PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22243648-2 2012 The tacrine fragment was selected for its inhibition of cholinesterases, and the flavonoid scaffold derived from 4-oxo-4H -chromene was chosen for its radical capture and beta-secretase 1 (BACE-1) inhibitory activities. Flavonoids 81-90 beta-secretase 1 Homo sapiens 172-188 25779965-3 2015 In pursuit to find a potent inhibitor of BACE1, we identified galangin, a natural flavonoid, had a significant lowering effect on Abeta levels. Flavonoids 82-91 beta-secretase 1 Homo sapiens 41-46 22243648-2 2012 The tacrine fragment was selected for its inhibition of cholinesterases, and the flavonoid scaffold derived from 4-oxo-4H -chromene was chosen for its radical capture and beta-secretase 1 (BACE-1) inhibitory activities. Flavonoids 81-90 beta-secretase 1 Homo sapiens 190-196 22243648-4 2012 They are also potent inhibitors of human BACE-1, better than the parent flavonoid, apigenin. Flavonoids 72-81 beta-secretase 1 Homo sapiens 41-47 32899576-2 2020 Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition. Flavonoids 13-22 beta-secretase 1 Homo sapiens 86-92 21982844-6 2012 Additional mechanisms have been suggested for the ability of flavonoids to delay the initiation of and/or slow the progression of AD-like pathology and related neurodegenerative disorders, including a potential to inhibit neuronal apoptosis triggered by neurotoxic species (e.g., oxidative stress and neuroinflammation) or disrupt amyloid beta aggregation and effects on amyloid precursor protein processing through the inhibition of beta-secretase (BACE-1) and/or activation of alpha-secretase (ADAM10). Flavonoids 61-71 beta-secretase 1 Homo sapiens 450-456 21077260-6 2011 Nevertheless, the C-5 hydroxyl group of prenylated flavonoids is important for inhibition of BACE1 and ChEs, indicating that the hydroxyl group at C-5 might be the main contributor to the augmentation and/or modification of prenylated flavonol activity. Flavonoids 51-61 beta-secretase 1 Homo sapiens 93-98 21738321-3 2011 Recently, it was suggested that the Abeta lowering properties of flavonoids are mediated by a direct inhibition the beta-secretase (BACE-1) activity, the rate limiting enzyme responsible for the production of Abeta peptides. Flavonoids 65-75 beta-secretase 1 Homo sapiens 132-138 21738321-5 2011 A cell free chemoluminescent assay using human recombinant BACE-1 was used to assess the effect of flavonoids on BACE-1 activity. Flavonoids 99-109 beta-secretase 1 Homo sapiens 113-119 21738321-7 2011 Molecular docking simulations were performed to predict the binding of flavonoids to the BACE-1 catalytic site. Flavonoids 71-81 beta-secretase 1 Homo sapiens 89-95 21738321-8 2011 Real time quantitative PCR was used to determine the effect of flavonoids on BACE-1 transcription. Flavonoids 63-73 beta-secretase 1 Homo sapiens 77-83 21738321-9 2011 We show in a cell free assay that flavonoids are only weak inhibitors of BACE-1 activity. Flavonoids 34-44 beta-secretase 1 Homo sapiens 73-79 21738321-10 2011 Docking simulation studies with different BACE-1 structures also suggest that flavonoids are poor BACE-1 inhibitors as they appear to adopt various docking poses in the active site pocket and have weak docking scores that differ as a function of the BACE-1 structures studied. Flavonoids 78-88 beta-secretase 1 Homo sapiens 42-48 21738321-10 2011 Docking simulation studies with different BACE-1 structures also suggest that flavonoids are poor BACE-1 inhibitors as they appear to adopt various docking poses in the active site pocket and have weak docking scores that differ as a function of the BACE-1 structures studied. Flavonoids 78-88 beta-secretase 1 Homo sapiens 98-104 21738321-10 2011 Docking simulation studies with different BACE-1 structures also suggest that flavonoids are poor BACE-1 inhibitors as they appear to adopt various docking poses in the active site pocket and have weak docking scores that differ as a function of the BACE-1 structures studied. Flavonoids 78-88 beta-secretase 1 Homo sapiens 98-104 21738321-11 2011 Moreover, a weak correlation was observed between the effect of flavonoids on Abeta production in vitro and their ability to lower BACE-1 activity suggesting that the Abeta lowering properties of flavonoids in whole cells are not mediated via direct inhibition of BACE-1 activity. Flavonoids 64-74 beta-secretase 1 Homo sapiens 131-137 18295609-3 2008 In this study, we discovered that natural flavonoids act as non-peptidic BACE-1 inhibitors and potently inhibit BACE-1 activity and reduce the level of secreted Abeta in primary cortical neurons. Flavonoids 42-52 beta-secretase 1 Homo sapiens 73-79 18295609-3 2008 In this study, we discovered that natural flavonoids act as non-peptidic BACE-1 inhibitors and potently inhibit BACE-1 activity and reduce the level of secreted Abeta in primary cortical neurons. Flavonoids 42-52 beta-secretase 1 Homo sapiens 112-118 18295609-4 2008 In addition, we demonstrated the calculated docking poses of flavonoids to BACE-1 and revealed the interactions of flavonoids with the BACE-1 catalytic center. Flavonoids 61-71 beta-secretase 1 Homo sapiens 75-81 18295609-4 2008 In addition, we demonstrated the calculated docking poses of flavonoids to BACE-1 and revealed the interactions of flavonoids with the BACE-1 catalytic center. Flavonoids 115-125 beta-secretase 1 Homo sapiens 135-141 33073981-0 2020 Scope of beta-Secretase (BACE1)-Targeted Therapy in Alzheimer"s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition. Flavonoids 89-98 beta-secretase 1 Homo sapiens 25-30 33073981-0 2020 Scope of beta-Secretase (BACE1)-Targeted Therapy in Alzheimer"s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition. Flavonoids 89-98 beta-secretase 1 Homo sapiens 126-131 33073981-10 2020 We have particularly highlighted the scope of flavonoids as a new generation of nontoxic BACE1 inhibitory scaffolds. Flavonoids 46-56 beta-secretase 1 Homo sapiens 89-94 21738321-13 2011 As NFkappaB has been shown to regulate BACE-1 expression, we show that NFkappaB lowering flavonoids inhibit BACE-1 transcription in human neuronal SH-SY5Y cells. Flavonoids 89-99 beta-secretase 1 Homo sapiens 39-45 21738321-13 2011 As NFkappaB has been shown to regulate BACE-1 expression, we show that NFkappaB lowering flavonoids inhibit BACE-1 transcription in human neuronal SH-SY5Y cells. Flavonoids 89-99 beta-secretase 1 Homo sapiens 108-114 21738321-14 2011 Altogether, our data suggest that flavonoids inhibit Abeta and sAPPbeta production by regulating BACE-1 expression and not by directly inhibiting BACE-1 activity. Flavonoids 34-44 beta-secretase 1 Homo sapiens 97-103 33010267-0 2020 Flavonoids as BACE1 inhibitors: QSAR modelling, screening and in vitro evaluation. Flavonoids 0-10 beta-secretase 1 Homo sapiens 14-19 32867308-2 2020 Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition. Flavonoids 18-27 beta-secretase 1 Homo sapiens 87-93 32785161-5 2020 A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models. Flavonoids 82-91 beta-secretase 1 Homo sapiens 205-211 32785161-6 2020 A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed. Flavonoids 47-57 beta-secretase 1 Homo sapiens 116-122