PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16087391-0 2005 Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs. Nitrogen 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-69 16802848-10 2006 Clearance is hepatic via N-oxidation by the hepatic cytochrome P450 (CYP) isoenzymes, CYP2C19, CYP2C9 and CYP3A4. Nitrogen 25-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-67 16802848-10 2006 Clearance is hepatic via N-oxidation by the hepatic cytochrome P450 (CYP) isoenzymes, CYP2C19, CYP2C9 and CYP3A4. Nitrogen 25-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-72 16087391-10 2005 In conclusion, our results suggested that the difference in the nitrogen-substituted position in the chrysene molecule might affect the mutagenic activity through influencing the ratio of participation of the metabolic activation enzyme isoforms of CYP. Nitrogen 64-72 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 249-252 11509577-2 2001 Cytochrome P450 (P450) 2D6 was first identified as the polymorphic human debrisoquine hydroxylase and subsequently shown to catalyze the oxidation of a variety of drugs containing a basic nitrogen. Nitrogen 188-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 15056479-1 2004 Identification of cytochrome P-450 isoenzymes (CYPs) involved in perazine 5-sulphoxidation and N-demethylation was carried out using human liver microsomes and cDNA-expressed human CYPs (Supersomes). Nitrogen 95-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-34 15268978-2 2004 The aim was to identify the individual human cytochrome P450 (CYP) enzymes responsible for the in vitro N-demethylation of hydromorphone and to determine the potential effect of the inhibition of this metabolic pathway on the formation of other hydromorphone metabolites. Nitrogen 104-105 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-60 15268978-2 2004 The aim was to identify the individual human cytochrome P450 (CYP) enzymes responsible for the in vitro N-demethylation of hydromorphone and to determine the potential effect of the inhibition of this metabolic pathway on the formation of other hydromorphone metabolites. Nitrogen 104-105 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-65 12967198-2 2003 It is metabolized in humans through the N-dealkylation pathway, to desethylchloroquine (DCQ) and bisdesethylchloroquine (BDCQ), by cytochrome P450 (CYP). Nitrogen 40-41 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 131-146 12967198-2 2003 It is metabolized in humans through the N-dealkylation pathway, to desethylchloroquine (DCQ) and bisdesethylchloroquine (BDCQ), by cytochrome P450 (CYP). Nitrogen 40-41 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-151 12893130-1 2003 Tramadol is an opioid drug metabolised in phase I by cytochrome P450 (CYP) enzymes, of which CYP2D6 is mainly responsible for the O-demethylation of tramadol, but is not involved in N-demethylation. Nitrogen 182-183 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-73 12206675-1 2002 Cytochrome P450 (P450) 2D6 was first identified as the polymorphic human debrisoquine hydroxylase and subsequently shown to catalyze the oxidation of a variety of drugs containing a basic nitrogen. Nitrogen 188-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 16393888-6 2005 Both CPA and IFO are prodrugs that require activation by hepatic cytochrome P450 (CYP)-catalyzed 4-hydroxylation, yielding cytotoxic nitrogen mustards capable of reacting with DNA molecules to form crosslinks and lead to cell apoptosis and/or necrosis. Nitrogen 133-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-80 16393888-6 2005 Both CPA and IFO are prodrugs that require activation by hepatic cytochrome P450 (CYP)-catalyzed 4-hydroxylation, yielding cytotoxic nitrogen mustards capable of reacting with DNA molecules to form crosslinks and lead to cell apoptosis and/or necrosis. Nitrogen 133-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-85 16393888-11 2005 The alternative CYP-catalyzed inactivation pathway by N-dechloroethylation generates the neurotoxic and nephrotoxic byproduct chloroacetaldehyde (CAA). Nitrogen 54-55 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 16-19 15801542-1 2004 The purpose of this paper was to characterize cytochrome P450 (CYP) enzymes involved in N-dealkylation of a new oral erectogenic, DA-8159 to DA-8164, a major circulating active metabolite, in human liver microsomes and to investigate the inhibitory potential of DA-8159 on CYP enzymes. Nitrogen 88-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-61 15801542-1 2004 The purpose of this paper was to characterize cytochrome P450 (CYP) enzymes involved in N-dealkylation of a new oral erectogenic, DA-8159 to DA-8164, a major circulating active metabolite, in human liver microsomes and to investigate the inhibitory potential of DA-8159 on CYP enzymes. Nitrogen 88-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-66 15801542-1 2004 The purpose of this paper was to characterize cytochrome P450 (CYP) enzymes involved in N-dealkylation of a new oral erectogenic, DA-8159 to DA-8164, a major circulating active metabolite, in human liver microsomes and to investigate the inhibitory potential of DA-8159 on CYP enzymes. Nitrogen 88-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 273-276 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Nitrogen 100-108 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-66 12936704-0 2003 Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. Nitrogen 92-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-64 12936704-2 2003 The aim was to identify the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of morphine in vitro. Nitrogen 78-79 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 12936704-2 2003 The aim was to identify the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of morphine in vitro. Nitrogen 78-79 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-48 12564927-1 2003 Human cytochrome P450 (P450) 2D6 is an important enzyme involved in the metabolism of drugs, many of which are amines or contain other basic nitrogen atoms. Nitrogen 141-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-32 12487729-7 2002 A sensitive fluorometric technique was employed to quantitate N-alkylPP formation after interaction of individual CYP enzymes with a porphyrinogenic xenobiotic. Nitrogen 62-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 114-117 12487729-9 2002 N-alkylPP formation was found following the interaction of three porphyrinogenic xenobiotics with CYP1A2, 2B1, 2C6, 2C11 and 3A2, in amounts ranging from 0.45 to 0.07 nmol N-alkylPP nmol(-1) CYP. Nitrogen 0-1 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-101 12214661-0 2002 Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase. Nitrogen 43-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-70 12214661-1 2002 Cytochrome P450 and nitric oxide synthase (NOS) oxidize nitrogen atoms, although the substrates and transformations are highly restricted for NOS. Nitrogen 56-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 11714275-1 2001 Cytochrome P450 (P450) 2D6 oxidizes a wide variety of drugs typically at a distance of 5-7 A from a basic nitrogen on the substrate. Nitrogen 106-114 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 11504269-1 2001 The authors assessed the in vitro contribution of cytochrome P450 (CYP) isoforms 1A2, 3A4, 2C9, 2C19, and 2D6 to the N-demethylation of clozapine mediated by human liver microsomal preparations (HLM). Nitrogen 117-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-65 11504269-1 2001 The authors assessed the in vitro contribution of cytochrome P450 (CYP) isoforms 1A2, 3A4, 2C9, 2C19, and 2D6 to the N-demethylation of clozapine mediated by human liver microsomal preparations (HLM). Nitrogen 117-118 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-70 11298070-0 2001 Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Nitrogen 62-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 22-37 11556812-1 2001 Cytochrome P450 (P450) 2D6 is a polymorphic human enzyme involved in the oxidation of >50 drugs, most of which contain a basic nitrogen. Nitrogen 130-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 11353758-2 2001 We identified the CYP enzymes involved in the N-demethylation of ketamine enantiomers using pooled human liver microsomes and microsomes from human B-lymphoblastoid cells that expressed CYP enzymes. Nitrogen 46-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-21 11353758-2 2001 We identified the CYP enzymes involved in the N-demethylation of ketamine enantiomers using pooled human liver microsomes and microsomes from human B-lymphoblastoid cells that expressed CYP enzymes. Nitrogen 46-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 186-189 11353758-5 2001 Among the 12 cDNA-expressed CYP enzymes examined, CYP2B6, CYP2C9, and CYP3A4 showed high activities for the N-demethylation of both enantiomers at the substrate concentration of 1 mM. Nitrogen 15-16 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-31 9635877-2 1998 They are thought to be metabolically activated by N-hydroxylation, catalysed by cytochrome P450 (CYP), followed by O-acetylation catalysed by N-acetyltransferases. Nitrogen 50-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-95 10424762-7 1999 While the N-hydroxylation of the guanidine involves the usual monooxygenase activity of cytochrome P-450 (Clement et al., Biochem Pharmacol 46: 2249-2267, 1993), the resultant N-hydroxyguanidine decoupled the monooxygenase. Nitrogen 10-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 88-104 10385214-8 1999 In microsomes from 12 livers from man the rate of N-debutylation of halofantrine correlated strongly with CYP 3A4 relative levels (P = 0.002) and less strongly, but significantly, with CYP 2C8 levels (P = 0.025). Nitrogen 50-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 106-109 9635877-2 1998 They are thought to be metabolically activated by N-hydroxylation, catalysed by cytochrome P450 (CYP), followed by O-acetylation catalysed by N-acetyltransferases. Nitrogen 50-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 97-100 9635877-7 1998 The higher adduct levels observed in cells treated with the N-OH metabolites suggests that N-hydroxylation is the rate-limiting step in HMECs and this may be due to low CYP levels. Nitrogen 60-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 169-172 8854046-2 1996 The study suggests that the "larger" inhibitors (such as the [2"(4"-aminophenyl)alkyl] pyrrolidine-2,5-dione based compounds), after an initial binding of the phenylamine nitrogen lone pair electrons with the Fe3+ haem of the cytochrome P-450, preferentially utilise the region of the AR active site which would normally bind C(17) = O of the substrate. Nitrogen 171-179 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 226-242 8737124-7 1996 The nitrogen atom is possibly the site that binds cytochrome P-450, which catalyses theophylline metabolism. Nitrogen 4-12 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-66 9600717-12 1998 These results show that CYP 3A4 is the primary hepatic CYP isoform mediating the N-demethylation of adinazolam and NDMAD. Nitrogen 81-82 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-27 9248661-11 1997 Nitrogen-containing systems may also inactivate CYP. Nitrogen 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-51 7895609-3 1994 We characterized cytochrome P450 isozymes responsible for propranolol metabolism, especially N-desisopropylation and 5-hydroxylation, in human liver microsomes. Nitrogen 93-94 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-32 8847710-1 1995 Indirect evidence of the participation of cytochrome P-450 (P-450) in the microsomal N-oxygenation of secondary and tertiary nitrogen functions is presented by studies employing diagnostic modifiers of the hemoprotein system as well as antibodies directed toward the diverse P-450 isoforms and NADPH-cytochrome P-450 reductase. Nitrogen 85-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 42-58 8847710-1 1995 Indirect evidence of the participation of cytochrome P-450 (P-450) in the microsomal N-oxygenation of secondary and tertiary nitrogen functions is presented by studies employing diagnostic modifiers of the hemoprotein system as well as antibodies directed toward the diverse P-450 isoforms and NADPH-cytochrome P-450 reductase. Nitrogen 125-133 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 42-58 7640150-2 1995 Studies using human liver microsomes and six recombinant human CYP isoforms (i.e. CYP1A2, 2A6, 2B6, 2D6, 2E1 and 3A4) were performed to identify the cytochrome P450 (CYP) isoform(s) involved in the ring 4-hydroxylation and side-chain N-desisopropylation of propranolol enantiomers in humans. Nitrogen 234-235 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 149-164 7496999-11 1995 The greatest increase in N-demethylation activity was observed in the reconstitution system with the lowest concentration of cytochrome P-450 reductase, conditions which most closely resemble intact microsomes. Nitrogen 25-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 125-141 7949373-1 1994 Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs and related N-alkylated amides, but surprisingly little is known about the cytochrome P-450 isozymes involved in these dealkylation reactions. Nitrogen 10-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 181-197 34648192-5 2022 RESULTS: The experiments in supersomes revealed CYP1A2 as the major CYP for 4-MAA N-demethylation and 4-FAA formation with CYP2C19 and CYP2D6 contributing to N-demethylation. Nitrogen 82-83 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-71 8082573-7 1994 Considering the selective prerequisites for oxidative attack by cytochrome P-450 at vulnerable nitrogen centers, many cytotoxic amines belonging to the category of relatively rigid, planar molecules undergo N-oxidative activation by the cytochrome P-450IA subfamily, while more bulky amines with flexible conformation are N-oxygenated preferentially by phenobarbital-inducible cytochromes P-450. Nitrogen 95-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-80 8082573-7 1994 Considering the selective prerequisites for oxidative attack by cytochrome P-450 at vulnerable nitrogen centers, many cytotoxic amines belonging to the category of relatively rigid, planar molecules undergo N-oxidative activation by the cytochrome P-450IA subfamily, while more bulky amines with flexible conformation are N-oxygenated preferentially by phenobarbital-inducible cytochromes P-450. Nitrogen 207-208 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-80 1519785-3 1992 It has been shown previously that alfentanil clearance is independent of the polymorphic debrisoquine hydroxylase (P-450 2D6), and it is therefore of interest to identify the human cytochrome P-450 enzymes involved in noralfentanil formation, the primary reaction involved in the oxidative N-dealkylation at the piperidine nitrogen. Nitrogen 323-331 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 181-197 1346997-0 1992 Characterization of the cytochrome P-450 gene family responsible for the N-dealkylation of the ergot alkaloid CQA 206-291 in humans. Nitrogen 73-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 2680407-0 1989 Induction of the alcohol-inducible form of cytochrome P-450 by nitrogen-containing heterocycles: effects on pyridine N-oxide production. Nitrogen 63-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-59 34180113-0 2021 Enzymatic Tailoring in Luzopeptin Biosynthesis Involves Cytochrome P450-Mediated Carbon-Nitrogen Bond Desaturation for Hydrazone Formation. Nitrogen 88-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-71 34180113-3 2021 Significantly, we revealed a multitasking cytochrome P450 enzyme that catalyzes four consecutive oxidations including the highly unusual carbon-nitrogen bond desaturation, forming the hydrazone-bearing 4-OH-Thp residues. Nitrogen 144-152 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 42-57 35483145-0 2022 In Silico simulation of Cytochrome P450-Mediated metabolism of aromatic amines: A case study of N-Hydroxylation. Nitrogen 96-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-39 2618083-4 1989 Spectral interactions of N-containing heteroaromatic compounds with the cytochrome P-450 system are type I or type II depending on the state of induction, and are relatively weak. Nitrogen 25-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-88 2677363-5 1989 However, because of the additional nitrogen atom in the triazole ring and the lipophilic tail, terconazole establishes a firmer and longer-lasting link with the membrane-bound fungal cytochrome P-450. Nitrogen 35-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 183-199 6661247-0 1983 Hepatic microsomal cytochrome p-450-dependent N-demethylation of methylguanidine. Nitrogen 46-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-35 6661247-5 1983 The direct involvement of cytochrome P-450 in the N-demethylation is supported by the observations that addition of methylguanidine to purified cytochrome P-450 preparation caused a type I spectral change and that inhibitors of cytochrome P-450, such as carbon monoxide and metyrapone, markedly decreased the rate of demethylation. Nitrogen 50-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-42 6661247-5 1983 The direct involvement of cytochrome P-450 in the N-demethylation is supported by the observations that addition of methylguanidine to purified cytochrome P-450 preparation caused a type I spectral change and that inhibitors of cytochrome P-450, such as carbon monoxide and metyrapone, markedly decreased the rate of demethylation. Nitrogen 50-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 144-160 6661247-5 1983 The direct involvement of cytochrome P-450 in the N-demethylation is supported by the observations that addition of methylguanidine to purified cytochrome P-450 preparation caused a type I spectral change and that inhibitors of cytochrome P-450, such as carbon monoxide and metyrapone, markedly decreased the rate of demethylation. Nitrogen 50-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 144-160 6870907-0 1983 Correlations between spin equilibrium shift, reduction rate, and N-demethylation activity in liver microsomal cytochrome P-450 and a series of benzphetamine analogues as substrates. Nitrogen 65-66 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 110-126 6288676-10 1982 The results provide persuasive evidence that oxidation of the nitrogen in DDEP by cytochrome P-450 proceeds in one-electron steps. Nitrogen 62-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-98 6802829-3 1982 A 200% stimulation of N-demethylation by cytochrome b5 was obtained at cytochrome P-450 reductase:cytochrome P-450 ratios similar to those in microsomes, compared to only a 20% stimulation at a ratio of 1:1. Nitrogen 22-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 6802829-3 1982 A 200% stimulation of N-demethylation by cytochrome b5 was obtained at cytochrome P-450 reductase:cytochrome P-450 ratios similar to those in microsomes, compared to only a 20% stimulation at a ratio of 1:1. Nitrogen 22-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-114 23870-0 1978 [Kinetics of N-dealkylation of amines with participation of microsomal cytochrome P-450]. Nitrogen 13-14 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 109441-4 1979 In agreement with this equation, the observed Vmax for benzphetamine N-demethylation was found to be directly proportional to the calculated concentration of the cytochrome P-450 . Nitrogen 69-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 162-178 182488-8 1976 This supports the model that one of the pyridine nitrogens of metyrapone is coordinated to the iron of cytochrome P-450. Nitrogen 49-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-119 853543-3 1977 The arylating metabolite is formed by a cytochrome P-450 dependent N-hydroxylation process. Nitrogen 67-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 1116950-5 1975 Subtraction of the nitrogen values from the carbon monoxide values, after allowing for an absorption shift, gives the absolute spectrum of cytochrome P450. Nitrogen 19-27 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-154 4122821-0 1973 The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene. Nitrogen 32-33 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-28 31151284-9 2019 AIs and N/DSs sharing the cytochrome P450 pathway are at risk of negative interactions. Nitrogen 8-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-41 32219694-4 2020 Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4). Nitrogen 86-88 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-17 32219694-4 2020 Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4). Nitrogen 86-88 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55 31605674-9 2019 Cytochrome P450 isozyme models accurately predicted the likelihood for terbinafine N-demethylation, but overestimated the likelihood for a minor N-denaphthylation pathway. Nitrogen 83-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 31605674-9 2019 Cytochrome P450 isozyme models accurately predicted the likelihood for terbinafine N-demethylation, but overestimated the likelihood for a minor N-denaphthylation pathway. Nitrogen 145-146 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 30205091-2 2018 Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. Nitrogen 20-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-63 30205091-2 2018 Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. Nitrogen 20-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 25343291-0 2014 Enantioselective N-demethylation and hydroxylation of sibutramine in human liver microsomes and recombinant cytochrome p-450 isoforms. Nitrogen 17-18 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 108-124 20081260-4 2009 A comparative in vitro study provides clear evidence that ticlopidine and DDC, applied at concentrations that inhibit the above-mentioned CYP isoforms, potently (as compared to furafylline) inhibit human CYP1A2 and caffeine metabolism, in particular 1-N- and 3-N-demethylation. Nitrogen 252-253 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 138-141 21504003-6 2011 The suggested reaction pathways included N-methylation leading to iminium formation in primary and/or secondary amines preceded by cytochrome P450 (CYP)-mediated reactions. Nitrogen 41-42 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 131-146 21504003-6 2011 The suggested reaction pathways included N-methylation leading to iminium formation in primary and/or secondary amines preceded by cytochrome P450 (CYP)-mediated reactions. Nitrogen 41-42 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-151 18311908-4 2008 In this study, the structural characteristics of nitrogen-containing compounds, which bind to the iron atom in two CYP isoforms (CYP2C9 and CYP3A4), were investigated. Nitrogen 49-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 115-118 18098061-0 2008 Identification of cytochrome P450 enzymes responsible for N -dealkylation of a new oral erectogenic, mirodenafil. Nitrogen 58-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-33