PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19666078-2 2009 In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated. Flavonoids 44-54 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 137-143 22743247-10 2012 Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation. Flavonoids 50-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 192-198 21482471-0 2011 Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Flavonoids 73-83 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 23-29 21482471-2 2011 Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports the concept of dietary chemoprevention. Flavonoids 88-98 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 35-41 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Flavonoids 114-124 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Flavonoids 114-123 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 21053930-1 2010 Structure-function relationships for the inhibition of human cytochrome P450s (P450s) 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives were studied. Flavonoids 120-129 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 61-104 21053930-2 2010 Thirty-two of the 33 flavonoids tested produced reverse type I binding spectra with P450 1B1, and the potencies of binding were correlated with the abilities to inhibit 7-ethoxyresorufin O-deethylation activity. Flavonoids 21-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 84-92 20696580-5 2010 Flavonoids used in this study selectively inhibited CYP1B1 activity. Flavonoids 0-10 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 52-58 20696580-9 2010 In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues. Flavonoids 73-83 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 237-243 20696580-9 2010 In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues. Flavonoids 157-167 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 237-243 23448447-10 2013 In this review, we provide a comprehensive overview of breast cancer and chemoprevention by flavonoids, mainly focusing on ER-mediated hormonal regulation, redox cycling of estrogen metabolites, and selective inhibition of CYP1B1. Flavonoids 92-102 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 223-229 19563207-0 2009 Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Flavonoids 71-80 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-59 19601638-1 2009 Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer. Flavonoids 0-10 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 122-128 19563207-5 2009 Among 14 flavonoids examined, 3,5,7-trihydroxyflavone and 4"-methoxy- and 3",4"-dimethoxy-5,7-dihydroxyflavone were more active than flavone in interacting with P450 1B1, but the respective 7,8-dihydroxyflavones were less active. Flavonoids 9-19 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 161-169 16530937-4 2007 The dietary flavonoid 5,7-dimethoxyflavone significantly inhibited BaP-DNA binding and down-regulated BaP-induced CYP1B1 mRNA and protein. Flavonoids 12-21 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 114-120 35387543-9 2022 Introduction of a 57diOHF moiety into these methoxylated flavonoids caused decreased in oxidation by CYP1B1 and 2A13. Flavonoids 57-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 101-116 10781868-0 2000 Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Flavonoids 0-13 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-87 16271822-2 2006 In order to investigate whether flavonoids could specifically inhibit CYP 1B1, seven flavonoids in St. John"s wort and apigenin were screened for their inhibition of recombinant human CYP 1B1 and CYP 1A1. Flavonoids 32-42 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 70-77 16271822-2 2006 In order to investigate whether flavonoids could specifically inhibit CYP 1B1, seven flavonoids in St. John"s wort and apigenin were screened for their inhibition of recombinant human CYP 1B1 and CYP 1A1. Flavonoids 32-42 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 184-191 16271822-3 2006 While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different. Flavonoids 12-22 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 138-145 16276964-2 2005 In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase. Flavonoids 88-98 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 345-351 15905203-10 2005 Methoxylated dietary flavonoids, e.g. DMF and 3",4"-DMF, may be potent chemoprotectants by direct inhibition of CYP1B1/1A1 function and/or their protein expression. Flavonoids 21-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 112-118 28119082-4 2017 Herein, we investigated the inhibitory activity of fisetin and flavone against CYP1B1 using estrogen E2 as substrate in vitro to reveal structure-activity relationship between structure of flavonoids and inhibition. Flavonoids 189-199 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 79-85 28322972-4 2017 Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3",5"-tetramethoxystilbene. Flavonoids 13-23 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 80-86 28259840-3 2017 Flavonoids have a compact rigid skeleton which fit precisely within the binding cavity of CYP1B1. Flavonoids 0-10 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 90-96 28259840-4 2017 Systematic isosteric replacement of flavonoid "O" atom with "N" atom led to the prediction that a "quinazoline" scaffold could be the basis for designing potential CYP1B1 inhibitors. Flavonoids 36-45 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 164-170 28119082-9 2017 Taken together the data suggested that fisetin is able to inhibit the formation of carcinogenic 4-OHE2 from E2, which reveals one of its anti-cancer mechanisms and helps to reveal the relationship between the structure of flavonoids and the inhibition CYP1B1 for discovering new drugs in cancer therapy and prevention. Flavonoids 222-232 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 252-258