PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9705326-1 1998 We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells. Resveratrol 22-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 151-156 9705326-4 1998 Resveratrol suppressed PMA-mediated increases in COX-2 mRNA and protein. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 49-54 9705326-5 1998 Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by resveratrol. Resveratrol 123-134 mitochondrially encoded cytochrome c oxidase II Homo sapiens 45-50 9705326-6 1998 PMA caused about a 6-fold increase in COX-2 promoter activity, which was suppressed by resveratrol. Resveratrol 87-98 mitochondrially encoded cytochrome c oxidase II Homo sapiens 38-43 9705326-7 1998 Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs, in which specific enhancer elements were mutagenized, indicated that the effects of PMA and resveratrol were mediated via a cyclic AMP response element. Resveratrol 192-203 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 9705326-8 1998 Resveratrol inhibited PMA-mediated activation of protein kinase C. Overexpressing protein kinase C-alpha, ERK1, and c-Jun led to 4.7-, 5.1-, and 4-fold increases in COX-2 promoter activity, respectively. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 165-170 9705326-11 1998 In addition to the above effects on gene expression, we found that resveratrol also directly inhibited the activity of COX-2. Resveratrol 67-78 mitochondrially encoded cytochrome c oxidase II Homo sapiens 119-124 32131707-3 2021 Among many of its disease preventing activities, RSV has been shown to ameliorate inflammation by directly binding the COX-1 and COX-2 enzymes, the established targets of common non-steroidal anti-inflammatory drugs (NSAIDs). Resveratrol 49-52 mitochondrially encoded cytochrome c oxidase II Homo sapiens 129-134 34749615-4 2021 RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-kappaB, EMT, and pentose phosphate pathway. Resveratrol 0-3 mitochondrially encoded cytochrome c oxidase II Homo sapiens 185-190 30027502-4 2018 Resveratrol is a stilbenoid phytoalexin which binds to a specific site on the cell surface integrin alphavbeta3 to trigger cancer cell death via nuclear translocation of COX-2. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 170-175 32545836-9 2020 Furthermore, resveratrol nanofibers suppressed particulate matter (PM)-induced expression of inflammatory proteins (COX-2 and MMP-9) in HaCaT keratinocytes. Resveratrol 13-24 mitochondrially encoded cytochrome c oxidase II Homo sapiens 116-121 31336132-4 2019 Moreover, resveratrol increases nuclear inducible cyclooxygenase (COX)-2 accumulation, complexes with p53, and induces p53-dependent anti-proliferation. Resveratrol 10-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-72 31336132-10 2019 T4 retained resveratrol-induced COX-2 in cytoplasm and prevented COX-2 nuclear accumulation when resveratrol treated cancer cells. Resveratrol 12-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-37 31336132-10 2019 T4 retained resveratrol-induced COX-2 in cytoplasm and prevented COX-2 nuclear accumulation when resveratrol treated cancer cells. Resveratrol 97-108 mitochondrially encoded cytochrome c oxidase II Homo sapiens 65-70 31336132-11 2019 A specific signal transducer and activator of transcription 3 (STAT3) inhibitor, S31-201, blocked T4-induced inhibition and restored resveratrol-induced nuclear COX-2 accumulation. Resveratrol 133-144 mitochondrially encoded cytochrome c oxidase II Homo sapiens 161-166 31336132-12 2019 By inhibiting the T4-activated STAT3 signal transduction axis with S31-201, resveratrol was able to sequentially reestablish COX-2/p53-dependent gene expressions and anti-proliferation. Resveratrol 76-87 mitochondrially encoded cytochrome c oxidase II Homo sapiens 125-130 30552915-4 2019 We found that resveratrol up-regulates DUSP1 expression in androgen-independent prostate cancer cells, which in turn, is involved in the inhibition of the NF-kappaB pathway and Cox-2 expression. Resveratrol 14-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 177-182 30026090-7 2018 Expressions of proapoptotic genes, such as cyclooxygenase (COX)-2, p21 and CDKN2, were induced by resveratrol in myoma cells. Resveratrol 98-109 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-65 30027502-6 2018 This unanticipated effect inhibits resveratrol-induced COX-2 nuclear accumulation. Resveratrol 35-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 55-60 30027502-7 2018 RRM2 downregulation, whether achieved by RNA interference or treatment with NDAT, enhanced resveratrol-induced COX-2 gene expression and nuclear uptake which is essential to integrin alphavbeta3-mediated-resveratrol-induced antiproliferation in cancer cells. Resveratrol 91-102 mitochondrially encoded cytochrome c oxidase II Homo sapiens 111-116 29872310-0 2018 Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 85-90 29872310-9 2018 Resveratrol at 60 mumol/L significantly inhibited A549 cells proliferation, S phase cells proportion and COX-2 expression (P<0.01). Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 105-110 29872310-11 2018 OD570 values, colony formation rate and S phase cells proportion of resveratrol + siRNA-COX-2 group were much lower than those of other groups (P<0.01). Resveratrol 68-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 29872310-12 2018 Conclusion: Resveratrol inhibits A549 cells proliferation by inhibiting COX-2 expression. Resveratrol 12-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-77 29555649-3 2018 The mechanism of resveratrol action requires nuclear accumulation of inducible cyclooxygenase (COX)-2 and its complexation with phosphorylated ERK1/2. Resveratrol 17-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 79-101 29555649-4 2018 In this study, we examined the mechanism by which T4 impairs resveratrol-induced antiproliferation in human ovarian cancer cells and found that T4 inhibited resveratrol-induced nuclear accumulation of COX-2. Resveratrol 61-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 201-206 29555649-6 2018 Knockdown of PD-L1 by small hairpin RNA (shRNA) relieved the inhibitory effect of T4 on resveratrol-induced nuclear accumulation of COX-2- and COX-2/p53-dependent gene expression. Resveratrol 88-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-137 29555649-6 2018 Knockdown of PD-L1 by small hairpin RNA (shRNA) relieved the inhibitory effect of T4 on resveratrol-induced nuclear accumulation of COX-2- and COX-2/p53-dependent gene expression. Resveratrol 88-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 143-148 29555649-4 2018 In this study, we examined the mechanism by which T4 impairs resveratrol-induced antiproliferation in human ovarian cancer cells and found that T4 inhibited resveratrol-induced nuclear accumulation of COX-2. Resveratrol 157-168 mitochondrially encoded cytochrome c oxidase II Homo sapiens 201-206 29316620-6 2018 Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2. Resveratrol 39-50 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-86 29242151-0 2018 Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 31-36 29242151-2 2018 However, resveratrol-induced nuclear accumulation of COX-2 enhances p53-dependent anti-proliferation in different types of cancers. Resveratrol 9-20 mitochondrially encoded cytochrome c oxidase II Homo sapiens 53-58 29242151-3 2018 Treatment with resveratrol leads to phosphorylation and nuclear translocation of mitogen-activated protein kinase (ERK1/2), and accumulation of nuclear COX-2 to complex with pERK1/2 and p53. Resveratrol 15-26 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 29242151-5 2018 We investigated the mechanisms by which resveratrol-inducible COX-2 facilitates p53-dependent anti-proliferation in prostate cancer LNCaP cells. Resveratrol 40-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-67 29242151-6 2018 Resveratrol treatment caused nuclear accumulation and complexing of ERK1/2, pSer15-p53 and COX-2 which was activated ERK1/2-dependent. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 91-96 29242151-12 2018 The inhibition of COX-2 expression and activity significantly blocks the pro-apoptotic effect of resveratrol. Resveratrol 97-108 mitochondrially encoded cytochrome c oxidase II Homo sapiens 18-23 28989083-13 2018 Co-treatment with resveratrol also significantly restored iNOS and COX-2 levels in Abeta-treated hNSCs. Resveratrol 18-29 mitochondrially encoded cytochrome c oxidase II Homo sapiens 67-72 28759712-4 2017 Resveratrol induces inducible COX-2-dependent antiproliferation via integrin alphav beta3 . Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-35 28759712-9 2017 Results suggest that nonpeptide hormones inhibit resveratrol-induced antiproliferation in cancer cells downstream of the interaction between ligand and receptor and ERK1/2 activation to interfere with nuclear COX-2 accumulation. Resveratrol 49-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 209-214 28759712-6 2017 Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. Resveratrol 17-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-106 28759712-6 2017 Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. Resveratrol 17-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 142-147 28759712-6 2017 Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. Resveratrol 73-84 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-106 28759712-7 2017 Subsequently, hormones impair resveratrol-induced COX-2-/p53-dependent gene expression. Resveratrol 30-41 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 28495310-9 2017 Thus, we concluded that resveratrol functions as a suppressor of PM-induced inflammatory signaling pathways by inhibiting COX-2/PGE2 expression. Resveratrol 24-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-127 28883751-0 2017 Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through COX-2 expression. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 93-98 28495310-0 2017 Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 54-59 28288820-0 2017 Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-kappaB in human rheumatoid arthritis synovial fibroblasts. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-37 28495310-6 2017 In the present study, we demonstrated that resveratrol reduced PM-induced COX-2/PGE2 expression in human FLSs, and attenuated PM-enhanced NADPH oxidase activity and ROS generation. Resveratrol 43-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 74-79 28288820-3 2017 Here, we investigated the mechanisms underlying BK-induced COX-2 expression which is modulated by resveratrol/Sirt1 in human rheumatoid arthritis synovial fibroblasts (RASFs). Resveratrol 98-109 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 28288820-6 2017 Up-regulation of Sirt1 by resveratrol suppressed the BK-induced COX-2/PGE2 production through inhibiting the interaction of AP-1 and NF-kappaB with COX-2 promoter in RASFs. Resveratrol 26-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 64-69 28288820-6 2017 Up-regulation of Sirt1 by resveratrol suppressed the BK-induced COX-2/PGE2 production through inhibiting the interaction of AP-1 and NF-kappaB with COX-2 promoter in RASFs. Resveratrol 26-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 148-153 28288820-8 2017 Resveratrol inhibited the phosphorylation and acetylation of p65, c-Jun, and Fos and reduced the binding to the COX-2 promoter, thereby attenuated the COX-2 expression. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 112-117 28288820-8 2017 Resveratrol inhibited the phosphorylation and acetylation of p65, c-Jun, and Fos and reduced the binding to the COX-2 promoter, thereby attenuated the COX-2 expression. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 151-156 27998828-10 2017 Resveratrol slightly decreased COX-2 expression after 18h but not after 6h, but reduced PGE2 levels after 6h. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 31-36 28338176-0 2017 The inhibitory effect of resveratrol on COX-2 expression in human colorectal cancer: a promising therapeutic strategy. Resveratrol 25-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 28338176-1 2017 OBJECTIVE: The objective of this study is to investigate the mechanism of resveratrol (RSVL) on the inhibitory effect on the expression of COX-2 in human colorectal cancer. Resveratrol 74-85 mitochondrially encoded cytochrome c oxidase II Homo sapiens 139-144 28338176-1 2017 OBJECTIVE: The objective of this study is to investigate the mechanism of resveratrol (RSVL) on the inhibitory effect on the expression of COX-2 in human colorectal cancer. Resveratrol 87-91 mitochondrially encoded cytochrome c oxidase II Homo sapiens 139-144 28338176-3 2017 The inhibitory effect induced by RSVL on the COX-2 expression in human colorectal cancer was investigated. Resveratrol 33-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 45-50 28338176-8 2017 According to the results from enzyme-linked immunosorbent assay (ELISA) and Western blot, the expression of the COX-2 protein in the observation group treated with RSVL was significantly lower than that in the blank control group; however, results from the observation group and the control group were similar. Resveratrol 164-168 mitochondrially encoded cytochrome c oxidase II Homo sapiens 112-117 28338176-10 2017 CONCLUSIONS: RSVL (in a certain concentration) can suppress the human colorectal cancer through inhibition of COX-2 expression. Resveratrol 13-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 110-115 26190093-5 2015 Resveratrol"s primary targets appear to be the transcription factors AP-1 and NF-kappaB, as well as the gene COX2. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 109-113 26456774-8 2015 DHT inhibited resveratrol-induced nuclear complex of p53-COX-2 formation which is required p53-dependent apoptosis. Resveratrol 14-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 26456774-9 2015 ChIP studies of COX-2/p53 binding to DNA and expression of p53-responsive genes indicated that DHT inhibited resveratrol-induced p53-directed transcriptional activity. Resveratrol 109-120 mitochondrially encoded cytochrome c oxidase II Homo sapiens 16-21 26456774-10 2015 In addition, DHT did inhibit resveratrol-induced COX-2/p53-dependent gene expression. Resveratrol 29-40 mitochondrially encoded cytochrome c oxidase II Homo sapiens 49-54 25612618-6 2015 On the basis of the resistance profile, we were able to successfully predict that a novel resveratrol-derived COX-2 inhibitor, M8, would be active against the vemurafenib-resistant but not the vemurafenib-sensitive melanoma cells. Resveratrol 90-101 mitochondrially encoded cytochrome c oxidase II Homo sapiens 110-115 22523472-0 2012 Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-106 25271420-5 2014 Our data showed that resveratrol, used in a concentration 20 times lower than 5-aminosalicylic acid, was able to significantly reduce NO and PGE2 production, iNOS and COX-2 expression and reactive oxidant species formation induced by the cytokine challenge. Resveratrol 21-32 mitochondrially encoded cytochrome c oxidase II Homo sapiens 167-172 22771391-0 2012 Modulation of NF-kappaB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression. Resveratrol 38-49 mitochondrially encoded cytochrome c oxidase II Homo sapiens 137-142 22771391-3 2012 Here we evaluated the effect of resveratrol on COX-2 and prostaglandin E(2) production in human intestinal cells Caco-2 cells treated with lipopolysaccharide (LPS). Resveratrol 32-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-52 22771391-4 2012 Resveratrol concentration-dependently inhibited the expression of COX-2 mRNA in the LPS-treated cells, as well as protein expression, resulting in a decreased production of PGE(2). Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 66-71 22771391-7 2012 These results suggest that the down-regulation of COX-2 and PGE(2) by resveratrol may be related to NF-kappaB inhibition through the negative regulation of IKK phosphorylation in intestinal cells. Resveratrol 70-81 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 24976682-5 2014 trans-Resveratrol was identified as an inhibitor of COX-1 (IC50 = 2.27 muM) and COX-2 (IC50 = 3.40 muM). Resveratrol 0-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 80-85 22523472-7 2012 HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB. Resveratrol 41-52 mitochondrially encoded cytochrome c oxidase II Homo sapiens 137-142 22523472-8 2012 We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression. Resveratrol 14-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 83-88 22523472-11 2012 Our results suggest that resveratrol may prevent BBB disruption during neuroinflammation by inhibiting MMP-9 and COX-2 and act as a pharmacological NF-kappaB signal transduction inhibitor independent of Sirt1. Resveratrol 25-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-118 20606295-11 2010 Resveratrol dose-dependently prevented both COX-2 induction and PGE(2) production in bFGF-stimulated fibroblasts. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 44-49 21261644-5 2011 By a PD98059-inhibitable process, resveratrol causes inducible COX-2 to accumulate in the nucleus where it complexes with pERK1/2 and p53. Resveratrol 34-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68 21261644-7 2011 NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved. Resveratrol 62-73 mitochondrially encoded cytochrome c oxidase II Homo sapiens 46-51 21261644-7 2011 NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved. Resveratrol 62-73 mitochondrially encoded cytochrome c oxidase II Homo sapiens 116-121 21261644-8 2011 Molecular steps in the pro-apoptotic action of resveratrol in cancer cells include induction of intranuclear COX-2 accumulation relevant to activation of p53. Resveratrol 47-58 mitochondrially encoded cytochrome c oxidase II Homo sapiens 109-114 19908231-7 2010 Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 211-216 20817448-4 2011 The assay was validated using four COX inhibitors, celecoxib, indomethacin, resveratrol, and diclofenac that exhibit different selectivities towards COX-1 and COX-2. Resveratrol 76-87 mitochondrially encoded cytochrome c oxidase II Homo sapiens 159-164 20817448-5 2011 The IC(50) values of celecoxib and resveratrol for ovine and human COX-2 were compared, and the K(m) values were determined. Resveratrol 35-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 67-72 21187340-3 2011 Resveratrol also causes nuclear accumulation of the enzyme cyclooxygenase (COX)-2 and of the oncogene suppressor protein, p53. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-81 21187340-6 2011 This finding implicates nuclear COX-2 in p53-mediated apoptosis induced by resveratrol. Resveratrol 75-86 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-37 21187340-7 2011 Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53. Resveratrol 113-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 55-60 21187340-7 2011 Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53. Resveratrol 113-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 104-109 21187340-7 2011 Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53. Resveratrol 113-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 104-109 21187340-8 2011 Nuclear accumulation of activated ERK1/2 and sumolyated COX-2 are essential to resveratrol-induced pSer-15-p53-mediated apoptosis in human ovarian cancer cells. Resveratrol 79-90 mitochondrially encoded cytochrome c oxidase II Homo sapiens 56-61 19908231-10 2010 As compared to vehicle control, resveratrol also suppressed the NF-kappaB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin. Resveratrol 32-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 114-119 20606295-12 2010 These results suggest that resveratrol exerts the inhibitory effects on VEGF- and bFGF-induced angiogenesis through different mechanisms including inhibition of NO production in VEGF-stimulated endothelial cells and inhibition of COX-2 induction in bFGF-stimulated fibroblasts. Resveratrol 27-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 230-235 19938227-7 2009 Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation. Resveratrol 13-24 mitochondrially encoded cytochrome c oxidase II Homo sapiens 160-182 19751497-8 2009 This effect was due, in part, to a reduction in COX enzymatic activity, mainly COX-2, at lower doses of resveratrol. Resveratrol 104-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 79-84 19751497-10 2009 The present work provides evidence that resveratrol reduces the formation of prostaglandins in neuroblastoma cells by reducing the enzymatic activity of inducible enzymes, such as COX-2, and not the transcription of the PG synthases, as demonstrated elsewhere. Resveratrol 40-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 180-185 19416633-7 2009 Moreover, resveratrol attenuated cyclooxygenase (COX)-2 expression and intracellular Ca2+ levels. Resveratrol 10-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 33-55 19416633-10 2009 Resveratrol suppressed the expression of TNF-alpha, IL-6, IL-8 and COX-2 through a decrease in the intracellular levels of Ca2+ and ERK 1/2, as well as activation of NF-kappaB. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 67-72 18487053-0 2009 Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. Resveratrol 52-63 mitochondrially encoded cytochrome c oxidase II Homo sapiens 98-103 18487053-1 2009 Resveratrol (4,3",5"-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 136-141 19938227-7 2009 Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation. Resveratrol 214-225 mitochondrially encoded cytochrome c oxidase II Homo sapiens 160-182 18549505-13 2008 Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM). Resveratrol 13-24 mitochondrially encoded cytochrome c oxidase II Homo sapiens 128-133 18606398-6 2008 In this study we provide experimental evidence that resveratrol inhibits the expression of VEGF, MMP-3, MMP-9 and COX-2 in human articular chondrocytes stimulated with the pro-inflammatory cytokine IL-1beta. Resveratrol 52-63 mitochondrially encoded cytochrome c oxidase II Homo sapiens 114-119 18759268-12 2008 These beneficial effects of resveratrol are due, in part, to its capacity to inhibit COX-2-derived PGE(2) synthesis. Resveratrol 28-39 mitochondrially encoded cytochrome c oxidase II Homo sapiens 85-90 17044934-3 2006 At the molecular level, resveratrol has been reported to inhibit cyclooxygenase (COX) expression and/or activity; in endometrial cancer cells, COX-2 is overexpressed and confers cellular resistance to apoptosis. Resveratrol 24-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 143-148 17604631-1 2007 Resveratrol ((E)-3,4",5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 17604631-1 2007 Resveratrol ((E)-3,4",5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. Resveratrol 13-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 17044934-4 2006 The aim of the present study was to determine if resveratrol could exert anti-proliferative and pro-apoptotic activity over uterine cancer cells upon inhibition of COX-2 expression and/or activity. Resveratrol 49-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 164-169 17044934-9 2006 Endogenous COX-2 protein levels were decreased, concomitant with a decrease in production of COX metabolites PGE2 and PGF2alpha, in each uterine cancer cell line expressing detectable levels of COX-1 and/or COX-2 in presence of resveratrol. Resveratrol 228-239 mitochondrially encoded cytochrome c oxidase II Homo sapiens 11-16 15239337-6 2004 Alimentary factors like resveratrol or insaturated fat acid reduce Cox2 expression in animal and could be investigated in human studies. Resveratrol 24-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 67-71 16685418-6 2006 Resveratrol also attenuated beta-amyloid-induced prostaglandin E2 (PGE2) release, which was associated with the inhibition of cyclooxygenase (COX)-2 expression. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 126-148 15688382-7 2005 Incubation of HCA-7 cancer cells for 24-96 hr with either stilbene derivative (1-50 microM) decreased prostaglandin E-2 (PGE-2) production, but only resveratrol decreased COX-2 protein expression. Resveratrol 149-160 mitochondrially encoded cytochrome c oxidase II Homo sapiens 171-176 15517885-4 2004 Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA. Resveratrol 0-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 277-282 15899633-6 2004 Alimentary factors like resveratrol or insaturated fat acid reduce Cox2 expression in animal and could be investigated in human studies. Resveratrol 24-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 67-71 12074974-6 2002 The enzymatic activities of COX-1 and -2 are inhibited by resveratrol in cell-free models, and COX-2 mRNA and TPA-induced activation of protein kinase C and AP-1-mediated gene expression are suppressed by resveratrol in mammary epithelial cells. Resveratrol 205-216 mitochondrially encoded cytochrome c oxidase II Homo sapiens 95-100