PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27989324-1	2017	MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.	malic acid	27-33	malate dehydrogenase 2	Homo sapiens	0-4	
29540758-7	2018	Moreover, we reveal that the ROS level and PCD are significantly increased in malate-treated HeLa cells, which can be dramatically attenuated by knockdown of the human gene MDH2, an ortholog of Arabidopsis mMDH1.	malic acid	78-84	malate dehydrogenase 2	Homo sapiens	173-177	
31489914-4	2019	The carbonic anhydrase (CA)-phosphoenolpyruvate carboxylase (PEPC)-malate dehydrogenase (MDH) is a key pathway inside nodules involved in this regulation, and malate seems to play a crucial role in many aspects of symbiotic N2 fixation control.	malic acid	67-73	malate dehydrogenase 2	Homo sapiens	89-92	
25766404-7	2015	Knockdown (KD) of MDH2 in HeLa cells by shRNA triggered the accumulation of both malate (mean +- SD: wild-type [WT] = 1+-0.18; KD = 2.24+-0.17, P = .043) and fumarate (WT = 1+-0.06; KD = 2.6+-0.25, P = .033), which was reversed by transient introduction of WT MDH2 cDNA.	malic acid	81-87	malate dehydrogenase 2	Homo sapiens	18-22	
24007662-6	2013	The concomitant down-regulation of all participating proteins (SLC25A11, SLC25A12, GOT2 and MDH2) of malate-aspartate shuttle might be responsible for the metabolic in-coordination between the cytosol and mitochondria resulting in the failure of energy metabolism.	malic acid	101-107	malate dehydrogenase 2	Homo sapiens	92-96	
11997255-6	2002	Enzymatic conversion of [3H]KG to Glu by glutamic dehydrogenase (GDH) or of [3H]OA to malate by malic dehydrogenase (MDH) "protects" the label from release by base, showing that base-induced isotope release is from keto acid rather than a result of release during the exchange process.	malic acid	86-92	malate dehydrogenase 2	Homo sapiens	96-115	
11997255-6	2002	Enzymatic conversion of [3H]KG to Glu by glutamic dehydrogenase (GDH) or of [3H]OA to malate by malic dehydrogenase (MDH) "protects" the label from release by base, showing that base-induced isotope release is from keto acid rather than a result of release during the exchange process.	malic acid	86-92	malate dehydrogenase 2	Homo sapiens	117-120	
35063410-7	2022	This new regulatory mechanism synergistically increases RC"s NADH oxidative capacity and rewires MDH2 driven anaplerosis of the TCA, preventing malate production from succinate to favour oxidation of cytosolic malate.	malic acid	144-150	malate dehydrogenase 2	Homo sapiens	97-101	
8398887-1	1993	Changes in the activity of lactate (EC 1.1.1.27, LDH) and malate (EC 1.1.1.37, MDH) dehydrogenases were measured in tissue extracts of human liver kept at 5 different temperatures until 35 days after death.	malic acid	58-64	malate dehydrogenase 2	Homo sapiens	79-82	
35063410-7	2022	This new regulatory mechanism synergistically increases RC"s NADH oxidative capacity and rewires MDH2 driven anaplerosis of the TCA, preventing malate production from succinate to favour oxidation of cytosolic malate.	malic acid	210-216	malate dehydrogenase 2	Homo sapiens	97-101