PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17971446-1 2007 Previous reports suggest heat shock protein 90 (hsp90) associates with endothelial nitric-oxide synthase (eNOS) to increase nitric oxide (*NO) generation. Nitric Oxide 124-136 nitric oxide synthase 3 Bos taurus 71-104 19608646-0 2009 The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production. Nitric Oxide 92-104 nitric oxide synthase 3 Bos taurus 31-35 11278264-0 2001 Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. Nitric Oxide 46-58 nitric oxide synthase 3 Bos taurus 85-118 15774480-2 2005 In these studies, we show that eNOS is dynamically regulated by S-nitrosylation, the covalent adduction of nitric oxide (NO)-derived nitrosyl groups to the cysteine thiols of proteins. Nitric Oxide 107-119 nitric oxide synthase 3 Bos taurus 31-35 12799359-1 2003 Endothelial nitric-oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. Nitric Oxide 86-98 nitric oxide synthase 3 Bos taurus 0-33 12799359-1 2003 Endothelial nitric-oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. Nitric Oxide 86-98 nitric oxide synthase 3 Bos taurus 35-39 12107173-1 2002 Peroxynitrite (ONOO(-)), a nitric oxide-derived oxidant, uncouples endothelial nitric oxide synthase (eNOS) and increases enzymatic production of superoxide anions (O(2)()) (Zou, M. H., Shi, C., and Cohen, R. A. Nitric Oxide 27-39 nitric oxide synthase 3 Bos taurus 67-100 11796200-5 2002 The effects of inhibitors of endothelial nitric oxide synthesis also suggested that extracellular L-arginine availability limits intracellular eNOS activity. Nitric Oxide 41-53 nitric oxide synthase 3 Bos taurus 143-147 17822962-1 2007 Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important modulator of vascular function. Nitric Oxide 12-24 nitric oxide synthase 3 Bos taurus 35-39 17028163-6 2007 TNF-alpha also induced nitric oxide production through activation of endothelial nitric oxide synthase (eNOS) present in the same membrane compartment. Nitric Oxide 23-35 nitric oxide synthase 3 Bos taurus 69-102 17028163-6 2007 TNF-alpha also induced nitric oxide production through activation of endothelial nitric oxide synthase (eNOS) present in the same membrane compartment. Nitric Oxide 23-35 nitric oxide synthase 3 Bos taurus 104-108 16842672-6 2006 RESULTS: In cultured BAEC, bezafibrate significantly upregulated eNOS expressions at protein and mRNA levels in a concentration-dependent fashion (50 - 200 micromol/L) (P < 0.05), and increased nitric oxide (NO) production, respectively[control (14.97 +/- 1.29) micromol/L, different concentration groups (25.12 +/- 1.25) micromol/L, (30.12 +/- 1.85) micromol/L, (33.47 +/- 1.22) micromol/L], and enhanced phosphorylation of eNOS-ser-1179 site (P < 0.05), but not eNOS-thr-497 site. Nitric Oxide 197-209 nitric oxide synthase 3 Bos taurus 65-69 15919765-5 2005 In accordance with its inhibition of nitric oxide release, cocaine decreased endothelial nitric-oxide synthase (eNOS) protein levels in BCAECs in a concentration-dependent manner. Nitric Oxide 37-49 nitric oxide synthase 3 Bos taurus 77-110 14984014-2 2003 The activation of eNOS results in the production of nitric oxide (NO), which is responsible for vasodilation of blood vessels. Nitric Oxide 52-64 nitric oxide synthase 3 Bos taurus 18-22 12501214-1 2002 The endothelial isoform of nitric oxide synthase (eNOS) is a calcium/calmodulin-dependent enzyme that catalyzes the synthesis of nitric oxide, a key mediator of vascular homeostasis. Nitric Oxide 27-39 nitric oxide synthase 3 Bos taurus 50-54 12501214-9 2002 Our results indicate that regulation of eNOS dephosphorylation may be a key point for control of nitric oxide-dependent signaling pathways in vascular endothelial cells. Nitric Oxide 97-109 nitric oxide synthase 3 Bos taurus 40-44 10692402-2 2000 Mutation of this residue to the negatively charged aspartate (S1179D eNOS) increases nitric oxide (NO) production constitutively, in the absence of agonist challenge. Nitric Oxide 85-97 nitric oxide synthase 3 Bos taurus 69-73 11744239-7 2000 BK-stimulated nitric oxide (NO) release is completely blocked by pretreatment with geldanamycin, a specific inhibitor of Hsp90, illustrating the importance of the Hsp90-eNOS interaction. Nitric Oxide 14-26 nitric oxide synthase 3 Bos taurus 169-173 10077589-10 1999 Use of the nitric oxide-specific dye diaminofluorescein shows that estradiol treatment increases nitric oxide generation by endothelial cells; this response is blocked by ICI 182,780 and by the eNOS inhibitor Nomega-nitro-L-arginine. Nitric Oxide 11-23 nitric oxide synthase 3 Bos taurus 194-198 10400908-1 1999 Synthesis of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) is critical for normal vascular homeostasis. Nitric Oxide 13-25 nitric oxide synthase 3 Bos taurus 34-67 10400908-1 1999 Synthesis of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) is critical for normal vascular homeostasis. Nitric Oxide 13-25 nitric oxide synthase 3 Bos taurus 69-73 10514497-1 1999 Endothelial cells release nitric oxide (NO) acutely in response to increased laminar fluid shear stress, and the increase is correlated with enhanced phosphorylation of endothelial nitric-oxide synthase (eNOS). Nitric Oxide 26-38 nitric oxide synthase 3 Bos taurus 169-202 10514497-1 1999 Endothelial cells release nitric oxide (NO) acutely in response to increased laminar fluid shear stress, and the increase is correlated with enhanced phosphorylation of endothelial nitric-oxide synthase (eNOS). Nitric Oxide 26-38 nitric oxide synthase 3 Bos taurus 204-208 10336519-1 1999 The aim of this study was to determine the effect of ethanol on endothelial nitric oxide synthase (eNOS), the enzyme responsible for the production of the important vasoactive agent nitric oxide. Nitric Oxide 76-88 nitric oxide synthase 3 Bos taurus 99-103 10235453-2 1999 We tested the hypothesis that ethanol increases the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production in bovine aortic endothelial cells (BAEC). Nitric Oxide 78-90 nitric oxide synthase 3 Bos taurus 101-105 10077589-10 1999 Use of the nitric oxide-specific dye diaminofluorescein shows that estradiol treatment increases nitric oxide generation by endothelial cells; this response is blocked by ICI 182,780 and by the eNOS inhibitor Nomega-nitro-L-arginine. Nitric Oxide 97-109 nitric oxide synthase 3 Bos taurus 194-198 7526706-1 1994 It is unknown whether high fetal pulmonary vascular tone is due in part to absent or decreased endothelial nitric oxide synthase (eNOS), the enzyme that produces nitric oxide in the vascular endothelium. Nitric Oxide 107-119 nitric oxide synthase 3 Bos taurus 130-134 8692835-1 1996 The membrane association of endothelial nitric oxide synthase (eNOS) plays an important role in the biosynthesis of nitric oxide (NO) in vascular endothelium. Nitric Oxide 40-52 nitric oxide synthase 3 Bos taurus 63-67 7531174-0 1995 Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Nitric oxide (NO) is an important molecular messenger accounting for endothelium-derived relaxing factor. Nitric Oxide 78-90 nitric oxide synthase 3 Bos taurus 14-47 8891749-1 1996 To determine whether angiotensin (ANG) II, a vasoconstrictor hormone, activates constitutive nitric oxide synthase (cNOS) in endothelial cells (ECs), we investigated the cellular mechanism by which ANG II induces nitric oxide (NO) formation in cultured bovine ECs. Nitric Oxide 93-105 nitric oxide synthase 3 Bos taurus 116-120 7526706-7 1994 We speculate that the early presence of eNOS in the fetal lung supports a possible role for endogenous nitric oxide activity in the regulation of vascular tone or angiogenesis in the developing pulmonary circulation. Nitric Oxide 103-115 nitric oxide synthase 3 Bos taurus 40-44 7519368-1 1994 BACKGROUND: Endothelial nitric oxide synthase (eNOS) is an important enzyme that controls the production of a potent vascular smooth muscle relaxing factor, nitric oxide. Nitric Oxide 24-36 nitric oxide synthase 3 Bos taurus 47-51 23007928-1 2013 BACKGROUND: C-peptide has been shown to stimulate the production of nitric oxide (NO) in aortic endothelial cells via activation of endothelial nitric oxide synthase (eNOS) through an increased calcium influx. Nitric Oxide 68-80 nitric oxide synthase 3 Bos taurus 132-165 34474112-3 2021 OBJECTIVE: We hypothesized that PKCbeta and PKCeta differentially modulate shear stress-induced nitric oxide (NO) production by regulating the transduced calcium signals and the resultant eNOS activation. Nitric Oxide 96-108 nitric oxide synthase 3 Bos taurus 188-192 33592314-2 2021 Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays an essential role in maintenance of endothelial integrity including endothelial cell (EC) survival. Nitric Oxide 0-12 nitric oxide synthase 3 Bos taurus 31-54 33592314-2 2021 Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays an essential role in maintenance of endothelial integrity including endothelial cell (EC) survival. Nitric Oxide 0-12 nitric oxide synthase 3 Bos taurus 56-60 29474156-1 2018 Endothelial nitric oxide synthase (eNOS), a constitutive enzyme expressed in vascular endothelial cells, is the main source of nitric oxide (NO), which plays key roles in diverse biological functions, including regulation of vascular tone. Nitric Oxide 12-24 nitric oxide synthase 3 Bos taurus 35-39 29474156-2 2018 Exposure to radiation has been known to generate nitric oxide from eNOS; however, the precise mechanism of its generation and function is not known. Nitric Oxide 49-61 nitric oxide synthase 3 Bos taurus 67-71 7680289-1 1993 Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine. Nitric Oxide 17-29 nitric oxide synthase 3 Bos taurus 40-45 24405159-1 2014 BACKGROUND AND PURPOSE: Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Nitric Oxide 24-36 nitric oxide synthase 3 Bos taurus 55-59 22155232-2 2012 Although decreased nitric oxide (NO) production via decreased phosphorylation of endothelial NO synthase at serine 1179 (eNOS-Ser(1179)) was reported to be partly involved in JNK2-derived endothelial dysfunction, JNK2 seems likely to be indirectly involved in this signaling pathway. Nitric Oxide 19-31 nitric oxide synthase 3 Bos taurus 121-125 22696221-1 2012 Endothelial nitric-oxide synthase (eNOS) utilizes l-arginine as its principal substrate, converting it to l-citrulline and nitric oxide (NO). Nitric Oxide 123-135 nitric oxide synthase 3 Bos taurus 0-33 21420267-12 2011 Nitric oxide increased the protein content of PGF synthase, PGE synthase, endothelial NOS, and inducible NOS (P < 0.05). Nitric Oxide 0-12 nitric oxide synthase 3 Bos taurus 74-89