PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22254000-4 2010 For example, their ability to activate ERK in neurons leads to a promotion of neuronal survival and cognitive enhancements, both of which influence the progression of Alzheimer"s disease, whilst ERK activation by polyphenols in vascular endothelial cells influences nitric oxide production, blood pressure and ultimately CVD risk. Nitric Oxide 266-278 mitogen-activated protein kinase 1 Homo sapiens 39-42 22254000-4 2010 For example, their ability to activate ERK in neurons leads to a promotion of neuronal survival and cognitive enhancements, both of which influence the progression of Alzheimer"s disease, whilst ERK activation by polyphenols in vascular endothelial cells influences nitric oxide production, blood pressure and ultimately CVD risk. Nitric Oxide 266-278 mitogen-activated protein kinase 1 Homo sapiens 195-198 19454490-7 2009 In addition to cell growth/proliferation, silencing TRPM7 also increased expression of nitric oxide synthase and nitric oxide production in an ERK pathway-dependent manner. Nitric Oxide 87-99 mitogen-activated protein kinase 1 Homo sapiens 143-146 19766439-0 2010 Advanced glycation endproducts increase EPC apoptosis and decrease nitric oxide release via MAPK pathways. Nitric Oxide 67-79 mitogen-activated protein kinase 1 Homo sapiens 92-96 19035132-0 2008 [Effect of extracellular signal-regulated kinase pathway on nitric oxide release by human umbilical vein endothelial cell induced by placental growth factor-1]. Nitric Oxide 60-72 mitogen-activated protein kinase 1 Homo sapiens 11-48 19111870-0 2009 Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons. Nitric Oxide 20-32 mitogen-activated protein kinase 1 Homo sapiens 46-49 18854222-0 2009 p38MAPK and ERK promote nitric oxide production in cultured human retinal pigmented epithelial cells induced by high concentration glucose. Nitric Oxide 24-36 mitogen-activated protein kinase 1 Homo sapiens 12-15 19039081-10 2008 We discovered that methylmercury could activate protein kinase A, which in turn would inhibit the activation of Raf-1-ERK and so inhibit the release of nitric oxide. Nitric Oxide 152-164 mitogen-activated protein kinase 1 Homo sapiens 118-121 19012740-0 2009 Glutamate and nitric oxide modulate ERK and CREB phosphorylation in the avian retina: evidence for direct signaling from neurons to Muller glial cells. Nitric Oxide 14-26 mitogen-activated protein kinase 1 Homo sapiens 36-39 19035132-1 2008 OBJECTIVE: To investigate the effect of extracellular signal-regulated kinase (ERK) pathway on nitric oxide (NO) release by human umbilical vein endothelial cell (HUVEC) induced by placental growth factor-1 (PLGF-1). Nitric Oxide 95-107 mitogen-activated protein kinase 1 Homo sapiens 40-77 19035132-1 2008 OBJECTIVE: To investigate the effect of extracellular signal-regulated kinase (ERK) pathway on nitric oxide (NO) release by human umbilical vein endothelial cell (HUVEC) induced by placental growth factor-1 (PLGF-1). Nitric Oxide 95-107 mitogen-activated protein kinase 1 Homo sapiens 79-82 18325324-0 2008 The nitric oxide-sensitive p21Ras-ERK pathway mediates S-nitrosoglutathione-induced apoptosis. Nitric Oxide 4-16 mitogen-activated protein kinase 1 Homo sapiens 34-37 16547595-10 2006 CONCLUSION: These results demonstrate that nitric oxide exerts its anti-apoptotic and cardioprotective effects, at least in part, by activation of ERK in ischemic/reperfused heart. Nitric Oxide 43-55 mitogen-activated protein kinase 1 Homo sapiens 147-150 18523870-0 2007 Effect of nitric oxide donor and gamma irradiation on modifications of ERK and JNK in murine peritoneal macrophages. Nitric Oxide 10-22 mitogen-activated protein kinase 1 Homo sapiens 71-74 17391532-0 2007 Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 82-85 18280666-2 2008 We have previously demonstrated that stimulation of the K(ATP) channel by nitric oxide (NO) requires activation of Ras- and extracellular signal-regulated kinase (ERK) of the mitogen-activated protein kinase (MAPK) family. Nitric Oxide 74-86 mitogen-activated protein kinase 1 Homo sapiens 124-161 18280666-2 2008 We have previously demonstrated that stimulation of the K(ATP) channel by nitric oxide (NO) requires activation of Ras- and extracellular signal-regulated kinase (ERK) of the mitogen-activated protein kinase (MAPK) family. Nitric Oxide 74-86 mitogen-activated protein kinase 1 Homo sapiens 163-166 16427328-0 2006 Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Nitric Oxide 109-121 mitogen-activated protein kinase 1 Homo sapiens 43-46 16467878-3 2006 Nitric oxide (NO) and its metabolites produced by inducible nitric oxide synthase (iNOS) are important products of hypoxic stress, and NO may activate or modulate extracellular signal regulated kinase (ERK). Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 163-200 16623825-0 2006 Role of intracellular Ca2+ and calmodulin/MAP kinase kinase/extracellular signal-regulated protein kinase signalling pathway in the mitogenic and antimitogenic effect of nitric oxide in glia- and neurone-derived cell lines. Nitric Oxide 170-182 mitogen-activated protein kinase 1 Homo sapiens 60-105 16467878-3 2006 Nitric oxide (NO) and its metabolites produced by inducible nitric oxide synthase (iNOS) are important products of hypoxic stress, and NO may activate or modulate extracellular signal regulated kinase (ERK). Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 202-205 16389725-5 2005 Treatment with 10 nM endothelin-1 (ET-1), a potent vasoconstrictor with vascular mitogenic properties, induced phosphorylation of both p44mapk and p42mapk, but treatment with the exogenous nitric oxide (NO) donor sodium nitroprusside inhibited both p44mapk and p42mapk phosphorylation by ET-1. Nitric Oxide 189-201 mitogen-activated protein kinase 1 Homo sapiens 147-154 14998552-0 2004 Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression. Nitric Oxide 63-75 mitogen-activated protein kinase 1 Homo sapiens 22-25 16142585-0 2005 Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells. Nitric Oxide 55-67 mitogen-activated protein kinase 1 Homo sapiens 30-33 15256218-0 2004 Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death. Nitric Oxide 99-111 mitogen-activated protein kinase 1 Homo sapiens 19-56 15256218-0 2004 Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death. Nitric Oxide 99-111 mitogen-activated protein kinase 1 Homo sapiens 61-64 15178764-0 2004 Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Nitric Oxide 134-146 mitogen-activated protein kinase 1 Homo sapiens 33-70 14998552-2 2004 The roles of p38 and extracellular signal-regulated kinase (ERK) in the regulation of nitric oxide (NO) and proinflammatory cytokine expression in J774A.1 macrophages in response to LPS were examined. Nitric Oxide 86-98 mitogen-activated protein kinase 1 Homo sapiens 60-63 14656708-0 2004 Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK. Nitric Oxide 10-22 mitogen-activated protein kinase 1 Homo sapiens 120-123 14726216-3 2004 Nitric oxide (NO)-releasing drugs have been reported to have an inhibitory effect on shear stress-induced extracellular signal-regulated kinase (ERK) activation in endothelial cells. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 106-143 14726216-3 2004 Nitric oxide (NO)-releasing drugs have been reported to have an inhibitory effect on shear stress-induced extracellular signal-regulated kinase (ERK) activation in endothelial cells. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 145-148 12048219-1 2002 In articular chondrocytes, nitric oxide (NO) production triggers dedifferentiation and apoptotic cell death that is regulated by the converse functions of two mitogen-activated protein kinase subtypes, extracellular signal-regulated kinase (ERK) and p38 kinase. Nitric Oxide 27-39 mitogen-activated protein kinase 1 Homo sapiens 202-239 14695202-0 2003 MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Nitric Oxide 101-113 mitogen-activated protein kinase 1 Homo sapiens 35-72 12907684-1 2003 Nitric oxide (NO) in articular chondrocytes regulates differentiation, survival, and inflammatory responses by modulating ERK-1 and -2, p38 kinase, and protein kinase C (PKC) alpha and zeta. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 136-139 12588866-1 2003 Nitric oxide (NO) causes apoptosis and dedifferentiation of articular chondrocytes by the modulation of extracellular signal-regulated kinase (ERK), p38 kinase, and protein kinase C (PKC) alpha and -zeta. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 104-141 12588866-1 2003 Nitric oxide (NO) causes apoptosis and dedifferentiation of articular chondrocytes by the modulation of extracellular signal-regulated kinase (ERK), p38 kinase, and protein kinase C (PKC) alpha and -zeta. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 143-146 12588866-1 2003 Nitric oxide (NO) causes apoptosis and dedifferentiation of articular chondrocytes by the modulation of extracellular signal-regulated kinase (ERK), p38 kinase, and protein kinase C (PKC) alpha and -zeta. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 149-152 12369731-0 2002 Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 70-73 12587977-0 2002 Nitric oxide as a modulator of gastric mucin synthesis: role of ERK and p38 mitogen-activated protein kinase activation. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 64-67 12048219-1 2002 In articular chondrocytes, nitric oxide (NO) production triggers dedifferentiation and apoptotic cell death that is regulated by the converse functions of two mitogen-activated protein kinase subtypes, extracellular signal-regulated kinase (ERK) and p38 kinase. Nitric Oxide 27-39 mitogen-activated protein kinase 1 Homo sapiens 241-244 10872747-0 2000 Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 76-79 11931846-4 2002 Since in vitro phosphorylation by ERK reduced the catalytic activity of eNOS, it was suggested that this mechanism may be an important determinant of nitric oxide signalling in endothelial cells. Nitric Oxide 150-162 mitogen-activated protein kinase 1 Homo sapiens 34-37 11931846-5 2002 To explore the physiological role of ERK as regulator of nitric oxide synthesis in intact cells, we measured the effects of the kinase inhibitor PD 98059 on BK- and ATP-induced nitric oxide formation in cultured endothelial cells and isolated vascular smooth muscle strips. Nitric Oxide 57-69 mitogen-activated protein kinase 1 Homo sapiens 37-40 10872747-0 2000 Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 84-87 33149755-8 2020 GO analysis showed that the 18 target genes were mainly enriched in angiogenesis, nitric oxide biosynthetic process, ERK1 and ERK2 cascade, cellular response to drug, and MAPK cascade. Nitric Oxide 82-94 mitogen-activated protein kinase 1 Homo sapiens 126-130 10753954-0 2000 Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k). Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 105-142 10588362-0 1999 Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide. Nitric Oxide 71-83 mitogen-activated protein kinase 1 Homo sapiens 47-50 10588362-4 1999 In cerebral cortical neurons, this calcium influx through NMDA receptors activates Ras and its downstream effector, Erk, via nitric oxide (NO) generation by calcium-dependent neuronal NO synthase. Nitric Oxide 125-137 mitogen-activated protein kinase 1 Homo sapiens 116-119 9461619-0 1998 Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 81-121 34746026-3 2021 p38 MAPK, ERK, and STAT3 in regulating iNOS expression and thereby the levels of the free radical Nitric oxide in senescent cells. Nitric Oxide 98-110 mitogen-activated protein kinase 1 Homo sapiens 10-13 33217980-6 2020 According to Gene Ontology enrichment analysis, these genes are associated with insulin secretion, glucose metabolism, glycogen biosynthesis, gluconeogenesis, MAPK and JAK-STAT cascades, protein kinase B signaling, cell proliferation, nitric oxide biosynthesis, etc. Nitric Oxide 235-247 mitogen-activated protein kinase 1 Homo sapiens 159-163 26086160-0 2015 Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure. Nitric Oxide 32-44 mitogen-activated protein kinase 1 Homo sapiens 64-67 28506076-2 2017 Unlike growth factors associated with a single oncogenic pathway, nitric oxide (NO) has a ubiquitous nature wherein it simultaneously mediates major oncogenic pathways from Akt/PI3K and RAS/ERK to HIF1a and TGFb. Nitric Oxide 66-78 mitogen-activated protein kinase 1 Homo sapiens 190-193 28380434-5 2017 Nitric oxide has a positive effect on glycolysis by inducing PKM2 nuclear translocation in an EGFR/ERK2 signaling-dependent manner. Nitric Oxide 0-12 mitogen-activated protein kinase 1 Homo sapiens 99-103 28401001-0 2017 Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway. Nitric Oxide 66-78 mitogen-activated protein kinase 1 Homo sapiens 88-91 27034160-6 2016 We further show that netrin-1 signals to UNC5B/FAK to stimulate nitric oxide production, which promotes PP2A-mediated inhibition of the MEK/ERK pathway and decreases phosphorylated-c-Jun recruitment to the ITGB4 promoter. Nitric Oxide 64-76 mitogen-activated protein kinase 1 Homo sapiens 140-143 26086160-0 2015 Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure. Nitric Oxide 32-44 mitogen-activated protein kinase 1 Homo sapiens 72-76 24982885-7 2014 Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension. Nitric Oxide 112-124 mitogen-activated protein kinase 1 Homo sapiens 130-133 26491301-8 2015 Following, by using specific MAPK inhibitors, we observed that lipopolysaccharide-induced production of monocyte chemotactic protein-1 and nitric oxide was significantly inhibited on the Ti/TiO2 surface via p38 and ERK1/2, but not via JNK. Nitric Oxide 139-151 mitogen-activated protein kinase 1 Homo sapiens 207-210 23892079-0 2013 IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly-I:C. Understanding nitric oxide (NO) in innate anti-viral immunity and immune-mediated pathology is hampered by incomplete details of its transcriptional and signaling factors. Nitric Oxide 33-45 mitogen-activated protein kinase 1 Homo sapiens 9-12 23892079-0 2013 IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly-I:C. Understanding nitric oxide (NO) in innate anti-viral immunity and immune-mediated pathology is hampered by incomplete details of its transcriptional and signaling factors. Nitric Oxide 113-125 mitogen-activated protein kinase 1 Homo sapiens 9-12 23441482-1 2013 Potential role of ERK1/2 kinase in conjunction with p38 in the regulation of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production, and superoxide anion generation by human neutrophils (PMNs) exposed to N-nitrosodimethylamine (NDMA) was determined. Nitric Oxide 87-99 mitogen-activated protein kinase 1 Homo sapiens 52-55 23657295-4 2013 In current study, we described that ERK undergoes S-nitrosylation by nitric oxide (NO). Nitric Oxide 69-81 mitogen-activated protein kinase 1 Homo sapiens 36-39 21933914-7 2012 These events were associated with regulation of mitogen-activated protein kinases (MAPK; including p38 MAPK, JNK, and ERK) phosphorylation and promoted downstream nitric oxide (NO) production. Nitric Oxide 163-175 mitogen-activated protein kinase 1 Homo sapiens 83-87 21933914-7 2012 These events were associated with regulation of mitogen-activated protein kinases (MAPK; including p38 MAPK, JNK, and ERK) phosphorylation and promoted downstream nitric oxide (NO) production. Nitric Oxide 163-175 mitogen-activated protein kinase 1 Homo sapiens 103-107 21933914-7 2012 These events were associated with regulation of mitogen-activated protein kinases (MAPK; including p38 MAPK, JNK, and ERK) phosphorylation and promoted downstream nitric oxide (NO) production. Nitric Oxide 163-175 mitogen-activated protein kinase 1 Homo sapiens 118-121 23543871-6 2012 These nitric oxide-mediated events in itiate oncogenic signaling pathways such as PI3K/Akt, Ras/ERK, beta-catenin, nuclear factor-kappaB, and AP-1. Nitric Oxide 6-18 mitogen-activated protein kinase 1 Homo sapiens 96-99 22506718-10 2012 The activation of both JNK and p38 mitogen-activated protein kinase mechanotransduction cascades is a crucial intracellular mechanism that mediates cyclooxygense-2/prostaglandin E2 and inducible NO synthase/nitric oxide production. Nitric Oxide 207-219 mitogen-activated protein kinase 1 Homo sapiens 31-34