrated that the radical nitric oxide (NO) stimulates the auto-ADP-ribosylation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) resulting in enzyme inhibition. Nitric Oxide 42-54 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 164-169 1446679-0 1992 Characterization of a nitric-oxide-catalysed ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 22-34 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-105 1446679-1 1992 Auto-ADP-ribosylation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GraPDH) has recently been demonstrated to be dramatically stimulated in the presence of nitric oxide. Nitric Oxide 177-189 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 47-87 1446679-1 1992 Auto-ADP-ribosylation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GraPDH) has recently been demonstrated to be dramatically stimulated in the presence of nitric oxide. Nitric Oxide 177-189 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 89-95 29539261-6 2018 The elevated levels of nitric oxide induces S-nitrosylation of key proteins like Actin, DJ-1, HSP70 UCHL1, Parkin, and GAPDH that alter cytoskeletal network, protein folding machinery, ubiquitin proteasome system inducing apoptosis. Nitric Oxide 23-35 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 119-124 1512218-0 1992 Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 55-95 1512218-4 1992 Nitric oxide stimulates the auto-ADP-ribosylation of GAPDH in a time and concentration-dependent manner with maximal effects after about 60 min. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 53-58 34827652-0 2021 Modification of Glyceraldehyde-3-Phosphate Dehydrogenase with Nitric Oxide: Role in Signal Transduction and Development of Apoptosis. Nitric Oxide 62-74 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 16-56 33185982-3 2021 We demonstrate that the metabolites generated by metalloenzymes nitric oxide synthase and the radical S-adenosylmethionine (SAM) enzyme RSAD2 inhibit the activity of the housekeeping and glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Nitric Oxide 64-76 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 205-245 33185982-3 2021 We demonstrate that the metabolites generated by metalloenzymes nitric oxide synthase and the radical S-adenosylmethionine (SAM) enzyme RSAD2 inhibit the activity of the housekeeping and glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Nitric Oxide 64-76 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 247-252 29665354-2 2018 In particular, when cells are exposed to cellular stressors involving nitric oxide (NO) production, GAPDH can undergo NO-induced S-nitrosylation and S-nitrosylated GAPDH has been shown to elicit apoptosis. Nitric Oxide 70-82 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 100-105 29665354-2 2018 In particular, when cells are exposed to cellular stressors involving nitric oxide (NO) production, GAPDH can undergo NO-induced S-nitrosylation and S-nitrosylated GAPDH has been shown to elicit apoptosis. Nitric Oxide 70-82 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 164-169 1409644-0 1992 Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 49-89 28167533-2 2017 We reported previously that the active-site cysteine (Cys-152) of GAPDH plays an essential role in oxidative stress-induced aggregation of GAPDH associated with cell death, and a C152A-GAPDH mutant rescues nitric oxide (NO)-induced cell death by interfering with the aggregation of wild type (WT)-GAPDH. Nitric Oxide 206-218 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 66-71 28612328-5 2017 We describe a signaling cascade wherein nitric oxide drives the formation of a ternary protein complex comprised of glyceraldehyde 3-phosphate dehydrogenase, seven in absentia homolog 1, and Ras homolog enriched in brain downstream of the glutamate N-methyl-D-aspartate receptor. Nitric Oxide 40-52 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 116-156 29289615-0 2018 The role of resveratrol and melatonin in the nitric oxide and its oxidation products mediated functional and structural modifications of two glycolytic enzymes: GAPDH and LDH. Nitric Oxide 45-57 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 161-166 28167533-2 2017 We reported previously that the active-site cysteine (Cys-152) of GAPDH plays an essential role in oxidative stress-induced aggregation of GAPDH associated with cell death, and a C152A-GAPDH mutant rescues nitric oxide (NO)-induced cell death by interfering with the aggregation of wild type (WT)-GAPDH. Nitric Oxide 206-218 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 139-144 28167533-2 2017 We reported previously that the active-site cysteine (Cys-152) of GAPDH plays an essential role in oxidative stress-induced aggregation of GAPDH associated with cell death, and a C152A-GAPDH mutant rescues nitric oxide (NO)-induced cell death by interfering with the aggregation of wild type (WT)-GAPDH. Nitric Oxide 206-218 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 139-144 28167533-2 2017 We reported previously that the active-site cysteine (Cys-152) of GAPDH plays an essential role in oxidative stress-induced aggregation of GAPDH associated with cell death, and a C152A-GAPDH mutant rescues nitric oxide (NO)-induced cell death by interfering with the aggregation of wild type (WT)-GAPDH. Nitric Oxide 206-218 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 139-144 23719162-0 2013 Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Nitric Oxide 42-54 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 55-60 26022259-0 2015 Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine. Nitric Oxide 0-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 13-18 26022259-3 2015 We describe a signaling system wherein lower behavioral stimulant doses of cocaine, as well as higher neurotoxic doses, activate a cascade wherein nitric oxide nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to generate a complex with the ubiquitin-E3-ligase Siah1 which translocates to the nucleus. Nitric Oxide 147-159 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 173-213 26022259-3 2015 We describe a signaling system wherein lower behavioral stimulant doses of cocaine, as well as higher neurotoxic doses, activate a cascade wherein nitric oxide nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to generate a complex with the ubiquitin-E3-ligase Siah1 which translocates to the nucleus. Nitric Oxide 147-159 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 215-220 27282776-0 2016 Enhancement by GOSPEL protein of GAPDH aggregation induced by nitric oxide donor and its inhibition by NAD(.). Nitric Oxide 62-74 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 33-38 26782056-3 2016 We report a novel signaling pathway wherein NMDA receptor activation stimulates generation of nitric oxide (NO), which S-nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 94-106 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 134-174 26782056-3 2016 We report a novel signaling pathway wherein NMDA receptor activation stimulates generation of nitric oxide (NO), which S-nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitric Oxide 94-106 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 176-181 26725192-0 2016 Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death. Nitric Oxide 83-95 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 26-66 26725192-0 2016 Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death. Nitric Oxide 83-95 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 68-73 26725192-2 2016 Our previous reports suggest that nitric oxide-induced intramolecular disulfide-bonding GAPDH aggregation, which occurs through oxidation of the active site cysteine (Cys-152), participates in a mechanism to account for nitric oxide-induced death signaling in some neurodegenerative/neuropsychiatric disorders. Nitric Oxide 34-46 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 88-93 26725192-2 2016 Our previous reports suggest that nitric oxide-induced intramolecular disulfide-bonding GAPDH aggregation, which occurs through oxidation of the active site cysteine (Cys-152), participates in a mechanism to account for nitric oxide-induced death signaling in some neurodegenerative/neuropsychiatric disorders. Nitric Oxide 220-232 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 88-93 26725192-3 2016 Here, we demonstrate a rescue strategy for nitric oxide-induced cell death accompanied by GAPDH aggregation in a mutant with a substitution of Cys-152 to alanine (C152A-GAPDH). Nitric Oxide 43-55 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 90-95 26725192-3 2016 Here, we demonstrate a rescue strategy for nitric oxide-induced cell death accompanied by GAPDH aggregation in a mutant with a substitution of Cys-152 to alanine (C152A-GAPDH). Nitric Oxide 43-55 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 169-174 26725192-4 2016 Pre-incubation of purified wild-type GAPDH with C152A-GAPDH under exposure to nitric oxide inhibited wild-type GAPDH aggregation in a concentration-dependent manner in vitro. Nitric Oxide 78-90 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 37-42 26725192-4 2016 Pre-incubation of purified wild-type GAPDH with C152A-GAPDH under exposure to nitric oxide inhibited wild-type GAPDH aggregation in a concentration-dependent manner in vitro. Nitric Oxide 78-90 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 54-59 26725192-4 2016 Pre-incubation of purified wild-type GAPDH with C152A-GAPDH under exposure to nitric oxide inhibited wild-type GAPDH aggregation in a concentration-dependent manner in vitro. Nitric Oxide 78-90 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 54-59 26725192-5 2016 Several lines of structural analysis revealed that C152A-GAPDH extensively interfered with nitric oxide-induced GAPDH-amyloidogenesis. Nitric Oxide 91-103 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 57-62 26725192-5 2016 Several lines of structural analysis revealed that C152A-GAPDH extensively interfered with nitric oxide-induced GAPDH-amyloidogenesis. Nitric Oxide 91-103 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 112-117 26725192-6 2016 Overexpression of doxycycline-inducible C152A-GAPDH in SH-SY5Y neuroblastoma significantly rescued nitric oxide-induced death, concomitant with the decreased formation of GAPDH aggregates. Nitric Oxide 99-111 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 46-51 26787898-0 2016 Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Nitric Oxide 46-58 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 59-64 25859407-7 2015 Several cancer-related factors, such as insulin, hypoxia inducible factor-1 (HIF-1), p53, nitric oxide (NO), and acetylated histone, not only modulate GAPDH gene expression but also affect protein functions via common pathways. Nitric Oxide 90-102 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 151-156 23719162-2 2013 We report that a signaling cascade involving nitric oxide (NO) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mediates cocaine"s transcriptional and behavioral actions. Nitric Oxide 45-57 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 109-114 22851450-6 2013 Two metabolic gases, nitric oxide and hydrogen sulfide, which are enzymatically produced, appear to exert their signaling properties through non-enzymatic reaction with GAPDH. Nitric Oxide 21-33 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 169-174 20601085-2 2010 Under apoptotic stresses, cells activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus. Nitric Oxide 41-53 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 94-99 23321474-6 2013 H2O2-mediated reduction in beta-cell viability is controlled by PARP, whereas cell death in response to nitric oxide is PARP independent but associated with the nuclear localization of GAPDH. Nitric Oxide 104-116 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 185-190 22847419-5 2012 Furthermore, the GAPDH substrate glyceraldehyde-3-phosphate (G3P) and the nitric oxide donor S-nitrosoglutathione (GSNO) both negatively regulate GAPDH inhibition of telomerase activity. Nitric Oxide 74-86 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 146-151 20797619-3 2010 Mechanistically, overexpression, as well as enhanced autoacetylation, of p300 induced by nucleophosmin (NPM1) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) causes the hyperacetylation, which is nitric oxide (NO) signal dependent. Nitric Oxide 201-213 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 114-154 20797619-3 2010 Mechanistically, overexpression, as well as enhanced autoacetylation, of p300 induced by nucleophosmin (NPM1) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) causes the hyperacetylation, which is nitric oxide (NO) signal dependent. Nitric Oxide 201-213 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 156-161 19874799-4 2009 Treatment of purified recombinant S284C-GAPDH in vitro with the nitric oxide donor NOR3 led to greater aggregation than wild type-GAPDH. Nitric Oxide 64-76 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 39-45 19874799-4 2009 Treatment of purified recombinant S284C-GAPDH in vitro with the nitric oxide donor NOR3 led to greater aggregation than wild type-GAPDH. Nitric Oxide 64-76 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 40-45