PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9804609-8 1998 The mitogen-activated protein kinase kinase inhibitor PD098059 markedly reduced induction of HIF-1 by mersalyl but not by hypoxia. Mersalyl 102-110 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-98 9804609-9 1998 These results indicate that mersalyl induces expression of HIF-1 and a subset of hypoxia-inducible genes by a mechanism, involving the insulin-like growth factor-1 receptor and mitogen-activated protein kinase activity, that is distinct from mechanisms of induction by hypoxia, CoCl2, or DFO. Mersalyl 28-36 hypoxia inducible factor 1 subunit alpha Homo sapiens 59-64