PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32269076-4 2020 The primate classical MHC class I allomorphs, Mamu-B*098 and Mamu-B*05104, are capable of binding the N-myristoylated 5-mer (C14-Gly-Gly-Ala-Ile-Ser) or 4-mer (C14-Gly-Gly-Ala-Ile) lipopeptides derived from the N-myristoylated SIV Nef protein, respectively, and of activating lipopeptide antigen-specific cytotoxic T lymphocytes. Nitrogen 102-103 S100 calcium binding protein B Homo sapiens 231-234 7811531-14 1994 Taken together, these results suggest that N-myristoylation of Nef affects its association with both membranes and cytoskeleton. Nitrogen 43-44 S100 calcium binding protein B Homo sapiens 63-66 8013286-10 1994 These N-dealkylated metabolites were also present in pooled human plasma samples along with nefazodone, OH-Nef, and an unknown metabolite that was present in plasma in large amounts relative to nefazodone and OH-Nef. Nitrogen 6-7 S100 calcium binding protein B Homo sapiens 107-110 8013286-10 1994 These N-dealkylated metabolites were also present in pooled human plasma samples along with nefazodone, OH-Nef, and an unknown metabolite that was present in plasma in large amounts relative to nefazodone and OH-Nef. Nitrogen 6-7 S100 calcium binding protein B Homo sapiens 212-215 32269076-4 2020 The primate classical MHC class I allomorphs, Mamu-B*098 and Mamu-B*05104, are capable of binding the N-myristoylated 5-mer (C14-Gly-Gly-Ala-Ile-Ser) or 4-mer (C14-Gly-Gly-Ala-Ile) lipopeptides derived from the N-myristoylated SIV Nef protein, respectively, and of activating lipopeptide antigen-specific cytotoxic T lymphocytes. Nitrogen 211-212 S100 calcium binding protein B Homo sapiens 231-234 31043477-5 2019 We, in this study, demonstrate that the MHC class I allele, Mamu-B*05104, binds the N-myristoylated 4-mer peptide (C14-Gly-Gly-Ala-Ile) derived from the viral Nef protein for its presentation to CTLs. Nitrogen 84-85 S100 calcium binding protein B Homo sapiens 159-162 31597760-9 2019 Residues 12-39 near the N-terminus of Nef have been described as interaction platform for the Nef-associated kinase complex (NAKC) and were recently identified as essential determinants for a broad range of Nef activities. Nitrogen 24-25 S100 calcium binding protein B Homo sapiens 38-41 31597760-9 2019 Residues 12-39 near the N-terminus of Nef have been described as interaction platform for the Nef-associated kinase complex (NAKC) and were recently identified as essential determinants for a broad range of Nef activities. Nitrogen 24-25 S100 calcium binding protein B Homo sapiens 94-97 23549797-8 2013 Using an arbitrary cut off value, S100B-positive CSF was detected in 2.5% of the CNS-N group and in 50% of the CNS+N group (p<0.05). Nitrogen 82-83 S100 calcium binding protein B Homo sapiens 34-39 23549797-8 2013 Using an arbitrary cut off value, S100B-positive CSF was detected in 2.5% of the CNS-N group and in 50% of the CNS+N group (p<0.05). Nitrogen 85-86 S100 calcium binding protein B Homo sapiens 34-39 21653836-3 2011 This biochemical reaction, referred to as N-myristoylation, assists its targeting to the plasma membrane, thereby supporting the immunosuppressive activity proposed for the Nef protein. Nitrogen 42-43 S100 calcium binding protein B Homo sapiens 173-176 23097434-7 2013 Given that N-myristoylation of the Nef protein occurs in the conserved motifs and is critical for viral pathogenesis, these observations predict that the lipopeptide-specific T cell response is difficult for viruses to avoid by simply introducing amino acid mutations. Nitrogen 11-12 S100 calcium binding protein B Homo sapiens 35-38 21653836-5 2011 A rhesus macaque CD8(+) T cell line was established that specifically recognized N-myristoylated, but not unmodified, peptides of the Nef protein. Nitrogen 81-82 S100 calcium binding protein B Homo sapiens 134-137 21653836-6 2011 Furthermore, the population size of N-myristoylated Nef peptide-specific T cells was found to increase significantly in the circulation of SIV-infected monkeys. Nitrogen 36-37 S100 calcium binding protein B Homo sapiens 52-55 21653836-4 2011 In this study, we show that the host immunity is equipped with CTLs capable of sensing N-myristoylation of the Nef protein. Nitrogen 87-88 S100 calcium binding protein B Homo sapiens 111-114