PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20876337-5	2010	The slow-growing mmdh1mmdh2 mutant has elevated leaf respiration rate in the dark and light, without loss of photosynthetic capacity, suggesting that mMDH normally uses NADH to reduce oxaloacetate to malate, which is then exported to the cytosol, rather than to drive mitochondrial respiration.	malic acid	200-206	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	150-154	
12499697-1	2002	Activities of malate dehydrogenase (MDH) and aspartate aminotransferase in the malate-aspartate shuttle were significantly increased in the cytosolic fractions of livers with early neoplastic symptoms such as swelling and discoloration in transgenic mice carrying the prototype human c-Ha-ras gene, Tg-rasH2 mice, which were administered with diethylnitrosamine (DEN) as a carcinogenic chemical at a dose of 200 mg/kg body weight.	malic acid	14-20	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-39	
25606689-3	2015	Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH.	malic acid	18-24	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	40-43	
25606689-3	2015	Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH.	malic acid	74-80	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	40-43	
15086813-7	2004	Citrate synthase (CS) and malate dehydrogenase (MDH) enzyme activities increased substantially during ripening, as did citrate and malate contents.	malic acid	26-32	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	48-51	
8479597-1	1993	Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats.	malic acid	10-16	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	155-158	
8479597-1	1993	Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats.	malic acid	186-192	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	155-158	
8479597-4	1993	This study also determined if endogenous compounds, previously shown to alter malate metabolism, affected MDH activities.	malic acid	78-84	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	106-109	
8479597-11	1993	The greater sensitivity of mMDH, compared to cMDH, to certain effectors may be related to the dual role of mMDH in the tricarboxylic acid cycle and the malate-aspartate shuttle.	malic acid	152-158	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	27-31	
1291764-2	1992	mMDH exhibited the highest activities in the oxidation and reduction reactions at pH 9.5 and pH 6.2, respectively, while mME did so in the malate decarboxylation reaction at pH 6.8.	malic acid	139-145	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	0-4	
1291764-4	1992	The Km values for malate (1.7 mM) and oxaloacetate (0.17 mM) and the ratio of Vmax oxidation: Vmax reduction (2.73) tend to favor the oxaloacetate reduction by mMDH.	malic acid	18-24	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	160-164	
27208265-1	2016	Mitochondrial malate dehydrogenase (mMDH; EC 1.1.1.37) has multiple roles; the most commonly described is its catalysis of the interconversion of malate and oxaloacetate in the tricarboxylic acid cycle.	malic acid	14-20	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40	
26889011-1	2016	Mitochondrial malate dehydrogenase (mMDH) catalyses the interconversion of malate and oxaloacetate (OAA) in the tricarboxylic acid (TCA) cycle.	malic acid	14-20	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40	
22442717-10	2012	Altered FAAH(-/-) mitochondrial malate dehydrogenase (MDH2) acetylation, which can affect the malate aspartate shuttle, was consistent with our observation of a 25% decrease in fed malate and aspartate levels.	malic acid	32-38	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	54-58	
18403382-3	2008	H. carnosa readily oxidized malate via mME and mMDH in the presence of some cofactors such as thiamine pyrophosphate (TPP), coenzyme A (CoA) or NAD(+).	malic acid	28-34	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	47-51	
18403382-8	2008	The data in this research suggest that during phase III of PCK-CAM, H. carnosa mitochondria oxidized malate via both mME and the mMDH systems depending on metabolic requirements.	malic acid	101-107	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	129-133	
18403382-9	2008	However, malate metabolism by the mMDH system did not operate via a malate-OAA shuttle similarly to Ananas comosus mitochondria, but it operated via a malate-Asp shuttle similarly to Kalanchoe daigremontiana mitochondria.	malic acid	9-15	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	34-38	
15361538-9	2004	These results suggest that OAA played a significant role in the mitochondrial malate metabolism of pineapple, in which malate was mainly oxidized by active mMDH to produce OAA which could be exported outside the mitochondria via a malate-OAA shuttle.	malic acid	119-125	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	156-160