PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24354565-6 2014 Our QM/MM computations also confirmed that these two flavonoids have lower reaction energetic barriers for COMT-catalyzed meta-O-methylation than para-O-methylation. Flavonoids 53-63 catechol-O-methyltransferase Homo sapiens 107-111 29168878-1 2018 Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins. Flavonoids 52-62 catechol-O-methyltransferase Homo sapiens 149-178 29168878-1 2018 Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins. Flavonoids 52-62 catechol-O-methyltransferase Homo sapiens 180-184 27826992-4 2017 In this review article, the important contribution of dietary catechol-containing flavonoids to modification of the relationships between the COMT genotype and cancer risk is discussed. Flavonoids 82-92 catechol-O-methyltransferase Homo sapiens 142-146 27826992-5 2017 Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens. Flavonoids 252-262 catechol-O-methyltransferase Homo sapiens 193-197 27826992-5 2017 Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens. Flavonoids 252-262 catechol-O-methyltransferase Homo sapiens 307-311 27826992-6 2017 Such a many-featured functioning of the COMT and its complex regulation by several different genetic and environmental factors, including plant-based food ingredients, emphasizes the necessity to further stratify the association studies between the COMT genotype and tumor risk by consumption of catechol-containing dietary flavonoids. Flavonoids 324-334 catechol-O-methyltransferase Homo sapiens 40-44 27826992-6 2017 Such a many-featured functioning of the COMT and its complex regulation by several different genetic and environmental factors, including plant-based food ingredients, emphasizes the necessity to further stratify the association studies between the COMT genotype and tumor risk by consumption of catechol-containing dietary flavonoids. Flavonoids 324-334 catechol-O-methyltransferase Homo sapiens 249-253 27522262-0 2016 Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT). Flavonoids 29-38 catechol-O-methyltransferase Homo sapiens 140-168 27522262-0 2016 Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT). Flavonoids 29-38 catechol-O-methyltransferase Homo sapiens 170-174 15100171-7 2004 We also determined, for comparison, two common bioflavonoids (quercetin and fisetin) for their inhibitory effects on human liver COMT-mediated O-methylation of catechol estrogens. Flavonoids 47-60 catechol-O-methyltransferase Homo sapiens 129-133 24588554-7 2014 Second, phase II metabolic enzymes (UGTs, SULTs and COMT) dominate the metabolism of flavonoids in vivo. Flavonoids 85-95 catechol-O-methyltransferase Homo sapiens 52-56 22696302-6 2012 It shows that although the prooxidant action of flavonoids may be the main factor in their cytotoxicity, the hydroxylation and oxidative demethylation by cytochromes P-450 and O-methylation by catechol-O-methyltransferase can significantly modulate the cytotoxicity of the parent compounds. Flavonoids 48-58 catechol-O-methyltransferase Homo sapiens 193-221 20300638-5 2010 High performance liquid chromatography (HPLC) and mass spectrometry (MS) showed that quercetin was transformed into a compound with a mass identical to tamarixetin, suggesting that the flavonoid was methylated by catechol-O-methyl transferase (COMT) within platelets. Flavonoids 185-194 catechol-O-methyltransferase Homo sapiens 213-242 20300638-5 2010 High performance liquid chromatography (HPLC) and mass spectrometry (MS) showed that quercetin was transformed into a compound with a mass identical to tamarixetin, suggesting that the flavonoid was methylated by catechol-O-methyl transferase (COMT) within platelets. Flavonoids 185-194 catechol-O-methyltransferase Homo sapiens 244-248 17880176-2 2007 In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins). Flavonoids 364-377 catechol-O-methyltransferase Homo sapiens 88-92 15100171-0 2004 Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. Flavonoids 54-67 catechol-O-methyltransferase Homo sapiens 146-174 15100171-9 2004 Enzyme kinetic analyses showed that both tea catechins and bioflavonoids inhibited human liver COMT-mediated O-methylation of 4-OH-E(2) (a representative substrate) with a mixed mechanism of inhibition (competitive plus noncompetitive). Flavonoids 59-72 catechol-O-methyltransferase Homo sapiens 95-99 15100171-10 2004 In summary, the catechol-containing tea catechins and bioflavonoids are strong inhibitors of human liver COMT-mediated O-methylation of catechol estrogens. Flavonoids 54-67 catechol-O-methyltransferase Homo sapiens 105-109 7347133-1 1981 The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition. Flavonoids 76-89 catechol-O-methyltransferase Homo sapiens 104-132 7347133-1 1981 The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition. Flavonoids 76-89 catechol-O-methyltransferase Homo sapiens 134-138 33932529-0 2021 Discovery and characterization of flavonoids in vine tea as catechol-O-methyltransferase inhibitors. Flavonoids 34-44 catechol-O-methyltransferase Homo sapiens 60-88 33932529-4 2021 Five flavonoids in vine tea displayed moderate to strong inhibition on hCOMT with IC50 values ranging from 0.96 muM to 42.47 muM, in which myricetin was the critically potent constituent against hCOMT. Flavonoids 5-15 catechol-O-methyltransferase Homo sapiens 71-76 33932529-4 2021 Five flavonoids in vine tea displayed moderate to strong inhibition on hCOMT with IC50 values ranging from 0.96 muM to 42.47 muM, in which myricetin was the critically potent constituent against hCOMT. Flavonoids 5-15 catechol-O-methyltransferase Homo sapiens 195-200 5028212-1 1972 Relationship between the structure of flavonoids and their ability to inhibit catechol-O-methyltransferase]. Flavonoids 38-48 catechol-O-methyltransferase Homo sapiens 78-106