PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33439402-2 2021 In this present work, a set of alkaloids and flavonoids against AChE enzyme were screened by computational chemistry techniques. Flavonoids 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). Flavonoids 169-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). Flavonoids 169-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 34887704-0 2021 Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin. Flavonoids 83-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 34252860-4 2021 The best 3D-QSAR acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors pharmacophore hypotheses Hypo1 A and Hypo1 B were generated and validated by HypoGen program in Discovery Studio 2016 based on the training set of flavonoids, and then they were used as 3D query for screening the ZINC database. Flavonoids 236-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 35527825-2 2022 We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids. Flavonoids 203-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35053900-4 2022 In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6.42 +- 0.07 microM, through a monophasic kinetic process. Flavonoids 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 33939580-0 2021 A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities. Flavonoids 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 34193695-1 2021 Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzheimer"s disease (AD). Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 34193695-1 2021 Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzheimer"s disease (AD). Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 34193695-2 2021 In present study, in line with our interests in flavonoid derivatives as AChE inhibitors, a four-dimensional quantitative structure-activity relationship (4D-QSAR) molecular model was proposed. Flavonoids 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 34193695-7 2021 The molecular docking analysis was also carried out to understand exceedingly the interactions between flavonoids and the AChE targets, which was in good agreement with the 4D-QSAR model. Flavonoids 103-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 34193695-8 2021 Based on the information provided by the 4D-QSAR model and molecular docking analysis, the idea for optimizing the structures of flavonoids as AChE inhibitors was put forward which maybe provide theoretical guidance for the research and development of new AChE inhibitors. Flavonoids 129-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 34193695-8 2021 Based on the information provided by the 4D-QSAR model and molecular docking analysis, the idea for optimizing the structures of flavonoids as AChE inhibitors was put forward which maybe provide theoretical guidance for the research and development of new AChE inhibitors. Flavonoids 129-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 32867308-2 2020 Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition. Flavonoids 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 33054569-10 2022 These findings broaden our understanding of Vincetoxicum metabolites and highlight the potential of glycosylated flavonoids as AChE inhibitors. Flavonoids 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 32899576-2 2020 Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition. Flavonoids 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32754990-0 2020 Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition. Flavonoids 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 32785161-0 2020 Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches. Flavonoids 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32785161-5 2020 A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models. Flavonoids 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 32785161-6 2020 A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed. Flavonoids 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 32785161-6 2020 A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed. Flavonoids 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 29258018-3 2018 Flavonoids with AChE inhibitory activities and low toxicity are used to developing new anti-AD agents. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 32765630-3 2020 The plant kingdom is extremely rich in a variety of compounds that are potent AChE inhibitors: flavonoids and other phenolic compounds have been recognized as promising Alzheimer"s treatment agents. Flavonoids 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 29635895-0 2018 Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 29635895-8 2018 This review deals with various plant-derived flavonoids, their preclinical potential as AChE inhibitors, in established assays, possible mechanisms of action, and structural activity relationship (SAR). Flavonoids 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 29635895-9 2018 RESULTS AND CONCLUSIONS: Subsequently, a number of plant-derived flavonoids with outstanding efficacy and potency as AChE inhibitors, the mechanistic, their safety profiles, and pharmacokinetic attributes have been discussed. Flavonoids 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 31983197-0 2020 Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions. Flavonoids 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 31983197-0 2020 Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions. Flavonoids 138-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30267791-0 2018 MIA-QSAR based model for bioactivity prediction of flavonoid derivatives as acetylcholinesterase inhibitors. Flavonoids 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). Flavonoids 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). Flavonoids 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Flavonoids 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-246 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Flavonoids 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 248-252 27871793-0 2017 Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer"s disease. Flavonoids 131-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 27871793-1 2017 The current objective of the study is to identify inhibitory affinity potential of the certain commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) enzyme using in silico and in vitro studies. Flavonoids 118-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 27871793-1 2017 The current objective of the study is to identify inhibitory affinity potential of the certain commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) enzyme using in silico and in vitro studies. Flavonoids 118-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 27871793-6 2017 In vitro results showed that all the selected flavonoids displayed excellent concentration-dependant inhibition of AChE. Flavonoids 46-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 23601990-1 2014 A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). Flavonoids 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 27591048-5 2017 Actually, it was shown that this flavonoid may bind to the red blood cell membrane surface, which may improve the interaction between EGCG and AChE. Flavonoids 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 25143139-1 2014 The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers. Flavonoids 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 25143139-1 2014 The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers. Flavonoids 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 25143139-2 2014 However, few reports have focused on the structure-activity relationship for AChE inhibition of flavonoids. Flavonoids 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 25143139-3 2014 This work mainly concerns the structural aspects of inhibitory activities and binding affinities of flavonoids as AChE inhibitors. Flavonoids 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 25143139-4 2014 The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the affinities for AChE. Flavonoids 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25143139-4 2014 The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the affinities for AChE. Flavonoids 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 25143139-6 2014 The glycosylation decreases the AChE inhibitory activities of flavonoids and lowers the affinities for AChE by 1 to 5 times depending on the conjunction site and the type of sugar moiety. Flavonoids 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 25143139-8 2014 The molecular property-affinity relationship reveals that the hydrogen bond force plays an important role in binding flavonoids to AChE. Flavonoids 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 25143139-9 2014 The AChE inhibitions generally increase with the increasing affinities of flavonoids within the class, especially for flavones and flavonols. Flavonoids 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 23601990-1 2014 A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). Flavonoids 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23601990-3 2014 Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE. Flavonoids 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23601990-3 2014 Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE. Flavonoids 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 23643881-1 2013 We have recently synthesized a series of phosphorylated flavonoids and identified some of them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity for CEase over acetylcholinesterase (AChE). Flavonoids 56-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 25312618-3 2014 Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD. Flavonoids 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 25312618-3 2014 Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD. Flavonoids 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 22087826-0 2011 Flavonoids as acetylcholinesterase inhibitors. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 23931437-7 2013 2) Coumarins, flavonoids, stilbenes, and other natural products are also important AChE inhibitors from natural products. Flavonoids 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 23511019-1 2013 A new series of flavonoid derivatives were designed, synthesized and evaluated as potential multifunctional AChE inhibitors against Alzheimer"s disease. Flavonoids 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 22087826-3 2011 Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22087826-4 2011 This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Flavonoids 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 22087826-4 2011 This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Flavonoids 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 19692250-0 2009 Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors. Flavonoids 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 20452337-3 2010 Here, we searched potential AChE inhibitors from flavonoids, a group of naturally occurring compounds in plants or traditional Chinese medicines (TCM). Flavonoids 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 20452337-4 2010 Twenty-one flavonoids, covered different subclasses, were tested for their potential function in inhibiting AChE activity from the brain in vitro. Flavonoids 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 20452337-6 2010 showed an inhibitory effect on AChE activity with the highest inhibition by over 55% and an IC(50) of 120 microM and an enzyme-flavonoid inhibition constant (K(i)) of 74 microM. Flavonoids 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 19692250-1 2009 A new series of flavonoid derivatives have been designed, synthesized and evaluated as potent AChE inhibitors. Flavonoids 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18830885-0 2009 Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors. Flavonoids 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18830885-1 2009 A new series of flavonoid derivatives have been designed, synthesised and evaluated as acetylcholinesterase inhibitors that could bind simultaneously to the peripheral and catalytic sites of the enzyme. Flavonoids 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107