PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21720915-0 2011 Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin. Flavonoids 47-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 22743247-10 2012 Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation. Flavonoids 50-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-187 22749133-2 2013 The present study aimed to characterize the metabolism and further antiproliferative activity of the natural flavonoid diosmetin in the CYP1-expressing human hepatoma cell line HepG2. Flavonoids 109-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 136-140 22743247-0 2012 Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. Flavonoids 28-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-55 22743247-1 2012 Recent studies have demonstrated cytochrome P450 CYP1-mediated metabolism and CYP1-enzyme induction by naturally occurring flavonoids in cancer cell line models. Flavonoids 123-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-82 21482471-9 2011 Homology modeling in conjunction with molecular docking calculations were employed in an effort to rationalize the activity of these flavonoids based on their CYP1-binding mode. Flavonoids 133-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 159-163 21482471-0 2011 Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Flavonoids 73-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 21482471-2 2011 Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports the concept of dietary chemoprevention. Flavonoids 88-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 21482471-3 2011 In parallel, recent studies have documented the ability of CYP1 enzymes to selectively metabolize dietary flavonoids to conversion products that inhibit cancer cell proliferation. Flavonoids 106-116 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-63 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Flavonoids 114-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Flavonoids 114-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-60 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Flavonoids 114-123 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Flavonoids 114-123 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-60 21329749-8 2011 The inhibitory potency of flavonols on CYP1A1 activity in presence of B[a]P was much stronger for the aglycones than for the 3-O-rutinosides, explaining the slight effect observed with the GBE, mainly composed of glycosylated flavonoids. Flavonoids 226-236 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 21482471-10 2011 Taken together the data suggest that dietary flavonoids exhibit three distinct modes of action with regard to cancer prevention, based on their hydroxyl and methoxy decoration: (1) inhibitors of CYP1 enzymatic activity, (2) CYP1 substrates and (3) substrates and inhibitors of CYP1 enzymes. Flavonoids 45-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 195-199 21482471-10 2011 Taken together the data suggest that dietary flavonoids exhibit three distinct modes of action with regard to cancer prevention, based on their hydroxyl and methoxy decoration: (1) inhibitors of CYP1 enzymatic activity, (2) CYP1 substrates and (3) substrates and inhibitors of CYP1 enzymes. Flavonoids 45-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 224-228 21482471-10 2011 Taken together the data suggest that dietary flavonoids exhibit three distinct modes of action with regard to cancer prevention, based on their hydroxyl and methoxy decoration: (1) inhibitors of CYP1 enzymatic activity, (2) CYP1 substrates and (3) substrates and inhibitors of CYP1 enzymes. Flavonoids 45-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 224-228 19608276-3 2010 Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1). Flavonoids 84-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 197-216 21053930-0 2010 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Flavonoids 107-116 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-91 19608276-3 2010 Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1). Flavonoids 84-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 218-224 20696580-3 2010 In this study, we first evaluated the structure-property relationship of 18 major flavonoids on inhibiting enzymatic activity of CYP1A1, 1A2 and 1B1 by using an ethoxyresorufin O-deethylation assay. Flavonoids 82-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 129-135 20696580-9 2010 In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues. Flavonoids 73-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-91 20696580-9 2010 In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues. Flavonoids 73-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 237-241 20696580-9 2010 In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues. Flavonoids 157-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-91 20696580-9 2010 In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues. Flavonoids 157-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 237-241 20550209-1 2010 Galangin, a dietary flavonoid, inhibited cytochrome P450 1A1 (CYP1A1) expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Flavonoids 20-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-60 20550209-1 2010 Galangin, a dietary flavonoid, inhibited cytochrome P450 1A1 (CYP1A1) expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Flavonoids 20-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 19766177-0 2009 CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells. Flavonoids 40-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 20153368-0 2010 Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes. Flavonoids 8-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-102 20153368-3 2010 Flavonoids have traditionally been described as CYP1 inhibitors due to the inhibition of carcinogenic product formation and consequent blockage of the initiation stage of carcinogenesis. Flavonoids 0-10 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-52 20153368-4 2010 However, mounting evidence indicate that flavonoids are also capable of acting as CYP1 substrates, undergoing bioactivation to more antiproliferative agents within cancer cells. Flavonoids 41-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-86 20153368-7 2010 Moreover, a thorough investigation of the substrate specificity of flavonoids for the active site of CYP1 enzymes is undertaken. Flavonoids 67-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 101-105 20153368-9 2010 Ultimately, the mode of flavonoid action, in terms of CYP1 inhibition or CYP1-mediated bioactivation, is dependent on the lipophilicity or hydrophilicity of each compound. Flavonoids 24-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-58 20153368-9 2010 Ultimately, the mode of flavonoid action, in terms of CYP1 inhibition or CYP1-mediated bioactivation, is dependent on the lipophilicity or hydrophilicity of each compound. Flavonoids 24-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-77 19666078-0 2009 CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells. Flavonoids 52-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 19666078-8 2009 Taken together the data suggests that CYP1 family enzymes enhance the antiproliferative activity of dietary flavonoids in breast cancer cells, through bioconversion to more active products. Flavonoids 108-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-42 19666078-1 2009 Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. Flavonoids 91-101 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 152-156 19666078-2 2009 In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated. Flavonoids 44-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 129-135 17090139-3 2006 When each flavonoid with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was added to dioxin-responsive HepG2 cells, seven flavonoids significantly restrained the TCDD-induced transcriptional activity of the CYP1A1 promoter. Flavonoids 10-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 203-209 17637178-5 2007 Previous observations in our laboratory demonstrated that methoxylated flavonoids may be effective inhibitors of CYP1A1 transcription and activity as well as being orally bioavailable. Flavonoids 71-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 19601638-1 2009 Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer. Flavonoids 0-10 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 19424633-0 2009 Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. Flavonoids 26-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 131-135 18976853-3 2009 In this study we investigated the anticancer activity of the flavonoid diosmetin, as a result of cytochrome P450 CYP1 metabolism. Flavonoids 61-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-117 18976853-9 2009 Taken together these data suggest that the flavonoid diosmetin is metabolised to the more active molecule luteolin by CYP1 family enzymes. Flavonoids 43-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-122 17159770-4 2006 Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. Flavonoids 29-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-73 17159770-4 2006 Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. Flavonoids 29-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 224-243 17159770-4 2006 Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. Flavonoids 166-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-73 17159770-5 2006 RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Flavonoids 24-34 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 17159770-5 2006 RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Flavonoids 24-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 17090139-0 2006 TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. Flavonoids 78-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 17090139-3 2006 When each flavonoid with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was added to dioxin-responsive HepG2 cells, seven flavonoids significantly restrained the TCDD-induced transcriptional activity of the CYP1A1 promoter. Flavonoids 118-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 203-209 17090139-4 2006 Furthermore, those seven flavonoids that had permeated the Caco-2 cell monolayers demonstrated an inhibitory effect on both the AhR transformation and on the transcriptional activity of the CYP1A1 promoter. Flavonoids 25-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 190-196 16454693-7 2006 Certain dietary indoles and flavonoids activate CYP1A expression either by direct ligand interaction with the aryl hydrocarbon receptor (AhR) or by augmenting the interaction of the AhR with xenobiotic response elements in CYP1A1 and other target genes. Flavonoids 28-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 223-229 16271822-0 2006 Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John"s wort. Flavonoids 48-58 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-36 16271822-2 2006 In order to investigate whether flavonoids could specifically inhibit CYP 1B1, seven flavonoids in St. John"s wort and apigenin were screened for their inhibition of recombinant human CYP 1B1 and CYP 1A1. Flavonoids 32-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 196-203 16271822-3 2006 While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different. Flavonoids 12-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 199-206 16271822-10 2006 Depending on their bioavailability, flavonoids that can selectively inhibit CYP1 enzymes may be useful as chemoprotective agents in prostate cancer prevention. Flavonoids 36-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-80 16484233-13 2006 Two methoxylated dietary flavonoids with highly specific effects on BaP bioactivation block this DNA binding and CYP1A1 protein expression as effectively as RV, thus making them potential chemopreventive agents for BaP-induced lung carcinogenesis. Flavonoids 25-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 16276964-2 2005 In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase. Flavonoids 88-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-131 16276964-2 2005 In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase. Flavonoids 88-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 326-332 11950788-3 2002 We also determined whether flavonoid treatment affected sulfate conjugation and CYP1A1 activity. Flavonoids 27-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 12970578-0 2003 Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Flavonoids 8-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 11454723-0 2001 The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Flavonoids 78-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 11752233-0 2002 Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Flavonoids 0-10 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 11454723-1 2001 We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction. Flavonoids 61-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-82 11454723-3 2001 Of these flavonoids, resveratrol produced the greatest increase in CYP1A1-mediated luciferase activity (10-fold), whereas GTE, apigenin, curcumin, and kaempferol produced 2- to 3-fold increases in activity. Flavonoids 9-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 11454723-6 2001 Cotreatment of cells with TCDD and GTE, naringenin, and apigenin resulted in 58, 77, and 74% reductions, respectively, in TCDD-mediated CYP1A1 induction, indicating that these flavonoids exhibit potential antagonist activity toward the aryl hydrocarbon (Ah) receptor. Flavonoids 176-186 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 136-142 10781868-1 2000 Interactions of six naturally occurring flavonoids (acacetin, diosmetin, eriodictyol, hesperetin, homoeriodictyol, and naringenin) with human cytochrome P450 (CYP1) enzymes were studied. Flavonoids 40-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 159-163 30680817-2 2019 In this study, inhibitory effects of flavonoids baicalein and oroxylin A, a metabolite of baicalein in human body, on CYP1A1 and 1B1 activities were investigated in vitro. Flavonoids 37-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-132 31655123-0 2020 Human CYP1A1 inhibition by flavonoids. Flavonoids 27-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-12 31655123-6 2020 In silico studies have shown that, Phe224 and other aromatic residues in the human CYP1A1 active site play an important role in flavonoid-CYP interaction, through a pi/pi stacking between the aminoacid and the flavonoid C-ring. Flavonoids 128-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 31655123-6 2020 In silico studies have shown that, Phe224 and other aromatic residues in the human CYP1A1 active site play an important role in flavonoid-CYP interaction, through a pi/pi stacking between the aminoacid and the flavonoid C-ring. Flavonoids 210-219 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 31721711-5 2019 A dataset of reported compounds against CYP1 belongs to 10 different classes (alkaloids, coumarins, flavonoids, natural compounds, synthetic inhibitors, drugs, MBI"s, PAHs, naphthoquinone and stilbenoids) was retrieved and utilized for the comparative molecular docking analyses followed by pharmacophore modeling. Flavonoids 100-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-44 30448188-2 2018 Hence, phytochemicals or dietary flavonoids, if identified as CYP1A1 inhibitors, may help in preventing PAH-mediated carcinogenesis and breast cancer. Flavonoids 33-43 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 28632894-2 2017 In vitro, flavonoids predominantly inhibit the major phase I drug-metabolizing enzyme CYP450 3A4 and the enzymes responsible for the bioactivation of procarcinogens (CYP1 enzymes) and upregulate the enzymes involved in carcinogen detoxification (UDP-glucuronosyltransferases, glutathione S-transferases (GSTs)). Flavonoids 10-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 166-170 29593542-8 2018 Both flavonoids suppressed pro-intravasative trigger factors in MDA-MB231 breast cancer cells, specifically MMP1 expression and CYP1A1 activity. Flavonoids 5-15 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 26757127-5 2015 The effects of flavonoids on CYP1A1/2, CYP1A2 or CYP2B1/2 enzyme activities in microsomes were measured using marker activities of these enzymes. Flavonoids 15-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 28273931-7 2017 In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and CYP1A1 genetic variants. Flavonoids 37-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 126-132 27551833-5 2016 This review summarizes the structural features responsible for the CYP1 inhibitory effects of the reported flavonoids and naphthoflavonoids. Flavonoids 107-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-71 25109996-4 2014 Other effects include the ability of flavonoids to modulate the CYP1 (cytochrome P450 1) and ABC (ATP-binding cassette) protein families, involved in carcinogenesis and drug delivery respectively. Flavonoids 37-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-68 23994263-0 2014 Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism. Flavonoids 92-101 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 174-178 23994263-2 2014 In the present study we investigated the interaction of the two flavonoids with cytochrome P450 CYP1 enzymes in breast cancer MCF7 cells. Flavonoids 64-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-100 25109996-4 2014 Other effects include the ability of flavonoids to modulate the CYP1 (cytochrome P450 1) and ABC (ATP-binding cassette) protein families, involved in carcinogenesis and drug delivery respectively. Flavonoids 37-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-87