PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	Flavonoids	30-40	monoamine oxidase A	Homo sapiens	184-190	
33212830-8	2020	The calculated binding free energies of the O-methylated flavonoids (1 and 4-6) and chalcones (2 and 3) to MAO-A matched closely with the trend in the experimental IC50"s.	Flavonoids	57-67	monoamine oxidase A	Homo sapiens	107-112	
33212830-10	2020	The natural O-methylated flavonoid (1) with highly potent inhibition (IC50 33 nM; Ki 37.9 nM) and >292 fold selectivity against human MAO-A (vs. MAO-B) provides a new drug lead for the treatment of neurological disorders.	Flavonoids	25-34	monoamine oxidase A	Homo sapiens	134-139	
30678358-4	2019	Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors.	Flavonoids	24-34	monoamine oxidase A	Homo sapiens	74-79	
30396116-5	2019	The IC50 value of 5 for hMAO-A was the lowest amongst all natural flavonoids reported to date, and the potency was 20.2 times higher than that of toloxatone (1.03 microM), a marketed drug.	Flavonoids	66-76	monoamine oxidase A	Homo sapiens	24-30	
32403270-4	2020	In this investigation, twenty synthesized flavonoid derivatives, defined as KKR compounds were screened for their inhibitory potentials against human MAO-A and MAO-B isozymes.	Flavonoids	42-51	monoamine oxidase A	Homo sapiens	150-155	
30933784-4	2019	Comparison of the inhibitory activities of 1a vs. 9a vs. 13a and 1b vs. 7b vs. 11b suggested that methoxy substitution at R1 on the A-rings of flavonoids increases MAO-A inhibition whereas methoxy substitution at R2 increased MAO-B inhibition.	Flavonoids	143-153	monoamine oxidase A	Homo sapiens	164-169	
27754693-3	2016	Further bioassay-guided fractionation led to the isolation of a flavonoid, acacetin, as the most prominent MAO inhibitory constituent, with IC50 values of 121 and 49 nM for MAO-A and -B, respectively.	Flavonoids	64-73	monoamine oxidase A	Homo sapiens	173-185	
29496172-0	2018	Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants.	Flavonoids	49-59	monoamine oxidase A	Homo sapiens	20-45	
29268246-8	2018	The flavonoids catechin and cyanidin were not inhibitors of MAO by HPLC-DAD but highly inhibited the oxidation of TMB (or Amplex Red) by peroxidase whereas quercetin and resveratrol were moderate inhibitors of MAO-A by HPLC-DAD, but inhibited the peroxidase assay in a higher level.	Flavonoids	4-14	monoamine oxidase A	Homo sapiens	210-215	
29568754-7	2018	Quercetin and flavonoids significantly contributed to MAO-A inhibition.	Flavonoids	14-24	monoamine oxidase A	Homo sapiens	54-59	
29268246-6	2018	The new method was applied to study the inhibition of human MAO-A and -B by bioactive compounds including beta-carboline alkaloids and flavonoids occurring in foods and plants.	Flavonoids	135-145	monoamine oxidase A	Homo sapiens	60-72	
21311414-10	2011	Flavonoids of several classes are inhibitors of monoamine oxidase A or B, thereby working as anti-depressants or to improve the conditions of Parkinson"s patients.	Flavonoids	0-10	monoamine oxidase A	Homo sapiens	48-72	
28962277-3	2014	Plant flavonoids, such as flavonol quercetin and flavone luteolin, have been suggested to be potential antidepressant compounds because they exert a suppressive effect on the MAO-A reaction.	Flavonoids	6-16	monoamine oxidase A	Homo sapiens	175-180	
28962277-4	2014	We evaluated the effects of these flavonoids on MAO-A activity and protein level using SH-SY5Y as model serotoninergic nerve cells.	Flavonoids	34-44	monoamine oxidase A	Homo sapiens	48-53	
25857233-8	2015	Flavonoids inhibited MAOs with variable degrees and were more prominent in inhibition toward MAO-A than hirsutinolides, while two of hirsutinolides inhibited MAO-B approximately comparable to two flavonoids.	Flavonoids	0-10	monoamine oxidase A	Homo sapiens	93-98