PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10679307-0 2000 Induction of COX-2 expression by nitric oxide in rheumatoid synovial cells. Nitric Oxide 33-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 13-18 10767759-6 2000 Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules. Nitric Oxide 117-129 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-20 10767759-6 2000 Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules. Nitric Oxide 117-129 mitochondrially encoded cytochrome c oxidase II Homo sapiens 189-195 10679307-3 2000 In this study, we evaluated the contribution of nitric oxide (NO) to COX-2 expression in rheumatoid synovial cells. Nitric Oxide 48-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 69-74 30312760-5 2018 This study shows that 27-OH and HNE promote up-regulation of both the inducible enzymes COX-2 and mPGES-1, leading to increased production of prostaglandin (PG) E2 and inducible nitric oxide synthase, and the subsequent release of nitric oxide in human promonocytic U937 cells. Nitric Oxide 178-190 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 19078324-2 1998 However, the complex physiologic responses to inflammation and disease suggest that COX-2 inhibition by NSAIDs is an action on only one several interrelated components of the inflammatory response, such as oxygen radical production, nitric oxide synthesis, and heme oxygenase activity, that may affect resolution of inflammation. Nitric Oxide 233-245 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-89 27305969-0 2016 Effect of ligand denticity on the nitric oxide reactivity of cobalt(ii) complexes. Nitric Oxide 34-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 68-70 30149323-0 2018 Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy. Nitric Oxide 95-107 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-123 30149323-1 2018 A series of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy were designed, synthesized and biologically evaluated. Nitric Oxide 60-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 83-88 27711752-0 2016 Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes. Nitric Oxide 61-73 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 20664853-1 2010 Nitric oxide (NO) and its reduced form nitroxyl (HNO), effective vasodilation agents that can inhibit platelet aggregation and adhesion, could suppress adverse cardiovascular effects associated with the use of selective COX-2 inhibitors. Nitric Oxide 0-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 220-225 22670565-0 2012 Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway. Nitric Oxide 0-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 125-130 23734008-12 2013 In small resistance arteries of essential hypertensive patients, COX-2 is overexpressed and reduces nitric oxide availability. Nitric Oxide 100-112 mitochondrially encoded cytochrome c oxidase II Homo sapiens 65-70 22354161-6 2012 Investigation of the antioxidative properties showed that the polymeric Co(II) complex has a strong radical scavenging potency against hydroxyl radicals, 2,2-diphenyl-1-picrylhydrazyl radicals, nitric oxide and superoxide anion radicals. Nitric Oxide 194-206 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-78 22134498-4 2012 Based on the spectroscopic operando results, a concise mechanistic scheme of the selective catalytic reduction of nitric oxide by propene, triggered by a two-electron Co(II)/Co(0) redox couple, was developed. Nitric Oxide 114-126 mitochondrially encoded cytochrome c oxidase II Homo sapiens 167-173 17612370-7 2007 Prostaglandins and nitric oxide biosynthesis is involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of these mediators. Nitric Oxide 19-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 19440636-5 2009 In particular, the reactivity of the isolated Co(II) porphyrin species towards nitric oxide (NO) is investigated, with possible implications in the understanding of the crucial role played by NO in biological systems. Nitric Oxide 79-91 mitochondrially encoded cytochrome c oxidase II Homo sapiens 46-52 19096033-5 2009 Endothelium-dependent contractions were triggered by acetylcholine (ACh) after inhibition of nitric oxide production and they were abolished by COX-2 but not COX-1 inhibitors or by thromboxane-prostanoid receptor antagonists. Nitric Oxide 93-105 mitochondrially encoded cytochrome c oxidase II Homo sapiens 144-149 16968790-12 2006 CONCLUSIONS: In sHT patients, low-grade chronic inflammation causes endothelial dysfunction and impaired nitric oxide availability by a COX-2-dependent pathway leading to increased production of oxidative stress. Nitric Oxide 105-117 mitochondrially encoded cytochrome c oxidase II Homo sapiens 136-141 17444277-5 2007 Such temporal adaptation occurs via modulators such as nitric oxide (NO), primarily derived from NOS-1, angiotensin II and COX-2 products. Nitric Oxide 55-67 mitochondrially encoded cytochrome c oxidase II Homo sapiens 123-128 16763169-0 2006 COX-2, another important player in the nitric oxide-endothelin cross-talk: good news for COX-2 inhibitors? Nitric Oxide 39-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 16900533-1 2006 BACKGROUND AND OBJECTIVES: It has been recognized that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) produce important endogenous factors of human tumors such as nitric oxide (NO) and prostaglandins, which is involved in the process of carcinogenesis and tumor progression. Nitric Oxide 65-77 mitochondrially encoded cytochrome c oxidase II Homo sapiens 114-119 16763169-0 2006 COX-2, another important player in the nitric oxide-endothelin cross-talk: good news for COX-2 inhibitors? Nitric Oxide 39-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 89-94 15781386-0 2005 Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents. Nitric Oxide 149-161 mitochondrially encoded cytochrome c oxidase II Homo sapiens 133-138 15852032-2 2005 AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl)propanoate] is a COX-inhibiting nitric oxide donor that inhibits COX-1 and COX-2. Nitric Oxide 88-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 17193179-0 2005 The furoxan system: design of selective nitric oxide (NO) donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities. Nitric Oxide 40-52 mitochondrially encoded cytochrome c oxidase II Homo sapiens 78-83 15990700-1 2005 Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke that is attributed to their ability to inhibit prostacyclin (PGI2), lipoxins, resolvins, and endothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A2 (TXA2). Nitric Oxide 186-198 mitochondrially encoded cytochrome c oxidase II Homo sapiens 10-15 15879708-4 2005 When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor). Nitric Oxide 196-208 mitochondrially encoded cytochrome c oxidase II Homo sapiens 53-58 15879708-8 2005 These data demonstrate that COX-2 expression is stimulated by the lowering of extracellular pH that could result from bacterial infection, and that this is countered by over-production of nitric oxide, which could also result from bacterial infection. Nitric Oxide 188-200 mitochondrially encoded cytochrome c oxidase II Homo sapiens 28-33 15781386-7 2005 The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects. Nitric Oxide 361-373 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 15781386-7 2005 The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects. Nitric Oxide 361-373 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 15125136-3 2004 Indomethacin and the new nitric oxide (NO)-donating NSAIDs block the activity of both COX-1 and COX-2. Nitric Oxide 25-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 96-101 12646188-1 2003 Nitric oxide (NO) regulates differentiation, survival, and cyclooxygenase (COX)-2 expression in articular chondrocytes. Nitric Oxide 0-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-81 11466573-4 2001 The early immediate response genes iNOS and COX-2 promote the inflammatory response by the rapid and excessive production of nitric oxide (NO) and prostaglandins. Nitric Oxide 125-137 mitochondrially encoded cytochrome c oxidase II Homo sapiens 44-49 11396478-3 2001 Furthermore, the product of iNOS catalysis, nitric oxide (NO), is an important regulator of COX-2 activity and expression, and the products of COX-1 and COX-2 (diverse prostanoids) may also influence iNOS expression. Nitric Oxide 44-56 mitochondrially encoded cytochrome c oxidase II Homo sapiens 92-97