PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20876337-5 2010 The slow-growing mmdh1mmdh2 mutant has elevated leaf respiration rate in the dark and light, without loss of photosynthetic capacity, suggesting that mMDH normally uses NADH to reduce oxaloacetate to malate, which is then exported to the cytosol, rather than to drive mitochondrial respiration. malic acid 200-206 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 150-154 12499697-1 2002 Activities of malate dehydrogenase (MDH) and aspartate aminotransferase in the malate-aspartate shuttle were significantly increased in the cytosolic fractions of livers with early neoplastic symptoms such as swelling and discoloration in transgenic mice carrying the prototype human c-Ha-ras gene, Tg-rasH2 mice, which were administered with diethylnitrosamine (DEN) as a carcinogenic chemical at a dose of 200 mg/kg body weight. malic acid 14-20 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 36-39 25606689-3 2015 Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH. malic acid 18-24 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 40-43 25606689-3 2015 Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH. malic acid 74-80 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 40-43 15086813-7 2004 Citrate synthase (CS) and malate dehydrogenase (MDH) enzyme activities increased substantially during ripening, as did citrate and malate contents. malic acid 26-32 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 48-51 8479597-1 1993 Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats. malic acid 10-16 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 155-158 8479597-1 1993 Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats. malic acid 186-192 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 155-158 8479597-4 1993 This study also determined if endogenous compounds, previously shown to alter malate metabolism, affected MDH activities. malic acid 78-84 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 106-109 8479597-11 1993 The greater sensitivity of mMDH, compared to cMDH, to certain effectors may be related to the dual role of mMDH in the tricarboxylic acid cycle and the malate-aspartate shuttle. malic acid 152-158 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 27-31 1291764-2 1992 mMDH exhibited the highest activities in the oxidation and reduction reactions at pH 9.5 and pH 6.2, respectively, while mME did so in the malate decarboxylation reaction at pH 6.8. malic acid 139-145 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 0-4 1291764-4 1992 The Km values for malate (1.7 mM) and oxaloacetate (0.17 mM) and the ratio of Vmax oxidation: Vmax reduction (2.73) tend to favor the oxaloacetate reduction by mMDH. malic acid 18-24 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 160-164 27208265-1 2016 Mitochondrial malate dehydrogenase (mMDH; EC 1.1.1.37) has multiple roles; the most commonly described is its catalysis of the interconversion of malate and oxaloacetate in the tricarboxylic acid cycle. malic acid 14-20 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 36-40 26889011-1 2016 Mitochondrial malate dehydrogenase (mMDH) catalyses the interconversion of malate and oxaloacetate (OAA) in the tricarboxylic acid (TCA) cycle. malic acid 14-20 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 36-40 22442717-10 2012 Altered FAAH(-/-) mitochondrial malate dehydrogenase (MDH2) acetylation, which can affect the malate aspartate shuttle, was consistent with our observation of a 25% decrease in fed malate and aspartate levels. malic acid 32-38 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 54-58 18403382-3 2008 H. carnosa readily oxidized malate via mME and mMDH in the presence of some cofactors such as thiamine pyrophosphate (TPP), coenzyme A (CoA) or NAD(+). malic acid 28-34 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 47-51 18403382-8 2008 The data in this research suggest that during phase III of PCK-CAM, H. carnosa mitochondria oxidized malate via both mME and the mMDH systems depending on metabolic requirements. malic acid 101-107 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 129-133 18403382-9 2008 However, malate metabolism by the mMDH system did not operate via a malate-OAA shuttle similarly to Ananas comosus mitochondria, but it operated via a malate-Asp shuttle similarly to Kalanchoe daigremontiana mitochondria. malic acid 9-15 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 34-38 15361538-9 2004 These results suggest that OAA played a significant role in the mitochondrial malate metabolism of pineapple, in which malate was mainly oxidized by active mMDH to produce OAA which could be exported outside the mitochondria via a malate-OAA shuttle. malic acid 119-125 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 156-160