PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	cAMP responsive element binding protein 1	Mus musculus	228-265	
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	cAMP responsive element binding protein 1	Mus musculus	267-271	
23208771-7	2013	These results indicate that the 4"-O-methyl group of flavonoids plays an important role in the induction of melanogenesis by activating its major signal transduction pathway through the upregulation of phospho-CREB in murine B16F10 melanoma cells.	Flavonoids	53-63	cAMP responsive element binding protein 1	Mus musculus	210-214