PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22206036-0	2011	IFN-gamma production depends on IL-12 and IL-18 combined action and mediates host resistance to dengue virus infection in a nitric oxide-dependent manner.	Nitric Oxide	124-136	interleukin 18	Mus musculus	42-47	
10768930-7	2000	We found that in the absence of endogenous IL-18, these mice showed prolonged footpad swelling as well as diminished nitric oxide production.	Nitric Oxide	117-129	interleukin 18	Mus musculus	43-48	
12829183-2	2003	IL-18 has proinflammatory properties, induces cell death and stimulates nitric oxide production.	Nitric Oxide	72-84	interleukin 18	Mus musculus	0-5	
21117450-5	2010	Pre-treatment of mice with either IL-10 or IL-18 followed by LPS, lead to reduction in SGPT and SGOT level, serum NOx, and altered hepatic anti-oxidant enzymes activity and myeloperoxidase activity than the only LPS treated group.	Nitric Oxide	114-117	interleukin 18	Mus musculus	43-48	
21117450-7	2010	Results suggested that attenuating the induction of TNF-alpha and IFN-gamma and subsequent induction of nitric oxide formation in response to LPS may in part account for efficient protection by IL-18 and IL-10 in the reduction of LPS-induced liver injury.	Nitric Oxide	104-116	interleukin 18	Mus musculus	194-199	
17075045-4	2006	In vitro, IL-18-stimulated islets produced nitric oxide, which closely matched islet apoptosis.	Nitric Oxide	43-55	interleukin 18	Mus musculus	10-15	
16481075-5	2006	Immunization with pAnti-CD3sFv/IL-18 DNA induced and maintained significantly higher levels of cytotoxic activity and nitric oxide production by the lung cells, as compared with the injection of pAnti-CD3sFv DNA, or of a simple mixture of pAnti-CD3sFv DNA and pIL-18 DNA.	Nitric Oxide	118-130	interleukin 18	Mus musculus	31-36	
16317388-0	2005	Role of interleukin 18 in nitric oxide production and pancreatic damage during acute pancreatitis.	Nitric Oxide	26-38	interleukin 18	Mus musculus	8-22	
16317388-2	2005	IL-18 induces nitric oxide (NO), which is involved in the pathophysiology of pancreatitis.	Nitric Oxide	14-26	interleukin 18	Mus musculus	0-5	
14769900-2	2004	IL-18-deficient (IL-18(-/-)) C57BL/6 mice that were inoculated intranasally with the mouse-adapted strain of human influenza A/PR/8/34 (H1N1) virus showed an increased mortality with the occurrence of pathogenic changes in the lung for the first 3 days of infection, which included pronounced virus growth with massive infiltration of inflammatory cells and elevated nitric oxide production.	Nitric Oxide	367-379	interleukin 18	Mus musculus	0-5	
14769900-2	2004	IL-18-deficient (IL-18(-/-)) C57BL/6 mice that were inoculated intranasally with the mouse-adapted strain of human influenza A/PR/8/34 (H1N1) virus showed an increased mortality with the occurrence of pathogenic changes in the lung for the first 3 days of infection, which included pronounced virus growth with massive infiltration of inflammatory cells and elevated nitric oxide production.	Nitric Oxide	367-379	interleukin 18	Mus musculus	17-22	
12593627-0	2003	Cytotoxicity in glioma cells due to interleukin-12 and interleukin-18-stimulated macrophages mediated by interferon-gamma-regulated nitric oxide.	Nitric Oxide	132-144	interleukin 18	Mus musculus	55-69	
12593627-5	2003	In response to the combined stimulation by IL-12 and IL-18, macrophages expressed potent cytotoxic activity against glioma cells in association with increasing production of IFNgamma and nitric oxide (NO).	Nitric Oxide	187-199	interleukin 18	Mus musculus	53-58	
11220678-5	2000	On the other hand, NK cells significantly potentiated the nitric oxide-mediated cryptococcocidal activity of thioglycolate-elicited peritoneal macrophages obtained from SCID mice upon stimulation with IL-12 and IL-18.	Nitric Oxide	58-70	interleukin 18	Mus musculus	211-216	
10562301-5	1999	IL-18 independently promoted GM-CSF and nitric oxide production, and it induced significant TNF-alpha synthesis by CD14(+) macrophages in synovial cultures; the latter effect was potentiated by IL-12 or IL-15.	Nitric Oxide	40-52	interleukin 18	Mus musculus	0-5	
10202108-1	1999	We have recently demonstrated that two IFN-gamma-inducing cytokines, interleukin (IL)-12 and IL-18, synergistically induced the fungicidal activity of mouse peritoneal exudate cells (PEC) against Cryptococcus neoformans through NK cell production of interferon (IFN)-gamma and nitric oxide (NO) synthesis.	Nitric Oxide	277-289	interleukin 18	Mus musculus	93-98	
9780184-0	1998	Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).	Nitric Oxide	0-12	interleukin 18	Mus musculus	35-60	
9780184-0	1998	Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).	Nitric Oxide	0-12	interleukin 18	Mus musculus	62-67	
9284124-1	1997	We examined the ability of interleukin-12 (IL-12) and IL-18 to induce the production of gamma interferon (IFN-gamma) and nitric oxide (NO) by murine peritoneal exudate cells (PEC) and to stimulate the growth-inhibitory activity of these cells against Cryptococcus neoformans.	Nitric Oxide	121-133	interleukin 18	Mus musculus	54-59