PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15331571-7	2004	Levels of pregnenolone and progesterone increased 2- and 4-fold, respectively, within 6 h of hCG treatment, whereas PFT completely blocked this hCG-induced effect.	Pregnenolone	10-22	hypertrichosis 2 (generalised, congenital)	Homo sapiens	93-96	
21527500-6	2011	cAMP accumulation in response to hCG stimulation in primary cultures of Leydig cells from Mek1(f/f);Mek2(-/-);iCre(+) mice is normal, but basal testosterone and testosterone syntheses provoked by addition of hCG or a cAMP analog, or by addition of substrates such as 22-hydroxycholesterol or pregnenolone, are barely detectable.	Pregnenolone	292-304	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36	
6323862-7	1984	Large doses of hCG cause "early" (prior to pregnenolone) and "late" steroidogenic lesions (17 alpha-hydroxylase, 17-20 desmolase) that are independent of receptor loss.	Pregnenolone	43-55	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18	
2561359-6	1989	LH, hCG and dbcAMP increased the synthesis of pregnenolon twice, and testosterone--three times.	Pregnenolone	46-57	hypertrichosis 2 (generalised, congenital)	Homo sapiens	4-7	
3036468-5	1987	The type I EPR signal increased with doses of hCG and correlated well with the pregnenolone production.	Pregnenolone	79-91	hypertrichosis 2 (generalised, congenital)	Homo sapiens	46-49	
3089339-10	1986	Similarly, in the presence of inhibitors of pregnenolone metabolism, rPRL also enhanced hCG-stimulated production of pregnenolone.	Pregnenolone	44-56	hypertrichosis 2 (generalised, congenital)	Homo sapiens	88-91	
3089339-10	1986	Similarly, in the presence of inhibitors of pregnenolone metabolism, rPRL also enhanced hCG-stimulated production of pregnenolone.	Pregnenolone	117-129	hypertrichosis 2 (generalised, congenital)	Homo sapiens	88-91	
6715352-5	1984	Under blockade of pregnenolone metabolism using cyanoketone and spironolactone, AVT, like hCG, stimulated pregnenolone accumulation with an ED50 dose of 5.8 +/- 0.3 X 10(-9) M. Similar effects were observed with several related neurohypophysial hormones, but not with nine unrelated peptides.	Pregnenolone	18-30	hypertrichosis 2 (generalised, congenital)	Homo sapiens	90-93	
6715352-5	1984	Under blockade of pregnenolone metabolism using cyanoketone and spironolactone, AVT, like hCG, stimulated pregnenolone accumulation with an ED50 dose of 5.8 +/- 0.3 X 10(-9) M. Similar effects were observed with several related neurohypophysial hormones, but not with nine unrelated peptides.	Pregnenolone	106-118	hypertrichosis 2 (generalised, congenital)	Homo sapiens	90-93	
36274-4	1979	Testicular stimulation in vitro with a high dose of hCG (360 pM) resulted in significantly greater production of testosterone, pregnenolone, and estradiol by cryptorchid than by control rat tissue.	Pregnenolone	127-139	hypertrichosis 2 (generalised, congenital)	Homo sapiens	52-55	
6276247-2	1981	injections of hCG (10 U) in adult male rats resulted, within 24 h, in a 2-fold decrease in the maximal LH-stimulated testosterone production in vitro, while pregnenolone production was not changed.	Pregnenolone	157-169	hypertrichosis 2 (generalised, congenital)	Homo sapiens	14-17	
7343084-0	1981	Effect in vitro of high doses of hCG in the progesterone synthesis from pregnenolone in human term placenta.	Pregnenolone	72-84	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36