PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35050153-8 2022 Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK). Flavonoids 45-55 dipeptidyl peptidase 4 Homo sapiens 163-185 35634373-9 2022 Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4. Flavonoids 110-120 dipeptidyl peptidase 4 Homo sapiens 420-425 21298326-0 2011 The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. Flavonoids 12-21 dipeptidyl peptidase 4 Homo sapiens 86-90 35634373-0 2022 Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism. Flavonoids 40-50 dipeptidyl peptidase 4 Homo sapiens 14-36 35634373-1 2022 With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner. Flavonoids 74-84 dipeptidyl peptidase 4 Homo sapiens 93-115 35634373-1 2022 With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner. Flavonoids 74-84 dipeptidyl peptidase 4 Homo sapiens 117-122 35634373-1 2022 With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner. Flavonoids 74-84 dipeptidyl peptidase 4 Homo sapiens 283-288 35634373-2 2022 Structure-activity relationship analysis revealed that introducing hydroxyl groups to C3", C4", and C6 of the flavonoid structure was beneficial to improving the inhibitory efficacy against DPP-4, whereas the hydroxylation at position 3 of ring C in the flavonoid structure was unfavorable for the inhibition. Flavonoids 110-119 dipeptidyl peptidase 4 Homo sapiens 190-195 35634373-2 2022 Structure-activity relationship analysis revealed that introducing hydroxyl groups to C3", C4", and C6 of the flavonoid structure was beneficial to improving the inhibitory efficacy against DPP-4, whereas the hydroxylation at position 3 of ring C in the flavonoid structure was unfavorable for the inhibition. Flavonoids 254-263 dipeptidyl peptidase 4 Homo sapiens 190-195 35634373-3 2022 Besides, the methylation of the hydroxyl groups at C3", C4", and C7 of the flavonoid structure tended to lower the inhibitory activity against DPP-4, and the 2,3-double bond and 4-carbonyl group on ring C of the flavonoid structure was essential for the inhibition. Flavonoids 75-84 dipeptidyl peptidase 4 Homo sapiens 143-148 35634373-3 2022 Besides, the methylation of the hydroxyl groups at C3", C4", and C7 of the flavonoid structure tended to lower the inhibitory activity against DPP-4, and the 2,3-double bond and 4-carbonyl group on ring C of the flavonoid structure was essential for the inhibition. Flavonoids 212-221 dipeptidyl peptidase 4 Homo sapiens 143-148 35634373-6 2022 Moreover, the fluorescence quenching analysis indicated that all the five flavonoid compounds could effectively quench the intrinsic fluorescence of DPP-4 by spontaneously binding with it to form an unstable complex. Flavonoids 74-83 dipeptidyl peptidase 4 Homo sapiens 149-154 35634373-7 2022 Hydrogen bonds and van der Waals were the predominant forces to maintain the complex of myricetin with DPP-4, and electrostatic forces might play an important role in stabilizing the complexes of the remaining four flavonoids with DPP-4. Flavonoids 215-225 dipeptidyl peptidase 4 Homo sapiens 231-236 35634373-8 2022 The binding of the tested flavonoids to DPP-4 could also induce the conformation change of DPP-4 and thus led to inhibition on the enzyme. Flavonoids 26-36 dipeptidyl peptidase 4 Homo sapiens 40-45 35634373-8 2022 The binding of the tested flavonoids to DPP-4 could also induce the conformation change of DPP-4 and thus led to inhibition on the enzyme. Flavonoids 26-36 dipeptidyl peptidase 4 Homo sapiens 91-96 35634373-9 2022 Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4. Flavonoids 110-120 dipeptidyl peptidase 4 Homo sapiens 82-87 35634373-9 2022 Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4. Flavonoids 110-120 dipeptidyl peptidase 4 Homo sapiens 247-252 35050153-8 2022 Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK). Flavonoids 45-55 dipeptidyl peptidase 4 Homo sapiens 198-203 33554619-0 2022 A comprehensive review on the antidiabetic activity of flavonoids targeting PTP1B and DPP-4: a structure-activity relationship analysis. Flavonoids 55-65 dipeptidyl peptidase 4 Homo sapiens 86-91 33554619-7 2022 We intend to provide the most favorable chemical features of flavonoids for the inhibition of PTP1B and DPP-4, gathering information for the future development of compounds with improved potential as T2D therapeutic agents. Flavonoids 61-71 dipeptidyl peptidase 4 Homo sapiens 104-109 33554619-6 2022 In the present study, a comprehensive review of the literature of both synthetic and natural isolated flavonoids as inhibitors of PTP1B and DPP-4 activities is made, including their type of inhibition and experimental conditions, and structure-activity relationship, covering a total of 351 compounds. Flavonoids 102-112 dipeptidyl peptidase 4 Homo sapiens 140-145 33427588-3 2021 In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods. Flavonoids 64-74 dipeptidyl peptidase 4 Homo sapiens 269-273 33063510-0 2020 Effects of Different Dietary Flavonoids on Dipeptidyl Peptidase-IV Activity and Expression: Insights into Structure-Activity Relationship. Flavonoids 29-39 dipeptidyl peptidase 4 Homo sapiens 43-66 33063510-1 2020 The inhibitory effects of 30 dietary flavonoids on dipeptidyl peptidase-IV (DPP-IV) were investigated to illustrate their quantitative structure-activity relationship (QSAR) and further explore their inhibition at the cellular level. Flavonoids 37-47 dipeptidyl peptidase 4 Homo sapiens 51-74 33063510-1 2020 The inhibitory effects of 30 dietary flavonoids on dipeptidyl peptidase-IV (DPP-IV) were investigated to illustrate their quantitative structure-activity relationship (QSAR) and further explore their inhibition at the cellular level. Flavonoids 37-47 dipeptidyl peptidase 4 Homo sapiens 76-82 33063510-6 2020 Moreover, the three flavonoids mentioned above could effectively suppress DPP-IV activity and expression in Caco-2 cells. Flavonoids 20-30 dipeptidyl peptidase 4 Homo sapiens 74-80 33063510-7 2020 This work may supply new insights into dietary flavonoids as DPP-IV inhibitors for controlling blood glucose. Flavonoids 47-57 dipeptidyl peptidase 4 Homo sapiens 61-67 31441917-0 2019 The dipeptidyl peptidase-4 inhibitory effect of flavonoids is hindered in protein rich environments. Flavonoids 48-58 dipeptidyl peptidase 4 Homo sapiens 4-26 31441917-2 2019 In the present study, the inhibition of DPP-4 was evaluated for a large panel of flavonoids, important components of the human diet, using in vitro and ex vivo models. Flavonoids 81-91 dipeptidyl peptidase 4 Homo sapiens 40-45 31441917-7 2019 This work provides a new insight into the inhibitory activity for DPP-4, based on the flavonoid scaffold. Flavonoids 86-95 dipeptidyl peptidase 4 Homo sapiens 66-71 31441917-8 2019 Additionally, the obtained results showed that the inhibitory effect of flavonoids against DPP-4 was hindered in protein rich environments, like that occurring in blood, and indicated the need for experimental refinement in drug discovery for blood targets. Flavonoids 72-82 dipeptidyl peptidase 4 Homo sapiens 91-96 29698678-5 2018 All of the tested individual citrus flavonoids demonstrated DPP-4 inhibitory activity, with IC50 values ranging from 485 muM (rutin) to 5700 muM (hesperitin and eriodictyol). Flavonoids 36-46 dipeptidyl peptidase 4 Homo sapiens 60-65 29698678-9 2018 While our data demonstrated that citrus bioflavonoid based supplements do possess DPP-4 inhibitory activity, they are several orders of magnitude less potent than gliptins. Flavonoids 40-52 dipeptidyl peptidase 4 Homo sapiens 82-87