PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19242108-7	2009	The enhanced apoptotic response was correlated with increased phosphorylation of N-terrninal p53-Ser15 and -Ser46 and increased expression of the pro-apoptotic Bax gene at both the mRNA and protein level.	Nitrogen	81-82	tumor protein p53	Homo sapiens	93-96	
19248770-4	2009	Introduction of the signal sequence from mIL-31 to human p53 protein failed to secrete the products, but further addition of the N-glycosylation site resulted in constitutive secretion of biologically active p53 protein into the medium in the N-glycosylated form.	Nitrogen	129-130	tumor protein p53	Homo sapiens	208-211	
19248770-4	2009	Introduction of the signal sequence from mIL-31 to human p53 protein failed to secrete the products, but further addition of the N-glycosylation site resulted in constitutive secretion of biologically active p53 protein into the medium in the N-glycosylated form.	Nitrogen	243-244	tumor protein p53	Homo sapiens	208-211	
17582597-9	2007	In the "inflammatory" scenario, p53, activated by DNA damage induced by oxygen and nitrogen species, recruits NF-kappaB to activate COX-2, resulting in antiapoptotic effects that contribute to cell expansion in inflammatory precursor lesions.	Nitrogen	83-91	tumor protein p53	Homo sapiens	32-35	
15665582-3	2004	UV-damage and the damage caused by certain chemotherapeutics including cisplatin and nitrogen mustards are known to be repaired by the nucleotide excision repair (NER) pathway which is reportedly regulated by p53 and its downstream genes.	Nitrogen	85-93	tumor protein p53	Homo sapiens	209-212	
9459175-0	1997	Relationship between nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia (B-CLL) and protein expression of Bcl-2, Bax, Bcl-X and p53.	Nitrogen	21-29	tumor protein p53	Homo sapiens	149-152	
12036943-4	2002	To test this hypothesis, the effect of exogenous mutant p53 protein expression on genomic instability in human p53-/- Saos-2 cells was measured by the frequency of formation of N-(phosphoacetyl)-L-aspartate (PALA)-resistant (PALA(R)) colonies, mediated by gene amplification.	Nitrogen	177-178	tumor protein p53	Homo sapiens	56-59	
11133809-1	2000	In human fibroblasts, N:-phosphoacetyl-L-aspartate (PALA) and gamma-radiation induce reversible and irreversible p53-mediated G(1) cell cycle arrest, respectively.	Nitrogen	22-23	tumor protein p53	Homo sapiens	113-116	
11050162-7	2000	These results are consistent with the hypothesis that the generation of oxygen/nitrogen species and unsaturated aldehydes from iron and copper overload in hemochromatosis and WD causes mutations in the p53 tumor suppressor gene.	Nitrogen	79-87	tumor protein p53	Homo sapiens	202-205	
15308759-1	2004	We tested the hypothesis that bifunctional DNA adducts formed by a nitrogen mustard-based anticancer drug were more efficient than monofunctional adducts at causing elevation of p53, consistent with the difference in cytotoxicity.	Nitrogen	67-75	tumor protein p53	Homo sapiens	178-181	
14965371-0	2004	p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid.	Nitrogen	42-50	tumor protein p53	Homo sapiens	0-3	
12505283-5	2002	For example, oxyradical overload diseases such as Wilson disease and hemochromatosis result in the generation of oxygen/nitrogen species that can cause mutations in the p53 tumor suppressor gene.	Nitrogen	120-128	tumor protein p53	Homo sapiens	169-172	
12058967-5	2002	Ultraviolet light, cisplatin, and nitrogen mustards produce damage that is repaired by a p53-regulated pathway.	Nitrogen	34-42	tumor protein p53	Homo sapiens	89-92	
11720736-7	2001	Although several different exogenous carcinogens have been shown to selectively target p53, evidence supporting the endogenous insult of p53 from oxyradical and nitrogen-oxyradicals is accumulating.	Nitrogen	161-169	tumor protein p53	Homo sapiens	137-140	
9816057-0	1995	Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard.	Nitrogen	126-134	tumor protein p53	Homo sapiens	71-74	
9816057-5	1995	Exposure of normal lymphocytes to 5 microM nitrogen mustard caused their arrest in G1, an increase in p53 expression which was maximal in such cells, and significant apoptosis in cells located beyond the arrest point (S and G2 + M cells).	Nitrogen	43-51	tumor protein p53	Homo sapiens	102-105	
9816057-7	1995	Expression of p53 was highest for S and G2 + M MOLT-4 cells in response to the nitrogen mustard.	Nitrogen	79-87	tumor protein p53	Homo sapiens	14-17	
9816057-9	1995	These data suggest that DNA damage caused by nitrogen mustard provides a signal that results in stabilization of wild-type p53, preferentially in G1 cells, causes cell arrest in G1, and induces apoptosis of the cells that either were in the S-phase at the time of drug administration and/or escaped G1 arrest.	Nitrogen	45-53	tumor protein p53	Homo sapiens	123-126	
35487360-11	2022	The metal ions with weak hydrolysis constants and strong polarization forces could readily interact with N-containing histidine and S-containing cysteine of p53 DBD, which resulted in high Ka values.	Nitrogen	105-106	tumor protein p53	Homo sapiens	157-160	
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Nitrogen	70-78	tumor protein p53	Homo sapiens	104-107	
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Nitrogen	70-78	tumor protein p53	Homo sapiens	401-404	
7954409-8	1994	We also observed an inverse sensitivity relationship between nitrogen mustard/cisplatin and etoposide in the mutant p53 lines and this was found to correlate with topoisomerase II mRNA levels in the cells.	Nitrogen	61-69	tumor protein p53	Homo sapiens	116-119	
32032660-12	2020	Moreover, cells exposed to A + N can influence neighboring cells in paracrine fashion, for instance, they shed ectodomain of COL17A1 protein and induce, in p53-dependent mode, the expression of gene for interleukin-7.	Nitrogen	31-32	tumor protein p53	Homo sapiens	156-159	
31112603-6	2020	We provide in silico, molecular dynamics and experimental data to support that CucWi-N (i) possesses high capability to target mortalin-p53 interaction and hnRNP-K proteins, (ii) triggers replicative senescence and inhibits metastatic potential of the cancer cells, and (iii) inhibits tumor progression and metastasis in vivo.	Nitrogen	85-86	tumor protein p53	Homo sapiens	136-139	
32032660-1	2020	Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392.	Nitrogen	33-34	tumor protein p53	Homo sapiens	45-48	
32318262-9	2020	By integrated analysis of both omic data, we found that in response to radiation insult, nitrogen metabolism, glutathione metabolism, arachidonic acid metabolism, and glycolysis or gluconeogenesis may be dysregulated due to p53.	Nitrogen	89-97	tumor protein p53	Homo sapiens	224-227	
31953488-4	2020	Truncated p53 mutants modulated droplet formation, suggesting the importance of multivalent electrostatic interactions among the N-terminal and C-terminal domains.	Nitrogen	129-130	tumor protein p53	Homo sapiens	10-13	
31638225-11	2019	Function enrichment analysis revealed the genes in the ceRNA network that participated in the p53 signaling pathway [cyclin E2 (CCNE2), ribonucleotide reductase M2 subunit (RRM2)] and nitrogen metabolism [carbonic anhydrase 2 (CA2)], which were also included in the pathways of the CTD.	Nitrogen	184-192	tumor protein p53	Homo sapiens	94-97	
26982372-3	2016	Linking benzamide substrates with a rotatable C-N bond, we constructed a novel semirigid pyramid-like scaffold that could support its two-turn alpha-helix mimicry without aromatic stacking interactions and could adopt the different dihedral angles of the key residues of p53 and BH3-only peptides.	Nitrogen	48-49	tumor protein p53	Homo sapiens	271-274	
31519237-0	2019	Ratiometric fluorescence strategy for p53 gene assay by using nitrogen doped graphene quantum dots and berberine as fluorescence reporters.	Nitrogen	62-70	tumor protein p53	Homo sapiens	38-41	
31519237-2	2019	Nitrogen doped graphene quantum dots (NGQDs) were firstly bound with a single-stranded DNA (P1 DNA), which contains berberine aptamer sequence and p53 gene complementary sequence (Cp53 DNA).	Nitrogen	0-8	tumor protein p53	Homo sapiens	147-150	
31652301-6	2019	Here we have used different approaches to show that this event is accompanied by a specific change in the HDM2 structure that affects the HDM2 interactome, such as the N-termini HDM2 - p53 protein-protein interaction.	Nitrogen	168-169	tumor protein p53	Homo sapiens	185-188