PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34661088-0	2021	The effect of N-glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor.	Nitrogen	14-15	angiotensin converting enzyme 2	Homo sapiens	102-106	
34839261-9	2021	FINDINGS: The receptor binding domain and three distinct SARS-CoV-2 surface N-glycosylation sites among 57,311 spike proteins retrieved from the NCBI-Virus-database are highly evolutionarily conserved (99.67%) and are involved in ACE2 interaction.	Nitrogen	76-77	angiotensin converting enzyme 2	Homo sapiens	230-234	
34965734-4	2022	Although high levels of reactive oxygen and nitrogen species (RONS) are produced during viral infections, it is not clear how they affect the RBD structure and its binding to ACE2 and GRP78.	Nitrogen	44-52	angiotensin converting enzyme 2	Homo sapiens	175-179	
34494876-0	2021	Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2.	Nitrogen	24-25	angiotensin converting enzyme 2	Homo sapiens	131-135	
34494876-5	2021	However, the contribution of N-glycosylation to ACE2 function is poorly understood.	Nitrogen	29-30	angiotensin converting enzyme 2	Homo sapiens	48-52	
34494876-7	2021	The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity.	Nitrogen	19-20	angiotensin converting enzyme 2	Homo sapiens	164-168	
34494876-7	2021	The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity.	Nitrogen	94-95	angiotensin converting enzyme 2	Homo sapiens	164-168	
34494876-10	2021	Impairment of hACE2 N-glycosylation decreased cell-to-cell fusion mediated by SARS-CoV S protein but not that mediated by SARS-CoV-2 S protein.	Nitrogen	20-21	angiotensin converting enzyme 2	Homo sapiens	14-19	
34494876-11	2021	Finally, we found that hACE2 N-glycosylation is required for an efficient viral entry of SARS-CoV/SARS-CoV-2 S pseudotyped viruses, which may be the result of low cell surface expression of the deglycosylated ACE2 receptor.	Nitrogen	29-30	angiotensin converting enzyme 2	Homo sapiens	23-28	
35385928-4	2022	Breathing air with high concentrations of nitrogen dioxide and PM can result in over-expression of the angiotensin converting enzyme-2 (ACE-2) leading to stress of organs, such as heart and kidneys.	Nitrogen	42-50	angiotensin converting enzyme 2	Homo sapiens	103-134	
35385928-4	2022	Breathing air with high concentrations of nitrogen dioxide and PM can result in over-expression of the angiotensin converting enzyme-2 (ACE-2) leading to stress of organs, such as heart and kidneys.	Nitrogen	42-50	angiotensin converting enzyme 2	Homo sapiens	136-141	
33552834-5	2021	Another striking observation is the absence of N-glycosylation site Asn103 in all mammals and many species, lack more than one N-linked glycosylation site in the ACE2 receptor.	Nitrogen	127-128	angiotensin converting enzyme 2	Homo sapiens	162-166	
32404529-6	2020	Some ACE2 proteins even tolerate the loss or acquisition of N-glycosylation sites located near the S interface.	Nitrogen	60-61	angiotensin converting enzyme 2	Homo sapiens	5-9	
32305506-6	2020	We decided to use the analogy of a play and speculate about the possible impact in this tragedy of 1) air pollution via the interference of nitrogen dioxide on ACE2 expression; 2) the dual role of nicotine; 3) the hypothetical involvement of ACE2 polymorphisms, the relationships of which with ethnic factors and susceptibility to cardiovascular disease seems intriguing; 4) the impact on the severity of infection of hypertension and related medications acting on the renin/angiotensin system, and, finally, 5) the possible helpful role of chloroquine, thanks to its capacity of modifying ACE2 affinity to the viral spike protein by altering glycosylation.	Nitrogen	140-148	angiotensin converting enzyme 2	Homo sapiens	160-164