PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32552390-10 2020 Spermidine treatment of PBMCs resulted in a significantly increased expression of all genes tested, whereas resveratrol treatment caused a significant increase of SIRT3, FOXO3 and SOD2 mRNA expression. Resveratrol 108-119 superoxide dismutase 2 Homo sapiens 180-184 33391410-8 2021 Results: Resveratrol-treated U251 cells, but not resveratrol-treated LN428 cells, exhibited remarkable growth arrest and extensive apoptosis accompanied by elevated intracellular ROS levels and attenuated SOD2 and catalase expression. Resveratrol 9-20 superoxide dismutase 2 Homo sapiens 205-209 31464618-13 2019 CONCLUSIONS: Resveratrol can activate p38 MAPK and repress FOXO3a, thereby causing repression of SOD2, catalase, and increase of ROS accumulation, leading to apoptosis in BPH-1 cells. Resveratrol 13-24 superoxide dismutase 2 Homo sapiens 97-101 28814292-6 2017 RESULTS: Compared to the vehicle control, treatment with resveratrol improved intestinal morphology, decreased apoptosis of crypt cells, maintained cell regeneration, and ameliorated SOD2 expression and activity. Resveratrol 57-68 superoxide dismutase 2 Homo sapiens 183-187 30116486-4 2018 The results revealed that resveratrol-treated THJ-16T rather than THJ-11T cells showed remarkable growth arrest and extensive apoptosis accompanied with the elevated ROS generation and the attenuated superoxide dismutase 2 (SOD2) and catalase (CAT) levels. Resveratrol 26-37 superoxide dismutase 2 Homo sapiens 200-222 30116486-4 2018 The results revealed that resveratrol-treated THJ-16T rather than THJ-11T cells showed remarkable growth arrest and extensive apoptosis accompanied with the elevated ROS generation and the attenuated superoxide dismutase 2 (SOD2) and catalase (CAT) levels. Resveratrol 26-37 superoxide dismutase 2 Homo sapiens 224-228 27126960-4 2016 Other beneficial effects of RSV include a decrease of total intracellular ROS and the up-regulation of the expression of mitochondrial superoxide dismutase (SOD2) protein, a key antioxidant defense enzyme. Resveratrol 28-31 superoxide dismutase 2 Homo sapiens 157-161 27489133-6 2016 RSV (2 muM) pretreatment not only recovered the activity of MnSOD, but also improved ZEA-induced cytotoxicity evidenced by increased MMP and cell viability, and decreased ROS. Resveratrol 0-3 superoxide dismutase 2 Homo sapiens 60-65 27126960-5 2016 The molecular mechanisms leading to the up-regulation of SOD2 protein expression by RSV require the estrogen receptor (ER) and the estrogen-related receptor alpha (ERRalpha). Resveratrol 84-87 superoxide dismutase 2 Homo sapiens 57-61 27126960-6 2016 Although RSV increases the level of SOD2 protein in patients" fibroblasts, the enzyme activity is not increased, in contrast to normal fibroblasts. Resveratrol 9-12 superoxide dismutase 2 Homo sapiens 36-40 24361291-0 2014 The stilbenes resveratrol, pterostilbene and piceid affect growth and stress resistance in mammalian cells via a mechanism requiring estrogen receptor beta and the induction of Mn-superoxide dismutase. Resveratrol 14-25 superoxide dismutase 2 Homo sapiens 177-200 26443543-0 2016 ERK5/HDAC5-mediated, resveratrol-, and pterostilbene-induced expression of MnSOD in human endothelial cells. Resveratrol 21-32 superoxide dismutase 2 Homo sapiens 75-80 26443543-4 2016 In this study, we tested the hypothesis that resveratrol and pterostilbene can activate the expression of MnSOD through an AMPK-ERK5/HDAC5-KLF2 pathway. Resveratrol 45-56 superoxide dismutase 2 Homo sapiens 106-111 26436888-9 2015 Levels of Cu/Zn-SOD, catalase, and Trx were also reduced, while Mn-SOD increased with 50 muM resveratrol treatment. Resveratrol 93-104 superoxide dismutase 2 Homo sapiens 64-70 25211703-7 2014 The fold change in PGC-1alpha, SIRT1, and SOD2 gene expression following training was significantly (p < 0.05) lower in the RSV group than placebo. Resveratrol 127-130 superoxide dismutase 2 Homo sapiens 42-46 26443543-9 2016 Furthermore, using a chromatin immunoprecipitation-PCR detection method, we found that resveratrol and pterostilbene promoted KLF2 binding to CACCC sites of the human MnSOD promoter. Resveratrol 87-98 superoxide dismutase 2 Homo sapiens 167-172 26443543-10 2016 CONCLUSION: Resveratrol and pterostilbene can activate MnSOD expression through ERK5/HDAC5 pathway, thus alleviating mitochondrial oxidative stress in endothelial cells that relates to cardiovascular disease. Resveratrol 12-23 superoxide dismutase 2 Homo sapiens 55-60 25753816-10 2015 In all SOD2 genotypes cells exposed to resveratrol resulted in an upregulation of Sirt1 levels. Resveratrol 39-50 superoxide dismutase 2 Homo sapiens 7-11 25753816-11 2015 Together, these results suggest that the effect of resveratrol on human PBMC activation is not universal and is dependent on the Ala16Val-SOD2 SNP. Resveratrol 51-62 superoxide dismutase 2 Homo sapiens 138-142 25522270-6 2014 Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells. Resveratrol 198-201 superoxide dismutase 2 Homo sapiens 141-145 25522270-6 2014 Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells. Resveratrol 198-201 superoxide dismutase 2 Homo sapiens 175-179 25522270-6 2014 Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells. Resveratrol 227-230 superoxide dismutase 2 Homo sapiens 141-145 25522270-6 2014 Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells. Resveratrol 227-230 superoxide dismutase 2 Homo sapiens 175-179 24361291-2 2014 Resveratrol, a phytoestrogen found in red wines and other foods, has been previously reported to increase MnSOD protein levels and activity both in vitro and in vivo. Resveratrol 0-11 superoxide dismutase 2 Homo sapiens 106-111 23526725-5 2014 Five of these, resveratrol, coumestrol, kaempferol, genistein and daidzein, significantly increased MnSOD expression, slowed proliferative growth and enhanced stress resistance (hydrogen peroxide LD50) . Resveratrol 15-26 superoxide dismutase 2 Homo sapiens 100-105 24040102-8 2013 In p53-independent cell protective pathway, we found that FOXO1, FOXO3a, and FOXO4 were involved in SOD2"s upregulation by resveratrol. Resveratrol 123-134 superoxide dismutase 2 Homo sapiens 100-104 24040102-9 2013 The knockdown of these three FOXOs by siRNAs completely abolished the SOD2 induction, ROS reduction, and anti-apoptotic function of resveratrol. Resveratrol 132-143 superoxide dismutase 2 Homo sapiens 70-74 20610621-9 2010 Treatment of human endothelial cells with resveratrol led to an up-regulation of SOD1, SOD2, SOD3, GPx1, catalase, and GCH1. Resveratrol 42-53 superoxide dismutase 2 Homo sapiens 87-91 23456297-6 2013 RSV-induced SOD2 expression was observed in cancer cells, although the expression of SOD1, CAT and GPX1 was unaffected. Resveratrol 0-3 superoxide dismutase 2 Homo sapiens 12-16 21215799-0 2011 Resveratrol interacts with estrogen receptor-beta to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase. Resveratrol 0-11 superoxide dismutase 2 Homo sapiens 131-165 20089851-7 2010 Nuclear but not cytoplasmic SIRT1-induced manganese superoxide dismutase (Mn-SOD), which was further enhanced by resveratrol, and increased the resistance of C2C12 myoblasts to oxidative stress. Resveratrol 113-124 superoxide dismutase 2 Homo sapiens 42-72 20089851-7 2010 Nuclear but not cytoplasmic SIRT1-induced manganese superoxide dismutase (Mn-SOD), which was further enhanced by resveratrol, and increased the resistance of C2C12 myoblasts to oxidative stress. Resveratrol 113-124 superoxide dismutase 2 Homo sapiens 74-80 20089851-8 2010 Resveratrol"s enhancement of Mn-SOD levels depended on the level of nuclear SIRT1, and it suppressed the cell death induced by antimycin A or angiotensin II. Resveratrol 0-11 superoxide dismutase 2 Homo sapiens 29-35 20089851-9 2010 The cell-protective effects of nuclear SIRT1 or resveratrol were canceled by the Mn-SOD small interfering RNA or SIRT1 small interfering RNA. Resveratrol 48-59 superoxide dismutase 2 Homo sapiens 81-87 20089851-10 2010 The oral administration of resveratrol to TO-2 hamsters increased Mn-SOD levels in cardiomyocytes, suppressed fibrosis, preserved cardiac function, and significantly improved survival. Resveratrol 27-38 superoxide dismutase 2 Homo sapiens 66-72 20089851-11 2010 Thus, Mn-SOD induced by resveratrol via nuclear SIRT1 reduced oxidative stress and participated in cardiomyocyte protection. Resveratrol 24-35 superoxide dismutase 2 Homo sapiens 6-12 19749157-7 2009 Resveratrol upregulated MnSOD expression and increased cellular GSH content in a concentration-dependent manner (measured by HPLC coulometric analysis). Resveratrol 0-11 superoxide dismutase 2 Homo sapiens 24-29 18167310-0 2008 Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD. Resveratrol 63-74 superoxide dismutase 2 Homo sapiens 114-119