PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 5158898-5 1971 Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate. malic acid 264-270 insulin Homo sapiens 48-55 1951684-8 1991 It is concluded that insulin (after 10-h fast) increases glycolytic flux and the content of malate in muscle, which is probably due to increased anaplerosis. malic acid 92-98 insulin Homo sapiens 21-28 19344310-0 2009 Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism. malic acid 22-28 insulin Homo sapiens 137-144 26811873-4 2016 The cellular contents of fumaric acid and malic acid were increased more by insulin than those of citric acid and succinic acid. malic acid 42-52 insulin Homo sapiens 76-83 19344310-4 2009 These findings indicate that increased malate-aspartate shuttle activity positively shifted beta-cell metabolism, thereby increasing glycolysis capacity, stimulus-secretion coupling and, ultimately, enhancing insulin secretion. malic acid 39-45 insulin Homo sapiens 209-216 12519834-9 2003 In addition, during the high-dose insulin clamp, the increase in cytosolic citrate and malate in muscle, which parallels and regulates malonyl CoA levels, was significantly less in the diabetic patients (P < 0.05 vs. P < 0.001). malic acid 87-93 insulin Homo sapiens 34-41 12070148-10 2002 Surprisingly the malate-aspartate shuttle inhibitor enabled pyruvate-stimulated insulin secretion. malic acid 17-23 insulin Homo sapiens 80-87