PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15720822-5 2004 Superoxide dismutase (SOD) and aminooxyacetate (AOA), a malate/aspartate shuttle inhibitor, strongly inhibited WST-1 reduction and reduced DCIP reduction by 40-60%, but failed to affect FeCN reduction, indicating involvement of mitochondrial TCA cycle-derived NADH and a possible role for superoxide in WST-1 but not FeCN reduction. malic acid 56-62 superoxide dismutase 1 Homo sapiens 0-20 20025971-1 2010 A gain of interaction of the amyotrophic lateral sclerosis (ALS)-linked G93A-superoxide dismutase-1 (G93A-hSOD1) with cytosolic malate dehydrogenase (cytMDH), a key enzyme in the malate-aspartate shuttle, diverts neurons towards anaerobic metabolism. malic acid 128-134 superoxide dismutase 1 Homo sapiens 106-111 20025971-5 2010 Amino-oxyacetate that inhibits the malate-aspartate shuttle caused a similar increase in VEGF mRNA and impaired response to H(2)O(2) in WT-hSOD1 expressing cells. malic acid 35-41 superoxide dismutase 1 Homo sapiens 139-144 20025971-7 2010 These results demonstrate that the ALS-linked G93A hSOD1 mutation impairs VEGF regulation compatible with the inhibition of neuronal malate-aspartate shuttle. malic acid 133-139 superoxide dismutase 1 Homo sapiens 51-56 18652897-2 2008 The FRET results confirmed by pull-down immunoprecipitation indicated "gain-of-interaction" of the G93A-hSOD1 mutant with cytosolic malate dehydrogenase (cytMDH)-a key enzyme in the malate-aspartate shuttle which is vital to neurons. malic acid 132-138 superoxide dismutase 1 Homo sapiens 104-109 18652897-4 2008 Consistent with inhibition of the malate-aspartate shuttle, G93A-hSOD1 had lower malate and higher lactate levels compared to non-induced or Wild-Type-hSOD1 expressing cells. malic acid 34-40 superoxide dismutase 1 Homo sapiens 65-70 18652897-4 2008 Consistent with inhibition of the malate-aspartate shuttle, G93A-hSOD1 had lower malate and higher lactate levels compared to non-induced or Wild-Type-hSOD1 expressing cells. malic acid 81-87 superoxide dismutase 1 Homo sapiens 65-70