PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33535417-8 2021 Patients with elevated IL-6 presented more frequently with anemia mellitus (64.3% vs. 41.7%; p = 0.046), atrial fibrillation (83.3% vs. 61.9% p = 0.036), dyslipidemia (76.2% vs. 58.2%; p = 0.03), higher creatinine levels (1.35 mg/dL vs. 1.08 mg/dL; p = 0.024), lower glomerular filtration rate (43.6 mL/min/m2 vs. 59.9 mL/min/m2; p = 0.007), and anemia 25% vs. 52.4% p = 0.014. Creatinine 203-213 interleukin 6 Homo sapiens 23-27 32296091-6 2020 There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC). Creatinine 149-159 interleukin 6 Homo sapiens 84-88 32710733-11 2020 The stimulation could occur by way of IL-6 / JAK2 / STAT3 / SOCS3 and NF-kappaB (p65)/IL-18, which work together to induce AKI and increase overall renal-related diagnostic markers, such as plasma creatinine and tubular cell damage. Creatinine 197-207 interleukin 6 Homo sapiens 38-42 32296091-6 2020 There were significant correlations between baseline and one-year dialysis effluent IL-6 and COX-2 levels with the corresponding dialysate-to-plasma creatinine level at 4 hours (D/P4) and mass transfer area coefficient of creatinine (MTAC). Creatinine 222-232 interleukin 6 Homo sapiens 84-88 32296091-10 2020 Dialysis effluent IL-6 and COX-2 levels correlate with the concomitant D/P4 and MTAC of creatinine. Creatinine 88-98 interleukin 6 Homo sapiens 18-22 31187425-9 2019 Multivariate analysis showed that low dialysate copeptin (beta = -0.30, p = 0.049) and high dialysate IL-6 (beta = + 0.40, p = 0.012) were independent determinants of higher D/P creatinine. Creatinine 178-188 interleukin 6 Homo sapiens 102-106 31442679-7 2020 In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6. Creatinine 37-47 interleukin 6 Homo sapiens 168-172 31773054-5 2019 In children with s-creatinine increase, IL-6 values were significantly different between AR and cAMR. Creatinine 19-29 interleukin 6 Homo sapiens 40-44 31250339-7 2019 The monocyte chemoattractant protein-1-to-creatinine ratio showed a significant correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P < 0.001). Creatinine 42-52 interleukin 6 Homo sapiens 156-169 31519530-9 2019 This study found the model to predict the hepcidin level using IL-6 ferritin and the creatinine level as the hepcidin level (predicted)=-23.76+0.396 (IL 6)+0.448 (ferritin)+0.310 (creatinine). Creatinine 85-95 interleukin 6 Homo sapiens 150-154 28747177-10 2017 RESULTS: Positive correlations of DeltaCr were found with BUN, admission Cr, GRACE score, IL-1beta, IL-6, NT-ProBNP and age, and negative correlations with systolic blood pressure, mean-BP, diastolic-BP and LxA4. Creatinine 39-41 interleukin 6 Homo sapiens 100-104 28703928-7 2018 RESULTS: We have found a peak of regulatory cytokines in RTR with low creatinine levels as well as a peak of IL-6 pro-inflammatory cytokine in patients with high creatinine levels. Creatinine 162-172 interleukin 6 Homo sapiens 109-113 26627016-3 2016 In CKD, interleukin-6 and hypersensitive C-reactive protein are known to be used for the evaluation of inflammation and serum levels increase with decreased creatinine clearance. Creatinine 157-167 interleukin 6 Homo sapiens 8-21 27353644-4 2016 RESULTS: The urinary IL-6 concentrations increased from uACR <10 (97.2+-26.4pg/ml) to uACR 10-30 (113.6+-28.0pg/ml) and to uACR >30mg/g creatinine (163.5+-25.6pg/ml) (P<0.05 and P<0.001, respectively) patients. Creatinine 142-152 interleukin 6 Homo sapiens 21-25 26981446-5 2016 RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P < 0.001), IL-6 (rho = 0.46, P < 0.001), and hyaluronan (rho = 0.27, P < 0.001), but not CA125 (rho = 0.13, P = 0.051). Creatinine 44-54 interleukin 6 Homo sapiens 188-192 26981446-5 2016 RESULTS: The ratio of the effluent level of creatinine (Cr) obtained 4 h after injection (D) to that of plasma was correlated with the effluent levels of MMP-2 (rho = 0.74, P < 0.001), IL-6 (rho = 0.46, P < 0.001), and hyaluronan (rho = 0.27, P < 0.001), but not CA125 (rho = 0.13, P = 0.051). Creatinine 56-58 interleukin 6 Homo sapiens 188-192 25384728-9 2015 CONCLUSIONS: These results suggest that IL6-174G>C may contribute to T1DM and increased albumin-to-creatinine ratio as well as to poor glycemic control and hyperlipidemia. Creatinine 102-112 interleukin 6 Homo sapiens 40-43 26187318-4 2015 IL-6 and CRP also influenced the extent of the arithmetic bias when calculating the GFR using the chronic kidney disease epidemiology (CKD-EPI) formula with just serum creatinine. Creatinine 168-178 interleukin 6 Homo sapiens 0-4 25384728-0 2015 Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio. Creatinine 103-113 interleukin 6 Homo sapiens 32-35 16736416-13 2006 Urinary excretion of IL-6 was significantly related with urinary IL-1 beta, both expressed as pg/ml/mg of urinary creatinine (r=0.85, p<0.0001). Creatinine 114-124 interleukin 6 Homo sapiens 21-25 25384728-7 2015 In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers. Creatinine 114-124 interleukin 6 Homo sapiens 19-22 25135658-9 2015 Serum IL-6 levels (pg/mL) were higher in the fatigued group (5.1 +- 3.4) than in the nonfatigued group (1.6 +- 1.5; P < 0.001); serum albumin and creatinine levels were significantly lower. Creatinine 149-159 interleukin 6 Homo sapiens 6-10 22527530-6 2012 To avoid dilution effects, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). Creatinine 110-120 interleukin 6 Homo sapiens 45-49 21511816-7 2011 Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Creatinine 183-193 interleukin 6 Homo sapiens 49-53 21755056-9 2011 Patients with dialysate/plasma creatinine 0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Creatinine 31-41 interleukin 6 Homo sapiens 132-136 21755056-9 2011 Patients with dialysate/plasma creatinine 0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Creatinine 31-41 interleukin 6 Homo sapiens 142-145 18948687-8 2009 However, in linear regression, change in interleukin-6 was correlated with change in creatinine. Creatinine 85-95 interleukin 6 Homo sapiens 41-54 25807640-10 2015 Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p < 0.001). Creatinine 176-186 interleukin 6 Homo sapiens 95-108 25485543-8 2014 Plasma levels of IL-6 were positively related to sCD14 and serum creatinine. Creatinine 65-75 interleukin 6 Homo sapiens 17-21 22052073-10 2012 Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P < 0.0001), and with IL-6 (P < 0.05). Creatinine 20-30 interleukin 6 Homo sapiens 101-105 22085404-10 2011 Disease severity characterized by elevated creatinine and low platelet counts was correlated with high pro-inflammatory IL-6 and TNF-alpha but low immunosuppressive TGF-beta1 levels and vice versa . Creatinine 43-53 interleukin 6 Homo sapiens 120-124 20171655-7 2010 Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 +/- 310.9 vs 115.0 +/- 65.9 ng/g urinary creatinine; P < .01), as were PI values (1.85 +/- 0.70 vs 1.44 +/- 0.53; P < .05). Creatinine 127-137 interleukin 6 Homo sapiens 8-26 20084405-6 2010 To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). Creatinine 141-151 interleukin 6 Homo sapiens 76-80 20084405-8 2010 In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p<0.05, R=0.305). Creatinine 87-97 interleukin 6 Homo sapiens 82-86 19164257-8 2009 The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2=0.1294, p<0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7+/-14.42 vs 116.8+/-88.91 pg/minute, p=0.0358). Creatinine 99-109 interleukin 6 Homo sapiens 50-54 18285417-10 2008 Finally, change in the PYR/Cr ratio was positively associated baseline IL-6, hs-CRP, and their changes (all P < 0.05) in women, but not men. Creatinine 27-29 interleukin 6 Homo sapiens 71-75 17230612-12 2007 In decompensated patients sFas, IL-6 and NOx levels correlated positively with creatinine levels, while IL-6 levels were dependent on Child class. Creatinine 79-89 interleukin 6 Homo sapiens 32-36 17284895-8 2007 Intraperitoneal IL-6 was the significant and positive determinant of the time course of the D/P creatinine ratio (p < 0.0001). Creatinine 96-106 interleukin 6 Homo sapiens 16-20 11695972-8 2001 RESULTS: The tumor IL-6 content was the independent factor that influenced the creatinine height index in the elderly patients, whereas Dukes classification was the only independent factor that influenced the creatinine height index in the younger patients. Creatinine 79-89 interleukin 6 Homo sapiens 19-23 17441364-8 2006 Serum creatinine correlated with IL-6, IL-18, TNFalpha, sTNFRII and hsCRP levels and serum urea-with TNFalpha, sTNFRII, IL-6 and IL-18. Creatinine 6-16 interleukin 6 Homo sapiens 33-37 15531669-9 2004 Moreover, negative correlations were observed between IL-6 and serum creatinine (rho = -0.19, P < 0.01), handgrip strength (rho = -0.24, P < 0.001), and serum albumin (rho = -0.34, P < 0.001). Creatinine 69-79 interleukin 6 Homo sapiens 54-58 15384786-8 2004 In EG, dialysate-to-plasma creatinine at 4 hours (D/P(Cr240)) correlated significantly with effluent CA125/min (r = 0.51, p = 0.006) and VEGF/min (r = 0.57, p = 0.001), but not with serum VEGF or IL-6. Creatinine 27-37 interleukin 6 Homo sapiens 196-200 12138260-16 2002 CONCLUSIONS: IL-6 and CRP were increased and were inversely related to creatinine clearance in our population of 103 chronic predialytic patients. Creatinine 71-81 interleukin 6 Homo sapiens 13-17 11845881-10 2002 In all patients, postoperative IL-6 levels were positively correlated with duration of inotropic support and serum creatinine value and inversely correlated with oxygenation index and diuresis. Creatinine 115-125 interleukin 6 Homo sapiens 31-35 9884428-6 1999 Among the patients positive for interleukin-6, 24-hour urinary protein excretion and serum creatinine levels were significantly higher at the time of biopsy than in the patients without interleukin-6 positivity, while creatinine clearance was significantly lower. Creatinine 91-101 interleukin 6 Homo sapiens 32-45 11687440-9 2001 Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P < 0.01). Creatinine 58-68 interleukin 6 Homo sapiens 108-112 11687440-10 2001 Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P < 0.01). Creatinine 56-66 interleukin 6 Homo sapiens 111-115 9884428-6 1999 Among the patients positive for interleukin-6, 24-hour urinary protein excretion and serum creatinine levels were significantly higher at the time of biopsy than in the patients without interleukin-6 positivity, while creatinine clearance was significantly lower. Creatinine 218-228 interleukin 6 Homo sapiens 32-45 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. Creatinine 70-80 interleukin 6 Homo sapiens 7-20 9884428-7 1999 In the interleukin-6-positive patients without steroid therapy, serum creatinine increased significantly after 1 year (Deltas-Cr; 1.04 +/- 0.45 mg/dl) and creatinine clearance decreased significantly (DeltaCcr; -11.7 +/- 3.2 ml/min) compared to the interleukin-6-negative patients without steroid therapy. Creatinine 155-165 interleukin 6 Homo sapiens 7-20 9884428-8 1999 Steroid therapy improved 24-hour urinary protein excretion, serum creatinine, and creatinine clearance in the interleukin-6-positive patients, while these parameters worsened without steroid therapy. Creatinine 82-92 interleukin 6 Homo sapiens 110-123 9139274-4 1996 Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine). Creatinine 127-137 interleukin 6 Homo sapiens 21-25 9267943-12 1997 Rectal temperature and creatinine concentrations correlated significantly with sTNFR 60, sTNFR 80, sIL-6R, and IL-6 concentrations. Creatinine 23-33 interleukin 6 Homo sapiens 100-104 9161853-2 1997 We measured creatinine-collected urinary levels of IL-6 and IL-8 by an enzyme-linked immunosorbent assay in 21 women with urethritis syndrome as well as 20 age-matched healthy women. Creatinine 12-22 interleukin 6 Homo sapiens 51-55 9822513-9 1998 0-12148, P =.01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P =.005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P =.005). Creatinine 49-59 interleukin 6 Homo sapiens 17-30 9853701-10 1998 A significant correlation was found between IL-6 values and CRP, ALT, total bilirubin, GGT and creatinine, but not amylase. Creatinine 95-105 interleukin 6 Homo sapiens 44-48 9430873-7 1997 Thus, urinary IL-6/EGF ratio was markedly increased in the former group (> 20-fold at day 1), where it paralleled the modifications of plasma creatinine over time (r:0.603, P < 0.0001), and was only slightly increased in the latter group (< 3-fold). Creatinine 145-155 interleukin 6 Homo sapiens 14-18 8943482-9 1996 IL-6 values: N, 2.04 +/- 0.51; IgAN Grades 1-2, 3.26 +/- 0.38; Grades 3-4, 5.67 +/- 0.92; Grade 5, 27.20 +/- 9.70 pg/mg urinary creatinine), that correlated with the degree of histological lesions, the presence of hypertension and serum creatinine level. Creatinine 128-138 interleukin 6 Homo sapiens 0-4 8943482-9 1996 IL-6 values: N, 2.04 +/- 0.51; IgAN Grades 1-2, 3.26 +/- 0.38; Grades 3-4, 5.67 +/- 0.92; Grade 5, 27.20 +/- 9.70 pg/mg urinary creatinine), that correlated with the degree of histological lesions, the presence of hypertension and serum creatinine level. Creatinine 237-247 interleukin 6 Homo sapiens 0-4 9139274-4 1996 Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine). Creatinine 189-199 interleukin 6 Homo sapiens 21-25 2044224-4 1991 IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin. Creatinine 239-249 interleukin 6 Homo sapiens 0-4 7987859-8 1994 Hypercalcemic subjects with increased IL-6 had higher urinary Ca/creatinine levels than patients with normal IL-6 levels (P < 0.005) but this was not the case in normocalcemic subjects. Creatinine 65-75 interleukin 6 Homo sapiens 38-42 8189461-7 1994 Interleukin 6 levels correlated positively with protein turnover (phenylalaninemia) and catabolism (3-methylhistidine/creatinine ratio) and negatively with levels of fibronectin and transthyretin. Creatinine 118-128 interleukin 6 Homo sapiens 0-13 7885789-2 1994 The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients. Creatinine 126-136 interleukin 6 Homo sapiens 10-14 1914227-9 1991 The patients with IL-6 in the urine had a mean serum creatinine significantly higher than those without IL-6. Creatinine 53-63 interleukin 6 Homo sapiens 18-22 34088317-9 2021 The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI). Creatinine 63-73 interleukin 6 Homo sapiens 14-18 35634998-4 2022 Spearman correlation test was used to analyze the correlation of the IL-6 with C-reactive protein(CRP), erythrocyte sedimentation rate (ESR), creatinine, and cystatin C. Creatinine 142-152 interleukin 6 Homo sapiens 69-73 35634998-7 2022 Correlation analysis showed that IL-6 in the group with disease course >= 5 years had a positive correlation with ESR (Rs=0.438, P=0.022) and CRP (Rs=0.825, P<0.001), whereas it was negatively correlated with creatinine (Rs=-0.481, P=0.011). Creatinine 209-219 interleukin 6 Homo sapiens 33-37 34843183-9 2022 Urine albumin/creatinine-ratios correlated positively with plasma IL-6 at baseline. Creatinine 14-24 interleukin 6 Homo sapiens 66-70 35051728-9 2022 Direct correlations between leptin and fat mass, TNF and IL-6 with creatinine and pre-dialysis urea were observed in all time-points (1, 6 and 12 months). Creatinine 67-77 interleukin 6 Homo sapiens 57-61 34020444-7 2021 RESULTS: We observed moderate positive associations of circulating choline, carnitine, and DMG with creatinine [beta (95% CI): 0.136 (0.084, 0.188), 0.106 (0.045, 0.168), and 0.128 (0.087, 0.169), respectively, for each SD increase in biomarkers on the log scale], carnitine with triglycerides (beta = 0.076; 95% CI: 0.042, 0.109), homocysteine (beta = 0.064; 95% CI: 0.033, 0.095), and LDL cholesterol (beta = 0.055; 95% CI: 0.013, 0.096), DMG with homocysteine (beta = 0.068; 95% CI: 0.023, 0.114), insulin (beta = 0.068; 95% CI: 0.043, 0.093), and IL-6 (beta = 0.060; 95% CI: 0.027, 0.094), but moderate inverse associations of betaine with triglycerides (beta = -0.146; 95% CI: -0.188, -0.104), insulin (beta = -0.106; 95% CI: -0.130, -0.082), homocysteine (beta = -0.097; 95% CI: -0.149, -0.045), and total cholesterol (beta = -0.074; 95% CI: -0.102, -0.047). Creatinine 100-110 interleukin 6 Homo sapiens 551-555