PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17222962-1	2007	Cytochrome P450 side-chain cleavage (CYP11A1) catalyzes the conversion of cholesterol to pregnenolone, the first step in steroidogenesis.	Pregnenolone	89-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
24760842-4	2014	Cytochrome P450 side chain cleavage (P450scc) converts cholesterol to pregnenolone, the rate-limiting enzymatic reaction in neurosteroidogenesis.	Pregnenolone	70-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
34273352-1	2021	Cytochrome P450 (P450) 17A1 catalyzes the 17alpha-hydroxylation of progesterone and pregnenolone as well as the subsequent lyase cleavage of both products to generate androgens.	Pregnenolone	84-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-27	
16338087-2	2006	The first step in steroidogenesis involves the delivery of free cholesterol to the inner mitochondrial membrane where it can be converted into pregnenolone by the enzyme cytochrome P450side chain cleavage.	Pregnenolone	143-155	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	170-185	
1346997-7	1992	This was substantiated by the finding that CQA metabolism was completely inhibited by a polyclonal antibody directed against a pregnenolone 16 alpha-carbonitrile-inducible cytochrome P-450 of rat liver.	Pregnenolone	127-139	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	172-188	
3435446-0	1987	Monoclonal antibodies against human cytochrome P-450 recognizing different pregnenolone 16 alpha-carbonitrile-inducible rat cytochromes P-450.	Pregnenolone	75-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-52	
2703963-6	1989	Of the cytochrome P-450 inducers, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin, increased the biliary excretion of AA-GS (2.9- and 3.2-fold, respectively) whereas ethanol and isoniazid did not affect it, and pregnenolone-16 alpha-carbonitrile tended to decrease it (43%).	Pregnenolone	224-236	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	7-23