PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32181981-11 2020 In conclusion, RSV can counteract IL-1beta-mediated degradation and distinctly improve cartilaginous ECM deposition in 3D long-term inflammatory cultures. Resveratrol 15-18 interleukin 1 alpha Homo sapiens 34-42 32948212-3 2020 The purpose of the experiment was to evaluate the protective role of RSV against the human OA chondrocyte injury induced by interleukin-1beta (IL-1beta). Resveratrol 69-72 interleukin 1 alpha Homo sapiens 143-151 32948212-9 2020 The mechanism of RSV for protecting IL-1beta induced chondrocytes injury was further measured through immunofluorescence and WB assays. Resveratrol 17-20 interleukin 1 alpha Homo sapiens 36-44 32948212-15 2020 RSV (24 muM) also markedly depressed the levels of PGE2 and NO induced by IL-1beta by 25% and 29% respectively (P < 0.05). Resveratrol 0-3 interleukin 1 alpha Homo sapiens 74-82 32948212-16 2020 Our experiment pointed out that RSV could dramatically inhibit the inflammatory response induced by IL-1beta, including the MMP-13, MMP-3, and MMP-1 in human OA chondrocytes by 50%, 35%, and 33% respectively. Resveratrol 32-35 interleukin 1 alpha Homo sapiens 100-108 32888128-0 2020 The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1beta protein. Resveratrol 26-37 interleukin 1 alpha Homo sapiens 97-105 32888128-12 2020 After treatment with Resveratrol, both IL-1beta mRNA and protein levels were reduced, while IL-11 protein levels showed any increase. Resveratrol 21-32 interleukin 1 alpha Homo sapiens 39-47 32888128-14 2020 Resveratrol can reverse the inflammatory effects of TNF-alpha by reducing IL-1beta and increasing IL-11 production. Resveratrol 0-11 interleukin 1 alpha Homo sapiens 74-82 32696949-5 2020 RESULTS: Flow cytometry analysis showed that IL-1beta increased the apoptosis rate of nucleus pulposus cells in each group, and RES significantly decreased the apoptosis rate, while rapamycin (RAPA) and SB216763 inhibited the effect of RES and increased the apoptosis rate again. Resveratrol 0-3 interleukin 1 alpha Homo sapiens 46-54 33289070-12 2021 Activation of SIRT1 by resveratrol had a neuroprotective effect, along with decreased levels of Ac-p65, IL-1beta, TNF-alpha, and apoptosis after ICH. Resveratrol 23-34 interleukin 1 alpha Homo sapiens 104-112 33184983-7 2021 Finally, resveratrol significantly reduced the serum levels of IL-1beta, CRP and PGE2 , as well as NF-kB synovial tissue expression, which showed a significant correlation with p62 expression. Resveratrol 9-20 interleukin 1 alpha Homo sapiens 63-71 32948212-18 2020 From a mechanistic perspective, RSV inhibited the degradation of IkappaB-alpha as well as the activation of nuclear factor-kappa B (NF-kappaB) induced by IL-1beta. Resveratrol 32-35 interleukin 1 alpha Homo sapiens 154-162 32181981-0 2020 Resveratrol counteracts IL-1beta-mediated impairment of extracellular matrix deposition in 3D articular chondrocyte constructs. Resveratrol 0-11 interleukin 1 alpha Homo sapiens 24-32 32581510-0 2020 Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-kappaB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1beta-Stimulated SW1353 Cells. Resveratrol 0-11 interleukin 1 alpha Homo sapiens 124-132 32581510-7 2020 Results: IL-1beta treatment increased the expression of TLR4/NF-kappaB and phosphorylation of PI3K/Akt and FoxO1, while additional resveratrol further upregulated the expression of PI3K/Akt and FoxO1 phosphorylation but downregulated TLR4 signals in SW1353 cells. Resveratrol 131-142 interleukin 1 alpha Homo sapiens 9-17 31969819-8 2019 Fluoxetine, simvastatin, and resveratrol significantly inhibited this IL-1beta- and TNF-alpha-induced ET-1 production. Resveratrol 29-40 interleukin 1 alpha Homo sapiens 70-78 32296107-7 2020 RSV treatment improved intracellular Ca2+ responses, mitochondrial function, suppressed the generation of cytokine (IL-1beta and TNF-alpha), cytosolic and mitochondrial ROS in the SH-SY5Y cells. Resveratrol 0-3 interleukin 1 alpha Homo sapiens 116-124 31052183-4 2019 The concentration-related effects of RSV on IL-1 alpha and NO levels were assessed using the respective ELISA kits. Resveratrol 37-40 interleukin 1 alpha Homo sapiens 44-54 32126555-14 2020 Resveratrol, an activator of sirtuin-1, postponed the IL-1beta-induced senescence through blocking the NF-kappaB/p53/p21 pathway and attenuated the osteoblastic transition and calcification in VSMCs. Resveratrol 0-11 interleukin 1 alpha Homo sapiens 54-62 31052183-8 2019 Significant increases in IL-1alpha levels were observed with lower concentrations of RSV. Resveratrol 85-88 interleukin 1 alpha Homo sapiens 25-34 31052183-9 2019 However, at higher RSV concentrations (10-100 muM), IL-1 levels decreased. Resveratrol 19-22 interleukin 1 alpha Homo sapiens 52-56 28278187-6 2017 Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue. Resveratrol 15-26 interleukin 1 alpha Homo sapiens 114-123 30637441-6 2019 Metabolic labeling and pull-down assays to investigate de novo protein synthesis clearly demonstrated that intracellular pro-IL-1beta synthesis is rapidly repressed in monocytes after resveratrol treatment due to decreased phosphorylation of Syk and p38. Resveratrol 184-195 interleukin 1 alpha Homo sapiens 125-133 30637441-5 2019 Here, we show that resveratrol suppresses secretion of active IL-1beta by human primary monocytes stimulated with MSU crystals through suppression of Syk activation. Resveratrol 19-30 interleukin 1 alpha Homo sapiens 62-70 20036937-6 2010 Administration of resveratrol can inhibit NF-kappaB activity as well as reduce the concentrations of TNF-alpha, IL-6 and IL-1. Resveratrol 18-29 interleukin 1 alpha Homo sapiens 121-125 17929310-5 2008 For glial cells, we observed that lipopolysaccharide (LPS)-induced mRNA levels of two proinflammatory genes, interleukin 1-alpha and tumor necrosis factor-alpha, are strongly decreased by treatments with resveratrol or quercetin. Resveratrol 204-215 interleukin 1 alpha Homo sapiens 109-160 19027816-6 2009 Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins. Resveratrol 0-11 interleukin 1 alpha Homo sapiens 139-147 35355720-13 2022 With regard to pro-inflammatory cytokines, resveratrol had a positive effect on the reduction of IL-1beta. Resveratrol 43-54 interleukin 1 alpha Homo sapiens 97-105 15517885-4 2004 Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA. Resveratrol 0-11 interleukin 1 alpha Homo sapiens 297-301 34303665-1 2021 The aim of the current study was to perform a meta-analysis of randomized clinical trials regarding the effect of resveratrol in decreasing the levels of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in a combination of inflammatory diseases. Resveratrol 114-125 interleukin 1 alpha Homo sapiens 188-206 34390063-5 2021 Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1beta suppression. Resveratrol 95-106 interleukin 1 alpha Homo sapiens 148-156 34215299-0 2021 Identification and validation of key long non-coding RNAs in resveratrol protect against IL-1beta-treated chondrocytes via integrated bioinformatic analysis. Resveratrol 61-72 interleukin 1 alpha Homo sapiens 89-97 34215299-2 2021 This study aimed to identify and validate the key lncRNAs in resveratrol protect against IL-1beta-treated chondrocytes. Resveratrol 61-72 interleukin 1 alpha Homo sapiens 89-97 34227646-3 2021 It was observed that the expression of IL-1beta, IL-6, IL-8 and TNFalpha in LPS-induced HGFs was significantly downregulated by RSV in a dose-dependent manner. Resveratrol 128-131 interleukin 1 alpha Homo sapiens 39-47 34227646-6 2021 Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs. Resveratrol 216-219 interleukin 1 alpha Homo sapiens 256-264 35355720-9 2022 There was a significant association of resveratrol with the levels of blood glucose (BG), serum creatinine (Scr), blood urea nitrogen (BUN), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), and interleukin-1beta (IL-1beta). Resveratrol 39-50 interleukin 1 alpha Homo sapiens 280-288