PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23603746-4 2013 Resveratrol treatment (150-250 micromol/l) for 48 h increased cell cycle arrest at the G1 phase in C33A (with mutation in p53) and HeLa cells (HPV18 positive), as well as in CaSki and SiHa cell lines (HPV16 positive). Resveratrol 0-11 tumor protein p53 Homo sapiens 122-125 24603648-5 2014 Resveratrol induced cell cycle arrest in the S- and G2/M- phase and apoptosis was mediated by activation of p53 and caspase-3 in HepG2 cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 108-111 24603648-6 2014 In contrast to primary hepatocytes, resveratrol treated HepG2 cells showed a reduction of NAMPT enzymatic activity and increased p53 acetylation (K382). Resveratrol 36-47 tumor protein p53 Homo sapiens 129-132 24239893-0 2014 Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 95-98 24239893-4 2014 Resveratrol, in combination with clofarabine, time-dependently induced a strong cytotoxic effect with the nuclear accumulation of phospho-p53 (p-p53) in MSTO-211H cells, but not in normal mesothelial MeT-5A cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 138-141 24239893-4 2014 Resveratrol, in combination with clofarabine, time-dependently induced a strong cytotoxic effect with the nuclear accumulation of phospho-p53 (p-p53) in MSTO-211H cells, but not in normal mesothelial MeT-5A cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 145-148 24239893-10 2014 Taken together, these results demonstrate that resveratrol and clofarabine synergistically elicit apoptotic signal via a p53-dependent pathway, and provide a scientific rationale for clinical evaluation of resveratrol as a promising chemopotentiator in MM. Resveratrol 47-58 tumor protein p53 Homo sapiens 121-124 24239893-10 2014 Taken together, these results demonstrate that resveratrol and clofarabine synergistically elicit apoptotic signal via a p53-dependent pathway, and provide a scientific rationale for clinical evaluation of resveratrol as a promising chemopotentiator in MM. Resveratrol 206-217 tumor protein p53 Homo sapiens 121-124 23603746-8 2013 Interestingly, after resveratrol treatment, the expression of p53 was decreased in HPV18-positive cell lines (CaLo and HeLa) and increased in HPV16-positive cell lines (CaSki and SiHa) and C33A cells. Resveratrol 21-32 tumor protein p53 Homo sapiens 62-65 23088850-8 2013 Mechanistic analysis revealed that Beclin-1 did not interact with proapoptotic proteins Bax and Bak; however, Beclin-1 was found to interact with p53 in the cytosol and mitochondria upon resveratrol treatment. Resveratrol 187-198 tumor protein p53 Homo sapiens 146-149 24055188-2 2013 The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation. Resveratrol 15-26 tumor protein p53 Homo sapiens 91-94 24055188-7 2013 P53 expression was up-regulated by resveratrol and etoposide and pre-incubation of both cells with resveratrol increased levels of etoposide-induced p53 expression. Resveratrol 35-46 tumor protein p53 Homo sapiens 0-3 24055188-7 2013 P53 expression was up-regulated by resveratrol and etoposide and pre-incubation of both cells with resveratrol increased levels of etoposide-induced p53 expression. Resveratrol 99-110 tumor protein p53 Homo sapiens 0-3 24055188-7 2013 P53 expression was up-regulated by resveratrol and etoposide and pre-incubation of both cells with resveratrol increased levels of etoposide-induced p53 expression. Resveratrol 99-110 tumor protein p53 Homo sapiens 149-152 24055188-9 2013 It seems that resveratrol exerts differential synergistic effect with etoposide on proliferation of cancer cells from different origin which is mainly accompanied by p53 activation. Resveratrol 14-25 tumor protein p53 Homo sapiens 166-169 23881456-6 2013 SIRT1 activator, resveratrol, dose-dependently attenuated the growth-inhibitory and apoptosis-inducing effect of cudraflavone B and blocked cudraflavone B-induced regulatory protein expressions in the mitochondrial pathway such as p53, p21, p27, Bax, caspase-3, and cytochrome-c. Conversely, treatment with SIRT1 inhibitor sirtinol caused opposite effects. Resveratrol 17-28 tumor protein p53 Homo sapiens 231-234 23495037-8 2013 In summary, resveratrol and ceramide converge on an endocytosis-requiring, ERK1/2-dependent signal transduction pathway and induction of COX-expression as an essential molecular antecedent for subsequent p53-dependent apoptosis. Resveratrol 12-23 tumor protein p53 Homo sapiens 204-207 24040102-7 2013 p53-knockdown experiment in C2C12 cells and experiment using p53-deficient HCT116 cells showed that splitomicin and resveratrol modulated apoptosis by p53-dependent and p53-independent pathways. Resveratrol 116-127 tumor protein p53 Homo sapiens 61-64 24040102-7 2013 p53-knockdown experiment in C2C12 cells and experiment using p53-deficient HCT116 cells showed that splitomicin and resveratrol modulated apoptosis by p53-dependent and p53-independent pathways. Resveratrol 116-127 tumor protein p53 Homo sapiens 61-64 24040102-8 2013 In p53-independent cell protective pathway, we found that FOXO1, FOXO3a, and FOXO4 were involved in SOD2"s upregulation by resveratrol. Resveratrol 123-134 tumor protein p53 Homo sapiens 3-6 23737838-0 2013 Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation. Resveratrol 0-11 tumor protein p53 Homo sapiens 154-157 23666059-0 2013 Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol. Resveratrol 142-153 tumor protein p53 Homo sapiens 34-37 23666059-10 2013 Thus, the hyperactivation of p53 by nutlin-3a helps to preserve the replicative potential of cells exposed to resveratrol. Resveratrol 110-121 tumor protein p53 Homo sapiens 29-32 23651583-0 2013 Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 67-70 23651583-6 2013 p53 activation is an important factor in Nanog suppression and treatment with resveratrol was also found to activate the p53/p21 pathway. Resveratrol 78-89 tumor protein p53 Homo sapiens 0-3 23651583-6 2013 p53 activation is an important factor in Nanog suppression and treatment with resveratrol was also found to activate the p53/p21 pathway. Resveratrol 78-89 tumor protein p53 Homo sapiens 121-124 23651583-9 2013 Our results also suggest that targeting GSCs via the p53-Nanog axis, with resveratrol for instance, could be a therapeutic strategy against glioblastoma. Resveratrol 74-85 tumor protein p53 Homo sapiens 53-56 23239315-1 2013 RATIONALE: The efficiency of Sirtuin1, a major target for the treatment of various metabolic disorders such as inflammation and type 2 diabetes mellitus, can be modulated via low molecular mass SIRT1 activators (e.g. resveratrol, SRT1720, and SRT2104).The administration of such compounds results in increased deacetylation of substrates including p53, FOXO1, and PGC1alpha, potentially leading to an improved physical performance. Resveratrol 217-228 tumor protein p53 Homo sapiens 348-351 22833338-4 2013 Here we show that RSV, at both concentration ranges, leads to a marked increase in p53, while a decrease of SIRT1 expression level, as well as enzyme activity, only occurred at the higher concentration range. Resveratrol 18-21 tumor protein p53 Homo sapiens 83-86 23737838-6 2013 We found that resveratrol impeded CSC properties through the activation of p53 and this effect could be reversed by knockdown of p53. Resveratrol 14-25 tumor protein p53 Homo sapiens 75-78 23737838-6 2013 We found that resveratrol impeded CSC properties through the activation of p53 and this effect could be reversed by knockdown of p53. Resveratrol 14-25 tumor protein p53 Homo sapiens 129-132 23737838-7 2013 Furthermore, resveratrol suppressed the stemness and EMT through reactivating p53 and inducing miR-145 and miR-200c, which were downregulated in NPC CSCs. Resveratrol 13-24 tumor protein p53 Homo sapiens 78-81 23737838-8 2013 In conclusion, we demonstrated that resveratrol employed the p53 pathway in regulating stemness, EMT, and metabolic reprogramming. Resveratrol 36-47 tumor protein p53 Homo sapiens 61-64 23737838-9 2013 Further investigation of the molecular mechanism of p53 activation by resveratrol may provide useful information for the development of novel therapies for cancer treatment through targeting to CSCs. Resveratrol 70-81 tumor protein p53 Homo sapiens 52-55 23065251-5 2013 We found that resveratrol treatment alone dose-dependently increased caspase-3 cleavage, as well as the levels of Bax, p53 and acetylated-p53. Resveratrol 14-25 tumor protein p53 Homo sapiens 119-122 23065251-5 2013 We found that resveratrol treatment alone dose-dependently increased caspase-3 cleavage, as well as the levels of Bax, p53 and acetylated-p53. Resveratrol 14-25 tumor protein p53 Homo sapiens 138-141 23469203-4 2013 We identified resveratrol as a regulator of MTA1/NuRD complex and re-activator of p53 acetylation in prostate cancer (PCa). Resveratrol 14-25 tumor protein p53 Homo sapiens 82-85 23469203-5 2013 In the current study, we addressed whether resveratrol analogues also possess the ability to inhibit MTA1 and to reverse p53 deacetylation. Resveratrol 43-54 tumor protein p53 Homo sapiens 121-124 22252971-9 2012 We propose that RSV exerts its chondroprotective functions, in part, by deactivating p53-induced apoptosis in human primary chondrocytes, but not human chondrosarcoma. Resveratrol 16-19 tumor protein p53 Homo sapiens 85-88 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Resveratrol 106-117 tumor protein p53 Homo sapiens 357-360 22561451-7 2012 In addition, resveratrol suppressed Ang II-induced induction of p53 and its downstream target gene p21, both of which play an important role in the induction of senescence. Resveratrol 13-24 tumor protein p53 Homo sapiens 64-67 24009836-10 2012 Resveratrol-induced p53 expression strongly correlated with the enhancement of cytotoxicity observed upon combination of resveratrol with DMS or 4-HPR. Resveratrol 0-11 tumor protein p53 Homo sapiens 20-23 24009836-10 2012 Resveratrol-induced p53 expression strongly correlated with the enhancement of cytotoxicity observed upon combination of resveratrol with DMS or 4-HPR. Resveratrol 121-132 tumor protein p53 Homo sapiens 20-23 22561451-8 2012 Resveratrol suppressed senescence of VSMC possibly through inhibition of AT1R-dependent induction of p53/p21. Resveratrol 0-11 tumor protein p53 Homo sapiens 101-104 22561451-9 2012 Suppression of p53 induction may be involved in the longevity by resveratrol. Resveratrol 65-76 tumor protein p53 Homo sapiens 15-18 23152798-0 2012 Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells. Resveratrol 56-67 tumor protein p53 Homo sapiens 38-41 22417066-6 2012 The antiproliferative effect of XRT/RSV treatment correlated with increased expression of p15, p21, and mutant p53 and decreased expression of cyclin B, cyclin D, and cdk2. Resveratrol 36-39 tumor protein p53 Homo sapiens 111-114 22415970-6 2012 The sensitization by RSV involved the enhancement of p53 levels, the decrease of procaspase 8 and the activation of caspases 7 and 9. Resveratrol 21-24 tumor protein p53 Homo sapiens 53-56 22689577-11 2012 Overall, these results suggest for the first time that Sirt-1 can regulate p53 and NF-kappaB signaling via deacetylation, demonstrating a novel role for resveratrol in the treatment of tendinitis/tendinopathy. Resveratrol 153-164 tumor protein p53 Homo sapiens 75-78 23152798-2 2012 p53 has been suggested to play a role in the anticancer properties of resveratrol. Resveratrol 70-81 tumor protein p53 Homo sapiens 0-3 23152798-3 2012 We investigated resveratrol-induced cytotoxicity in H1299 cells, which are non-small lung cancer cells that have a partial deletion of the gene that encodes the p53 protein. Resveratrol 16-27 tumor protein p53 Homo sapiens 161-164 23152798-7 2012 Resveratrol also increased the p53 protein levels in MCF-7 cells without altering the p53 mRNA levels, suggesting a post-translational modulation of the protein. Resveratrol 0-11 tumor protein p53 Homo sapiens 31-34 23152798-8 2012 The resveratrol-induced cytotoxicity in these cells was partially mediated by p53 and involved the activation of caspases 9 and 7 and the cleavage of PARP. Resveratrol 4-15 tumor protein p53 Homo sapiens 78-81 23152798-11 2012 The transient transfection of a wild-type p53-GFP gene caused H1299 cells to become more responsive to the pro-apoptotic properties of resveratrol, similarly to findings in the p53-positive MCF-7 cells. Resveratrol 135-146 tumor protein p53 Homo sapiens 42-45 23152798-12 2012 Our results suggest a possible therapeutic strategy based on the use of resveratrol for the treatment of tumors that are typically unresponsive to conventional therapies because of the loss of normal p53 function. Resveratrol 72-83 tumor protein p53 Homo sapiens 200-203 21225623-0 2011 Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin alphavbeta3. Resveratrol 44-55 tumor protein p53 Homo sapiens 14-17 21225623-8 2011 Further, stilbene-elicited signaling cascade leading to p53 activation was examined in MCF-7 cells and results showed that resveratrol and triacetyl-resveratrol induced both ERK and p38 phosphorylation, whereas only marginal changes in state of phosphorylation in these two kinases were observed in trimethoxy-resveratrol-treated cells. Resveratrol 123-134 tumor protein p53 Homo sapiens 56-59 22260024-0 2011 [Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells]. Resveratrol 42-53 tumor protein p53 Homo sapiens 20-23 22029423-12 2011 CONCLUSIONS: Our results suggest that RSV arrests cell cycle, promotes apoptosis and sensitizes PrCa cells to IR likely through a desirable dual action to activate the ATM-AMPK-p53-p21(cip1)/p27(kip1) and inhibit the Akt signalling pathways. Resveratrol 38-41 tumor protein p53 Homo sapiens 177-180 21946130-3 2011 Resveratrol may arrest, among various tumors, cell growth in both papillary and follicular thyroid cancer by activation of the mitogen-activated protein kinase (MAPK) signal transduction pathway as well as increase of p53 and its phosphorylation. Resveratrol 0-11 tumor protein p53 Homo sapiens 218-221 22260024-7 2011 Resveratrol could induce apoptosis and activate p38 and p53 in a time dependent manner in MCF-7 cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 56-59 22260024-8 2011 In addition, the cell growth inhibitory ratio and the apoptotic ratio of resveratrol-treated group decreased markedly by the p38 MAPK inhibitor SB203580 or p53 inhibitor pifithrin-alpha. Resveratrol 73-84 tumor protein p53 Homo sapiens 156-159 22260024-9 2011 Further experiments confirmed that resveratrol-induced p53 activation was reduced by SB203580 whereas the activation of p38 was not affected by pifithrin-alpha. Resveratrol 35-46 tumor protein p53 Homo sapiens 55-58 22260024-10 2011 In conclusion, resveratrol induced apoptosis in MCF-7 cells could be through activating p38-p53 signal pathway. Resveratrol 15-26 tumor protein p53 Homo sapiens 92-95 21743969-8 2011 Moreover, simultaneous treatment with resveratrol and a Notch-1 inhibitor (MRK-003) partially attenuated the apoptosis and completely blocked the activation of Notch-1 and the increase in wild-type p53. Resveratrol 38-49 tumor protein p53 Homo sapiens 198-201 21737614-0 2011 Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor alpha gene expression via p38MAPK/CK2 signaling in human breast cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 26-29 21743969-0 2011 Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Resveratrol 60-71 tumor protein p53 Homo sapiens 29-32 21740780-9 2011 In resveratrol sensitive cells, capan-2 and colo357, the activation of caspase-3 was detected and showed significant caspase-3 activation upon resveratrol treatment; p53 and p21 were also detected up-regulated upon resveratrol treatment. Resveratrol 143-154 tumor protein p53 Homo sapiens 166-169 21743969-5 2011 We demonstrated that resveratrol strongly suppressed cell growth and induced apoptosis in A172 and T98G glioblastoma cells, which have low active Notch-1 expression and a heterozygous p53 mutation. Resveratrol 21-32 tumor protein p53 Homo sapiens 184-187 21743969-6 2011 Our results suggest that resveratrol significantly activates intracellular Notch-1 and restores wild-type p53 expression in a time-dependent manner. Resveratrol 25-36 tumor protein p53 Homo sapiens 106-109 21712378-0 2011 Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. Resveratrol 0-11 tumor protein p53 Homo sapiens 20-23 21712378-2 2011 Here, we show that resveratrol induced p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated translocation of Bax to mitochondria where it underwent oligomerization to initiate apoptosis. Resveratrol 19-30 tumor protein p53 Homo sapiens 39-42 21740780-9 2011 In resveratrol sensitive cells, capan-2 and colo357, the activation of caspase-3 was detected and showed significant caspase-3 activation upon resveratrol treatment; p53 and p21 were also detected up-regulated upon resveratrol treatment. Resveratrol 3-14 tumor protein p53 Homo sapiens 166-169 21622155-4 2011 In this study, we showed that RSV (~25 micromolar) potentiated GSE (<= 35 microg/mL) induced colon cancer cell apoptosis via activation of p53 dependent pathways. Resveratrol 30-33 tumor protein p53 Homo sapiens 142-145 21740780-9 2011 In resveratrol sensitive cells, capan-2 and colo357, the activation of caspase-3 was detected and showed significant caspase-3 activation upon resveratrol treatment; p53 and p21 were also detected up-regulated upon resveratrol treatment. Resveratrol 143-154 tumor protein p53 Homo sapiens 166-169 21479363-3 2011 Here, we used MCF-7 and MDA-MB231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of ASPP1, a new member of the ASPP (apoptosis stimulation protein of p53) family, which plays an important role in the regulation of apoptosis. Resveratrol 85-96 tumor protein p53 Homo sapiens 189-192 20972827-6 2011 Exposure to resveratrol decreased SIRT1 content, concomitant with an increase in the acetylated form of sirtuin substrates p53 and NFkappa-beta. Resveratrol 12-23 tumor protein p53 Homo sapiens 123-126 21471201-4 2011 Treating human squamous cell carcinoma (SCC) cells with the anti-cancer compounds, resveratrol and doxorubicin, triggered p53-independent premature senescence by invoking oxidative stress-mediated DNA damage. Resveratrol 83-94 tumor protein p53 Homo sapiens 122-125 21261644-3 2011 Resveratrol treatment in vitro causes activation and nuclear translocation of mitogen-activated protein kinase (ERK1/2), consequent phosphorylation of Ser-15 of p53, and apoptosis. Resveratrol 0-11 tumor protein p53 Homo sapiens 161-164 21261644-5 2011 By a PD98059-inhibitable process, resveratrol causes inducible COX-2 to accumulate in the nucleus where it complexes with pERK1/2 and p53. Resveratrol 34-45 tumor protein p53 Homo sapiens 134-137 21261644-7 2011 NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved. Resveratrol 62-73 tumor protein p53 Homo sapiens 139-142 21261644-8 2011 Molecular steps in the pro-apoptotic action of resveratrol in cancer cells include induction of intranuclear COX-2 accumulation relevant to activation of p53. Resveratrol 47-58 tumor protein p53 Homo sapiens 154-157 21045015-8 2011 Exposure to resveratrol or triacetyl-resveratrol activated p53, increased p21 and p53R2 and decreased PSA expression in LNCaP cells. Resveratrol 12-23 tumor protein p53 Homo sapiens 59-62 21045015-12 2011 CWR22Rv1 cells exposed to resveratrol and triacetyl-resveratrol showed a G1S block, concomitant with increased p53 and p21 expression; however, identically treated PC-3 cells showed attenuated progression through the SG2M phases. Resveratrol 26-37 tumor protein p53 Homo sapiens 111-114 21291372-5 2011 Resveratrol impacts on the mitochondrial functions (respiratory chain, oncoproteins, gene expression, etc), in which p53 protein can be involved and its acetylated or phosphorylated forms. Resveratrol 0-11 tumor protein p53 Homo sapiens 117-120 21187340-3 2011 Resveratrol also causes nuclear accumulation of the enzyme cyclooxygenase (COX)-2 and of the oncogene suppressor protein, p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 122-125 21187340-6 2011 This finding implicates nuclear COX-2 in p53-mediated apoptosis induced by resveratrol. Resveratrol 75-86 tumor protein p53 Homo sapiens 41-44 21187340-7 2011 Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53. Resveratrol 113-124 tumor protein p53 Homo sapiens 321-324 21187340-8 2011 Nuclear accumulation of activated ERK1/2 and sumolyated COX-2 are essential to resveratrol-induced pSer-15-p53-mediated apoptosis in human ovarian cancer cells. Resveratrol 79-90 tumor protein p53 Homo sapiens 107-110 20797428-0 2010 Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation. Resveratrol 0-11 tumor protein p53 Homo sapiens 20-23 20725098-0 2010 Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of DeltaNp63. Resveratrol 0-11 tumor protein p53 Homo sapiens 20-23 20725098-2 2010 Trans-resveratrol (RSV) has been shown to exert proapoptotic activities through a p53-dependent or p53-independent pathway in various cancer cells. Resveratrol 0-17 tumor protein p53 Homo sapiens 82-85 20725098-2 2010 Trans-resveratrol (RSV) has been shown to exert proapoptotic activities through a p53-dependent or p53-independent pathway in various cancer cells. Resveratrol 0-17 tumor protein p53 Homo sapiens 99-102 20725098-2 2010 Trans-resveratrol (RSV) has been shown to exert proapoptotic activities through a p53-dependent or p53-independent pathway in various cancer cells. Resveratrol 19-22 tumor protein p53 Homo sapiens 82-85 20725098-2 2010 Trans-resveratrol (RSV) has been shown to exert proapoptotic activities through a p53-dependent or p53-independent pathway in various cancer cells. Resveratrol 19-22 tumor protein p53 Homo sapiens 99-102 20725098-6 2010 The RSV effect was accompanied by the downregulation of DeltaNp63 and the upregulation of p53 protein in a dose-dependent manner. Resveratrol 4-7 tumor protein p53 Homo sapiens 90-93 20797428-6 2010 Consistent with previous studies, RSVL induces the nuclear translocation of p53 and the expression of p53-responsive genes such as Cdkn1a, Gadd45a, Gadd45, and Fas. Resveratrol 34-38 tumor protein p53 Homo sapiens 76-79 20797428-6 2010 Consistent with previous studies, RSVL induces the nuclear translocation of p53 and the expression of p53-responsive genes such as Cdkn1a, Gadd45a, Gadd45, and Fas. Resveratrol 34-38 tumor protein p53 Homo sapiens 102-105 20443159-8 2009 Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins. Resveratrol 105-116 tumor protein p53 Homo sapiens 167-170 19800779-8 2010 Moreover, resveratrol significantly enhanced p53-dependent transcriptional activity, but slightly reduced NF-kappaB-dependent transcriptional activity. Resveratrol 10-21 tumor protein p53 Homo sapiens 45-48 21090107-7 2010 We further proved fact that resveratrol can specifically promote the activity of sirt1; moreover, activated sirt1 modulates the activity of caspase-3 and bcl-2 family, involving in transcriptional regulation of p53 and NF-kappaB through antagonizing factor-induced acetylation. Resveratrol 28-39 tumor protein p53 Homo sapiens 211-214 20504360-0 2010 Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. Resveratrol 0-11 tumor protein p53 Homo sapiens 146-149 20504360-8 2010 Resveratrol treatment induced apoptosis by activating tumor suppressor p53 protein, whereas IGF-1R siRNA treatment did not affect apoptosis. Resveratrol 0-11 tumor protein p53 Homo sapiens 71-74 20504360-9 2010 Our data suggests that resveratrol not only suppresses cell proliferation by inhibiting IGF-1R and its downstream signaling pathways similar to that of IGF-1R siRNA but also enhances apoptosis via activation of the p53 pathway. Resveratrol 23-34 tumor protein p53 Homo sapiens 215-218 20504360-10 2010 CONCLUSIONS: For the first time, we report that resveratrol suppresses colon cancer cell proliferation and elevates apoptosis even in the presence of IGF-1 via suppression of IGF-1R/Akt/Wnt signaling pathways and activation of p53, suggesting its potential role as a chemotherapeutic agent. Resveratrol 48-59 tumor protein p53 Homo sapiens 227-230 19810103-0 2010 Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. Resveratrol 0-11 tumor protein p53 Homo sapiens 21-24 18446786-10 2008 Resveratrol-inducible nuclear accumulation of COX-2 is essential for p53 activation and p53-dependent apoptosis in these cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 69-72 19661313-1 2009 BACKGROUND: We have reported that resveratrol (RSV) and 5-fluorouracil (5-FU) evoked apoptosis through caspase-6 activation in wild-type (p53+/+) and knockout (p53(-/-)) HCT116 human colon cancer cells. Resveratrol 34-45 tumor protein p53 Homo sapiens 138-141 19661313-1 2009 BACKGROUND: We have reported that resveratrol (RSV) and 5-fluorouracil (5-FU) evoked apoptosis through caspase-6 activation in wild-type (p53+/+) and knockout (p53(-/-)) HCT116 human colon cancer cells. Resveratrol 34-45 tumor protein p53 Homo sapiens 160-163 19661313-1 2009 BACKGROUND: We have reported that resveratrol (RSV) and 5-fluorouracil (5-FU) evoked apoptosis through caspase-6 activation in wild-type (p53+/+) and knockout (p53(-/-)) HCT116 human colon cancer cells. Resveratrol 47-50 tumor protein p53 Homo sapiens 138-141 19661313-1 2009 BACKGROUND: We have reported that resveratrol (RSV) and 5-fluorouracil (5-FU) evoked apoptosis through caspase-6 activation in wild-type (p53+/+) and knockout (p53(-/-)) HCT116 human colon cancer cells. Resveratrol 47-50 tumor protein p53 Homo sapiens 160-163 19559722-8 2009 Moreover, resveratrol induced telomeric instability in U-2 OS cells and the activation of DNA damage signaling in both cell lines, manifested as the phosphorylation of histone H2AX at serine 139 and of p53 at serines 15 and 37. Resveratrol 10-21 tumor protein p53 Homo sapiens 202-205 19838927-4 2009 Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Resveratrol 40-51 tumor protein p53 Homo sapiens 107-110 19838927-4 2009 Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Resveratrol 40-51 tumor protein p53 Homo sapiens 129-132 19846903-3 2009 Capsaicin and resveratrol, alone or in combination, inhibited cell growth and promoted apoptosis by the elevation of NO; combined treatment in p53-WT cells was most effective. Resveratrol 14-25 tumor protein p53 Homo sapiens 143-146 19846903-7 2009 These findings provide insight into the mechanism of apoptotic action of capsaicin and resveratrol based on p53 status and indicate manipulation of NO may offer exciting opportunities to improve the effectiveness of colon cancer treatment. Resveratrol 87-98 tumor protein p53 Homo sapiens 108-111 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Resveratrol 214-225 tumor protein p53 Homo sapiens 66-69 18446786-0 2008 Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 30-33 18446786-6 2008 Resveratrol also caused p53 binding to the p21 promoter and increased abundance of COX-2 protein in UMSCC-22B cell nuclei. Resveratrol 0-11 tumor protein p53 Homo sapiens 24-27 18446786-10 2008 Resveratrol-inducible nuclear accumulation of COX-2 is essential for p53 activation and p53-dependent apoptosis in these cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 88-91 18454317-7 2008 In melanoma cells, resveratrol inhibits STAT3 and NF-kappaB-dependent transcription, culminating in suppression of cFLIP and Bcl-xL expression, while activating the MAPK- and the ATM-Chk2-p53 pathways. Resveratrol 19-30 tumor protein p53 Homo sapiens 188-191 18497562-1 2008 We have reported that resveratrol (RSV) evoked apoptosis through caspase-6 activation in HCT116 human colon cancer cells wild-type (p53+/+) or knockout (p53-/-) for p53. Resveratrol 35-38 tumor protein p53 Homo sapiens 153-156 18497562-7 2008 Moreover, G(1)-arrest of the p53+/+ cells was elicited by lower doses of RSV and 5-FU in combination, but not with either agent alone. Resveratrol 73-76 tumor protein p53 Homo sapiens 29-32 18497562-0 2008 Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 132-135 18497562-1 2008 We have reported that resveratrol (RSV) evoked apoptosis through caspase-6 activation in HCT116 human colon cancer cells wild-type (p53+/+) or knockout (p53-/-) for p53. Resveratrol 22-33 tumor protein p53 Homo sapiens 132-135 18497562-1 2008 We have reported that resveratrol (RSV) evoked apoptosis through caspase-6 activation in HCT116 human colon cancer cells wild-type (p53+/+) or knockout (p53-/-) for p53. Resveratrol 22-33 tumor protein p53 Homo sapiens 153-156 18497562-1 2008 We have reported that resveratrol (RSV) evoked apoptosis through caspase-6 activation in HCT116 human colon cancer cells wild-type (p53+/+) or knockout (p53-/-) for p53. Resveratrol 22-33 tumor protein p53 Homo sapiens 153-156 18497562-1 2008 We have reported that resveratrol (RSV) evoked apoptosis through caspase-6 activation in HCT116 human colon cancer cells wild-type (p53+/+) or knockout (p53-/-) for p53. Resveratrol 35-38 tumor protein p53 Homo sapiens 132-135 18497562-1 2008 We have reported that resveratrol (RSV) evoked apoptosis through caspase-6 activation in HCT116 human colon cancer cells wild-type (p53+/+) or knockout (p53-/-) for p53. Resveratrol 35-38 tumor protein p53 Homo sapiens 153-156 18507431-3 2008 We show that resveratrol induces apoptosis in Jeko-1 cells and modulates several key molecules, including cyclin D1 (CCND1), p53 (TP53), p21 (CDKN1A), BCL2, BAX, Bcl XL (BCL2L1), caspase 9 (CASP9) and p27 (CDKN1B). Resveratrol 13-24 tumor protein p53 Homo sapiens 125-128 18507431-3 2008 We show that resveratrol induces apoptosis in Jeko-1 cells and modulates several key molecules, including cyclin D1 (CCND1), p53 (TP53), p21 (CDKN1A), BCL2, BAX, Bcl XL (BCL2L1), caspase 9 (CASP9) and p27 (CDKN1B). Resveratrol 13-24 tumor protein p53 Homo sapiens 130-134 18174244-0 2008 Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Resveratrol 0-11 tumor protein p53 Homo sapiens 76-79 17968319-4 2008 Resveratrol results in immortalization of mixed progenitor cells with mutant p53, but not human epithelial cells with wild type p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 77-80 17626009-0 2007 Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells. Resveratrol 23-34 tumor protein p53 Homo sapiens 121-124 17959154-9 2008 Finally, we show that resveratrol induced ubiquitin-independent degradation of tumor suppressor gene protein p53 and inhibited p53-induced apoptosis in chondrocytes in a dose-dependent manner. Resveratrol 22-33 tumor protein p53 Homo sapiens 109-112 17959154-9 2008 Finally, we show that resveratrol induced ubiquitin-independent degradation of tumor suppressor gene protein p53 and inhibited p53-induced apoptosis in chondrocytes in a dose-dependent manner. Resveratrol 22-33 tumor protein p53 Homo sapiens 127-130 17959154-10 2008 Our results indicate that resveratrol seems to be an effective in vitro anti-inflammatory agent and has a chondroprotective capacity through suppression of (1) IL-1beta- (2) ROS- and (3) tumor suppressor protein p53-production. Resveratrol 26-37 tumor protein p53 Homo sapiens 212-215 17984113-1 2008 The stilbene resveratrol (RV) initiates p53-dependent apoptosis via plasma membrane integrin alphaVbeta3 in human cancer cells. Resveratrol 13-24 tumor protein p53 Homo sapiens 40-43 17984113-1 2008 The stilbene resveratrol (RV) initiates p53-dependent apoptosis via plasma membrane integrin alphaVbeta3 in human cancer cells. Resveratrol 26-28 tumor protein p53 Homo sapiens 40-43 17718901-5 2007 Treatment of LNCaP cells with resveratrol resulted in generation of reactive oxygen species, translocation of Bax and p53 to mitochondria, subsequent drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, AIF, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and caspase-9 and induction of apoptosis. Resveratrol 30-41 tumor protein p53 Homo sapiens 118-121 17174366-6 2007 We first established that resveratrol (10 microM), a pro-apoptotic agent in other cancer cells, induced p53-dependent apoptosis and c-fos, c-jun and p21 gene expression in both papillary and follicular thyroid cancer cells. Resveratrol 26-37 tumor protein p53 Homo sapiens 104-107 17050787-10 2007 However, modulator proteins p53, p21, and p27 were increased by resveratrol only in LNCaP cells. Resveratrol 64-75 tumor protein p53 Homo sapiens 28-31 17147953-9 2007 Moreover, MNNG-induced increase in acetylation of p53, a representative target of sirtuin deacetylase activity, was suppressed by resveratrol. Resveratrol 130-141 tumor protein p53 Homo sapiens 50-53 17088997-4 2006 Resveratrol decreased the expression of BCL6 protein, concomitant with the increased expression of several BCL6 regulated gene products, including p27, p53 and CD69. Resveratrol 0-11 tumor protein p53 Homo sapiens 152-155 17534123-0 2007 Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 63-66 17534123-7 2007 RSVL-induced apoptosis is associated with the activation of the p53 in a dose- and a time-dependent manner. Resveratrol 0-4 tumor protein p53 Homo sapiens 64-67 17534123-8 2007 Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002 abolished the effect of RSVL on p53 activation. Resveratrol 97-101 tumor protein p53 Homo sapiens 105-108 17534123-10 2007 CONCLUSIONS AND IMPLICATIONS: These findings demonstrate that RSVL affects multiple intracellular signaling transduction pathways such as p53 activation/protein translation inhibition/apoptosis, and strongly support a contemplated use of this natural compound as a preventive and/or an adjuvant therapeutic drug for breast cancer. Resveratrol 62-66 tumor protein p53 Homo sapiens 138-141 16790523-3 2006 This receptor is linked to induction by resveratrol of extracellular-regulated kinases 1 and 2 (ERK1/2)- and serine-15-p53-dependent phosphorylation leading to apoptosis. Resveratrol 40-51 tumor protein p53 Homo sapiens 119-122 16790523-4 2006 The integrin receptor is near the Arg-Gly-Asp (RGD) recognition site on the integrin; an integrin-binding RGD peptide inhibits induction by resveratrol of ERK1/2- and p53-dependent apoptosis. Resveratrol 140-151 tumor protein p53 Homo sapiens 167-170 16790523-9 2006 In conclusion, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells. Resveratrol 26-37 tumor protein p53 Homo sapiens 155-158 17007014-5 2006 Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. Resveratrol 0-11 tumor protein p53 Homo sapiens 25-28 20641411-8 2004 Several research studies have reported that resveratrol has the ability to induce p53-dependent apoptosis in several cancer cell lines, and that the signal transduction pathways implicated in resveratrol action includes those of extracellular-regulated kinases 1 and 2 (ERK1/2), p38 kinase, and Jun N-terminal kinase (JNK) (6, 7). Resveratrol 44-55 tumor protein p53 Homo sapiens 82-85 20641411-8 2004 Several research studies have reported that resveratrol has the ability to induce p53-dependent apoptosis in several cancer cell lines, and that the signal transduction pathways implicated in resveratrol action includes those of extracellular-regulated kinases 1 and 2 (ERK1/2), p38 kinase, and Jun N-terminal kinase (JNK) (6, 7). Resveratrol 192-203 tumor protein p53 Homo sapiens 82-85 20641411-10 2004 showed that the binding of resveratrol to integrin alphaVss3, principally to the ss3 monomer, was essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells. Resveratrol 27-38 tumor protein p53 Homo sapiens 153-156 16928824-7 2006 A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. Resveratrol 186-197 tumor protein p53 Homo sapiens 112-115 16928824-0 2006 Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 49-52 16928824-5 2006 Nuclear COX-2 in resveratrol-treated cells colocalizes with Ser(15)-phosphorylated p53 and with p300, a coactivator for p53-dependent gene expression. Resveratrol 17-28 tumor protein p53 Homo sapiens 83-86 16928824-5 2006 Nuclear COX-2 in resveratrol-treated cells colocalizes with Ser(15)-phosphorylated p53 and with p300, a coactivator for p53-dependent gene expression. Resveratrol 17-28 tumor protein p53 Homo sapiens 120-123 16928824-7 2006 A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. Resveratrol 186-197 tumor protein p53 Homo sapiens 159-162 16928824-8 2006 We conclude that nuclear accumulation of COX-2 can be induced by resveratrol and that the COX has a novel intranuclear colocalization with Ser(15)-phosphorylated p53 and p300, which facilitates apoptosis in resveratrol-treated breast cancer cells. Resveratrol 207-218 tumor protein p53 Homo sapiens 162-165 16814113-0 2006 Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. Resveratrol 36-47 tumor protein p53 Homo sapiens 128-131 16759640-4 2006 Suppression of HASMC proliferation by resveratrol was accompanied by a dose-dependent increase in the expression of tumor suppressor gene p53 and heat shock protein HSP27. Resveratrol 38-49 tumor protein p53 Homo sapiens 138-141 16814113-3 2006 In this study, we investigated the involvement of the mitogen activated protein kinase (MAPK)/p53 signal transduction mechanism in RSVL-induced growth inhibition using a human osteosarcoma cell line. Resveratrol 131-135 tumor protein p53 Homo sapiens 94-97 16814113-8 2006 Likewise, RSVL increased the phosphorylation of p53 tumor suppressor protein (at Ser15). Resveratrol 10-14 tumor protein p53 Homo sapiens 48-51 16814113-9 2006 The effects of RSVL on ERKs and on p53 phosphorylation were abrogated by either the MAPK inhibitor PD98059 or the p53 inhibitor pifithrine-alpha. Resveratrol 15-19 tumor protein p53 Homo sapiens 35-38 16814113-9 2006 The effects of RSVL on ERKs and on p53 phosphorylation were abrogated by either the MAPK inhibitor PD98059 or the p53 inhibitor pifithrine-alpha. Resveratrol 15-19 tumor protein p53 Homo sapiens 114-117 16814113-10 2006 The present study indicates that RSVL antiproliferative effects on osteosarcoma cells are mediated by the activation of the ERKs/p53 signaling pathway and therefore identifies new targets for strategies to treat and/or prevent osteosarcoma. Resveratrol 33-37 tumor protein p53 Homo sapiens 129-132 16518869-2 2006 RSV induced apoptosis in all the cells in a dose-dependent manner; however, Bax+/- and p53+/+ cells were more susceptible than their knockout counterparts (Bax-/- and p53-/-, respectively). Resveratrol 0-3 tumor protein p53 Homo sapiens 87-90 16761963-2 2006 We investigated the mechanism of the antiproliferative effect of resveratrol in A431-transformed keratinocytes harbouring mutant p53, and show that it is accompanied by G1 cell cycle arrest, which coincides with a marked inhibition of G1 cell cycle regulatory proteins, including cyclins A and D1 and cyclin-dependent kinase (CDK)6 and p53-independent induction of p21WAF1. Resveratrol 65-76 tumor protein p53 Homo sapiens 129-132 16761963-2 2006 We investigated the mechanism of the antiproliferative effect of resveratrol in A431-transformed keratinocytes harbouring mutant p53, and show that it is accompanied by G1 cell cycle arrest, which coincides with a marked inhibition of G1 cell cycle regulatory proteins, including cyclins A and D1 and cyclin-dependent kinase (CDK)6 and p53-independent induction of p21WAF1. Resveratrol 65-76 tumor protein p53 Homo sapiens 336-339 16518869-2 2006 RSV induced apoptosis in all the cells in a dose-dependent manner; however, Bax+/- and p53+/+ cells were more susceptible than their knockout counterparts (Bax-/- and p53-/-, respectively). Resveratrol 0-3 tumor protein p53 Homo sapiens 167-170 16081268-7 2005 Resveratrol consistently increased by > or =6-fold Mdm2 expression and other downstream p53 effectors, but not p53 itself at 24 h. Subsequent cell cycle analysis indicated a significant accumulation of cells in G2/M, and a decrease in G1/G0 suggesting a G2/M blockade. Resveratrol 0-11 tumor protein p53 Homo sapiens 91-94 16369916-2 2006 Both processes may be modulated at the level of gene expression, viz., p53 and c-Ha-ras, by dietary bioactive components such as resveratrol. Resveratrol 129-140 tumor protein p53 Homo sapiens 71-74 16369916-8 2006 In summary, resveratrol at <8 h induced p53-mediated effects, including apoptosis and cell-cycle arrest (G2/M). Resveratrol 12-23 tumor protein p53 Homo sapiens 43-46 15542774-10 2004 Resveratrol also induced p53 phosphorylation in LNCaP prostate cancer cells, an effect also inhibited by EGF. Resveratrol 0-11 tumor protein p53 Homo sapiens 25-28 15542774-1 2004 Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2)] activation, nuclear translocation of Ser15-phosphorylated p53, and p53-dependent apoptosis in hormone-insensitive DU145 prostate cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 228-231 15993843-0 2005 Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53. Resveratrol 45-56 tumor protein p53 Homo sapiens 116-119 15744586-3 2005 Here we demonstrate that treatment of gastric adenocarcinoma SNU-1 cells with resveratrol results in time and concentration dependent accumulation of tumor suppressors p21(cip1/WAF-1) and p53 and is preceded by loss of membrane-associated PKC delta protein and a concomitant increase in cytosolic PKC alpha. Resveratrol 78-89 tumor protein p53 Homo sapiens 188-191 15542774-1 2004 Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2)] activation, nuclear translocation of Ser15-phosphorylated p53, and p53-dependent apoptosis in hormone-insensitive DU145 prostate cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 237-240 15542774-4 2004 An inhibitor of protein kinase C (PKC)-alpha, -beta, and -gamma (CGP41251) enhanced Ser15 phosphorylation of p53 by resveratrol in the absence of EGF and blocked EGF inhibition of the resveratrol effect. Resveratrol 116-127 tumor protein p53 Homo sapiens 109-112 15542774-4 2004 An inhibitor of protein kinase C (PKC)-alpha, -beta, and -gamma (CGP41251) enhanced Ser15 phosphorylation of p53 by resveratrol in the absence of EGF and blocked EGF inhibition of the resveratrol effect. Resveratrol 184-195 tumor protein p53 Homo sapiens 109-112 15542774-7 2004 DU145 cells transfected with a dominant-negative PKC-alpha construct showed resveratrol-induced ERK1/2 phosphorylation and Ser15 phosphorylation of p53 but were unresponsive to EGF. Resveratrol 76-87 tumor protein p53 Homo sapiens 148-151 15165403-0 2004 Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol. Resveratrol 125-136 tumor protein p53 Homo sapiens 20-23 15517885-3 2004 The growth-inhibitory effects of resveratrol are mediated through cell-cycle arrest; upregulation of p21Cip1/WAF1, p53 and Bax; down-regulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL and clAPs; and activation of caspases. Resveratrol 33-44 tumor protein p53 Homo sapiens 115-118 15188005-0 2004 Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Resveratrol 19-30 tumor protein p53 Homo sapiens 74-77 15188005-4 2004 E(2) inhibited resveratrol-stimulated phosphorylation of serines 15, 20 and 392 of p53 and acetylation of p53 in a concentration- and time-dependent manner. Resveratrol 15-26 tumor protein p53 Homo sapiens 83-86 15188005-4 2004 E(2) inhibited resveratrol-stimulated phosphorylation of serines 15, 20 and 392 of p53 and acetylation of p53 in a concentration- and time-dependent manner. Resveratrol 15-26 tumor protein p53 Homo sapiens 106-109 15188005-7 2004 Electrophoretic mobility studies of p53 binding to DNA and of p21 expression indicated that E(2) inhibited resveratrol-induced, p53-directed transcriptional activity. Resveratrol 107-118 tumor protein p53 Homo sapiens 36-39 15188005-7 2004 Electrophoretic mobility studies of p53 binding to DNA and of p21 expression indicated that E(2) inhibited resveratrol-induced, p53-directed transcriptional activity. Resveratrol 107-118 tumor protein p53 Homo sapiens 128-131 15165403-5 2004 RESULTS: Apoptosis induced by resveratrol was found to occur only in breast cancer cells expressing wild-type p53 but not in mutant p53-expressing cells. Resveratrol 30-41 tumor protein p53 Homo sapiens 110-113 15165403-6 2004 CONCLUSIONS: We therefore conclude that the natural product, resveratrol, induces apoptosis in breast cancer cells via p53-dependent pathways. Resveratrol 61-72 tumor protein p53 Homo sapiens 119-122 14729643-3 2004 Here, we discovered a novel function of the chemopreventive agent resveratrol: resveratrol is a potent sensitizer of tumor cells for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through p53-independent induction of p21 and p21-mediated cell cycle arrest associated with survivin depletion. Resveratrol 79-90 tumor protein p53 Homo sapiens 223-226 15161054-7 2004 CONCLUSION: Observations suggest that the cytotoxicity, cell cycle arrest and apoptosis induced by curcumin and resveratrol in NB cells may be mediated via functionally activated p53 and merit further study. Resveratrol 112-123 tumor protein p53 Homo sapiens 179-182 14719081-4 2004 The anti-proliferative effects of resveratrol were associated with a marked inhibition of cyclin D and cyclin-dependent kinase (Cdk) 4 proteins, and induction of p53 and Cdk inhibitor p21WAF1/CIP. Resveratrol 34-45 tumor protein p53 Homo sapiens 162-165 15161054-0 2004 Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Resveratrol 13-24 tumor protein p53 Homo sapiens 86-89 14729643-3 2004 Here, we discovered a novel function of the chemopreventive agent resveratrol: resveratrol is a potent sensitizer of tumor cells for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through p53-independent induction of p21 and p21-mediated cell cycle arrest associated with survivin depletion. Resveratrol 66-77 tumor protein p53 Homo sapiens 223-226 12939617-6 2003 We show that the potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD(+), and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. Resveratrol 34-45 tumor protein p53 Homo sapiens 240-243 15582268-3 2004 In our earlier studies with prostate cancer cells using cDNA microarray analysis, we indicated the importance of p53-mediated molecular targets of resveratrol. Resveratrol 147-158 tumor protein p53 Homo sapiens 113-116 14592451-0 2003 Profound negative regulatory effects by resveratrol on vascular smooth muscle cells: a role of p53-p21(WAF1/CIP1) pathway. Resveratrol 40-51 tumor protein p53 Homo sapiens 95-98 14592451-5 2003 Resveratrol caused a dose-dependent increase in intracellular p53 and p21(WAF1/CIP1) levels. Resveratrol 0-11 tumor protein p53 Homo sapiens 62-65 12963997-4 2003 This anti-proliferative effect of resveratrol was associated with a marked inhibition of the phosphorylation of the retinoblastoma protein (pRB) and concomitant induction of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP, which appears to be transcriptionally upregulated and is p53- dependent. Resveratrol 34-45 tumor protein p53 Homo sapiens 284-287 12644594-0 2003 Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 77-80 12569576-0 2003 Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Resveratrol 44-55 tumor protein p53 Homo sapiens 72-75 12687016-2 2003 Our previous study showed that the antitumor activity of resveratrol occurs through mitogen-activated protein kinases-mediated p53 activation and induction of apoptosis. Resveratrol 57-68 tumor protein p53 Homo sapiens 127-130 14977434-4 2003 The antiproliferative effect of resveratrol was associated with the inhibition of D-type cyclins and cyclin-dependent kinase (Cdk) 4 expression, and the induction of tumor suppressor p53 and Cdk inhibitor p21. Resveratrol 32-43 tumor protein p53 Homo sapiens 183-186 12628512-6 2003 We also found that resveratrol-induced activation of p53 and resveratrol-induced apoptosis occurred through a p53-dependent pathway. Resveratrol 19-30 tumor protein p53 Homo sapiens 53-56 12628512-6 2003 We also found that resveratrol-induced activation of p53 and resveratrol-induced apoptosis occurred through a p53-dependent pathway. Resveratrol 19-30 tumor protein p53 Homo sapiens 110-113 12628512-6 2003 We also found that resveratrol-induced activation of p53 and resveratrol-induced apoptosis occurred through a p53-dependent pathway. Resveratrol 61-72 tumor protein p53 Homo sapiens 110-113 12628512-7 2003 The MAP kinases, ERKs, JNKs, or p38 kinases, are involved in resveratrol-induced activation of p53 and apoptosis. Resveratrol 61-72 tumor protein p53 Homo sapiens 95-98 12392819-4 2002 In MDA-MB-231, resveratrol (up to 200 microM) lowered the expression and kinase activities of positive G1/S and G2/M cell cycle regulators and inhibited ribonucleotide reductase activity in a concentration dependent manner, without a significant effect on the low expression of tumor suppressors p21, p27, and p53. Resveratrol 15-26 tumor protein p53 Homo sapiens 310-313 12409142-0 2002 Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 46-49 12409142-3 2002 Our results showed that resveratrol inhibited cell growth in p53-positive Hep G2 cells only. Resveratrol 24-35 tumor protein p53 Homo sapiens 61-64 12409142-4 2002 This anticancer effect was a result of cellular apoptotic death induced by resveratrol via the p53-dependent pathway. Resveratrol 75-86 tumor protein p53 Homo sapiens 95-98 12409142-7 2002 In contrast, the p53-negative Hep 3B cells treated with resveratrol did not show the antiproliferation effect neither did they show significant changes in p21 nor Fas/APO-1 levels. Resveratrol 56-67 tumor protein p53 Homo sapiens 17-20 12409142-9 2002 Furthermore, these results implied that resveratrol might also be a new potent chemopreventive drug candidate for liver cancer as it played an important role to trigger p53-mediated molecules involved in the mechanism of p53-dependent apoptotic signal pathway. Resveratrol 40-51 tumor protein p53 Homo sapiens 169-172 12409142-9 2002 Furthermore, these results implied that resveratrol might also be a new potent chemopreventive drug candidate for liver cancer as it played an important role to trigger p53-mediated molecules involved in the mechanism of p53-dependent apoptotic signal pathway. Resveratrol 40-51 tumor protein p53 Homo sapiens 221-224 11889192-0 2002 Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. Resveratrol 0-11 tumor protein p53 Homo sapiens 75-78 11895857-0 2002 Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 131-134 11895857-5 2002 Resveratrol increases the expression of p53, tumor suppressor protein, prior to NAG-1 induction, indicating that NAG-1 expression by resveratrol is mediated by p53 expression. Resveratrol 0-11 tumor protein p53 Homo sapiens 40-43 11895857-5 2002 Resveratrol increases the expression of p53, tumor suppressor protein, prior to NAG-1 induction, indicating that NAG-1 expression by resveratrol is mediated by p53 expression. Resveratrol 133-144 tumor protein p53 Homo sapiens 160-163 11895857-6 2002 We also show that the p53 binding sites within the promoter region of NAG-1 play a pivotal role to control NAG-1 expression by resveratrol. Resveratrol 127-138 tumor protein p53 Homo sapiens 22-25 11895857-7 2002 Derivatives of resveratrol were examined for NAG-1 induction, and the data suggest that resveratrol-induced NAG-1 and p53 induction is not dependent on its anti-oxidant activity. Resveratrol 88-99 tumor protein p53 Homo sapiens 118-121 12131363-0 2002 Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. Resveratrol 0-11 tumor protein p53 Homo sapiens 46-49 12131363-0 2002 Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. Resveratrol 0-11 tumor protein p53 Homo sapiens 79-82 12131363-9 2002 Resveratrol induced serine-15 phosphorylation of p53 was blocked by PD 98059 (Calbiochem), a MAPK kinase inhibitor, implicating MAPK activation in the phosphorylation of p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 49-52 12131363-9 2002 Resveratrol induced serine-15 phosphorylation of p53 was blocked by PD 98059 (Calbiochem), a MAPK kinase inhibitor, implicating MAPK activation in the phosphorylation of p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 170-173 12131363-11 2002 These results suggest that apoptosis induction by resveratrol in DU 145 cells requires serine-15 phosphorylation of p53 by MAPK. Resveratrol 50-61 tumor protein p53 Homo sapiens 116-119 12131363-13 2002 Pifithrin-alpha (Calbiochem), a p53 inhibitor, blocked resveratrol induced serine-15 phosphorylation of p53 and p53 binding to DNA. Resveratrol 55-66 tumor protein p53 Homo sapiens 32-35 12131363-13 2002 Pifithrin-alpha (Calbiochem), a p53 inhibitor, blocked resveratrol induced serine-15 phosphorylation of p53 and p53 binding to DNA. Resveratrol 55-66 tumor protein p53 Homo sapiens 104-107 12131363-13 2002 Pifithrin-alpha (Calbiochem), a p53 inhibitor, blocked resveratrol induced serine-15 phosphorylation of p53 and p53 binding to DNA. Resveratrol 55-66 tumor protein p53 Homo sapiens 104-107 12131363-14 2002 Resveratrol caused a p53 stimulated increase in p21 messenger RNA. Resveratrol 0-11 tumor protein p53 Homo sapiens 21-24 12131363-15 2002 Transfection of additional wild-type p53 into DU 145 cells induced apoptosis, which was further enhanced by resveratrol treatment. Resveratrol 108-119 tumor protein p53 Homo sapiens 37-40 11245472-0 2001 Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Resveratrol 0-11 tumor protein p53 Homo sapiens 34-37 11522280-5 2001 p53 content of MCF-7 breast cancer cells (wild-type) was increased by caffeic acid, decreased by resveratrol, and showed a twofold increase with catechin, that reached borderline statistical significance; however, none of these effects were dose-responsive. Resveratrol 97-108 tumor protein p53 Homo sapiens 0-3 11522280-6 2001 Colo 320 HSR (+) cells (with a mutant p53 gene) had lower p53 content upon stimulation, reaching borderline statistical significance, but without being dose-responsive, in the presence of caffeic acid and resveratrol. Resveratrol 205-216 tumor protein p53 Homo sapiens 38-41 11745454-3 2001 Using the human wild-type p53-expressing HCT116 colon carcinoma cell line and HCT116 cells with both p53 alleles inactivated by homologous recombination, we show in the current study that resveratrol at concentrations comparable to those found in some foods can induce apoptosis independently of p53. Resveratrol 188-199 tumor protein p53 Homo sapiens 26-29 11745454-3 2001 Using the human wild-type p53-expressing HCT116 colon carcinoma cell line and HCT116 cells with both p53 alleles inactivated by homologous recombination, we show in the current study that resveratrol at concentrations comparable to those found in some foods can induce apoptosis independently of p53. Resveratrol 188-199 tumor protein p53 Homo sapiens 101-104 11745454-3 2001 Using the human wild-type p53-expressing HCT116 colon carcinoma cell line and HCT116 cells with both p53 alleles inactivated by homologous recombination, we show in the current study that resveratrol at concentrations comparable to those found in some foods can induce apoptosis independently of p53. Resveratrol 188-199 tumor protein p53 Homo sapiens 101-104 11745454-6 2001 When compared with 5-FU, resveratrol stimulated p53 accumulation and activity only weakly and with delayed kinetics and neither the increased levels nor the activity affected apoptosis detectably. Resveratrol 25-36 tumor protein p53 Homo sapiens 48-51 11745454-9 2001 Thus, resveratrol triggers a p53-independent apoptotic pathway in HCT116 cells that may be linked to differentiation. Resveratrol 6-17 tumor protein p53 Homo sapiens 29-32 11245472-2 2001 Our previous study showed that the antitumor activity of resveratrol occurs through p53-mediated apoptosis. Resveratrol 57-68 tumor protein p53 Homo sapiens 84-87 11245472-3 2001 In this study, we have elucidated the potential signaling components underlying resveratrol-induced p53 activation and induction of apoptosis. Resveratrol 80-91 tumor protein p53 Homo sapiens 100-103 11245472-4 2001 We found that in a mouse JB6 epidermal cell line, resveratrol activated extracellular-signal-regulated protein kinases (ERKs), c-Jun NH2-terminal kinases (JNKs), and p38 kinase and induced serine 15 phosphorylation of p53. Resveratrol 50-61 tumor protein p53 Homo sapiens 218-221 11245472-7 2001 Most importantly, ERKs and p38 kinase formed a complex with p53 after treatment with resveratrol. Resveratrol 85-96 tumor protein p53 Homo sapiens 60-63 11245472-8 2001 Strikingly, resveratrol-activated ERKs and p38 kinase, but not JNKs, phosphorylated p53 at serine 15 in vitro. Resveratrol 12-23 tumor protein p53 Homo sapiens 84-87 11245472-9 2001 Furthermore, pretreatment of the cells with PD98059 or SB202190 or stable expression of a dominant negative mutant of ERK2 or p38 kinase impaired resveratrol-induced p53-dependent transcriptional activity and apoptosis, whereas constitutively active MEK1 increased the transcriptional activity of p53. Resveratrol 146-157 tumor protein p53 Homo sapiens 166-169 11245472-9 2001 Furthermore, pretreatment of the cells with PD98059 or SB202190 or stable expression of a dominant negative mutant of ERK2 or p38 kinase impaired resveratrol-induced p53-dependent transcriptional activity and apoptosis, whereas constitutively active MEK1 increased the transcriptional activity of p53. Resveratrol 146-157 tumor protein p53 Homo sapiens 297-300 11245472-10 2001 These data strongly suggest that both ERKs and p38 kinase mediate resveratrol-induced activation of p53 and apoptosis through phosphorylation of p53 at serine 15. Resveratrol 66-77 tumor protein p53 Homo sapiens 100-103 11245472-10 2001 These data strongly suggest that both ERKs and p38 kinase mediate resveratrol-induced activation of p53 and apoptosis through phosphorylation of p53 at serine 15. Resveratrol 66-77 tumor protein p53 Homo sapiens 145-148 11042678-1 2000 Resveratrol (3,5,4"-trihydroxy-trans-stilbene), in the concentration range of 20 microM and above, induced arrest in the S-phase and apoptosis in the T cell-derived T-ALL lymphocytic leukemia cell line CEM-C7H2 which is deficient in functional p53 and p16. Resveratrol 0-11 tumor protein p53 Homo sapiens 244-247 11181455-0 2001 Resveratrol analog, 3,4,5,4"-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts. Resveratrol 0-11 tumor protein p53 Homo sapiens 88-91 34204834-4 2021 In FaDu cells, combined CisPt + RSV treatment induced an increase in apoptosis, which was associated with an increase in c-MYC and TP53 and a decrease in BCL-2 expression. Resveratrol 32-35 tumor protein p53 Homo sapiens 131-135 34856073-12 2022 This study constructed a TF-miRNA regulatory network with TP53 and E2F as the main central genes to elucidate the molecular mechanism of resveratrol in the treatment of breast cancer. Resveratrol 137-148 tumor protein p53 Homo sapiens 58-62 34919323-6 2022 And then it was attested that cells had a lower level of p53 but SIRT1 expression was upregulated on RSV-AA-P(CL-DLLA), which might be related with resveratrol release from RSV-AA-P(CL-DLLA). Resveratrol 148-159 tumor protein p53 Homo sapiens 57-60 34500758-0 2021 Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach. Resveratrol 27-38 tumor protein p53 Homo sapiens 55-58 34500758-6 2021 This review aims to collect and present the latest published studies on resveratrol and its impact on cancer prevention, molecular signals (especially p53 protein participation), and its therapeutic prospects. Resveratrol 72-83 tumor protein p53 Homo sapiens 151-154 34335587-12 2021 In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI. Resveratrol 94-105 tumor protein p53 Homo sapiens 57-60 10069459-0 1999 Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Resveratrol 0-11 tumor protein p53 Homo sapiens 75-78 10069459-4 1999 Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Resveratrol 0-11 tumor protein p53 Homo sapiens 117-120 10069459-4 1999 Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Resveratrol 0-11 tumor protein p53 Homo sapiens 148-151 10069459-5 1999 Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. Resveratrol 6-17 tumor protein p53 Homo sapiens 78-81 10069459-5 1999 Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. Resveratrol 6-17 tumor protein p53 Homo sapiens 83-86 10069459-5 1999 Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. Resveratrol 6-17 tumor protein p53 Homo sapiens 83-86 10069459-5 1999 Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. Resveratrol 6-17 tumor protein p53 Homo sapiens 83-86 10069459-6 1999 These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis. Resveratrol 50-61 tumor protein p53 Homo sapiens 102-105 33236130-4 2021 In the present study, it was confirmed that resveratrol inhibited the HPV E6 mRNA, HPV E6 protein and phosphorylated retinoblastoma protein (p-pRb1) levels, and increased the p53 protein levels in HeLa and Ca Ski cells, as well as in subcutaneous tumor tissue grown from HeLa cells. Resveratrol 44-55 tumor protein p53 Homo sapiens 175-178 34502426-8 2021 The effect of resveratrol and IR enhanced the expression of apoptotic genes, such as Bax, p53, and caspase 8, leading to apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 90-93 34257824-7 2021 Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Resveratrol 26-37 tumor protein p53 Homo sapiens 49-52 34257824-7 2021 Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Resveratrol 26-37 tumor protein p53 Homo sapiens 106-109 34257824-7 2021 Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Resveratrol 26-37 tumor protein p53 Homo sapiens 178-181 34204834-5 2021 While CisPt + RSV treatment induced apoptosis in PE/CA-PJ49 cells by inhibition of BCL-2 associated with high levels of MDM-2 and subsequently led to inhibition of TP53 gene expression. Resveratrol 14-17 tumor protein p53 Homo sapiens 164-168 32377740-2 2020 Rsv induces expression of the human TP53 and HELB genes, which are involved in the regulation of DNA maintenance. Resveratrol 0-3 tumor protein p53 Homo sapiens 36-40 34749615-4 2021 RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-kappaB, EMT, and pentose phosphate pathway. Resveratrol 0-3 tumor protein p53 Homo sapiens 158-161 35221291-13 2022 Our study confirms the protective role of RES as an anti-ROS agent and its ability to alleviate DNA damage through a pathway involving p53/p21 signaling. Resveratrol 42-45 tumor protein p53 Homo sapiens 135-138 35517847-1 2022 Background: Resveratrol, a well-known natural compound and nutrient, activates the deacetylation ability of SIRT1, demonstrating p53-dependent apoptosis functions in many diseases. Resveratrol 12-23 tumor protein p53 Homo sapiens 129-132 35517847-10 2022 Knockdown of SIRT1 and Hsp60 provides evidence that resveratrol downregulated Hsp60 through SIRT1 and that Hsp60 decreased p53 through the Akt pathway. Resveratrol 52-63 tumor protein p53 Homo sapiens 123-126 35517847-11 2022 Conclusions: This study revealed dynamic changes in the nascent proteome and transcriptome in response to resveratrol in HEK 293T cells and demonstrated that resveratrol downregulates Hsp60 by activating SIRT1, which may be a possible mechanism by which resveratrol prevents p53-dependent apoptosis by regulating Hsp60. Resveratrol 158-169 tumor protein p53 Homo sapiens 275-278 33968980-10 2021 RSV significantly ameliorated the release of apoptosis-related cytokines, namely P53, cleaved caspase-3, cytochrome c, and BAX, leading to the amelioration of neuronal apoptosis, brain edema, and neurological impairment 24 h after SAH. Resveratrol 0-3 tumor protein p53 Homo sapiens 81-84 32945383-0 2020 Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53-dependent pathway: Integrated bioinformatics analysis and experimental validation. Resveratrol 0-11 tumor protein p53 Homo sapiens 103-106 32945383-7 2020 By bioinformatics analysis, a total of 1,031 DEGs were identified in the RSV-treated A549 cells, which were enriched in apoptosis-, or autophagy-related biological functions and the p53 signaling pathway. Resveratrol 73-76 tumor protein p53 Homo sapiens 182-185 32945383-12 2020 RSV elevated the p53 levels and decreased the phosphorylated (p-)Mdm2 and p-Akt levels. Resveratrol 0-3 tumor protein p53 Homo sapiens 17-20 32945383-13 2020 Pifithrin-alpha, an inhibitor of p53, partially reduced RSV-induced apoptosis and autophagy. Resveratrol 56-59 tumor protein p53 Homo sapiens 33-36 32945383-14 2020 On the whole, the results of the present study demonstrated that RSV initiates the apoptosis and autophagic death of A549 cells via the activation of the p53 signaling pathway, further highlighting the potential of RSV for the treatment of NSCLC. Resveratrol 65-68 tumor protein p53 Homo sapiens 154-157 32945383-14 2020 On the whole, the results of the present study demonstrated that RSV initiates the apoptosis and autophagic death of A549 cells via the activation of the p53 signaling pathway, further highlighting the potential of RSV for the treatment of NSCLC. Resveratrol 215-218 tumor protein p53 Homo sapiens 154-157 32397868-0 2020 Expression of Concern: Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53. Resveratrol 23-34 tumor protein p53 Homo sapiens 155-158 33747905-5 2021 The RNA-seq analysis results demonstrated that genes affected by RSV treatment were mainly involved in apoptosis and the p53 signaling pathway. Resveratrol 65-68 tumor protein p53 Homo sapiens 121-124 33580595-1 2021 The present study sought to evaluate the effect of resveratrol supplementation on mRNA expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha), p53, p21, p16, and serum levels of cluster of differentiation 163 (CD163) to TNF-like weak inducer of apoptosis (TWEAK) ratio in patients with type 2 diabetes. Resveratrol 51-62 tumor protein p53 Homo sapiens 170-173 33580595-4 2021 Resveratrol supplementation significantly increased mRNA expression levels of p53 and p21 genes, compared with the placebo group (fold change of p53 = 1.29, p = .04; fold change of p21 = 1.46, p = .006). Resveratrol 0-11 tumor protein p53 Homo sapiens 78-81 33580595-4 2021 Resveratrol supplementation significantly increased mRNA expression levels of p53 and p21 genes, compared with the placebo group (fold change of p53 = 1.29, p = .04; fold change of p21 = 1.46, p = .006). Resveratrol 0-11 tumor protein p53 Homo sapiens 145-148 33580595-7 2021 Resveratrol supplementation resulted in significant changes in p53 and p21 genes expression, while serum levels of sCD163/sTWEAK ratio also improved in the resveratrol group, without any significant change in adjusted sCD163 levels. Resveratrol 0-11 tumor protein p53 Homo sapiens 63-66 33108147-0 2020 Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 78-81 32111491-1 2020 Resveratrol modulates the transcription factor NF-kappaB, cytochrome P450 isoenzyme CYP1A1, expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated apoptosis, p53, mTOR and cyclins and various phospho-diesterases resulting in an increase in cytosolic cAMP levels. Resveratrol 0-11 tumor protein p53 Homo sapiens 184-187 32377734-9 2020 Of these agents, it was found that resveratrol increased p53 expression by 4.1-fold, decreased SIRT1 expression by 0.2-fold, and it was the most potent inducer of apoptosis. Resveratrol 35-46 tumor protein p53 Homo sapiens 57-60 32459661-0 2020 Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53. Resveratrol 0-11 tumor protein p53 Homo sapiens 76-79 32459661-6 2020 In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. Resveratrol 106-117 tumor protein p53 Homo sapiens 142-145 32459661-7 2020 These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway. Resveratrol 23-34 tumor protein p53 Homo sapiens 102-105 32126555-14 2020 Resveratrol, an activator of sirtuin-1, postponed the IL-1beta-induced senescence through blocking the NF-kappaB/p53/p21 pathway and attenuated the osteoblastic transition and calcification in VSMCs. Resveratrol 0-11 tumor protein p53 Homo sapiens 113-116 31438780-4 2019 Results: Cell senescence, characterized by senescence beta-galactosidase staining and senescence-related genes (p16, p21, and p53) expression, was attenuated by resveratrol. Resveratrol 161-172 tumor protein p53 Homo sapiens 126-129 30881498-0 2019 Resveratrol induces p53 in colorectal cancer through SET7/9. Resveratrol 0-11 tumor protein p53 Homo sapiens 20-23 31317586-0 2019 Resveratrol modulates epigenetic regulators of promoter histone methylation and acetylation that restores BRCA1, p53, p21CIP1 in human breast cancer cell lines. Resveratrol 0-11 tumor protein p53 Homo sapiens 113-116 31317586-2 2019 Resveratrol (RVT) a much studied anti-cancer natural molecule is known for restoration of BRCA1, p53, and p21 in cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 97-100 31278094-6 2019 We will aim to evaluate the effects of resveratrol supplementation on mRNA expression of PPARalpha, p53, p21 and p16 in patients with T2D. Resveratrol 39-50 tumor protein p53 Homo sapiens 100-103 31441212-0 2019 Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters. Resveratrol 25-36 tumor protein p53 Homo sapiens 99-102 31441212-7 2019 Senescence is induced through the p53/p21Cip1/Waf1 and p16INK4a /Rb pathways, depending on the RSV metabolite, and requires ABC transporters, but not estrogen receptors. Resveratrol 95-98 tumor protein p53 Homo sapiens 34-37 31095781-0 2019 Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status. Resveratrol 47-58 tumor protein p53 Homo sapiens 98-102 31095781-3 2019 The aim of this study was to evaluate resveratrol antitumor activity (12.5, 25, 50, 100, 150, 200, and 250 muM) and its possible mechanisms of action in bladder tumor cells with different TP53 gene status (RT4, grade 1, TP53 wild type; 5637-grade 2 and T24-grade 3, TP53 mutated). Resveratrol 38-49 tumor protein p53 Homo sapiens 220-224 31095781-3 2019 The aim of this study was to evaluate resveratrol antitumor activity (12.5, 25, 50, 100, 150, 200, and 250 muM) and its possible mechanisms of action in bladder tumor cells with different TP53 gene status (RT4, grade 1, TP53 wild type; 5637-grade 2 and T24-grade 3, TP53 mutated). Resveratrol 38-49 tumor protein p53 Homo sapiens 220-224 31095781-8 2019 In addition, the resveratrol antiproliferative effects in wild type TP53 cells were accompanied by modulation of the DNMT1 gene. Resveratrol 17-28 tumor protein p53 Homo sapiens 68-72 31095781-11 2019 In conclusion, resveratrol has antiproliferative activity in bladder tumor cells; however, the mechanisms of action are dependent on TP53 status. Resveratrol 15-26 tumor protein p53 Homo sapiens 133-137 31336132-4 2019 Moreover, resveratrol increases nuclear inducible cyclooxygenase (COX)-2 accumulation, complexes with p53, and induces p53-dependent anti-proliferation. Resveratrol 10-21 tumor protein p53 Homo sapiens 102-105 31336132-4 2019 Moreover, resveratrol increases nuclear inducible cyclooxygenase (COX)-2 accumulation, complexes with p53, and induces p53-dependent anti-proliferation. Resveratrol 10-21 tumor protein p53 Homo sapiens 119-122 31336132-12 2019 By inhibiting the T4-activated STAT3 signal transduction axis with S31-201, resveratrol was able to sequentially reestablish COX-2/p53-dependent gene expressions and anti-proliferation. Resveratrol 76-87 tumor protein p53 Homo sapiens 131-134 31376399-7 2019 We demonstrate that the synergistic action of phosphate overload and IL-6 enhances senescence-associated calcification in a p53-dependent manner and is inhibited by an anti-aging agent (resveratrol) in a dose-dependent manner. Resveratrol 186-197 tumor protein p53 Homo sapiens 124-127 30959047-6 2019 On the contrary, resveratrol promoted the accumulation of SIRT-1, PCNA, caspase 3, and p53. Resveratrol 17-28 tumor protein p53 Homo sapiens 87-90 30881498-5 2019 Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 68-71 30881498-5 2019 Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 73-76 30881498-5 2019 Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 73-76 30881498-5 2019 Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 73-76 30881498-6 2019 Furthermore, treating cells with resveratrol upregulated SET domain containing lysine methyltransferase 7/9 (SET7/9) expression, which positively regulates p53 through its mono-methylation at lysine 372, compared with untreated cells. Resveratrol 33-44 tumor protein p53 Homo sapiens 156-159 30881498-8 2019 However, the genetic knockdown of SET7/9 by short hairpin RNA attenuated the resveratrol-driven overexpression of p53, cleaved caspase-3 and PARP. Resveratrol 77-88 tumor protein p53 Homo sapiens 114-117 30881498-9 2019 Collectively, these results reveal the molecular mechanisms by which resveratrol induces p53 stability in colon cancer that results in the activation of p53-mediated apoptosis. Resveratrol 69-80 tumor protein p53 Homo sapiens 89-92 30881498-9 2019 Collectively, these results reveal the molecular mechanisms by which resveratrol induces p53 stability in colon cancer that results in the activation of p53-mediated apoptosis. Resveratrol 69-80 tumor protein p53 Homo sapiens 153-156 30132535-0 2018 Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3-kinase/protein kinase B pathway. Resveratrol 0-11 tumor protein p53 Homo sapiens 109-112 30387805-7 2019 Additionally, resveratrol treatment decreased the protein expression levels of cyclin D1, cyclin E2 and BCL2 apoptosis regulator, while it increased BCL2 associated X and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 185-188 30588012-8 2018 Results: In the present study, we found that resveratrol dramatically inhibited melanoma cell proliferation and induced cell apoptosis through upregulation of p53 in a concentration-dependent manner. Resveratrol 45-56 tumor protein p53 Homo sapiens 159-162 30446350-14 2019 We conclude that in fibroblasts RSV stimulates the PGC-1alpha and p53 pathways, and up-regulates genes affecting the glucose metabolism, mitochondrial beta-oxidation, and mitochondrial biogenesis. Resveratrol 32-35 tumor protein p53 Homo sapiens 66-69 30132535-7 2018 It was revealed that resveratrol upregulated the expression of p53 while decreasing the ratio of phosphorylated protein kinase B (p-Akt)/Akt in HCC cells. Resveratrol 21-32 tumor protein p53 Homo sapiens 63-66 30132535-8 2018 Treatment with p53 inhibitor pifithrin-alpha and Akt activator insulin-like growth factor-1 decreased the expression of Beclin1 while significantly promoting cell proliferation, invasion and migration compared with the resveratrol treatment group. Resveratrol 219-230 tumor protein p53 Homo sapiens 15-18 30132535-9 2018 Taken together, the results of the present study revealed that resveratrol inhibited the proliferation and mobility of HCC cells through inducing autophagy via activating p53 and inhibiting phosphoinositide 3-kinase/Akt. Resveratrol 63-74 tumor protein p53 Homo sapiens 171-174 29555649-2 2018 In contrast, resveratrol binds to integrin alphavbeta3 at a discrete site and induces p53-dependent antiproliferation in malignant neoplastic cells. Resveratrol 13-24 tumor protein p53 Homo sapiens 86-89 29916532-8 2018 Resveratrol induced the ROS-p38-p53 pathway by increasing the gene expression of phosphorylated p38 mitogen-activated protein kinase, while it induced the p53 and ER stress pathway by increasing the gene expression levels of phosphorylated eukaryotic initiation factor 2alpha and C/EBP homologous protein. Resveratrol 0-11 tumor protein p53 Homo sapiens 32-35 29916532-8 2018 Resveratrol induced the ROS-p38-p53 pathway by increasing the gene expression of phosphorylated p38 mitogen-activated protein kinase, while it induced the p53 and ER stress pathway by increasing the gene expression levels of phosphorylated eukaryotic initiation factor 2alpha and C/EBP homologous protein. Resveratrol 0-11 tumor protein p53 Homo sapiens 155-158 30142917-0 2018 Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin. Resveratrol 49-60 tumor protein p53 Homo sapiens 13-16 30142917-0 2018 Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin. Resveratrol 49-60 tumor protein p53 Homo sapiens 85-88 30142917-4 2018 Resveratrol (Resv) is a natural compound representing a promising chemosensitizer for cancer treatment that has been shown to sensitize tumor cells through upregulation and phosphorylation of p53 and inhibition of RAD51. Resveratrol 0-11 tumor protein p53 Homo sapiens 192-195 30142917-4 2018 Resveratrol (Resv) is a natural compound representing a promising chemosensitizer for cancer treatment that has been shown to sensitize tumor cells through upregulation and phosphorylation of p53 and inhibition of RAD51. Resveratrol 0-4 tumor protein p53 Homo sapiens 192-195 29855544-6 2018 Moreover, resveratrol, a HDAC inhibitor, controlled not only acetylated p53 status but also DNTTIP1 expression, leading to a similar phenotype of siDNTTIP1 cells. Resveratrol 10-21 tumor protein p53 Homo sapiens 72-75 29754265-0 2018 Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53-p21CIP1/WAF1 in human colorectal HCT116 cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 134-137 29928358-0 2018 Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Resveratrol 0-11 tumor protein p53 Homo sapiens 116-119 29928358-7 2018 In addition, p53, a protein that is essential for cell survival and cell cycle progression, exhibited elevated expression levels in resveratrol-treated HeLa cells. Resveratrol 132-143 tumor protein p53 Homo sapiens 13-16 30349639-0 2018 Unfolding the roles of resveratrol in p53 regulation. Resveratrol 23-34 tumor protein p53 Homo sapiens 38-41 30031063-0 2018 Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-kappaB signaling. Resveratrol 0-11 tumor protein p53 Homo sapiens 52-55 30031063-10 2018 FINDINGS: Resveratrol is a polyphenolic compound capable of activation of tumor suppressor p53 and its pro-apoptotic modulator PUMA. Resveratrol 10-21 tumor protein p53 Homo sapiens 91-94 30018739-0 2018 Resveratrol prevents p53 aggregation in vitro and in breast cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 21-24 30018739-3 2018 We tested the potential of resveratrol, a naturally occurring polyphenol, to interact and prevent the aggregation of wild-type and mutant p53 in vitro using fluorescence spectroscopy techniques and in human breast cancer cells (MDA-MB-231, HCC-70 and MCF-7) using immunofluorescence co-localization assays. Resveratrol 27-38 tumor protein p53 Homo sapiens 138-141 30018739-4 2018 Based on our data, an interaction occurs between resveratrol and the wild-type p53 core domain (p53C). Resveratrol 49-60 tumor protein p53 Homo sapiens 79-82 30018739-6 2018 Additionally, resveratrol reduces mutant p53 protein aggregation in MDA-MB-231 and HCC-70 cells but not in the wild-type p53 cell line MCF-7. Resveratrol 14-25 tumor protein p53 Homo sapiens 41-44 30018739-9 2018 Our study provides evidence that resveratrol directly modulates p53, enhancing our understanding of the mechanisms involved in p53 aggregation and its potential as a therapeutic strategy for cancer treatment. Resveratrol 33-44 tumor protein p53 Homo sapiens 64-67 30018739-9 2018 Our study provides evidence that resveratrol directly modulates p53, enhancing our understanding of the mechanisms involved in p53 aggregation and its potential as a therapeutic strategy for cancer treatment. Resveratrol 33-44 tumor protein p53 Homo sapiens 127-130 29872500-5 2018 Here we show that resveratrol controls breast cancer cell proliferation by inducing tumor-suppressive miRNAs (miR-34a, miR-424, and miR-503) via the p53 pathway and then by suppressing heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), which is associated with tumorigenesis and tumor progression. Resveratrol 18-29 tumor protein p53 Homo sapiens 149-152 29555649-6 2018 Knockdown of PD-L1 by small hairpin RNA (shRNA) relieved the inhibitory effect of T4 on resveratrol-induced nuclear accumulation of COX-2- and COX-2/p53-dependent gene expression. Resveratrol 88-99 tumor protein p53 Homo sapiens 149-152 29185024-7 2018 However, fluoride-induced Ac-p53 was suppressed by the SIRT1 activator resveratrol (50 microM). Resveratrol 71-82 tumor protein p53 Homo sapiens 29-32 29115429-0 2018 Resveratrol-mediated apoptosis in renal cell carcinoma via the p53/AMP-activated protein kinase/mammalian target of rapamycin autophagy signaling pathway. Resveratrol 0-11 tumor protein p53 Homo sapiens 63-66 29255096-2 2018 Resveratrol - the polyphenolic phytoalexin - binds to integrin alphavbeta3 to induce apoptosis in cancer cells via cyclooxygenase 2 (COX-2) nuclear accumulation and p53-dependent apoptosis. Resveratrol 0-11 tumor protein p53 Homo sapiens 165-168 29485619-9 2018 Resveratrol and to a greater extent pterostilbene downregulates the HPV oncoprotein E6, induces caspase-3 activation, and upregulates p53 protein levels. Resveratrol 0-11 tumor protein p53 Homo sapiens 134-137 29242151-2 2018 However, resveratrol-induced nuclear accumulation of COX-2 enhances p53-dependent anti-proliferation in different types of cancers. Resveratrol 9-20 tumor protein p53 Homo sapiens 68-71 29242151-3 2018 Treatment with resveratrol leads to phosphorylation and nuclear translocation of mitogen-activated protein kinase (ERK1/2), and accumulation of nuclear COX-2 to complex with pERK1/2 and p53. Resveratrol 15-26 tumor protein p53 Homo sapiens 186-189 29242151-5 2018 We investigated the mechanisms by which resveratrol-inducible COX-2 facilitates p53-dependent anti-proliferation in prostate cancer LNCaP cells. Resveratrol 40-51 tumor protein p53 Homo sapiens 80-83 29242151-6 2018 Resveratrol treatment caused nuclear accumulation and complexing of ERK1/2, pSer15-p53 and COX-2 which was activated ERK1/2-dependent. Resveratrol 0-11 tumor protein p53 Homo sapiens 83-86 29274324-7 2018 The results demonstrate that two AHR antagonists, alpha-naphthoflavone (alpha-NF) and resveratrol, decreased cell proliferation, arrested cells in the gap 1/synthesis (G1/S) phases, and increased p53 levels and apoptosis. Resveratrol 86-97 tumor protein p53 Homo sapiens 196-199 29115429-8 2018 Resveratrol also promoted the expression of p53 and activated phospho-AMP-activated protein kinase (AMPK). Resveratrol 0-11 tumor protein p53 Homo sapiens 44-47 29115429-10 2018 In conclusion, resveratrol suppressed RCC viability and migration, and promoted RCC apoptosis via the p53/AMPK/mTOR-induced autophagy signaling pathway. Resveratrol 15-26 tumor protein p53 Homo sapiens 102-105 28366708-7 2017 Moreover, the simultaneous treatment of leukemia cells with ABT-737 and resveratrol resulted in a reduction in mitochondrial membrane potential, an increase of p53 protein level and up-regulation of the Bax/Bcl-2 ratio. Resveratrol 72-83 tumor protein p53 Homo sapiens 160-163 28759712-6 2017 Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. Resveratrol 17-28 tumor protein p53 Homo sapiens 59-62 28759712-6 2017 Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. Resveratrol 17-28 tumor protein p53 Homo sapiens 138-141 28759712-7 2017 Subsequently, hormones impair resveratrol-induced COX-2-/p53-dependent gene expression. Resveratrol 30-41 tumor protein p53 Homo sapiens 57-60 29073244-5 2017 We found that 10 muM resveratrol improved the proliferation of porcine PSCs, increased the expression of A-beta-catenin (active beta-catenin), Pcna, C-Myc, Bcl-2 and sirtuin-1 (Sirt1), and decreased the expression of P53, Caspase3. Resveratrol 21-32 tumor protein p53 Homo sapiens 217-220 28950914-9 2017 CONCLUSIONS: Our results provide in vitro evidence that RSV produces anti-tumor effect by activating DDR pathway in an ATM/Chk2/p53 dependent manner. Resveratrol 56-59 tumor protein p53 Homo sapiens 128-131 28814292-7 2017 Resveratrol also regulated Sirt1 and acetylated p53 expression perturbed by irradiation in the small intestine. Resveratrol 0-11 tumor protein p53 Homo sapiens 48-51 28646291-9 2017 Two resveratrol-associated genes, adenomatous polyposis coli (APC) and TP53, found in CRC were further mined, using cBio portal and Colorectal Cancer Atlas which predicted a mechanistic link to exist between resveratrol QR2/TP53 CIN. Resveratrol 4-15 tumor protein p53 Homo sapiens 71-75 28646291-9 2017 Two resveratrol-associated genes, adenomatous polyposis coli (APC) and TP53, found in CRC were further mined, using cBio portal and Colorectal Cancer Atlas which predicted a mechanistic link to exist between resveratrol QR2/TP53 CIN. Resveratrol 4-15 tumor protein p53 Homo sapiens 224-228 28646291-9 2017 Two resveratrol-associated genes, adenomatous polyposis coli (APC) and TP53, found in CRC were further mined, using cBio portal and Colorectal Cancer Atlas which predicted a mechanistic link to exist between resveratrol QR2/TP53 CIN. Resveratrol 208-219 tumor protein p53 Homo sapiens 71-75 28629161-0 2017 Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target. Resveratrol 26-37 tumor protein p53 Homo sapiens 43-46 28629161-4 2017 The aim of this review is to collect and present recent evidence from the literature regarding resveratrol and its effects on cancer prevention, molecular signaling (especially regarding the involvement of p53 protein), and therapeutic perspectives with an emphasis on clinical trial results to date. Resveratrol 95-106 tumor protein p53 Homo sapiens 206-209 27419830-0 2017 Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration. Resveratrol 0-11 tumor protein p53 Homo sapiens 33-36 27419830-4 2017 METHODS Resveratrol"s effects on cell proliferation, sphere-forming ability, and invasion were tested using multiple patient-derived GBM stem-like cell (GSC) lines and established U87 glioma cells, and changes in oncogenic AKT and tumor suppressive p53 were analyzed. Resveratrol 8-19 tumor protein p53 Homo sapiens 249-252 27419830-10 2017 In U87 glioma cells and GSCs, resveratrol reduced AKT phosphorylation and induced p53 expression and activation that led to transcription of downstream p53 target genes. Resveratrol 30-41 tumor protein p53 Homo sapiens 82-85 27419830-10 2017 In U87 glioma cells and GSCs, resveratrol reduced AKT phosphorylation and induced p53 expression and activation that led to transcription of downstream p53 target genes. Resveratrol 30-41 tumor protein p53 Homo sapiens 152-155 27419830-13 2017 CONCLUSIONS Resveratrol potently inhibited GBM and GSC growth and infiltration, acting partially via AKT deactivation and p53 induction, and suppressed glioblastoma growth in vivo. Resveratrol 12-23 tumor protein p53 Homo sapiens 122-125 27419830-14 2017 The ability of resveratrol to modulate AKT and p53, as well as reportedly many other antitumorigenic pathways, is attractive for therapy against a genetically heterogeneous tumor such as GBM. Resveratrol 15-26 tumor protein p53 Homo sapiens 47-50 28303009-0 2017 Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 77-80 29082697-9 2017 The protein expressions of Caspase-3, PTEN and p53 were all increased after being treated with resveratrol, while the expression of p-AKT was decreased after the treatment. Resveratrol 95-106 tumor protein p53 Homo sapiens 47-50 28303009-9 2017 We also demonstrated a critical role of the p53-CXCR2 axis in mediating RSV-induced senescence. Resveratrol 72-75 tumor protein p53 Homo sapiens 44-47 28024576-6 2017 We have found that apoptosis induced by RSV-DF was associated with the higher expression of p53, caspase-3, and BAX than the free RSV. Resveratrol 40-43 tumor protein p53 Homo sapiens 92-95 28212547-0 2017 Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Resveratrol 0-11 tumor protein p53 Homo sapiens 98-101 29081884-7 2017 These results indicate that SIRT1 activation by either RSV or overexpression of SIRT1 can exert neuroprotective effects partly by inhibiting p53 acetylation in NMDA-induced neurotoxicity. Resveratrol 55-58 tumor protein p53 Homo sapiens 141-144 27506388-8 2016 RSV-GSE also induced mitochondrial-mediated apoptosis in colon CSCs characterized by elevated p53, Bax/Bcl-2 ratio and cleaved PARP. Resveratrol 0-3 tumor protein p53 Homo sapiens 94-97 27779703-6 2016 In addition, resveratrol was observed to arrest cell cycle progression in G1/S phase by increasing the protein expression levels of p53 and p21, and concurrently reducing the protein expression levels of CDK2, cyclin A and cyclin E. Furthermore, resveratrol treatment significantly induced apoptosis in eosinophils, likely through the upregulation of Bim and Bax protein expression levels and the downregulation of Bcl-2 protein expression. Resveratrol 13-24 tumor protein p53 Homo sapiens 132-135 27232943-7 2016 Refined analysis of KEGG pathways showed that 2 - one linked to p53 and a second to prostate cancer - have functional connectivity to resveratrol and its four direct protein targets. Resveratrol 134-145 tumor protein p53 Homo sapiens 64-67 26498391-6 2016 Furthermore, we showed that resveratrol enhanced glioblastoma-initiating cells to temozolomide-induced apoptosis through DNA double-stranded breaks/pATM/pATR/p53 pathway activation, and promoted glioblastoma-initiating cell differentiation involving p-STAT3 inactivation. Resveratrol 28-39 tumor protein p53 Homo sapiens 158-161 26706021-1 2016 Flavonoid resveratrol modulates the transcription factor NF-kappaB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. Resveratrol 10-21 tumor protein p53 Homo sapiens 231-234 27109601-9 2016 However, resveratrol displayed synergism when combined with metformin as shown by the downregulation of p53/gammaH2AX/p-chk2. Resveratrol 9-20 tumor protein p53 Homo sapiens 104-107 26684585-2 2016 It has recently been reported that p53 regulates glucose metabolism and that an increase in p53 protein level is induced after serum deprivation or treatments with a natural compound,trans-Resveratrol (Rsv). Resveratrol 183-200 tumor protein p53 Homo sapiens 35-38 26684585-2 2016 It has recently been reported that p53 regulates glucose metabolism and that an increase in p53 protein level is induced after serum deprivation or treatments with a natural compound,trans-Resveratrol (Rsv). Resveratrol 183-200 tumor protein p53 Homo sapiens 92-95 26629991-0 2015 Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway. Resveratrol 14-25 tumor protein p53 Homo sapiens 119-122 26629991-9 2015 Furthermore, we found that RSV or MET treatment prevented senescent "memory" by modulating SIRT1/p300/p53/p21 pathway. Resveratrol 27-30 tumor protein p53 Homo sapiens 102-105 26231140-4 2015 In the resting neutrophils resveratrol and to lesser extent other polyphenols increased DNA damage and increased the level of p53. Resveratrol 27-38 tumor protein p53 Homo sapiens 126-129 26456774-3 2015 Resveratrol induces p53-dependent apoptosis via plasma membrane integrin alphavbeta3. Resveratrol 0-11 tumor protein p53 Homo sapiens 20-23 26456774-6 2015 DHT inhibited resveratrol-stimulated phosphorylation of Ser-15 of p53 in a concentration-dependent manner. Resveratrol 14-25 tumor protein p53 Homo sapiens 66-69 26456774-8 2015 DHT inhibited resveratrol-induced nuclear complex of p53-COX-2 formation which is required p53-dependent apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 53-56 26456774-8 2015 DHT inhibited resveratrol-induced nuclear complex of p53-COX-2 formation which is required p53-dependent apoptosis. Resveratrol 14-25 tumor protein p53 Homo sapiens 91-94 26456774-9 2015 ChIP studies of COX-2/p53 binding to DNA and expression of p53-responsive genes indicated that DHT inhibited resveratrol-induced p53-directed transcriptional activity. Resveratrol 109-120 tumor protein p53 Homo sapiens 22-25 26456774-9 2015 ChIP studies of COX-2/p53 binding to DNA and expression of p53-responsive genes indicated that DHT inhibited resveratrol-induced p53-directed transcriptional activity. Resveratrol 109-120 tumor protein p53 Homo sapiens 59-62 26456774-9 2015 ChIP studies of COX-2/p53 binding to DNA and expression of p53-responsive genes indicated that DHT inhibited resveratrol-induced p53-directed transcriptional activity. Resveratrol 109-120 tumor protein p53 Homo sapiens 59-62 26456774-10 2015 In addition, DHT did inhibit resveratrol-induced COX-2/p53-dependent gene expression. Resveratrol 29-40 tumor protein p53 Homo sapiens 55-58 26041883-5 2015 Tetraiodothyroacetic acid (tetrac) is a T4 derivative that, in a model of resveratrol-induced p53-dependent apoptosis in glioma cells, blocks the anti-apoptotic action of thyroid hormone, permitting specific serine phosphorylation of p53 and apoptosis to proceed. Resveratrol 74-85 tumor protein p53 Homo sapiens 94-97 25991017-4 2015 Pre-treatment with resveratrol, a SIRT1 activator, could attenuate rotenone-induced cell injury and p53 expression, whereas down-regulation of SIRT1 directly increased p53 expression. Resveratrol 19-30 tumor protein p53 Homo sapiens 100-103 25952326-0 2015 Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis. Resveratrol 0-11 tumor protein p53 Homo sapiens 123-126 25952326-5 2015 We show that the tumor suppressor p53 is activated in response to RSV and participates to the apoptotic process. Resveratrol 66-69 tumor protein p53 Homo sapiens 34-37 25952326-6 2015 Additionally, we show that HCT-116 p53 wt colon carcinoma cells are significantly more sensitive than HCT-116 p53-/- cells to RSV. Resveratrol 126-129 tumor protein p53 Homo sapiens 35-38 25952326-6 2015 Additionally, we show that HCT-116 p53 wt colon carcinoma cells are significantly more sensitive than HCT-116 p53-/- cells to RSV. Resveratrol 126-129 tumor protein p53 Homo sapiens 110-113 25991017-9 2015 Resveratrol activated SIRT1 can target H3K9 and regulate p53 gene expression at the transcriptional level, thus inhibiting p53 transcription to enhance neuroprotection, alleviating rotenone induced dopaminergic neurodegeneration. Resveratrol 0-11 tumor protein p53 Homo sapiens 57-60 25991017-9 2015 Resveratrol activated SIRT1 can target H3K9 and regulate p53 gene expression at the transcriptional level, thus inhibiting p53 transcription to enhance neuroprotection, alleviating rotenone induced dopaminergic neurodegeneration. Resveratrol 0-11 tumor protein p53 Homo sapiens 123-126 25840356-8 2015 However, overexpression of SIRT1 through resveratrol treatment or transfection clearly attenuated the NiONPs-induced apoptosis and activation of p53 and Bax. Resveratrol 41-52 tumor protein p53 Homo sapiens 145-148 25665036-9 2015 Resveratrol also ameliorated the augmentation of pro-apoptotic markers including p53, Bax, caspase 3 activity and apoptotic DNA fragmentation induced by doxorubicin in hearts from aged animals, whereas these reductions were diminished by combined treatment with SIRT1 inhibitors. Resveratrol 0-11 tumor protein p53 Homo sapiens 81-84 24998844-1 2015 Resveratrol (trans-3,5,4"-truhydroxystilbene) possesses a strong anticancer activity exhibited as the induction of apoptosis through p53 activation. Resveratrol 0-11 tumor protein p53 Homo sapiens 133-136 24998844-2 2015 However, the molecular mechanism and direct target(s) of resveratrol-induced p53 activation remain elusive. Resveratrol 57-68 tumor protein p53 Homo sapiens 77-80 24998844-4 2015 Depletion of G3BP1 significantly diminishes resveratrol-induced p53 expression and apoptosis. Resveratrol 44-55 tumor protein p53 Homo sapiens 64-67 24998844-7 2015 Resveratrol, on the other hand, directly binds to G3BP1 and prevents the G3BP1/USP10 interaction, resulting in enhanced USP10-mediated deubiquitination of p53, and consequently increased p53 expression. Resveratrol 0-11 tumor protein p53 Homo sapiens 155-158 24998844-7 2015 Resveratrol, on the other hand, directly binds to G3BP1 and prevents the G3BP1/USP10 interaction, resulting in enhanced USP10-mediated deubiquitination of p53, and consequently increased p53 expression. Resveratrol 0-11 tumor protein p53 Homo sapiens 187-190 24998844-8 2015 These findings disclose a novel mechanism of resveratrol-induced p53 activation and resveratrol-induced apoptosis by direct targeting of G3BP1. Resveratrol 45-56 tumor protein p53 Homo sapiens 65-68 25436977-6 2014 Resveratrol-induced gene expression, including transcription of the most up-regulated genes and pro-apoptotic p53-dependent genes, was not affected by culture pH changes. Resveratrol 0-11 tumor protein p53 Homo sapiens 110-113 25776512-9 2015 Moreover, Western blotting analysis showed that apoptosis induced by RSV-GNPs is associated with the increased Bax, p53, p21, caspase-3 protein levels, and decreased Bcl-2 and NF-kappaB proteins expression, which indicates the involvement of mitochondria-dependent apoptosis in the anticancer efficacy of RSV-GNPs in NCI-H460 cells. Resveratrol 69-72 tumor protein p53 Homo sapiens 116-119 25515619-0 2015 Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells. Resveratrol 0-11 tumor protein p53 Homo sapiens 44-47 25515619-6 2015 The immunofluorescence and western blot analysis results revealed that resveratrol upregulated the nuclear expression of p53 in A549 cells. Resveratrol 71-82 tumor protein p53 Homo sapiens 121-124 25515619-9 2015 The present study may offer a scientific basis for the further in-depth evaluation of resveratrol in the association of p53 and cell cycle arrest. Resveratrol 86-97 tumor protein p53 Homo sapiens 120-123 25776512-11 2015 CONCLUSIONS: Taken together, the results of our study clearly suggested that the cell death induced by the combination of RSV-GNPs would involve alteration in expression of p53, p21, caspase-3, Bax, Bcl-2 and NF-kappaB, indicating oxidative mechanism in NCI-H460 cells. Resveratrol 122-125 tumor protein p53 Homo sapiens 173-176 25311616-6 2014 Under these same conditions, we also found that resveratrol altered the phosphorylation of several proteins involved in various biological processes, most notably transcriptional modulators, represented by p53, FOXA1, and AATF. Resveratrol 48-59 tumor protein p53 Homo sapiens 206-209 25269486-3 2014 Resveratrol inhibited proliferation and induced apoptosis in HepG2 cells via activation of caspase-9 and caspase-3, upregulation of the Bax/Bcl-2 ratio and induction of p53 expression. Resveratrol 0-11 tumor protein p53 Homo sapiens 169-172